{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T01:51:48Z","timestamp":1785808308427,"version":"3.56.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,2,1]],"date-time":"2015-02-01T00:00:00Z","timestamp":1422748800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003968","name":"Iran National Science Foundation","doi-asserted-by":"publisher","award":["91001448"],"award-info":[{"award-number":["91001448"]}],"id":[{"id":"10.13039\/501100003968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology & Behavior"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1016\/j.physbeh.2014.10.038","type":"journal-article","created":{"date-parts":[[2014,11,6]],"date-time":"2014-11-06T17:05:03Z","timestamp":1415293503000},"page":"26-33","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Effects of treadmill running exercise during the adolescent period of life on behavioral deficits in juvenile rats induced by prenatal morphine exposure"],"prefix":"10.1016","volume":"139","author":[{"given":"Ali","family":"Ahmadalipour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Rashidy-Pour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2014.10.038_bb0005","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0095-5108(18)30075-7","article-title":"Early development of infants exposed to drugs prenatally","volume":"26","author":"Eyler","year":"1999","journal-title":"Clin Perinatol"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0010","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.neulet.2005.01.061","article-title":"The effect of prenatal morphine exposure on memory consolidation in the chick","volume":"380","author":"Che","year":"2005","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0015","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/S0091-3057(96)00274-2","article-title":"Prenatal exposure to morphine affects juvenile play behavior and adult social behavior in rats","volume":"55","author":"Hol","year":"1996","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0020","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1111\/j.1460-9568.2004.03597.x","article-title":"Beneficial effects of enriched environment on adolescent rats from stressed pregnancies","volume":"20","author":"Laviola","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0025","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1111\/j.1460-9568.2005.04004.x","article-title":"Voluntary exercise rescues deficits in spatial memory and long-term potentiation in prenatal ethanol-exposed male rats","volume":"21","author":"Christie","year":"2005","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0030","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.braindev.2008.12.012","article-title":"Physical exercise during the adolescent period of life increases hippocampal parvalbumin expression","volume":"32","author":"Gomes da Silva","year":"2010","journal-title":"Brain and Dev"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0035","doi-asserted-by":"crossref","first-page":"8680","DOI":"10.1523\/JNEUROSCI.1731-05.2005","article-title":"Exercise enhances learning and hippocampal neurogenesis in aged mice","volume":"25","author":"Van Praag","year":"2005","journal-title":"J Neurosci"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0040","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1111\/j.1460-9568.2004.03720.x","article-title":"Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition","volume":"20","author":"Vaynman","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0045","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.brainres.2007.02.065","article-title":"Exercise intensity influences the temporal profile of growth factors involved in neuronal plasticity following focal ischemia","volume":"1150","author":"Ploughman","year":"2007","journal-title":"Brain Res"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0050","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/361031a0","article-title":"A synaptic model of memory: long-term potentiation in the hippocampus","volume":"361","author":"Bliss","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0055","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1073\/pnas.0911725107","article-title":"Running enhances spatial pattern separation in mice","volume":"107","author":"Creer","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0060","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0031-9384(00)00282-1","article-title":"Exercise influences spatial learning in the radial arm maze","volume":"70","author":"Anderson","year":"2000","journal-title":"Physiol Behav"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0065","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/6368","article-title":"Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus","volume":"2","author":"Van Praag","year":"1999","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0070","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.physbeh.2011.08.010","article-title":"Anxiety profile in morphine-dependent and withdrawn rats: effect of voluntary exercise","volume":"105","author":"Miladi-Gorji","year":"2012","journal-title":"Physiol Behav"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0075","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.nlm.2011.08.001","article-title":"Voluntary exercise ameliorates cognitive deficits in morphine dependent rats: the role of hippocampal brain-derived neurotrophic factor","volume":"96","author":"Miladi-Gorji","year":"2011","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0080","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0091-3057(85)90382-X","article-title":"Effects of prenatal exposure to morphine on the development of sexual behavior in rats","volume":"22","author":"Vathy","year":"1985","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0085","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.physbeh.2010.09.021","article-title":"Treadmill exercise inhibits traumatic brain injury-induced hippocampal