{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T08:31:46Z","timestamp":1782549106760,"version":"3.54.5"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,10,1]],"date-time":"2015-10-01T00:00:00Z","timestamp":1443657600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,6,25]],"date-time":"2016-06-25T00:00:00Z","timestamp":1466812800000},"content-version":"vor","delay-in-days":268,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100011919","name":"Universidade Federal do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011919","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology & Behavior"],"published-print":{"date-parts":[[2015,10]]},"DOI":"10.1016\/j.physbeh.2015.06.025","type":"journal-article","created":{"date-parts":[[2015,6,19]],"date-time":"2015-06-19T08:08:04Z","timestamp":1434701284000},"page":"303-309","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Effects of alpha-tocopherol associated with lovastatin on brain tissue and memory function in SHRSPs"],"prefix":"10.1016","volume":"149","author":[{"given":"Marcela Rodrigues Moreira","family":"Guimar\u00e3es","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Borges","family":"Murad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Paganelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Alberto Bas\u00edlio","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia Marques Alves","family":"Vianna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2015.06.025_bb0005","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s12035-012-8344-z","article-title":"Molecular mechanism of ischemia-reperfusion injury in brain: pivotal role of the mitochondrial membrane potential in reactive species generation","volume":"47","author":"Sanderson","year":"2013","journal-title":"Mol. Neurobiol."},{"issue":"8","key":"10.1016\/j.physbeh.2015.06.025_bb0010","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1503\/cmaj.140053","article-title":"Case management for blood pressure and lipid level control after minor stroke: prevention randomized controlled trial","volume":"186","author":"McAlister","year":"2014","journal-title":"CMAJ"},{"issue":"3","key":"10.1016\/j.physbeh.2015.06.025_bb0015","first-page":"1","article-title":"Statins for the prevention of stroke: a meta-analysis of randomized controlled trials","volume":"9","author":"Wang","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.physbeh.2015.06.025_bb0020","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.atherosclerosis.2015.01.036","article-title":"Statin therapy is associated with lower all-cause mortality in patients with non-obstructive coronary artery disease","volume":"293","author":"Hwang","year":"2015","journal-title":"Atherosclerosis"},{"issue":"3","key":"10.1016\/j.physbeh.2015.06.025_bb0025","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/biof.1157","article-title":"HMG-CoA reductase inhibitors (statins), inflammation, and endothelial progenitor cells\u2014new mechanistic insights of atherosclerosis","volume":"40","author":"Blum","year":"2014","journal-title":"Biofactors"},{"issue":"9","key":"10.1016\/j.physbeh.2015.06.025_bb0030","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/j.amjmed.2011.04.019","article-title":"Dose-related effect of statins in venous thrombosis risk reduction","volume":"124","author":"Khemasuwan","year":"2011","journal-title":"Am. J. Med."},{"issue":"3","key":"10.1016\/j.physbeh.2015.06.025_bb0035","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s40263-013-0135-1","article-title":"Neuropsychiatric adverse events associated with statins: epidemiology, pathophysiology, prevention and management","volume":"28","author":"Tuccori","year":"2014","journal-title":"CNS Drugs"},{"issue":"6","key":"10.1016\/j.physbeh.2015.06.025_bb0040","first-page":"448","article-title":"Statins in nervous system-associated diseases: angels or devils?","volume":"69","author":"Lei","year":"2014","journal-title":"Pharmazie"},{"key":"10.1016\/j.physbeh.2015.06.025_bb0045","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1001\/jama.287.5.598","article-title":"Effects of diet and simvastatin on serum lipids, insulin, and antioxidants in hypercholesterolemic men: a randomized controlled trial","volume":"287","author":"Jula","year":"2002","journal-title":"J. Am. Med. Assoc."},{"issue":"1","key":"10.1016\/j.physbeh.2015.06.025_bb0050","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s13105-013-0279-y","article-title":"Alpha-tocopherol in the brain tissue preservation of stroke-prone spontaneously hypertensive rats","volume":"70","author":"Murad","year":"2014","journal-title":"J. Physiol. Biochem."