{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:13:25Z","timestamp":1790716405631,"version":"4.1.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,7,1]],"date-time":"2018-07-01T00:00:00Z","timestamp":1530403200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology & Behavior"],"published-print":{"date-parts":[[2018,7]]},"DOI":"10.1016\/j.physbeh.2018.04.025","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T22:36:56Z","timestamp":1524004616000},"page":"131-137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Anxiety- but not depressive-like behaviors are related to facial hyperalgesia in a model of trigeminal neuropathic pain in rats"],"prefix":"10.1016","volume":"191","author":[{"given":"Eder","family":"Gambeta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcio Augusto","family":"Batista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel Paz","family":"Maschio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joelle de Melo","family":"Turnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika Ivanna","family":"Araya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5392-5117","authenticated-orcid":false,"given":"Juliana Geremias","family":"Chichorro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.physbeh.2018.04.025_bb0005","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1177\/1073858416633104","article-title":"The effects of extended pain on behavior: recent progress","volume":"22","author":"Usdin","year":"2016","journal-title":"Neuroscientist"},{"key":"10.1016\/j.physbeh.2018.04.025_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2017.05.012","article-title":"Epidemiology of pain and relation to psychiatric disorders","author":"Velly","year":"2017","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.physbeh.2018.04.025_bb0015","first-page":"2014","article-title":"Trigeminal neuralgia","volume":"06","author":"Zakrzewska","year":"2014","journal-title":"BMJ Clin Evid, vol."},{"issue":"7","key":"10.1016\/j.physbeh.2018.04.025_bb0020","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3390\/medicina47070055","article-title":"Associations between chronic pain and depressive symptoms in patients with trigeminal neuralgia","volume":"47","author":"Macianskyte","year":"2011","journal-title":"Medicina (Kaunas)"},{"issue":"3","key":"10.1016\/j.physbeh.2018.04.025_bb0025","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1533-2500.2006.00079.x","article-title":"Patient burden of trigeminal neuralgia: results from a cross-sectional survey of health state impairment and treatment patterns in six European countries","volume":"6","author":"Tolle","year":"2006","journal-title":"Pain Pract"},{"issue":"6","key":"10.1016\/j.physbeh.2018.04.025_bb0030","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1097\/j.pain.0000000000000853","article-title":"Evaluating the impact of trigeminal neuralgia","volume":"158","author":"Zakrzewska","year":"2017","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.physbeh.2018.04.025_bb0035","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0006-8993(91)90844-L","article-title":"MK-801 blocks the development of thermal hyperalgesia in a rat model of experimental painful neuropathy","volume":"553","author":"Davar","year":"1991","journal-title":"Brain Res."},{"issue":"5 Pt 1","key":"10.1016\/j.physbeh.2018.04.025_bb0040","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1523\/JNEUROSCI.14-05-02708.1994","article-title":"Behavioral evidence of trigeminal neuropathic pain following chronic constriction injury to the rat's infraorbital nerve","volume":"14","author":"Vos","year":"1994","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.physbeh.2018.04.025_bb0045","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.npep.2008.12.001","article-title":"Mechanisms operated by endothelin ETA and ETB receptors in the trigeminal ganglion contribute to orofacial thermal hyperalgesia induced by infraorbital nerve constriction in rats","volume":"43","author":"Chichorro","year":"2009","journal-title":"Neuropeptides"},{"issue":"1","key":"10.1016\/j.physbeh.2018.04.025_bb0050","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/PL00005748","article-title":"Characterization of heat-hyperalgesia in an experimental trigeminal neuropathy in rats","volume":"116","author":"Imamura","year":"1997","journal-title":"Exp. Brain Res."},{"issue":"6","key":"10.1016\/j.physbeh.2018.04.025_bb0055","first-page":"1136","article-title":"Endothelin ET(B) receptor antagonist reduces mechanical allodynia in rats with trigeminal neuropathic pain","volume":"231","author":"Chichorro","year":"2006","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.physbeh.2018.04.025_bb0060","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neulet.2017.02.047","article-title":"Descending facilitatory pain pathways mediate ongoing pain and tactile hypersensitivity in a rat model of trigeminal neuropathic pain","volume":"644","author":"Nones","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.physbeh.2018.04.025_bb0065","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3389\/fncel.2015.00493","article-title":"Corticotrigeminal projections from the insular cortex to the trigeminal caudal subnucleus regulate orofacial pain after nerve injury via extracellular signal-regulated kinase activation in insular cortex neurons","volume":"9","author":"Wang","year":"2015","journal-title":"Front. Cell. Neurosci."