{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T22:58:48Z","timestamp":1791932328589,"version":"4.3.4"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation, China","doi-asserted-by":"crossref","award":["2014M562675"],"award-info":[{"award-number":["2014M562675"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology & Behavior"],"published-print":{"date-parts":[[2016,2]]},"DOI":"10.1016\/j.physbeh.2015.11.016","type":"journal-article","created":{"date-parts":[[2015,11,22]],"date-time":"2015-11-22T06:59:05Z","timestamp":1448175545000},"page":"114-125","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":114,"special_numbering":"C","title":["Protective effect of tetrahydropalmatine against d-galactose induced memory impairment in rat"],"prefix":"10.1016","volume":"154","author":[{"given":"Zhuo","family":"Qu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingze","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honggai","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqin","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyuan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2015.11.016_bb0005","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0531-5565(02)00160-2","article-title":"The neurobiology of memory changes in normal aging","volume":"38","author":"Erickson","year":"2003","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.physbeh.2015.11.016_bb0010","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.fct.2013.06.009","article-title":"Mussel oligopeptides ameliorate cognition deficit and attenuate brain senescence in d-galactose-induced aging mice","volume":"59","author":"Zhou","year":"2013","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.physbeh.2015.11.016_bb0015","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.fct.2014.08.020","article-title":"Curcumin and hesperidin improve cognition by suppressing mitochondrial dysfunction and apoptosis induced by d-galactose in rat brain","volume":"74","author":"Banji","year":"2014","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.physbeh.2015.11.016_bb0020","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.pbb.2010.05.021","article-title":"Icariin isolated from Epimedium brevicornum Maxim attenuates learning and memory deficits induced by d-galactose in rats","volume":"96","author":"Li","year":"2010","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2015.11.016_bb0025","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.anaerobe.2014.03.003","article-title":"Lactobacillus pentosus var. plantarum C29 ameliorates memory impairment and inflammation in a d-galactose-induced accelerated aging mouse model","volume":"27","author":"Woo","year":"2014","journal-title":"Anaerobe"},{"key":"10.1016\/j.physbeh.2015.11.016_bb0030","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/jnr.20899","article-title":"Chronic systemic d-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-a-Lipoic acid","volume":"84","author":"Cui","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.physbeh.2015.11.016_bb0035","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.bbr.2004.07.003","article-title":"Behavioural study of the d-galactose induced aging model in C57BL\/6 J mice","volume":"157","author":"Wei","year":"2005","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2015.11.016_bb0040","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.pbb.2013.12.006","article-title":"Berberine rescues d-galactose-induced synaptic\/memory impairment by regulating the levels of Arc","volume":"117","author":"Zhang","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2015.11.016_bb0045","doi-asserted-by":"crossref","first-page":"4075","DOI":"10.1016\/j.bmc.2011.05.014","article-title":"New vasorelaxant indole alkaloids, villocarines A\u2013D from Uncaria villosa","volume":"19","author":"Matsuo","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.physbeh.2015.11.016_bb0050","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1590\/S0074-02761991000600039","article-title":"Development of natural products as drugs acting on central nervous system","volume":"86","author":"Zhu","year":"1991","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.physbeh.2015.11.016_bb0055","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1111\/j.1440-1681.1996.tb01769.x","article-title":"Antihypertensive effects of dl-tetrahydropalmatine: an active principle isolated from corydalis","volume":"23","author":"Chueh","year":"1996","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.physbeh.2015.11.016_bb0060","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.lfs.2010.05.011","article-title":"Protective effects of tetrahydropalmatine against \u03b3-radiation induced damage to human endothelial cells","volume":"87","author":"Yu","year":"2010","journal-title":"Life Sci."},{"key":"10.1016\/j.physbeh.2015.11.016_bb0065","first-page":"S75","article-title":"Evaluation of the anxiolytic properties of tetrahydropalmatine, a Corydalis yanhusuo compound, in the male Sprague\u2013Dawley rat","volume":"79","author":"Henkes","year":"2011","journal-title":"AANA J."},{"key":"10.1016\/j.physbeh.2015.11.016_bb0070","article-title":"l-Tetrahydropalmatine, an active component of Corydalis yanhusuo W.T. Wang, protects against myocardial ischaemia\u2013reperfusion injury in rats","volume":"7","author":"Han","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.physbeh.2015.11.016_bb0075","first-page":"300","article-title":"New pharmacological effects of tetrahydroprotoberberines on dopamine receptor","volume":"14","author":"Jin","year":"2000","journal-title":"Bull. Nat. Sci. Found. China"},{"key":"10.1016\/j.physbeh.2015.11.016_bb0080","first-page":"487","article-title":"Studies on the pharmacological actions of Corydalis. Viii. Structure\u2013activity relationship of analogues of Corydalis B (tetrahydropalmatine)","volume":"40","author":"Kin","year":"1962","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.physbeh.2015.11.016_bb0085","first-page":"182","article-title":"Pharmacologic actions of tetrahydroberberine on the central nervous system","volume":"25","author":"Kin","year":"1962","journal-title":"Acta Phys. Sin."