{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:26:19Z","timestamp":1787905579640,"version":"build-2784847793"},"reference-count":80,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["20590711"],"award-info":[{"award-number":["20590711"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["23390189"],"award-info":[{"award-number":["23390189"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2015,8]]},"DOI":"10.1016\/j.physbeh.2015.04.050","type":"journal-article","created":{"date-parts":[[2015,5,3]],"date-time":"2015-05-03T01:22:54Z","timestamp":1430616174000},"page":"264-273","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Prior chronic stress induces persistent polyI:C-induced allodynia and depressive-like behavior in rats: Possible involvement of glucocorticoids and microglia"],"prefix":"10.1016","volume":"147","author":[{"given":"Takeharu","family":"Chijiwa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takakazu","family":"Oka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Battuvshin","family":"Lkhagvasuren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazufumi","family":"Yoshihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Sudo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2015.04.050_bb0005","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1749-6632.2001.tb05827.x","article-title":"Cytokine-induced sickness behavior: mechanisms and implications","volume":"933","author":"Dantzer","year":"2001","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0010","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0149-7634(88)80004-6","article-title":"Biological basis of the behavior of sick animals","volume":"12","author":"Hart","year":"1988","journal-title":"Neuroscience & Biobehavioral Reviews."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0015","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1523\/JNEUROSCI.21-08-02669.2001","article-title":"Coexpression of microsomal-type prostaglandin E synthase with cyclooxygenase-2 in brain endothelial cells of rats during endotoxin-induced fever","volume":"21","author":"Yamagata","year":"2001","journal-title":"J Neurosci."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0020","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nature Reviews Neuroscience."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0025","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/0031-9384(90)90024-X","article-title":"The effects of psychological stress on plasma interleukin-6 activity in rats","volume":"47","author":"LeMay","year":"1990","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0030","doi-asserted-by":"crossref","first-page":"R1799","DOI":"10.1152\/ajpregu.2001.280.6.R1799","article-title":"Social stress induces glucocorticoid resistance in macrophages","volume":"280","author":"Stark","year":"2001","journal-title":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0035","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1034\/j.1601-5215.2003.00026.x","article-title":"The role of the cytokine network in psychological stress","volume":"15","author":"Kim","year":"2003","journal-title":"Acta Neuropsychiatrica."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0040","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/0304-3940(91)90944-O","article-title":"Immobilization stress induces interleukin-1\u03b2 mRNA in the rat hypothalamus","volume":"123","author":"Minami","year":"1991","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0045","doi-asserted-by":"crossref","first-page":"R422","DOI":"10.1152\/ajpregu.00230.2002","article-title":"Effects of prior stress on LPS-induced cytokine and sickness responses","volume":"284","author":"Johnson","year":"2003","journal-title":"Am J Physiol Regul Integr Comp Physiol."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0050","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.bbi.2007.12.001","article-title":"Synergistic and additive actions of a psychosocial stressor and endotoxin challenge: circulating and brain cytokines, plasma corticosterone and behavioral changes in mice","volume":"22","author":"Gibb","year":"2008","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0055","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jneuroim.2007.02.008","article-title":"Interferon-\u03b1 effects are exaggerated when administered on a psychosocial stressor backdrop: cytokine, corticosterone and brain monoamine variations","volume":"186","author":"Anisman","year":"2007","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0060","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.bbi.2006.12.005","article-title":"Influence of poly I: C on sickness behaviors, plasma cytokines, corticosterone and central monoamine activity: moderation by social stressors","volume":"21","author":"Gandhi","year":"2007","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0065","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.2174\/13894501113149990208","article-title":"Acute and chronic stress-induced disturbances of microglial plasticity, phenotype and function","volume":"14","author":"Walker","year":"2013","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.physbeh.2015.04.050_bb0070","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.bbi.2006.03.005","article-title":"Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses","volume":"21","author":"Frank","year":"2007","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0075","doi-asserted-by":"crossref","first-page":"6277","DOI":"10.1523\/JNEUROSCI.0450-11.2011","article-title":"Beta-adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat","volume":"31","author":"Wohleb","year":"2011","journal-title":"J Neurosci."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0080","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.psyneuen.2012.02.003","article-title":"Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice","volume":"37","author":"Wohleb","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.physbeh.2015.04.050_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2013.02.004","article-title":"Stress-induced glucocorticoids as a neuroendocrine alarm signal of danger","volume":"33","author":"Frank","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0090","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.neuron.2009.09.032","article-title":"The stressed CNS: when glucocorticoids aggravate inflammation","volume":"64","author":"Sorrells","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.physbeh.2015.04.050_bb0095","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.bbi.2011.10.005","article-title":"Glucocorticoids mediate stress-induced priming of microglial pro-inflammatory responses","volume":"26","author":"Frank","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0100","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/MOP.0b013e32835c1108","article-title":"Chronic fatigue syndrome following infections in adolescents","volume":"25","author":"Katz","year":"2013","journal-title":"Curr. Opin. Pediatr."