{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:27:36Z","timestamp":1790735256871,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,11,1]],"date-time":"2015-11-01T00:00:00Z","timestamp":1446336000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"publisher","award":["R01 DK078201"],"award-info":[{"award-number":["R01 DK078201"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"publisher","award":["DK017844"],"award-info":[{"award-number":["DK017844"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology & Behavior"],"published-print":{"date-parts":[[2015,11]]},"DOI":"10.1016\/j.physbeh.2015.08.038","type":"journal-article","created":{"date-parts":[[2015,9,3]],"date-time":"2015-09-03T21:54:26Z","timestamp":1441317266000},"page":"623-628","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Inconsistencies in the hypophagic action of intracerebroventricular insulin in mice"],"prefix":"10.1016","volume":"151","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7117-840X","authenticated-orcid":false,"given":"Eugenia","family":"Mc Allister","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Pacheco-Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Woods","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Langhans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2015.08.038_bb0005","first-page":"A40","article-title":"Melanocortins mediate insulin-induced hypophagia","volume":"51","author":"Air","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.physbeh.2015.08.038_bb0010","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.physbeh.2006.08.008","article-title":"Intraventricular insulin and leptin reduce food intake and body weight in C57BL\/6J mice","volume":"89","author":"Brown","year":"2006","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2015.08.038_bb0015","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.2337\/db08-1039","article-title":"Hypothalamic reactive oxygen species are required for insulin-induced food intake inhibition: an NADPH oxidase-dependent mechanism","volume":"58","author":"Jaillard","year":"2009","journal-title":"Diabetes"},{"key":"10.1016\/j.physbeh.2015.08.038_bb0020","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0091-3057(01)00780-8","article-title":"Acute third ventricular administration of insulin decreases food intake in two paradigms","volume":"72","author":"Air","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2015.08.038_bb0025","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/0031-9384(86)90177-0","article-title":"Dependence of food intake on acute and chronic ventricular administration of insulin","volume":"37","author":"Plata-Salaman","year":"1986","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2015.08.038_bb0030","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/282503a0","article-title":"Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons","volume":"282","author":"Woods","year":"1979","journal-title":"Nature"},{"key":"10.1016\/j.physbeh.2015.08.038_bb0035","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0031-9384(91)90053-Q","article-title":"Intraventricular insulin reduces food-intake and body-weight of marmots during the summer feeding period","volume":"49","author":"Florant","year":"1991","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2015.08.038_bb0040","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.neulet.2007.07.004","article-title":"Central administration of insulin suppresses food intake in chicks","volume":"423","author":"Honda","year":"2007","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.physbeh.2015.08.038_bb0045","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1517\/17425247.4.4.319","article-title":"Targeting metabolic and cognitive pathway of the CNS by intranasal insulin administration","volume":"4","author":"Hallschmidt","year":"2007","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.physbeh.2015.08.038_bb0050","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1038\/oby.2009.194","article-title":"Central administration of an endoplasmic reticulum stress inducer inhibits the anorexigenic effects of leptin and insulin","volume":"17","author":"Won","year":"2009","journal-title":"Obesity"},{"key":"10.1016\/j.physbeh.2015.08.038_bb0055","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1097\/HJH.0b013e32833c2289","article-title":"Differential effects of insulin on sympathetic nerve activity in agouti obese mice","volume":"28","author":"Morgan","year":"2010","journal-title":"J. Hypertens."},{"key":"10.1016\/j.physbeh.2015.08.038_bb0060","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1002\/hipo.20822","article-title":"Exercise increases insulin signaling in the hippocampus: physiological effects and pharmacological impact of intracerebroventricular insulin administration in mice","volume":"21","author":"Muller","year":"2011","journal-title":"Hippocampus"},{"key":"10.1016\/j.physbeh.2015.08.038_bb0065","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.physbeh.2011.01.010","article-title":"Consumption of a high-fat diet induces central insulin resistance independent of adiposity","volume":"103","author":"Clegg","year":"2011","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2015.08.038_bb0070","doi-asserted-by":"crossref","first-page":"E1408","DOI":"10.1152\/ajpendo.00415.2012","article-title":"Inconsistencies in the assessment of food intake","volume":"303","author":"Woods","year":"2012","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.physbeh.2015.08.038_bb0075","doi-asserted-by":"crossref","first-page":"R43","DOI":"10.1152\/ajpregu.90736.2008","article-title":"Evaluation of the lack of anorectic effect of intracerebroventricular insulin in rats","volume":"298","author":"Jessen","year":"2010","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.physbeh.2015.08.038_bb0080","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1743-8454-2-5","article-title":"In normal rat, intraventricularly administered insulin-like growth factor-1 is rapidly cleared from CSF with limited distribution into brain","volume":"2","author":"Nagaraja","year":"2005","journal-title":"Cerebrospinal Fluid Res."