{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:05:47Z","timestamp":1791273947585,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["PSI2011-24231"],"award-info":[{"award-number":["PSI2011-24231"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["PSI2012-38019"],"award-info":[{"award-number":["PSI2012-38019"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003086","name":"Basque Government","doi-asserted-by":"publisher","award":["IT-694-13"],"award-info":[{"award-number":["IT-694-13"]}],"id":[{"id":"10.13039\/501100003086","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.physbeh.2014.12.046","type":"journal-article","created":{"date-parts":[[2014,12,29]],"date-time":"2014-12-29T20:02:37Z","timestamp":1419883357000},"page":"58-64","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Prenatal exposure to vanilla or alcohol induces crawling after these odors in the neonate rat: The role of mu and kappa opioid receptor systems"],"prefix":"10.1016","volume":"148","author":[{"given":"Mirari","family":"Gazta\u00f1aga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Ezequiel","family":"Aranda-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Gabriela","family":"Chotro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.physbeh.2014.12.046_bb0005","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1530-0277.2000.tb04551.x","article-title":"Fetal associative learning mediated through maternal alcohol intoxication","volume":"24","author":"Abate","year":"2000","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"2","key":"10.1016\/j.physbeh.2014.12.046_bb0010","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0014-2999(93)90809-V","article-title":"Blockade of delta-opioid receptors in the nucleus accumbens prevents ethanol-induced stimulation of dopamine release","volume":"230","author":"Acquas","year":"1993","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.physbeh.2014.12.046_bb0015","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.pbb.2005.09.015","article-title":"Increased palatability of ethanol after prenatal ethanol exposure is mediated by the opioid system","volume":"82","author":"Arias","year":"2005","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"3","key":"10.1016\/j.physbeh.2014.12.046_bb0020","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/01.ALC.0000156115.35817.21","article-title":"Increased preference for ethanol in the infant rat after prenatal ethanol exposure, expressed on intake and taste reactivity tests","volume":"29","author":"Arias","year":"2005","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"3","key":"10.1016\/j.physbeh.2014.12.046_bb0025","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.physbeh.2009.11.012","article-title":"Differential role of mu, delta and kappa opioid receptors in ethanol-mediated locomotor activation and ethanol intake in preweanling rats","volume":"99","author":"Arias","year":"2010","journal-title":"Physiol. Behav."},{"issue":"4","key":"10.1016\/j.physbeh.2014.12.046_bb0030","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/ptr.2975","article-title":"Pharmacokinetics of vanillin and its effects on mechanical hypersensitivity in a rat model of neuropathic pain","volume":"24","author":"Beaudry","year":"2010","journal-title":"Phytother. Res."},{"issue":"2","key":"10.1016\/j.physbeh.2014.12.046_bb0035","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0149-7634(99)00072-X","article-title":"Measuring hedonic impact in animals and infants: microstructure of affective taste reactivity patterns","volume":"24","author":"Berridge","year":"2000","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1","key":"10.1016\/j.physbeh.2014.12.046_bb0040","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/dev.20108","article-title":"Trace conditioning in 1-day-old rats","volume":"48","author":"Bordner","year":"2006","journal-title":"Dev. Psychobiol."},{"issue":"1","key":"10.1016\/j.physbeh.2014.12.046_bb0045","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0741-8329(03)00037-5","article-title":"Prenatal exposure to ethanol increases ethanol consumption: a conditioned response?","volume":"30","author":"Chotro","year":"2003","journal-title":"Alcohol"},{"issue":"2","key":"10.1016\/j.physbeh.2014.12.046_bb0050","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.neubiorev.2006.06.021","article-title":"Increased ethanol intake after prenatal ethanol exposure: studies with animals","volume":"31","author":"Chotro","year":"2007","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"6","key":"10.1016\/j.physbeh.2014.12.046_bb0055","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.alcohol.2009.08.001","article-title":"Binge ethanol exposure in late gestation induces ethanol aversion in the dam but enhances ethanol intake in the offspring and affects their postnatal learning about ethanol","volume":"43","author":"Chotro","year":"2009","journal-title":"Alcohol"},{"issue":"2","key":"10.1016\/j.physbeh.2014.12.046_bb0060","first-page":"360","article-title":"Repeated exposure to moderate doses of alcohol in the rat fetus: evidence of sensitization to toxic and chemosensory aspects of alcohol","volume":"21","author":"Chotro","year":"1997","journal-title":"Alcohol. Clin. Exp. Res."