},{"issue":"12","key":"10.1016\/j.physbeh.2015.06.025_bb0055","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/j.exger.2013.09.006","article-title":"Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults","volume":"48","author":"Mangialasche","year":"2013","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.physbeh.2015.06.025_bb0060","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S0022-2275(20)40727-8","article-title":"Absorption, lipoprotein transport, and regulation of plasma concentrations of vitamin E in humans","volume":"34","author":"Kayden","year":"1993","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.physbeh.2015.06.025_bb0065","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0014-5793(02)02706-0","article-title":"Non-antioxidant molecular functions of alpha-tocopherol (vitamin E)","volume":"519","author":"Azzi","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.physbeh.2015.06.025_bb0070","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1515\/BC.2002.048","article-title":"The 80th anniversary of vitamin E: beyond its antioxidant properties","volume":"383","author":"Ricciarelli","year":"2002","journal-title":"Biol. Chem."},{"key":"10.1016\/j.physbeh.2015.06.025_bb0075","series-title":"Manual de Fisiologia Experimental","author":"Vianna","year":"2009"},{"issue":"4","key":"10.1016\/j.physbeh.2015.06.025_bb0080","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.neubiorev.2004.06.002","article-title":"Motor and function evaluation following experimental traumatic brain injury","volume":"28","author":"Fujimoto","year":"2004","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.physbeh.2015.06.025_bb0085","series-title":"Methods of Enzymatic Analysis","author":"Bergmeyer","year":"1983"},{"issue":"2","key":"10.1016\/j.physbeh.2015.06.025_bb0090","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.neuroscience.2009.12.062","article-title":"Simvastatin enhances hippocampal long-potentiation in C57BL\/6 mice","volume":"166","author":"Mans","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2015.06.025_bb0095","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1177\/1545968309348318","article-title":"Vitamin E protects against oxidative injury and learning disability after mild traumatic brain injury in rats","volume":"24","author":"Wu","year":"2010","journal-title":"Neurorehabil. Neural Repair"},{"issue":"1\u20132","key":"10.1016\/j.physbeh.2015.06.025_bb0100","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0006-8993(95)00271-Q","article-title":"Impairment of long-term potentiation in rats fed with vitamin E-deficient diet","volume":"681","author":"Xie","year":"1995","journal-title":"Brain Res."},{"issue":"12","key":"10.1016\/j.physbeh.2015.06.025_bb0105","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1016\/j.freeradbiomed.2010.09.034","article-title":"Modulation of gene expression by \u03b1-tocopherol and \u03b1-tocopheryl phosphate in THP-1 monocytes","volume":"49","author":"Zingg","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.physbeh.2015.06.025_bb0110","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3164\/jcbn.10-58","article-title":"Glucocorticoids generates ROS to induce oxidative injury in the hippocampus, leading to impairment of cognitive function of rats","volume":"47","author":"Sato","year":"2010","journal-title":"J. Clin. Biochem. Nutr."},{"issue":"11","key":"10.1016\/j.physbeh.2015.06.025_bb0115","first-page":"1415","article-title":"Vitamin E prevents apoptosis in cortical neurons during hypoxia and oxygen reperfusion","volume":"78","author":"Tagami","year":"1998","journal-title":"Lab. Investig."},{"issue":"2","key":"10.1016\/j.physbeh.2015.06.025_bb0120","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1161\/01.STR.14.2.266","article-title":"CSF enzymes in lacunar and cortical stroke","volume":"14","author":"Donnan","year":"1983","journal-title":"Stroke"},{"issue":"7","key":"10.1016\/j.physbeh.2015.06.025_bb0125","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1007\/s00268-002-6271-2","article-title":"Intramuscular administration of very high dose of alpha-tocopherol protects liver from severe ischemia\/reperfusion injury","volume":"26","author":"Giakoustidis","year":"2002","journal-title":"World J. Surg."},{"key":"10.1016\/j.physbeh.2015.06.025_bb0130","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.jvs.2007.04.044","article-title":"Resveratrol neuroprotective effects during focal cerebral ischemia injury via nitric oxide mechanism in rats","volume":"46","author":"Tsai","year":"2007","journal-title":"J. Vasc. Surg."},{"key":"10.1016\/j.physbeh.2015.06.025_bb0135","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1186\/1471-2202-13-103","article-title":"Failure of delayed nonsynaptic neuronal plasticity underlies age-associated long-term associative memory impairment","volume":"13","author":"Watson","year":"2012","journal-title":"BMC Neurosci."},{"issue":"3","key":"10.1016\/j.physbeh.2015.06.025_bb0140","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/01.fjc.0000211708.03111.6e","article-title":"Inhibitory effect of Magnolia officinalis and lovastatin on aortic oxidative stress and apoptosis in hyperlipidemic rabbits","volume":"47","author":"Chang","year":"2006","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"4","key":"10.1016\/j.physbeh.2015.06.025_bb0145","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.fct.2010.12.014","article-title":"The effect of lovastatin on oxidative stress and antioxidante enzymes in hydrogen peroxide intoxicated rats","volume":"49","author":"Kumar","year":"2011","journal-title":"Food Chem. Toxicol."