},{"key":"10.1016\/j.physbeh.2015.08.038_bb0085","series-title":"Current Protocols in Molecular Biology","article-title":"Evaluation of glucose homeostasis","author":"Heikkinen","year":"2007"},{"key":"10.1016\/j.physbeh.2015.08.038_bb0090","doi-asserted-by":"crossref","first-page":"682","DOI":"10.2337\/diabetes.52.3.682","article-title":"Differential sensitivity to central leptin and insulin in male and female rats","volume":"52","author":"Clegg","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.physbeh.2015.08.038_bb0095","doi-asserted-by":"crossref","first-page":"3024","DOI":"10.2337\/diabetes.53.11.3024","article-title":"Intranasal insulin reduces body fat in men but not in women","volume":"53","author":"Hallschmid","year":"2004","journal-title":"Diabetes"},{"key":"10.1016\/j.physbeh.2015.08.038_bb0100","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1006\/anbe.2001.1950","article-title":"Incorrect analysis of crossover trials in animal behaviour research","volume":"63","author":"Diaz-Uriarte","year":"2002","journal-title":"Anim. Behav."},{"key":"10.1016\/j.physbeh.2015.08.038_bb0105","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.0105-1873.2006.0866g.x","article-title":"Severe adverse cutaneous reaction to insulin due to cresol sensitivity","volume":"55","author":"Rajpar","year":"2006","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.physbeh.2015.08.038_bb0110","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1007\/s00125-011-2111-y","article-title":"Unconditioned and conditioned effects of intranasally administered insulin vs placebo in healthy men: a randomised controlled trial","volume":"54","author":"Stockhorst","year":"2011","journal-title":"Diabetologia"},{"key":"10.1016\/j.physbeh.2015.08.038_bb0115","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.physbeh.2011.01.014","article-title":"Unconditioned and conditioned effects of intravenous insulin and glucose on heart rate variability in healthy men","volume":"103","author":"Stockhorst","year":"2011","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2015.08.038_bb0120","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1037\/h0040308","article-title":"Conditioning of a hyper-insulin type of behavior in the white rat","volume":"51","author":"Reiss","year":"1958","journal-title":"J. Comp. Physiol. Psychol."},{"key":"10.1016\/j.physbeh.2015.08.038_bb0125","first-page":"53","article-title":"Insulin and the brain: a mutual dependency. In Fluharty, S., A.R. Morrison, J. Sprague and E. Stellar (eds.):","volume":"16","author":"Woods","year":"1995","journal-title":"Prog. Psychobiol. Physiol. Psychol."},{"key":"10.1016\/j.physbeh.2015.08.038_bb0130","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1037\/h0028186","article-title":"Temporal parameters of conditioned hypoglycemia","volume":"69","author":"Woods","year":"1969","journal-title":"J. Comp. Physiol. Psychol."},{"key":"10.1016\/j.physbeh.2015.08.038_bb0135","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/0031-9384(95)00108-U","article-title":"Central insulin enhances sensitivity to cholecystokinin","volume":"58","author":"Riedy","year":"1995","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2015.08.038_bb0140","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1210\/endo.143.6.8948","article-title":"Insulin and leptin combine additively to reduce food intake and body weight in rats","volume":"143","author":"Air","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.physbeh.2015.08.038_bb0145","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0014-4886(66)90122-1","article-title":"Effect of insulin administered intracisternally on the glucose level of the blood and the cerebrospinal fluid in vagotomized dogs","volume":"14","author":"Chowers","year":"1966","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.physbeh.2015.08.038_bb0150","doi-asserted-by":"crossref","first-page":"905","DOI":"10.2337\/diab.24.10.905","article-title":"Effect of intracisternal insulin on plasma glucose and insulin in the dog","volume":"24","author":"Woods","year":"1975","journal-title":"Diabetes"},{"key":"10.1016\/j.physbeh.2015.08.038_bb0155","doi-asserted-by":"crossref","first-page":"910","DOI":"10.2337\/diab.24.10.910","article-title":"Effect of cerebral intraventricular insulin on pancreatic insulin secretion in the dog","volume":"24","author":"Chen","year":"1975","journal-title":"Diabetes"},{"key":"10.1016\/j.physbeh.2015.08.038_bb0160","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1037\/0033-295X.104.1.170","article-title":"Biological consequences of drug administration: implications for acute and chronic tolerance","volume":"104","author":"Ramsay","year":"1997","journal-title":"Psychol. Rev."},{"key":"10.1016\/j.physbeh.2015.08.038_bb0165","doi-asserted-by":"crossref","first-page":"9048","DOI":"10.1523\/JNEUROSCI.22-20-09048.2002","article-title":"The catabolic action of insulin in the brain is mediated by melanocortins","volume":"22","author":"Benoit","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.physbeh.2015.08.038_bb0170","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1097\/01.sla.0000183349.16877.84","article-title":"Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters","volume":"243","author":"le Roux","year":"2006","journal-title":"Ann. Surg."},{"key":"10.1016\/j.physbeh.2015.08.038_bb0175","doi-asserted-by":"crossref","DOI":"10.1038\/nature02665","article-title":"Physiology: does gut hormone PYY3-36 decrease food intake in rodents?","volume":"430","author":"Tschop","year":"2004","journal-title":"Nature"}],"container-title":["Physiology & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938415300925?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938415300925?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,30]],"date-time":"2019-08-30T01:16:42Z","timestamp":1567127802000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938415300925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11]]},"references-count":35,"alternative-id":["S0031938415300925"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2015.08.038","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inconsistencies in the hypophagic action of intracerebroventricular insulin in mice","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2015.08.038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}