},{"issue":"1","key":"10.1016\/j.physbeh.2014.12.046_bb0065","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0165-3806(90)90065-7","article-title":"Ontogeny of mu-opioid, delta-opioid and kappa-opioid receptors mediating inhibition of neurotransmitter release and adenylate-cyclase activity in rat-brain","volume":"54","author":"Devries","year":"1990","journal-title":"Dev. Brain Res."},{"issue":"3","key":"10.1016\/j.physbeh.2014.12.046_bb0070","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1037\/a0019482","article-title":"Prenatal binge ethanol exposure on gestation days 19\u201320, but not on days 17\u201318, increases postnatal ethanol acceptance in rats","volume":"124","author":"Diaz-Cenzano","year":"2010","journal-title":"Behav. Neurosci."},{"issue":"6","key":"10.1016\/j.physbeh.2014.12.046_bb0075","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1002\/dev.21162","article-title":"Exposure to ethanol on prenatal days 19\u201320 increases ethanol intake and palatability in the infant rat: involvement of kappa and mu opioid receptors","volume":"56","author":"D\u00edaz-Cenzano","year":"2014","journal-title":"Dev. Psychobiol."},{"issue":"2","key":"10.1016\/j.physbeh.2014.12.046_bb0080","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0741-8329(97)00169-9","article-title":"Neonatal responsiveness to alcohol odor and infant alcohol intake as a function of alcohol experience during late gestation","volume":"16","author":"Dominguez","year":"1998","journal-title":"Alcohol"},{"issue":"4","key":"10.1016\/j.physbeh.2014.12.046_bb0085","first-page":"304","article-title":"Influence of the endogenous opioid system on high alcohol consumption and genetic predisposition to alcoholism","volume":"26","author":"Gianoulakis","year":"2001","journal-title":"J. Psychiatry Neurosci."},{"issue":"2","key":"10.1016\/j.physbeh.2014.12.046_bb0090","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0741-8329(85)90057-6","article-title":"Acetaldehyde and alcohol levels in pregnant rats and their fetuses","volume":"2","author":"Guerri","year":"1985","journal-title":"Alcohol"},{"issue":"4","key":"10.1016\/j.physbeh.2014.12.046_bb0095","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1093\/chemse\/24.4.465","article-title":"The influence of early experience with vanillin on food preference later in life","volume":"24","author":"Haller","year":"1999","journal-title":"Chem. Senses"},{"issue":"2","key":"10.1016\/j.physbeh.2014.12.046_bb0100","first-page":"89","article-title":"Ethanol and acetaldehyde concentrations in pregnant rats after administration of ethanol","volume":"26","author":"Hayashi","year":"1991","journal-title":"Arukoru Kenkyuto Yakubutsu Ison"},{"issue":"2","key":"10.1016\/j.physbeh.2014.12.046_bb0105","first-page":"147","article-title":"Human fetal olfactory learning","volume":"7","author":"Hepper","year":"1995","journal-title":"Int. J. Prenat. Perinat. Psychol. Med."},{"issue":"2","key":"10.1016\/j.physbeh.2014.12.046_bb0110","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s002130050169","article-title":"Endogenous opioid systems and alcohol addiction","volume":"129","author":"Herz","year":"1997","journal-title":"Psychopharmacology (Berl)"},{"issue":"4404","key":"10.1016\/j.physbeh.2014.12.046_bb0115","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1126\/science.451612","article-title":"Appetitive learning in 1-day-old rat pups","volume":"205","author":"Johanson","year":"1979","journal-title":"Science"},{"issue":"2\u20133","key":"10.1016\/j.physbeh.2014.12.046_bb0120","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/0014-2999(92)90055-9","article-title":"Long-term kappa-opioid receptor blockade following nor-binaltorphimine","volume":"215","author":"Jones","year":"1992","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.physbeh.2014.12.046_bb0125","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/(SICI)1098-2302(199811)33:3<235::AID-DEV4>3.0.CO;2-S","article-title":"Effects of amniotic fluid on opioid activity and fetal responses to chemosensory stimuli","volume":"33","author":"Korthank","year":"1998","journal-title":"Dev. Psychobiol."