{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:12:37Z","timestamp":1791299557384,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"by National Institutes of Health (NIH)","award":["DK41004 (HER)"],"award-info":[{"award-number":["DK41004 (HER)"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology & Behavior"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.physbeh.2014.10.032","type":"journal-article","created":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T16:54:37Z","timestamp":1415292877000},"page":"188-194","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":130,"special_numbering":"C","title":["Chronic exposure to Low dose bacterial lipopolysaccharide inhibits leptin signaling in vagal afferent neurons"],"prefix":"10.1016","volume":"139","author":[{"given":"Claire B.","family":"de La Serre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"de Lartigue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen E.","family":"Raybould","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2014.10.032_bb0005","doi-asserted-by":"crossref","first-page":"11070","DOI":"10.1073\/pnas.0504978102","article-title":"Obesity alters gut microbial ecology","volume":"102","author":"Ley","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0010","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/nature05414","article-title":"An obesity-associated gut microbiome with increased capacity for energy harvest","volume":"444","author":"Turnbaugh","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0015","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1038\/4441022a","article-title":"Microbial ecology: human gut microbes associated with obesity","volume":"444","author":"Ley","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0020","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3945\/ajcn.110.010132","article-title":"Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans","volume":"94","author":"Jumpertz","year":"2011","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0025","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.chom.2008.02.015","article-title":"Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome","volume":"3","author":"Turnbaugh","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0030","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.2337\/db06-1491","article-title":"Metabolic endotoxemia initiates obesity and insulin resistance","volume":"56","author":"Cani","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0035","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1097\/MCO.0b013e3282efdebb","article-title":"Gut microflora as a target for energy and metabolic homeostasis","volume":"10","author":"Cani","year":"2007","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0040","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1136\/gut.2008.165886","article-title":"Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability","volume":"58","author":"Cani","year":"2009","journal-title":"Gut"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0045","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1053\/j.gastro.2012.01.034","article-title":"A high-fat diet is associated with endotoxemia that originates from the gut","volume":"142","author":"Pendyala","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0050","doi-asserted-by":"crossref","first-page":"G440","DOI":"10.1152\/ajpgi.00098.2010","article-title":"Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation","volume":"299","author":"de La Serre","year":"2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0055","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.2337\/db06-1595","article-title":"Loss-of-function utation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance","volume":"56","author":"Tsukumo","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0060","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.autneu.2009.03.004","article-title":"Neuronal activation in the nucleus of the solitary tract following jejunal lipopolysaccharide in the rat","volume":"148","author":"Gakis","year":"2009","journal-title":"Auton Neurosci"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0065","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1371\/journal.pone.0032967","article-title":"Leptin Resistance in Vagal Afferent Neurons Inhibits Cholecystokinin Signaling and Satiation in Diet Induced Obese Rats","volume":"7","author":"de Lartigue","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0070","doi-asserted-by":"crossref","first-page":"595-60","DOI":"10.1016\/j.molmet.2014.06.003","article-title":"Deletion of leptin signaling in vagal afferent neurons results in hyperphagia and obesity","volume":"3","author":"de Lartigue","year":"2014","journal-title":"Mol Metab"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0075","doi-asserted-by":"crossref","first-page":"G321","DOI":"10.1152\/ajpgi.1993.265.2.G321","article-title":"Substance P levels in experimental ileitis in guinea pigs: effects of misoprostol","volume":"265","author":"Miller","year":"1993","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0080","doi-asserted-by":"crossref","first-page":"2876","DOI":"10.1523\/JNEUROSCI.5508-06.2007","article-title":"Cocaine- and amphetamine-regulated transcript: Stimulation of expression in rat vagal afferent neurons by cholecystokinin and suppression by ghrelin","volume":"27","author":"de Lartigue","year":"2007","journal-title":"J Neurosci"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0085","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/j.neuroscience.2005.10.057","article-title":"Feeding-dependent depression of melanin-concentrating hormone and melanin-concentrating hormone receptor-1 expression in vagal afferent neurones","volume":"137","author":"Burdyga","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0090","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.physbeh.2009.01.009","article-title":"The versatility of the vagus","volume":"97","author":"Dockray","year":"2009","journal-title":"Physiol Behav"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0095","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.autneu.2004.11.012","article-title":"Novel pathway for LPS-induced afferent vagus nerve activation: possible role of nodose ganglion","volume":"120","author":"Hosoi","year":"2005","journal-title":"Auton