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0105","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1053\/j.gastro.2009.02.074","article-title":"Postinfectious irritable bowel syndrome","volume":"136","author":"Spiller","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.physbeh.2015.04.050_bb0110","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1034\/j.1600-0447.2001.00162.x","article-title":"Raised levels of plasma interleukin\u20101\u03b2 in major and postviral depression","volume":"103","author":"Owen","year":"2001","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0115","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0149-7634(96)00057-7","article-title":"The temporal dynamics of the stress response","volume":"21","author":"Koolhaas","year":"1997","journal-title":"Neuroscience & Biobehavioral Reviews."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0120","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/35099560","article-title":"Recognition of double-stranded RNA and activation of NF-kB by toll-like receptor 3","volume":"413","author":"Alexopoulou","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.physbeh.2015.04.050_bb0125","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.bbi.2012.11.010","article-title":"Poly I: C-induced activation of the immune response is accompanied by depression and anxiety-like behaviours, kynurenine pathway activation and reduced BDNF expression","volume":"28","author":"Gibney","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0130","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.bbi.2006.12.007","article-title":"The sickness behaviour and CNS inflammatory mediator profile induced by systemic challenge of mice with synthetic double-stranded RNA (poly I: C)","volume":"21","author":"Cunningham","year":"2007","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0135","doi-asserted-by":"crossref","first-page":"R759","DOI":"10.1152\/ajpregu.00293.2004","article-title":"The viral mimic, polyinosinic: polycytidylic acid, induces fever in rats via an interleukin-1-dependent mechanism","volume":"287","author":"Fortier","year":"2004","journal-title":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0140","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1113\/jphysiol.2005.102939","article-title":"Neonatal programming of the rat neuroimmune response: stimulus specific changes elicited by bacterial and viral mimetics","volume":"571","author":"Ellis","year":"2006","journal-title":"J Physiol (Lond)"},{"key":"10.1016\/j.physbeh.2015.04.050_bb0145","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1139\/Y09-003","article-title":"Comparison of anorexia, lethargy, and fever induced by bacterial and viral mimetics in rats","volume":"87","author":"Hopwood","year":"2009","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0150","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0306-4522(03)00365-8","article-title":"Prolonged effects of polyriboinosinic: polyribocytidylic acid on spontaneous running wheel activity and brain interferon-\u03b1 mRNA in rats: a model for immunologically induced fatigue","volume":"120","author":"Katafuchi","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2015.04.050_bb0155","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1097\/01.wnr.0000179072.86293.7e","article-title":"Spinal cord glia activation following peripheral polyinosine-polycytidylic acid administration","volume":"16","author":"Zhang","year":"2005","journal-title":"Neuroreport"},{"key":"10.1016\/j.physbeh.2015.04.050_bb0160","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.physbeh.2010.04.027","article-title":"Repeated social defeat stress induces chronic hyperthermia in rats","volume":"101","author":"Hayashida","year":"2010","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0165","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1111\/j.1460-9568.2011.07863.x","article-title":"Social defeat stress induces hyperthermia through activation of thermoregulatory sympathetic premotor neurons in the medullary raphe region","volume":"34","author":"Lkhagvasuren","year":"2011","journal-title":"Eur J Neurosci."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0170","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neuroscience.2014.04.047","article-title":"Distribution of fos-immunoreactive cells in rat forebrain and midbrain following social defeat stress and diazepam treatment","volume":"272","author":"Lkhagvasuren","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2015.04.050_bb0175","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.yfrne.2005.03.001","article-title":"Social stress: from rodents to primates","volume":"26","author":"Tamashiro","year":"2005","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0180","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1248\/bpb.30.990","article-title":"Contribution of ca(2+)-dependent protein kinase C in the spinal cord to the development of mechanical allodynia in diabetic mice","volume":"30","author":"Honda","year":"2007","journal-title":"Biol Pharm Bull."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0185","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0031-9384(94)90097-3","article-title":"Open field, learned helplessness, conditioned defensive burying, and forced-swim tests in WKY rats","volume":"55","author":"Par\u00e9","year":"1994","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0190","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0014-2999(78)90118-8","article-title":"Behavioural despair in rats: a new model sensitive to antidepressant treatments","volume":"47","author":"Porsolt","year":"1978","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0195","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3233\/NIB-2012-011030","article-title":"Mechanisms of psychogenic fever","volume":"3","author":"Oka","year":"2012","journal-title":"Advances in Neuroimmune Biology."