{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,30]],"date-time":"2026-03-30T11:30:21Z","timestamp":1774870221959,"version":"3.50.1"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100012021","name":"Iran University of Medical Sciences","doi-asserted-by":"publisher","award":["18227"],"award-info":[{"award-number":["18227"]}],"id":[{"id":"10.13039\/100012021","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.physbeh.2018.04.029","type":"journal-article","created":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T13:03:08Z","timestamp":1524488588000},"page":"9-14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Axonal transport proteins and depressive like behavior, following Chronic Unpredictable Mild Stress in male rat"],"prefix":"10.1016","volume":"194","author":[{"given":"Fatemeh","family":"Bakhtiarzadeh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5317-6056","authenticated-orcid":false,"given":"Arezo","family":"Nahavandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mina","family":"Goudarzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakine","family":"Shirvalilou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamran","family":"Rakhshan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9985-2144","authenticated-orcid":false,"given":"Somayeh","family":"Niknazar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.physbeh.2018.04.029_bb0005","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.jad.2011.12.036","article-title":"Depression as a disease of modernity: explanations for increasing prevalence","volume":"140","author":"Hidaka","year":"2012","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.physbeh.2018.04.029_bb0010","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev-publhealth-031912-114409","article-title":"The epidemiology of depression across cultures","volume":"34","author":"Kessler","year":"2013","journal-title":"Annu. Rev. Public Health"},{"issue":"2","key":"10.1016\/j.physbeh.2018.04.029_bb0015","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2478\/cipms-2014-0022","article-title":"Utility of the chronic unpredictable mild stress model in research on new antidepressants","volume":"27","author":"Pekala","year":"2014","journal-title":"Curr. Issues Pharm. Med. Sci."},{"issue":"3","key":"10.1016\/j.physbeh.2018.04.029_bb0020","doi-asserted-by":"crossref","first-page":"271","DOI":"10.31887\/DCNS.2008.10.3\/shkennedy","article-title":"Core symptoms of major depressive disorder: relevance to diagnosis and treatment","volume":"10","author":"Kennedy","year":"2008","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.physbeh.2018.04.029_bb0025","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.pnpbp.2017.08.014","article-title":"Sex differences in cardiovascular, neuroendocrine and behavioral changes evoked by chronic stressors in rats","volume":"81","author":"Vieira","year":"2018","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"5","key":"10.1016\/j.physbeh.2018.04.029_bb0030","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1017\/S1461145713001661","article-title":"Effects of curcumin on chronic, unpredictable, mild, stress-induced depressive-like behaviour and structural plasticity in the lateral amygdala of rats","volume":"17","author":"Zhang","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"35","key":"10.1016\/j.physbeh.2018.04.029_bb0035","doi-asserted-by":"crossref","first-page":"10883","DOI":"10.1523\/JNEUROSCI.2594-09.2009","article-title":"NGF is essential for hippocampal plasticity and learning","volume":"29","author":"Conner","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.physbeh.2018.04.029_bb0040","first-page":"925","article-title":"Significantly lower nerve growth factor levels in patients with major depressive disorder than in healthy subjects: a meta-analysis and systematic review","volume":"11","author":"Chen","year":"2015","journal-title":"Neuropsychiatr. Dis. Treat."},{"issue":"1","key":"10.1016\/j.physbeh.2018.04.029_bb0045","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0163-1047(85)91510-9","article-title":"Development of place navigation in rats from weaning to puberty","volume":"43","author":"Schenk","year":"1985","journal-title":"Behav. Neural Biol."},{"issue":"1","key":"10.1016\/j.physbeh.2018.04.029_bb0050","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.bbadis.2009.06.008","article-title":"Impaired mitochondrial trafficking in Huntington's disease","volume":"1802","author":"Li","year":"2010","journal-title":"Biochim. et Biophys. Acta (BBA)-Mol. Basis Dis."},{"issue":"14","key":"10.1016\/j.physbeh.2018.04.029_bb0055","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1016\/j.cub.2004.07.027","article-title":"Nerve growth factor signaling regulates motility and docking of axonal mitochondria","volume":"14","author":"Chada","year":"2004","journal-title":"Curr. Biol."},{"issue":"2","key":"10.1016\/j.physbeh.2018.04.029_bb0060","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nrn3156","article-title":"Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration","volume":"13","author":"Sheng","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"issue":"19","key":"10.1016\/j.physbeh.2018.04.029_bb0065","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1039\/c003385e","article-title":"Single-molecule imaging of NGF axonal transport in microfluidic devices","volume":"10","author":"Zhang","year":"2010","journal-title":"Lab Chip"},{"issue":"4","key":"10.1016\/j.physbeh.2018.04.029_bb0070","first-page":"197","article-title":"Transplantation of olfactory mucosa improve functional recovery and axonal regeneration following sciatic nerve repair in rats","volume":"12","author":"Delaviz","year":"2008","journal-title":"Iran. Biomed. J."},{"key":"10.1016\/j.physbeh.2018.04.029_bb0075","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/784040","article-title":"NGF, brain and behavioral plasticity","volume":"2012","author":"Berry","year":"2012","journal-title":"Neural Plast."