},{"key":"10.1016\/j.physbeh.2015.11.016_bb0090","first-page":"110","article-title":"Studies on the pharmacological actions of Corydalis. VI. Effects of Corydalis B on the central nervous system","volume":"24","author":"Kin","year":"1960","journal-title":"Acta Phys. Sin."},{"key":"10.1016\/j.physbeh.2015.11.016_bb0095","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0304-3940(01)01962-0","article-title":"dl-Tetrahydropalmatine may act through inhibition of amygdaloid release of dopamine to inhibit an epileptic attack in rats","volume":"307","author":"Chang","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.physbeh.2015.11.016_bb0100","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1007\/s12264-012-1236-4","article-title":"Tetrahydropalmatine protects against methamphetamine-induced spatial learning and memory impairment in mice","volume":"28","author":"Chen","year":"2012","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.physbeh.2015.11.016_bb0105","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1097\/ALN.0b013e31824be8c7","article-title":"Tau phosphorylation and sevoflurane anesthesia: an association to postoperative cognitive impairment","volume":"116","author":"Le Freche","year":"2012","journal-title":"Anesthesiology"},{"key":"10.1016\/j.physbeh.2015.11.016_bb0110","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1016\/j.neurobiolaging.2014.03.027","article-title":"Beneficial effects of caffeine in a transgenic model of Alzheimer's disease-like tau pathology","volume":"35","author":"Laurent","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.physbeh.2015.11.016_bb0115","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1016\/j.neurobiolaging.2014.06.003","article-title":"Beneficial synergistic effects of microdose lithium with pyrroloquinoline quinone in an Alzheimer's disease mouse model","volume":"35","author":"Zhao","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.physbeh.2015.11.016_bb0120","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.lfs.2011.02.010","article-title":"Ganoderma atrum polysaccharide attenuates oxidative stress induced by d-galactose in mouse brain","volume":"88","author":"Li","year":"2011","journal-title":"Life Sci."},{"key":"10.1016\/j.physbeh.2015.11.016_bb0125","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/nature02621","article-title":"Pathways towards and away from Alzheimer's disease","volume":"430","author":"Mattson","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.physbeh.2015.11.016_bb0130","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1093\/gerona\/59.5.M478","article-title":"Free radicals: key to brain aging and heme oxygenase as a cellular response to oxidative stress","volume":"59","author":"Poon","year":"2004","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.physbeh.2015.11.016_bb0135","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1749-6632.2001.tb03627.x","article-title":"Free radical-mediated molecular damage","volume":"939","author":"Reiter","year":"2001","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.physbeh.2015.11.016_bb0140","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1146\/annurev.psych.48.1.649","article-title":"Central cholinergic systems and cognition","volume":"48","author":"Everitt","year":"1997","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.physbeh.2015.11.016_bb0145","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/j.neurobiolaging.2004.07.015","article-title":"Forebrain acetylcholine regulates adult hippocampal neurogenesis and learning","volume":"26","author":"Mohapel","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.physbeh.2015.11.016_bb0150","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.lfs.2015.01.016","article-title":"A high dose of short term exogenous d-galactose administration in young male rats produces symptoms simulating the natural aging process","volume":"124","author":"Haider","year":"2015","journal-title":"Life Sci."},{"key":"10.1016\/j.physbeh.2015.11.016_bb0155","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/jpi.12194","article-title":"Melatonin attenuates d-galactose-induced memory impairment, neuroinflammation and neurodegeneration via RAGE\/NF-\u03baB\/JNK signaling pathway in aging mouse model","volume":"58","author":"Ali","year":"2015","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.physbeh.2015.11.016_bb0160","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.jep.2012.02.050","article-title":"Danggui-Shaoyao-San ameliorates cognition deficits and attenuates oxidative stress-related neuronal apoptosis in d-galactose-induced senescent mice","volume":"141","author":"Lan","year":"2012","journal-title":"J. Ethnopharmacol."}],"container-title":["Physiology & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938415301773?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938415301773?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,17]],"date-time":"2018-09-17T14:23:27Z","timestamp":1537194207000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938415301773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2]]},"references-count":32,"alternative-id":["S0031938415301773"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2015.11.016","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2016,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Protective effect of tetrahydropalmatine against d-galactose induced memory impairment in rat","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2015.11.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}