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0200","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0079-6123(08)62036-1","article-title":"Immunological and neuroendocrine modulation of fever in stress","volume":"115","author":"Roth","year":"1998","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0205","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/0031-9384(91)90556-4","article-title":"The effect of physical restraint on IL-1 [beta]-and LPS-induced fever","volume":"50","author":"Long","year":"1991","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0210","doi-asserted-by":"crossref","first-page":"R1666","DOI":"10.1152\/ajpregu.00865.2007","article-title":"Restraint increases afebrile body temperature but attenuates fever in pekin ducks (Anas platyrhynchos)","volume":"294","author":"Gray","year":"2008","journal-title":"Am J Physiol Regul Integr Comp Physiol."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0215","doi-asserted-by":"crossref","first-page":"R1010","DOI":"10.1152\/ajpregu.1993.264.5.R1010","article-title":"Glucocorticoids alter fever and IL-6 responses to psychological stress and to lipopolysaccharide","volume":"264","author":"Morrow","year":"1993","journal-title":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0220","doi-asserted-by":"crossref","first-page":"R423","DOI":"10.1152\/ajpregu.1992.263.2.R423","article-title":"Endotoxin-induced fever is modulated by endogenous glucocorticoids in rats","volume":"263","author":"Coelho","year":"1992","journal-title":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0225","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0306-4530(01)00057-9","article-title":"Prior stressor exposure primes the HPA axis","volume":"27","author":"Johnson","year":"2002","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.physbeh.2015.04.050_bb0230","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1096\/fj.05-3776fje","article-title":"Exaggerated neuroinflammation and sickness behavior in aged mice following activation of the peripheral innate immune system","volume":"19","author":"Godbout","year":"2005","journal-title":"FASEB J."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0235","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/nri2015","article-title":"Systemic infections and inflammation affect chronic neurodegeneration","volume":"7","author":"Perry","year":"2007","journal-title":"Nature Reviews Immunology."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0240","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jneuroim.2012.08.007","article-title":"Beta-adrenergic receptor activation primes microglia cytokine production","volume":"254","author":"Johnson","year":"2013","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0245","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.jneuroim.2005.03.014","article-title":"Microglia activation in rat spinal cord by systemic injection of TLR3 and TLR7\/8 agonists","volume":"164","author":"Zhang","year":"2005","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0250","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1002\/jnr.21958","article-title":"Peripheral challenge with double\u2010stranded RNA elicits global up\u2010regulation of cytokine gene expression in the brain","volume":"87","author":"Konat","year":"2009","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0255","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0006-8993(93)90060-Z","article-title":"Intracerebroventricular injection of interleukin-1 beta induces hyperalgesia in rats","volume":"624","author":"Oka","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0260","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/0006-8993(94)91466-4","article-title":"Intracerebroventricular injection of interleukin-1\u03b2 enhances nociceptive neuronal responses of the trigeminal nucleus caudalis in rats","volume":"656","author":"Oka","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0265","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0006-8993(95)00691-I","article-title":"Intracerebroventricular injection of interleukin-6 induces thermal hyperalgesia in rats","volume":"692","author":"Oka","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0270","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000097238","article-title":"Intracerebroventricular injection of tumor necrosis factor-alpha induces thermal hyperalgesia in rats","volume":"3","author":"Oka","year":"1996","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.physbeh.2015.04.050_bb0275","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3233\/NIB-130077","article-title":"Influence of psychological stress on chronic fatigue syndrome","volume":"4","author":"Oka","year":"2013","journal-title":"Advances in Neuroimmune Biology."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0280","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.pnpbp.2010.06.020","article-title":"Cytokines mediated inflammation and decreased neurogenesis in animal models of depression","volume":"35","author":"Song","year":"2011","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.physbeh.2015.04.050_bb0285","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.biopsych.2008.11.029","article-title":"Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression","volume":"65","author":"Miller","year":"2009","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.physbeh.2015.04.050_bb0290","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.it.2005.11.006","article-title":"Cytokines sing the blues: inflammation and the pathogenesis of depression","volume":"27","author":"Raison","year":"2006","journal-title":"Trends Immunol."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0295","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.jneuroim.2005.11.021","article-title":"The involvement of norepinephrine and microglia in hypothalamic and splenic IL-1\u03b2 responses to stress","volume":"173","author":"Blandino","year":"2006","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0300","doi-asserted-by":"crossref","first-page":"3813","DOI":"10.1523\/JNEUROSCI.4398-05.2006","article-title":"Chronic unpredictable stress exacerbates lipopolysaccharide-induced activation of nuclear factor-kappaB in the frontal cortex and hippocampus via glucocorticoid secretion","volume":"26","author":"Munhoz","year":"2006","journal-title":"J Neurosci."