},{"issue":"8","key":"10.1016\/j.physbeh.2014.12.046_bb0130","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1002\/dev.20469","article-title":"Opioid mediation of amniotic fluid effects on chemosensory responsiveness in the neonatal rat","volume":"52","author":"Mendez-Gallardo","year":"2010","journal-title":"Dev. Psychobiol."},{"issue":"3","key":"10.1016\/j.physbeh.2014.12.046_bb0135","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/dev.21102","article-title":"Odor-induced crawling locomotion in the newborn rat: effects of amniotic fluid and milk","volume":"56","author":"Mendez-Gallardo","year":"2014","journal-title":"Dev. Psychobiol."},{"issue":"7","key":"10.1016\/j.physbeh.2014.12.046_bb0140","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1111\/j.1753-4887.1998.tb01749.x","article-title":"Early flavor experiences: research update","volume":"56","author":"Mennella","year":"1998","journal-title":"Nutr. Rev."},{"issue":"6","key":"10.1016\/j.physbeh.2014.12.046_bb0145","doi-asserted-by":"crossref","first-page":"E88","DOI":"10.1542\/peds.107.6.e88","article-title":"Prenatal and postnatal flavor learning by human infants","volume":"107","author":"Mennella","year":"2001","journal-title":"Pediatrics"},{"issue":"3","key":"10.1016\/j.physbeh.2014.12.046_bb0150","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/dev.20000","article-title":"Repeated exposures to gustatory stimuli produce habituation or positive contrast effects in perinatal rats","volume":"44","author":"Mickley","year":"2003","journal-title":"Dev. Psychobiol."},{"issue":"3","key":"10.1016\/j.physbeh.2014.12.046_bb0155","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0091-3057(00)00391-9","article-title":"Ketamine blocks a taste recognition memory in fetal rats","volume":"67","author":"Mickley","year":"2000","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"3\u20134","key":"10.1016\/j.physbeh.2014.12.046_bb0160","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0031-9384(00)00229-8","article-title":"Detection of novelty by perinatal rats","volume":"70","author":"Mickley","year":"2000","journal-title":"Physiol. Behav."},{"issue":"1","key":"10.1016\/j.physbeh.2014.12.046_bb0165","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.physbeh.2010.04.033","article-title":"Participation of the endogenous opioid system in the acquisition of a prenatal ethanol-related memory: effects on neonatal and preweanling responsiveness to ethanol","volume":"101","author":"Miranda-Morales","year":"2010","journal-title":"Physiol. Behav."},{"issue":"3","key":"10.1016\/j.physbeh.2014.12.046_bb0170","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s00213-005-0067-7","article-title":"A single injection of the kappa opioid antagonist nor-binaltorphimine increases ethanol consumption in rats","volume":"182","author":"Mitchell","year":"2005","journal-title":"Psychopharmacology (Berl)"},{"issue":"1","key":"10.1016\/j.physbeh.2014.12.046_bb0175","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/0163-1047(91)80126-Y","article-title":"Association between chemosensory stimuli and cesarean delivery in rat fetuses: neonatal presentation of similar stimuli increases motor activity","volume":"55","author":"Molina","year":"1991","journal-title":"Behav. Neural Biol."},{"issue":"4","key":"10.1016\/j.physbeh.2014.12.046_bb0180","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/dev.420150407","article-title":"Prenatal and postnatal determinants of the 1st suckling episode in albino rats","volume":"15","author":"Pedersen","year":"1982","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.physbeh.2014.12.046_bb0185","series-title":"Handbook of Behavioral Neurobiology","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/978-1-4613-2113-2_5","article-title":"Early development of olfactory function","volume":"vol. 8","author":"Pedersen","year":"1986"},{"issue":"5","key":"10.1016\/j.physbeh.2014.12.046_bb0190","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0031-9384(97)00310-7","article-title":"The newborn rat ingests fluids through a surrogate nipple: a new technique for the study of early suckling behavior","volume":"62","author":"Petrov","year":"1997","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2014.12.046_bb0195","series-title":"Handbook of Developmental Science, Behavior and Genetics","article-title":"Amniotic fluid as an extended milieu interieur","author":"Robinson","year":"2010"},{"issue":"6","key":"10.1016\/j.physbeh.2014.12.046_bb0200","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1093\/chemse\/25.6.729","article-title":"Human