apoptosis","volume":"101","author":"Kim","year":"2010","journal-title":"Physiol Behav"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0090","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0149-7634(85)90030-2","article-title":"Exploratory behavior models of anxiety in mice","volume":"9","author":"Crawley","year":"1985","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0095","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0014-2999(03)01274-3","article-title":"The mouse light\/dark box test","volume":"463","author":"Bourin","year":"2003","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0100","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0163-7258(90)90021-S","article-title":"Ethologically-based animal models of anxiety disorders","volume":"46","author":"Lister","year":"1990","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0105","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1038\/nprot.2007.44","article-title":"The use of the elevated plus maze as an assay of anxiety-related behavior in rodents","volume":"2","author":"Walf","year":"2007","journal-title":"Nat Protoc"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0110","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0006-8993(03)02485-5","article-title":"Exposure to forced swim stress does not alter central production of IL-1","volume":"972","author":"Deak","year":"2003","journal-title":"Brain Res"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0115","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0165-6147(02)02017-5","article-title":"Assessing antidepressant activity in rodents: recent developments and future needs","volume":"23","author":"Cryan","year":"2002","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0120","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.neulet.2005.01.083","article-title":"Prenatal morphine exposure affects sympathoadrenal axis activity and serotonin metabolism in adult male rats both under basal conditions and after an ether inhalation stress","volume":"381","author":"Laborie","year":"2005","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0125","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1016\/j.neuroscience.2008.11.007","article-title":"Prenatal morphine alters the synaptic complex of postsynaptic density 95 with N-methyl-d-aspartate receptor subunit in hippocampal CA1 subregion of rat offspring leading to long-term cognitive deficits","volume":"158","author":"Lin","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0130","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/hipo.20540","article-title":"Impaired in vivo synaptic plasticity in dentate gyrus and spatial memory in juvenile rats induced by prenatal morphine exposure","volume":"19","author":"Niu","year":"2009","journal-title":"Hippocampus"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0135","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1423-0127-17-46","article-title":"Enhancement of tolerance development to morphine in rats prenatally exposed to morphine, methadone, and buprenorphine","volume":"17","author":"Chiang","year":"2010","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0140","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.bbr.2010.12.034","article-title":"Early prenatal morphine exposure impairs performance of learning tasks and attenuates in vitro heterosynaptic long-term potentiation of intermediate medial mesopallium in day-old chicks","volume":"219","author":"Jiang","year":"2011","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0145","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.brainresbull.2005.02.030","article-title":"Alterations of prenatal morphine exposure in mu-opioid receptor density in hypothalamic nuclei associated with sexual behavior","volume":"65","author":"Slamberov\u00e1","year":"2005","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0150","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1002\/hipo.20179","article-title":"Alterations of postsynaptic density proteins in the hippocampus of rat offspring from the morphine-addicted mother: beneficial effect of dextromethorphan","volume":"16","author":"Yang","year":"2006","journal-title":"Hippocampus"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0155","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/0091-3057(86)90552-6","article-title":"Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat","volume":"24","author":"Pellow","year":"1986","journal-title":"Pharmacol Biochem Behav"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0160","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1159\/000112549","article-title":"Serotonin as a differentiation signal in early neurogenesis","volume":"1","author":"Lauder","year":"1978","journal-title":"Dev Neurosci"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0165","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0165-3806(87)90161-1","article-title":"Postnatal changes in serotonin receptors following prenatal alterations in serotonin levels: further evidence for functional fetal serotonin receptors","volume":"33","author":"Whitaker-Azmitia","year":"1987","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0170","first-page":"331","article-title":"Consequences of prenatal morphine exposure on the hypothalamo-pituitary-adrenal axis in the newborn rat: effect of maternal adrenalectomy","volume":"10","author":"Lesage","year":"1998","journal-title":"J Neuroendocrinol"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0175","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1523\/JNEUROSCI.23-07-02889.2003","article-title":"Freewheel running prevents learned helplessness\/behavioral depression: role of dorsal raphe serotonergic neurons","volume":"23","author":"Greenwood","year":"2003","journal-title":"J Neurosci"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0180","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1210\/en.2003-0097","article-title":"Effects of long-term voluntary exercise on the mouse