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0305","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1093\/cercor\/bhr229","article-title":"Evidence that microglia mediate the neurobiological effects of chronic psychological stress on the medial prefrontal cortex","volume":"22","author":"Hinwood","year":"2012","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.physbeh.2015.04.050_bb0310","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0031-9384(01)00541-8","article-title":"Alterations in core body temperature, locomotor activity, and corticosterone following acute and repeated social defeat of male NMRI mice","volume":"74","author":"Keeney","year":"2001","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0315","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.mehy.2011.03.030","article-title":"Chronic fatigue syndrome\u2014a neuroimmunological model","volume":"77","author":"Arnett","year":"2011","journal-title":"Med. Hypotheses"},{"key":"10.1016\/j.physbeh.2015.04.050_bb0320","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1741-7015-11-64","article-title":"A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) and sickness behavior","volume":"11","author":"Morris","year":"2013","journal-title":"BMC Med."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0325","doi-asserted-by":"crossref","first-page":"945","DOI":"10.2967\/jnumed.113.131045","article-title":"Neuroinflammation in patients with chronic fatigue syndrome\/myalgic encephalomyelitis: an 11C-(R)-PK11195 PET study","volume":"55","author":"Nakatomi","year":"2014","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0330","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.pnpbp.2010.08.026","article-title":"In animal models, psychosocial stress-induced (neuro) inflammation, apoptosis and reduced neurogenesis are associated to the onset of depression","volume":"35","author":"Kubera","year":"2011","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.physbeh.2015.04.050_bb0335","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11011-008-9118-1","article-title":"The inflammatory & neurodegenerative (I&ND) hypothesis of depression: leads for future research and new drug developments in depression","volume":"24","author":"Maes","year":"2009","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0340","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/j.neubiorev.2010.09.010","article-title":"Depression: a repair response to stress-induced neuronal microdamage that can grade into a chronic neuroinflammatory condition?","volume":"35","author":"Wager-Smith","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0345","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.psychres.2011.07.015","article-title":"Cumulative life stress in chronic fatigue syndrome","volume":"189","author":"Nater","year":"2011","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0350","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1017\/S0033291703008274","article-title":"Life events, difficulties and dilemmas in the onset of chronic fatigue syndrome: a case\u2013control study","volume":"33","author":"Hatcher","year":"2003","journal-title":"Psychol. Med."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0355","author":"Kessler"},{"key":"10.1016\/j.physbeh.2015.04.050_bb0360","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1186\/1742-2094-5-15","article-title":"Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia","volume":"5","author":"Henry","year":"2008","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.physbeh.2015.04.050_bb0365","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.bbr.2008.09.040","article-title":"Minocycline and neurodegenerative diseases","volume":"196","author":"Kim","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0370","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.bcp.2009.07.028","article-title":"Mitochondria and calcium flux as targets of neuroprotection caused by minocycline in cerebellar granule cells","volume":"79","author":"Garcia-Martinez","year":"2010","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0375","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ejphar.2011.04.014","article-title":"Minocycline attenuates the development of diabetic neuropathic pain: possible anti-inflammatory and anti-oxidant mechanisms","volume":"661","author":"Pabreja","year":"2011","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0380","doi-asserted-by":"crossref","first-page":"19948","DOI":"10.1074\/jbc.M313629200","article-title":"Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria","volume":"279","author":"Wang","year":"2004","journal-title":"J Biol Chem."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0385","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00702-011-0713-7","article-title":"The effect of intrathecal administration of glial activation inhibitors on dorsal horn BDNF overexpression and hind paw mechanical allodynia in spinal nerve ligated rats","volume":"119","author":"Zhang","year":"2012","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.physbeh.2015.04.050_bb0390","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1093\/brain\/awg178","article-title":"Neuroprotection by minocycline facilitates significant recovery from spinal cord injury in mice","volume":"126","author":"Wells","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.physbeh.2015.04.050_bb0395","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1111\/j.1460-9568.2007.05873.x","article-title":"Neuroprotectant minocycline depresses glutamatergic neurotransmission and Ca2 signalling in hippocampal neurons","volume":"26","author":"Gonz\u00e1lez","year":"2007","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.physbeh.2015.04.050_bb0400","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.neuroscience.2010.07.049","article-title":"Minocycline prevents impaired glial glutamate uptake in the spinal sensory synapses of neuropathic rats","volume":"170","author":"Nie","year":"2010","journal-title":"Neuroscience"}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938415002577?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938415002577?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T19:05:21Z","timestamp":1598987121000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938415002577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":80,"alternative-id":["S0031938415002577"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2015.04.050","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2015,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prior chronic stress induces persistent polyI:C-induced allodynia and depressive-like behavior in rats: Possible involvement of glucocorticoids and microglia","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2015.04.050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}