foetuses learn odours from their pregnant mother's diet","volume":"25","author":"Schaal","year":"2000","journal-title":"Chem. Senses"},{"issue":"2","key":"10.1016\/j.physbeh.2014.12.046_bb0205","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/dev.10016","article-title":"Classical conditioning in the rat fetus: involvement of mu and kappa opioid systems in the conditioned response","volume":"40","author":"Smotherman","year":"2002","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.physbeh.2014.12.046_bb0210","series-title":"Handbook of Behavioral Neurobiology. Developmental Psychobiology and Behavioral Ecology","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4684-5421-5_5","article-title":"The uterus as environment: the ecology of fetal behavior","author":"Smotherman","year":"1988"},{"issue":"3\u20134","key":"10.1016\/j.physbeh.2014.12.046_bb0215","first-page":"215","article-title":"Habituation in the rat fetus","volume":"44","author":"Smotherman","year":"1992","journal-title":"Q. J. Exp. Psychol. B"},{"issue":"1","key":"10.1016\/j.physbeh.2014.12.046_bb0220","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/0031-9384(94)00198-E","article-title":"Dopamine D1 and D2 effects on fetal mouthing responses to milk","volume":"57","author":"Smotherman","year":"1995","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2014.12.046_bb0225","series-title":"Functional Disorders of Memory","article-title":"Experimental analysis of infantile amnesia","author":"Spear","year":"1979"},{"issue":"1","key":"10.1016\/j.physbeh.2014.12.046_bb0230","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0031-9384(82)90093-2","article-title":"In utero taste\/odor aversion conditioning in the rat","volume":"28","author":"Stickrod","year":"1982","journal-title":"Physiol. Behav."},{"issue":"4","key":"10.1016\/j.physbeh.2014.12.046_bb0235","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0741-8329(97)00131-6","article-title":"A comparison of the effects of the opioid antagonists naltrexone, naltrindole, and beta-funaltrexamine on ethanol consumption in the rat","volume":"15","author":"Stromberg","year":"1998","journal-title":"Alcohol"},{"key":"10.1016\/j.physbeh.2014.12.046_bb0240","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1749-6632.1989.tb21006.x","article-title":"Maternal-fetal pharmacokinetics and fetal dose\u2013response relationships","volume":"562","author":"Szeto","year":"1989","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"1","key":"10.1016\/j.physbeh.2014.12.046_bb0245","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1037\/0735-7044.110.1.154","article-title":"Classical conditioning in the fetal rat: reinforcing properties of dynorphin A (1\u201313)","volume":"110","author":"Varlinskaya","year":"1996","journal-title":"Behav. Neurosci."},{"issue":"4","key":"10.1016\/j.physbeh.2014.12.046_bb0250","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00213-009-1563-y","article-title":"Inhibition of kappa opioid receptors attenuated increased cocaine intake in rats with extended access to cocaine","volume":"205","author":"Wee","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"issue":"2","key":"10.1016\/j.physbeh.2014.12.046_bb0255","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0091-3057(95)02043-8","article-title":"Opioid antagonist profile of SC nor-binaltorphimine in the formalin paw assay","volume":"53","author":"Wettstein","year":"1996","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"10","key":"10.1016\/j.physbeh.2014.12.046_bb0260","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1258\/ebm.2012.012132","article-title":"Gestational naltrexone ameliorates fetal ethanol exposures enhancing effect on the postnatal behavioral and neural response to ethanol","volume":"237","author":"Youngentob","year":"2012","journal-title":"Exp. Biol. Med."}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938414006702?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938414006702?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T01:37:44Z","timestamp":1717637864000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938414006702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":52,"alternative-id":["S0031938414006702"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2014.12.046","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prenatal exposure to vanilla or alcohol induces crawling after these odors in the neonate rat: The role of mu and kappa opioid receptor systems","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2014.12.046","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}