{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T06:04:57Z","timestamp":1791612297698,"version":"4.3.4"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["2014R1A2A1A09006320"],"award-info":[{"award-number":["2014R1A2A1A09006320"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.physbeh.2016.12.043","type":"journal-article","created":{"date-parts":[[2017,1,7]],"date-time":"2017-01-07T01:19:43Z","timestamp":1483751983000},"page":"243-248","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["Loganin enhances long-term potentiation and recovers scopolamine-induced learning and memory impairments"],"prefix":"10.1016","volume":"171","author":[{"given":"Eun-Sang","family":"Hwang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Bum","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Ji","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Ok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Moo","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9347-7902","authenticated-orcid":false,"given":"Sungho","family":"Maeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9722-8463","authenticated-orcid":false,"given":"Ji-Ho","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2016.12.043_bb0005","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1111\/j.1476-5381.2012.02057.x","article-title":"Alzheimer's disease, beta-amyloid, glutamate, NMDA receptors and memantine\u2013searching for the connections","volume":"167","author":"Danysz","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.physbeh.2016.12.043_bb0010","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jep.2016.06.010","article-title":"The ethanolic extract of the Eclipta prostrata L. ameliorates the cognitive impairment in mice induced by scopolamine","volume":"190","author":"Jung","year":"2016","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.physbeh.2016.12.043_bb0015","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1039\/C5FO00055F","article-title":"Neuroprotective effect of loganin against Abeta25-35-induced injury via the NF-kappaB-dependent signaling pathway in PC12 cells","volume":"6","author":"Kim","year":"2015","journal-title":"Food Funct."},{"key":"10.1016\/j.physbeh.2016.12.043_bb0020","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ejphar.2009.06.062","article-title":"Loganin improves learning and memory impairments induced by scopolamine in mice","volume":"619","author":"Kwon","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.physbeh.2016.12.043_bb0025","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/361031a0","article-title":"A synaptic model of memory: long-term potentiation in the hippocampus","volume":"361","author":"Bliss","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.physbeh.2016.12.043_bb0030","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1113\/jphysiol.1973.sp010273","article-title":"Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path","volume":"232","author":"Bliss","year":"1973","journal-title":"J. Physiol."},{"key":"10.1016\/j.physbeh.2016.12.043_bb0035","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0959-4388(94)90101-5","article-title":"Synaptic plasticity: LTP and LTD","volume":"4","author":"Bear","year":"1994","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.physbeh.2016.12.043_bb0040","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1093\/brain\/awl082","article-title":"Plasticity in the human central nervous system","volume":"129","author":"Cooke","year":"2006","journal-title":"Brain"},{"key":"10.1016\/j.physbeh.2016.12.043_bb0045","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0165-0270(91)90128-M","article-title":"A simple method for organotypic cultures of nervous tissue","volume":"37","author":"Stoppini","year":"1991","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.physbeh.2016.12.043_bb0050","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S1385-299X(98)00013-0","article-title":"A novel organotypic long-term culture of the rat hippocampus on substrate-integrated multielectrode arrays","volume":"2","author":"Egert","year":"1998","journal-title":"Brain Res. Brain Res. Protoc."},{"key":"10.1016\/j.physbeh.2016.12.043_bb0055","first-page":"71","article-title":"Long-term treatment with oriental medicinal herb Artemisia princeps alters neuroplasticity in a rat model of ovarian hormone deficiency","volume":"24","author":"Kim","year":"2015","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.physbeh.2016.12.043_bb0060","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s10059-012-0254-4","article-title":"Gintonin, a ginseng-derived novel ingredient, evokes long-term potentiation through N-methyl-d-aspartic acid receptor activation: involvement of LPA receptors","volume":"34","author":"Shin","year":"2012","journal-title":"Mol Cells."