hypothalamic\u2013pituitary\u2013adrenocortical axis","volume":"144","author":"Droste","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0185","doi-asserted-by":"crossref","first-page":"4668","DOI":"10.2174\/092986709789878292","article-title":"Pharmacomimetics of exercise: novel approaches for hippocampally-targeted neuroprotective agents","volume":"16","author":"Stranahan","year":"2009","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0190","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.neuron.2008.06.023","article-title":"TrkB regulates hippocampal neurogenesis and governs sensitivity to antidepressive treatment","volume":"59","author":"Li","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0195","article-title":"Reversal of prenatal morphine exposure-induced memory deficit in male but not female rats","volume":"58\u201369","author":"Nasiraei-Moghadam","year":"2013","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0200","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0031-9384(01)00469-3","article-title":"Prenatal morphine exposure differentially alters learning and memory in male and female rats","volume":"73","author":"Slamberov\u00e1","year":"2001","journal-title":"Physiol Behav"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0205","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.nlm.2007.08.004","article-title":"Treadmill exercise enhances passive avoidance learning in rats: the role of down-regulated serotonin system in the limbic system","volume":"89","author":"Chen","year":"2008","journal-title":"Neurobiol Learn Mem"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0210","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/00131746-199609000-00001","article-title":"Exercise therapy for the prevention and treatment of depression","volume":"2","author":"Gullette","year":"1996","journal-title":"J Pract Psychiatry Behav Health"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0215","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1097\/00131746-200607000-00002","article-title":"Exercise as an augmentation strategy for treatment of major depression","volume":"12","author":"Trivedi","year":"2006","journal-title":"J Psychiatr Pract"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0220","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1055\/s-2003-38202","article-title":"Magnitude-and time-dependence of the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats","volume":"24","author":"Kim","year":"2003","journal-title":"Int J Sports Med"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0225","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/S0022-3565(25)20220-8","article-title":"Neural adaptation in imipramine-treated rats processed in forced swim test: assessment of time course, handling, rat strain and amine uptake","volume":"252","author":"Paul","year":"1990","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0230","first-page":"19","article-title":"Animal models of depression: validity and applications","volume":"49","author":"Willner","year":"1995","journal-title":"Adv Biochem Psychopharmacol"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0235","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0031-9384(86)90110-1","article-title":"Does the behavioral \u201cdespair\u201d test measure \u201cdespair\u201d?","volume":"38","author":"Borsini","year":"1986","journal-title":"Physiol Behav"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0240","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/0031-9384(91)90411-G","article-title":"Effects of diazepam, pentobarbital, scopolamine and the timing of saline injection on learned immobility in rats","volume":"50","author":"De Pablo","year":"1991","journal-title":"Physiol Behav"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0245","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00213-007-0751-x","article-title":"Chronic methadone treatment and repeated withdrawal impair cognition and increase the expression of apoptosis-related proteins in mouse brain","volume":"193","author":"Tramullas","year":"2007","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0250","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.devbrainres.2005.06.012","article-title":"Effects of maternal oral morphine consumption on neural tube development in Wistar rats","volume":"159","author":"Nasiraei-Moghadam","year":"2005","journal-title":"Dev Brain Res"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0255","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s12031-009-9312-6","article-title":"Maternal oral consumption of morphine increases Bax\/Bcl-2 ratio and caspase 3 activity during early neural system development in rat embryos","volume":"41","author":"Nasiraei-Moghadam","year":"2010","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.physbeh.2014.10.038_bb0260","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1002\/hipo.10137","article-title":"Prenatal administration of morphine decreases CREBSerine-133 phosphorylation and synaptic plasticity range mediated by glutamatergic transmission in the hippocampal CA1 area of cognitive-deficient rat offspring","volume":"13","author":"Yang","year":"2003","journal-title":"Hippocampus"}],"container-title":["Physiology & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938414005150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938414005150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T15:39:08Z","timestamp":1747150748000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938414005150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2]]},"references-count":52,"alternative-id":["S0031938414005150"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2014.10.038","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of treadmill running exercise during the adolescent period of life on behavioral deficits in juvenile rats induced by prenatal morphine exposure","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2014.10.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}