Neurosci"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0100","doi-asserted-by":"crossref","first-page":"E187","DOI":"10.1152\/ajpendo.00056.2011","article-title":"Diet-induced obesity leads to the development of leptin resistance in vagal afferent neurons","volume":"301","author":"de Lartigue","year":"2011","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0105","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.coph.2009.06.016","article-title":"Interplay between obesity and associated metabolic disorders: new insights into the gut microbiota","volume":"9","author":"Cani","year":"2009","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0110","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jnutbio.2009.11.011","article-title":"Emulsified lipids increase endotoxemia: possible role in early postprandial low-grade inflammation","volume":"22","author":"Laugerette","year":"2011","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0115","doi-asserted-by":"crossref","first-page":"11583","DOI":"10.1523\/JNEUROSCI.2493-08.2008","article-title":"Cholecystokinin regulates expression of Y2 receptors in vagal afferent neurons serving the stomach","volume":"28","author":"Burdyga","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0120","doi-asserted-by":"crossref","first-page":"1241214","DOI":"10.1126\/science.1241214","article-title":"Gut microbiota from twins discordant for obesity modulate metabolism in mice","volume":"341","author":"Ridaura","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0125","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1093\/ajcn\/87.5.1219","article-title":"Energy intake is associated with endotoxemia in apparently healthy men","volume":"87","author":"Amar","year":"2008","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0130","doi-asserted-by":"crossref","first-page":"E898","DOI":"10.1152\/ajpendo.90796.2008","article-title":"Increased expression of receptors for orexigenic factors in nodose ganglion of diet-induced obese rats","volume":"296","author":"Paulino","year":"2009","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0135","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.2337\/db06-1656","article-title":"Visceral fat adipokine secretion is associated with systemic inflammation in obese humans","volume":"56","author":"Fontana","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0140","first-page":"R384","article-title":"Vagal and splanchnic afferents are not necessary for the anorexia produced by peripheral IL-1beta, LPS, and MDP","volume":"275","author":"Porter","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0145","first-page":"R1193","article-title":"Subdiaphragmatic vagal deafferentation fails to block feeding-suppressive effects of LPS and IL-1 beta in rats","volume":"273","author":"Schwartz","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0150","first-page":"R741","article-title":"TNF-alpha tolerance blocks LPS-induced hypophagia but LPS tolerance fails to prevent TNF-alpha-induced hypophagia","volume":"274","author":"Porter","year":"1998","journal-title":"Am J Physiol"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0155","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1182\/blood-2010-11-317479","article-title":"MPO and neutrophils: a magnetic attraction","volume":"117","author":"Hickey","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0160","doi-asserted-by":"crossref","first-page":"R2113","DOI":"10.1152\/ajpregu.2000.279.6.R2113","article-title":"Inhibition of TNF-alpha production contributes to the attenuation of LPS-induced hypophagia by pentoxifylline","volume":"279","author":"Porter","year":"2000","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0165","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1006\/brbi.1999.0565","article-title":"The roles of IL-1, IL-6, and TNFalpha in the feeding responses to endotoxin and influenza virus infection in mice","volume":"13","author":"Swiergiel","year":"1999","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0170","doi-asserted-by":"crossref","first-page":"E858","DOI":"10.1152\/ajpendo.00558.2010","article-title":"Leptin resistance and desensitization of hypophagia during prolonged inflammatory challenge","volume":"300","author":"Borges","year":"2011","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0175","first-page":"R181","article-title":"LPS-induced anorexia in leptin-deficient (ob\/ob) and leptin receptor-deficient (db\/db) mice","volume":"273","author":"Faggioni","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0180","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.physbeh.2004.11.003","article-title":"Acute and chronic administration of immunomodulators induces anorexia in Zucker rats","volume":"84","author":"Lugarini","year":"2005","journal-title":"Physiol Behav"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0185","doi-asserted-by":"crossref","first-page":"1470","DOI":"10.2337\/db07-1403","article-title":"Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice","volume":"57","author":"Cani","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0190","doi-asserted-by":"crossref","first-page":"R1681","DOI":"10.1152\/ajpregu.90733.2008","article-title":"A high-fat diet attenuates the central response to within-meal satiation signals and modifies the receptor expression of vagal afferents in mice","volume":"296","author":"Nefti","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.physbeh.2014.10.032_bb0195","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1093\/jn\/135.8.1953","article-title":"Adaptation to a high-fat diet leads to hyperphagia and diminished sensitivity to cholecystokinin in rats","volume":"135","author":"Savastano","year":"2005","journal-title":"J Nutr"}],"container-title":["Physiology & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938414005095?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938414005095?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T03:31:56Z","timestamp":1566012716000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938414005095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":39,"alternative-id":["S0031938414005095"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2014.10.032","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic exposure to Low dose bacterial lipopolysaccharide inhibits leptin signaling in vagal afferent neurons","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2014.10.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}