},{"issue":"12","key":"10.1016\/j.physbeh.2018.04.025_bb0070","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1016\/j.pain.2012.08.016","article-title":"Exacerbated mechanical hyperalgesia in rats with genetically predisposed depressive behavior: role of melatonin and NMDA receptors","volume":"153","author":"Wang","year":"2012","journal-title":"Pain"},{"key":"10.1016\/j.physbeh.2018.04.025_bb0075","first-page":"40","article-title":"Temporal dynamics of anxiety phenotypes in a dental pulp injury model","volume":"11","author":"Shang","year":"2015","journal-title":"Mol. Pain"},{"key":"10.1016\/j.physbeh.2018.04.025_bb0080","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.neuroscience.2015.03.051","article-title":"Trigeminal inflammatory compression (TIC) injury induces chronic facial pain and susceptibility to anxiety-related behaviors","volume":"295","author":"Lyons","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2018.04.025_bb0085","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.neuropharm.2017.07.035","article-title":"Facial pain and anxiety-like behavior are reduced by pregabalin in a model of facial carcinoma in rats","volume":"125","author":"Gambeta","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.physbeh.2018.04.025_bb0090","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s12264-017-0131-4","article-title":"Proteomic Analysis of the Hippocampus in Mouse Models of Trigeminal Neuralgia and Inescapable Shock-Induced Depression","volume":"34","author":"Guo","year":"2017","journal-title":"Neurosci. Bull."},{"issue":"3","key":"10.1016\/j.physbeh.2018.04.025_bb0095","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0165-0270(85)90031-7","article-title":"Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat","volume":"14","author":"Pellow","year":"1985","journal-title":"J. Neurosci. Methods"},{"issue":"2","key":"10.1016\/j.physbeh.2018.04.025_bb0100","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0091-3057(80)90067-2","article-title":"Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines","volume":"13","author":"Crawley","year":"1980","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"2","key":"10.1016\/j.physbeh.2018.04.025_bb0105","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/BF02244188","article-title":"An animal model of anhedonia: attenuation of sucrose consumption and place preference conditioning by chronic unpredictable mild stress","volume":"104","author":"Papp","year":"1991","journal-title":"Psychopharmacology"},{"issue":"4","key":"10.1016\/j.physbeh.2018.04.025_bb0110","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0014-2999(78)90118-8","article-title":"Behavioural despair in rats: a new model sensitive to antidepressant treatments","volume":"47","author":"Porsolt","year":"1978","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.physbeh.2018.04.025_bb0115","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"},{"key":"10.1016\/j.physbeh.2018.04.025_bb0120","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.bbr.2013.10.011","article-title":"Increased oxidative stress in prefrontal cortex and hippocampus is related to depressive-like behavior in streptozotocin-diabetic rats","volume":"258","author":"de Morais","year":"2014","journal-title":"Behav. Brain Res."},{"issue":"3","key":"10.1016\/j.physbeh.2018.04.025_bb0125","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1037\/0033-2909.83.3.482","article-title":"The open-field test: a critical review","volume":"83","author":"Walsh","year":"1976","journal-title":"Psychol. Bull."},{"issue":"4","key":"10.1016\/j.physbeh.2018.04.025_bb0130","doi-asserted-by":"crossref","first-page":"296","DOI":"10.11607\/ofph.1675","article-title":"Prevalence of suicidal ideation, depression, and anxiety in chronic temporomandibular disorder patients","volume":"30","author":"Bertoli","year":"2016","journal-title":"J. Oral Facial Pain Headache"},{"issue":"4","key":"10.1016\/j.physbeh.2018.04.025_bb0135","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/s12529-016-9620-5","article-title":"Comorbidity of migraine, major depressive disorder, and generalized anxiety disorder in adolescents and young adults","volume":"24","author":"Dindo","year":"2017","journal-title":"Int. J. Behav. Med."},{"key":"10.1016\/j.physbeh.2018.04.025_bb0140","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00415-017-8439-6","article-title":"Vestibular migraine patients are more anxious than migraine patients without vestibular symptoms","volume":"264","author":"Kutay","year":"2017","journal-title":"J. Neurol."