},{"key":"10.1016\/j.physbeh.2016.12.043_bb0065","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13024-015-0013-z","article-title":"Synaptic dysfunction and septin protein family members in neurodegenerative diseases","volume":"10","author":"Marttinen","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.physbeh.2016.12.043_bb0070","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/cercor\/3.6.515","article-title":"Information cascade from primary auditory cortex to the amygdala: corticocortical and corticoamygdaloid projections of temporal cortex in the rat","volume":"3","author":"Romanski","year":"1993","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.physbeh.2016.12.043_bb0075","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ejphar.2009.06.062","article-title":"Loganin improves learning and memory impairments induced by scopolamine in mice","volume":"619","author":"Kwon","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.physbeh.2016.12.043_bb0080","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s12272-009-1505-6","article-title":"Cognitive-enhancing activity of loganin isolated from Cornus officinalis in scopolamine-induced amnesic mice","volume":"32","author":"Lee","year":"2009","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.physbeh.2016.12.043_bb0085","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.neuron.2012.12.002","article-title":"The role of medial prefrontal cortex in memory and decision making","volume":"76","author":"Euston","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.physbeh.2016.12.043_bb0090","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0014-2999(99)00643-3","article-title":"Effect of rivastigmine on scopolamine-induced memory impairment in rats","volume":"383","author":"Bejar","year":"1999","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.physbeh.2016.12.043_bb0095","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/0166-2236(91)90117-D","article-title":"Cholinergic mechanisms in learning, memory and dementia: a review of recent evidence","volume":"14","author":"Fibiger","year":"1991","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.physbeh.2016.12.043_bb0100","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/0091-3057(92)90206-U","article-title":"Differential effects of scopolamine on working and reference memory depend upon level of training","volume":"43","author":"Lydon","year":"1992","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2016.12.043_bb0105","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/0091-3057(87)90488-6","article-title":"Effects of chronic diisopropylfluorophosphate treatment on spatial learning in mice","volume":"27","author":"Upchurch","year":"1987","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2016.12.043_bb0110","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1460-9568.2008.06562.x","article-title":"Intracellular mechanisms underlying the nicotinic enhancement of LTP in the rat dentate gyrus","volume":"29","author":"Welsby","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.physbeh.2016.12.043_bb0115","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.nlm.2008.05.013","article-title":"Cholinergic modulation of hippocampal CA1 basal-dendritic long-term potentiation","volume":"90","author":"Doralp","year":"2008","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.physbeh.2016.12.043_bb0120","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.bbr.2015.10.022","article-title":"The dual-acting H3 receptor antagonist and AChE inhibitor UW-MD-71 dose-dependently enhances memory retrieval and reverses dizocilpine-induced memory impairment in rats","volume":"297","author":"Khan","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2016.12.043_bb0125","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.neurobiolaging.2004.12.005","article-title":"Inhibition of hippocampal function in mild cognitive impairment: targeting the cholinergic hypothesis","volume":"27","author":"Gron","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.physbeh.2016.12.043_bb0130","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1021\/acschemneuro.5b00329","article-title":"Sunitinib, a clinically used anticancer drug, is a potent AChE inhibitor and attenuates cognitive impairments in mice","volume":"7","author":"Huang","year":"2016","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.physbeh.2016.12.043_bb0135","doi-asserted-by":"crossref","first-page":"9852536","DOI":"10.1155\/2016\/9852536","article-title":"Sodium tanshinone IIA sulfonate attenuates scopolamine-induced cognitive dysfunctions via improving cholinergic system","volume":"2016","author":"Xu","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.physbeh.2016.12.043_bb0140","first-page":"91","article-title":"Effect of acute administration of loganin on spatial memory in diabetic male rats","volume":"3","author":"Babri","year":"2013","journal-title":"Adv. Pharm. Bull."},{"key":"10.1016\/j.physbeh.2016.12.043_bb0145","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.neuint.2011.01.012","article-title":"Loganin protects against hydrogen peroxide-induced apoptosis by inhibiting phosphorylation of JNK, p38, and ERK 1\/2 MAPKs in SH-SY5Y cells","volume":"58","author":"Kwon","year":"2011","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.physbeh.2016.12.043_bb0150","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1080\/14786419.2012.718774","article-title":"beta-Secretase (BACE1) inhibitory property of loganin isolated from Corni fructus","volume":"27","author":"Youn","year":"2013","journal-title":"Nat. Prod. Res."}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938416309623?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938416309623?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T03:53:29Z","timestamp":1536119609000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938416309623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":30,"alternative-id":["S0031938416309623"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2016.12.043","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Loganin enhances long-term potentiation and recovers scopolamine-induced learning and memory impairments","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2016.12.043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}