},{"issue":"22","key":"10.1016\/j.physbeh.2015.06.025_bb0150","doi-asserted-by":"crossref","first-page":"2542","DOI":"10.2174\/1568026614666141203130324","article-title":"Pleiotropic effects of statins in atherosclerotic disease: focus on the antioxidant activity of atorvastatin","volume":"14","author":"Profumo","year":"2014","journal-title":"Curr. Top. Med. Chem."},{"issue":"9","key":"10.1016\/j.physbeh.2015.06.025_bb0155","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1093\/eurheartj\/ehn138","article-title":"Prolonged statin-associated reduction in neutrophil reactive oxygen species and angiotensin II type 1 receptor expression: 1-year follow-up","volume":"29","author":"Guasti","year":"2008","journal-title":"Eur. Heart J."},{"issue":"7","key":"10.1016\/j.physbeh.2015.06.025_bb0160","first-page":"3313","article-title":"Neuroprotective effect of lovastatin by inhibiting NMDA receptor 1 in 6-hydroxydopamine treated PC12 cells","volume":"15","author":"Yan","year":"2014","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"4","key":"10.1016\/j.physbeh.2015.06.025_bb0165","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.pediatrneurol.2011.06.016","article-title":"Lovastatin as treatment for neurocognitive deficits in neurofibromatosis type 1: phase I study","volume":"45","author":"Acosta","year":"2011","journal-title":"Pediatr. Neurol."},{"issue":"5","key":"10.1016\/j.physbeh.2015.06.025_bb0170","first-page":"333","article-title":"Impairment of learning and memory ability in mice with latent infection of Toxoplasma gondii","volume":"29","author":"Zhou","year":"2011","journal-title":"Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi"},{"issue":"62 (5)","key":"10.1016\/j.physbeh.2015.06.025_bb0175","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/QAI.0b013e31827f1bdb","article-title":"Neurovirological correlation with HIV-associated neurocognitive disorders and encephalitis in a HAART-era cohort","volume":"15","author":"Gelman","year":"2013","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"10.1016\/j.physbeh.2015.06.025_bb0180","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0006-8993(01)02822-0","article-title":"Cycloheximide reduces infarct volume when administered up to 6h after mild focal ischemia in rats","volume":"917","author":"Snider","year":"2001","journal-title":"Brain Res."},{"issue":"4","key":"10.1016\/j.physbeh.2015.06.025_bb0185","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1161\/01.HYP.0000154879.49245.39","article-title":"Reduction of Gstm1 expression in the stroke-prone spontaneously hypertension rat contributes to increased oxidative stress","volume":"45","author":"McBride","year":"2005","journal-title":"Hypertension"},{"issue":"6","key":"10.1016\/j.physbeh.2015.06.025_bb0190","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1248\/bpb.25.734","article-title":"Comparison of subcellular distribution of mevalonate pyrophosphate decarboxylase between stroke-prone spontaneously hypertensive rat and Wistar Kyoto rat","volume":"25","author":"Michihara","year":"2002","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.physbeh.2015.06.025_bb0195","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1097\/01.WCB.0000041283.53351.CB","article-title":"Temporal profile of angiogenesis and expression of related genes in the brain after ischemia","volume":"23","author":"Hayashi","year":"2003","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.physbeh.2015.06.025_bb0200","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1161\/01.STR.28.3.564","article-title":"A putative role for platelet-derived growth factor in angiogenesis and neuroprotection after ischemic stroke in humans","volume":"28","author":"Krupinski","year":"1997","journal-title":"Stroke"},{"key":"10.1016\/j.physbeh.2015.06.025_bb0205","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s00392-003-1007-3","article-title":"Neuropathological findings after cardiac surgery\u2014retrospective study over 6years","volume":"92","author":"Emmrich","year":"2003","journal-title":"Z. Kardiol."}],"container-title":["Physiology & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003193841500373X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003193841500373X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T16:17:48Z","timestamp":1691770668000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S003193841500373X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":41,"alternative-id":["S003193841500373X"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2015.06.025","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2015,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of alpha-tocopherol associated with lovastatin on brain tissue and memory function in SHRSPs","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2015.06.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}