},{"issue":"1","key":"10.1016\/j.physbeh.2018.04.025_bb0145","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s10194-017-0742-1","article-title":"Anxiety and depression symptoms and migraine: a symptom-based approach research","volume":"18","author":"Peres","year":"2017","journal-title":"J Headache Pain"},{"issue":"1","key":"10.1016\/j.physbeh.2018.04.025_bb0150","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s10194-017-0736-z","article-title":"Depression and anxiety behaviour in a rat model of chronic migraine","volume":"18","author":"Zhang","year":"2017","journal-title":"J Headache Pain"},{"key":"10.1016\/j.physbeh.2018.04.025_bb0155","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.neulet.2016.03.001","article-title":"Evaluation of heat hyperalgesia and anxiety like-behaviors in a rat model of orofacial cancer","volume":"619","author":"Gambeta","year":"2016","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.physbeh.2018.04.025_bb0160","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.pain.2008.05.003","article-title":"Anxiety-like behaviour in rats with mononeuropathy is reduced by the analgesic drugs morphine and gabapentin","volume":"139","author":"Roeska","year":"2008","journal-title":"Pain"},{"issue":"3","key":"10.1016\/j.physbeh.2018.04.025_bb0165","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.neuroimage.2009.05.068","article-title":"MRI structural brain changes associated with sensory and emotional function in a rat model of long-term neuropathic pain","volume":"47","author":"Seminowicz","year":"2009","journal-title":"NeuroImage"},{"issue":"10","key":"10.1016\/j.physbeh.2018.04.025_bb0170","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.biopsych.2011.07.017","article-title":"A time-dependent history of mood disorders in a murine model of neuropathic pain","volume":"70","author":"Yalcin","year":"2011","journal-title":"Biol. Psychiatry"},{"issue":"6","key":"10.1016\/j.physbeh.2018.04.025_bb0175","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1213\/01.ane.0000261514.19946.66","article-title":"Experimental neuropathy in mice is associated with delayed behavioral changes related to anxiety and depression","volume":"104","author":"Suzuki","year":"2007","journal-title":"Anesth. Analg."},{"issue":"4","key":"10.1016\/j.physbeh.2018.04.025_bb0180","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/sj.npp.1300858","article-title":"Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala","volume":"31","author":"Narita","year":"2006","journal-title":"Neuropsychopharmacology"},{"issue":"2","key":"10.1016\/j.physbeh.2018.04.025_bb0185","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.neuron.2014.12.021","article-title":"Coexistence of two forms of LTP in ACC provides a synaptic mechanism for the interactions between anxiety and chronic pain","volume":"85","author":"Koga","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.physbeh.2018.04.025_bb0190","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s10194-015-0548-y","article-title":"Risk of psychiatric disorders following trigeminal neuralgia: a nationwide population-based retrospective cohort study","volume":"16","author":"Wu","year":"2015","journal-title":"J Headache Pain"},{"issue":"10","key":"10.1016\/j.physbeh.2018.04.025_bb0195","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1080\/17460441.2017.1362385","article-title":"Animal inflammation-based models of depression and their application to drug discovery","volume":"12","author":"Ma","year":"2017","journal-title":"Expert Opin. Drug Discovery"},{"issue":"Suppl. 2","key":"10.1016\/j.physbeh.2018.04.025_bb0200","doi-asserted-by":"crossref","first-page":"S101","DOI":"10.1590\/1516-4446-2013-1139","article-title":"Animal models of anxiety disorders and stress","volume":"35","author":"Campos","year":"2013","journal-title":"Rev. Bras. Psiquiatr."},{"issue":"2","key":"10.1016\/j.physbeh.2018.04.025_bb0205","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.vascn.2013.12.005","article-title":"Assessing anxiety in C57BL\/6J mice: a pharmacological characterization of the open-field and light\/dark tests, (in English)","volume":"69","author":"Heredia","year":"2014","journal-title":"J. Pharmacol. Toxicol. Methods"},{"issue":"1\u20132","key":"10.1016\/j.physbeh.2018.04.025_bb0210","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S0166-4328(01)00291-1","article-title":"Measuring normal and pathological anxiety-like behaviour in mice: a review (in English)","volume":"125","author":"Belzung","year":"2001","journal-title":"Behav. Brain Res."},{"issue":"6","key":"10.1016\/j.physbeh.2018.04.025_bb0215","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/S0031-9384(96)00305-8","article-title":"Chronic mild stress and sucrose consumption: validity as a model of depression","volume":"60","author":"Forbes","year":"1996","journal-title":"Physiol. Behav."},{"issue":"4","key":"10.1016\/j.physbeh.2018.04.025_bb0220","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3109\/07853891003769957","article-title":"Rodent models in depression research: classical strategies and new directions","volume":"42","author":"Pollak","year":"2010","journal-title":"Ann. Med."}],"container-title":["Physiology & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938418302063?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938418302063?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T23:18:24Z","timestamp":1571181504000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938418302063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7]]},"references-count":44,"alternative-id":["S0031938418302063"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2018.04.025","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2018,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anxiety- but not depressive-like behaviors are related to facial hyperalgesia in a model of trigeminal neuropathic pain in rats","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2018.04.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}