},{"issue":"1","key":"10.1016\/j.physbeh.2018.04.029_bb0080","first-page":"39","article-title":"The effects of schwann and bone marrow stromal stem cells on sciatic nerve injury in rat: a comparison of functional recovery","volume":"14","author":"Zarbakhsh","year":"2012","journal-title":"Cell J. (Yakhteh)"},{"issue":"1","key":"10.1016\/j.physbeh.2018.04.029_bb0085","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0091-3057(02)00757-8","article-title":"Stress and nerve growth factor: findings in animal models and humans","volume":"73","author":"Aloe","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"4","key":"10.1016\/j.physbeh.2018.04.029_bb0090","first-page":"515","article-title":"Effect of fluoxetine and resveratrol on testicular functions and oxidative stress in a rat model of chronic mild stress-induced depression","volume":"66","author":"Sakr","year":"2015","journal-title":"J. Physiol. Pharmacol."},{"issue":"23","key":"10.1016\/j.physbeh.2018.04.029_bb0095","doi-asserted-by":"crossref","first-page":"5411","DOI":"10.1242\/jcs.02745","article-title":"The axonal transport of mitochondria","volume":"118","author":"Hollenbeck","year":"2005","journal-title":"J. Cell Sci."},{"issue":"5","key":"10.1016\/j.physbeh.2018.04.029_bb0100","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.bbabio.2006.04.013","article-title":"The relationship between mitochondrial shape and function and the cytoskeleton","volume":"1757","author":"Anesti","year":"2006","journal-title":"Biochim. et Biophys. Acta (BBA)-Bioenergetics"},{"issue":"11","key":"10.1016\/j.physbeh.2018.04.029_bb0105","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1016\/j.bpj.2015.04.036","article-title":"Retrograde NGF axonal transport\u2014motor coordination in the unidirectional motility regime","volume":"108","author":"Chowdary","year":"2015","journal-title":"Biophys. J."},{"key":"10.1016\/j.physbeh.2018.04.029_bb0110","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.1611","article-title":"Chronic unpredicted mild stress-induced depression alter saxagliptin pharmacokinetics and CYP450 activity in GK rats","volume":"4","author":"Xia","year":"2016","journal-title":"PeerJ"},{"issue":"9","key":"10.1016\/j.physbeh.2018.04.029_bb0115","first-page":"2095","article-title":"The axonal transport of mitochondria","volume":"125","author":"Saxton","year":"2012","journal-title":"J. Cell Sci."},{"issue":"2","key":"10.1016\/j.physbeh.2018.04.029_bb0120","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0005-2728(98)00168-6","article-title":"Nitric oxide, mitochondria and neurological disease","volume":"1410","author":"Heales","year":"1999","journal-title":"Biochim. et Biophys. Acta (BBA)-Bioenergetics"},{"issue":"5","key":"10.1016\/j.physbeh.2018.04.029_bb0125","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/BF01170822","article-title":"AVEC-DIC and electron microscopic analyses of axonally transported particles in cold-blocked squid giant axons","volume":"14","author":"Fahim","year":"1985","journal-title":"J. Neurocytol."},{"issue":"3","key":"10.1016\/j.physbeh.2018.04.029_bb0130","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.conb.2008.08.005","article-title":"Action in the axon: generation and transport of signaling endosomes","volume":"18","author":"Cosker","year":"2008","journal-title":"Curr. Opin. Neurobiol."},{"issue":"43","key":"10.1016\/j.physbeh.2018.04.029_bb0135","doi-asserted-by":"crossref","first-page":"18670","DOI":"10.1073\/pnas.1006586107","article-title":"Early deficits in synaptic mitochondria in an Alzheimer's disease mouse model","volume":"107","author":"Du","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"3","key":"10.1016\/j.physbeh.2018.04.029_bb0140","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0162-3109(95)00026-P","article-title":"The effect of chronic treatment with imipramine on the immunoreactivity of animals subjected to a chronic mild stress model of depression","volume":"30","author":"Kubera","year":"1995","journal-title":"Immunopharmacology"},{"issue":"2","key":"10.1016\/j.physbeh.2018.04.029_bb0145","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"issue":"8","key":"10.1016\/j.physbeh.2018.04.029_bb0150","doi-asserted-by":"crossref","first-page":"3174","DOI":"10.1523\/JNEUROSCI.22-08-03174.2002","article-title":"Prolonged seizures increase proliferating neuroblasts in the adult rat subventricular zone\u2013olfactory bulb pathway","volume":"22","author":"Parent","year":"2002","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.physbeh.2018.04.029_bb0155","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.neuroscience.2007.12.032","article-title":"A study in male and female 5-HT transporter knockout rats: an animal model for anxiety and depression disorders","volume":"152","author":"Olivier","year":"2008","journal-title":"Neuroscience"},{"issue":"106","key":"10.1016\/j.physbeh.2018.04.029_bb0160","article-title":"An unpredictable chronic mild stress protocol for instigating depressive symptoms, behavioral changes and negative health outcomes in rodents","author":"Frisbee","year":"2015","journal-title":"JoVE (Journal of Visualized Experiments)"},{"key":"10.1016\/j.physbeh.2018.04.029_bb0165","article-title":"The forced swim test as a model of depressive-like behavior","volume":"97","author":"Yankelevitch-Yahav","year":"2015","journal-title":"J. Vis. Exp."},{"issue":"2\u20133","key":"10.1016\/j.physbeh.2018.04.029_bb0170","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0014-2999(81)90269-7","article-title":"Effects of antidepressants in the rat forced swimming test","volume":"72","author":"Kitada","year":"1981","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.physbeh.2018.04.029_bb0175","first-page":"171","article-title":"Role of stress, immune system and well-being in patients with Alzheimer's disease","volume":"8","author":"Garcia-Pardo","year":"2017","journal-title":"J. Neurol. Neurosci."},{"issue":"3","key":"10.1016\/j.physbeh.2018.04.029_bb0180","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.pnpbp.2010.07.030","article-title":"Beyond the serotonin hypothesis: mitochondria, inflammation and neurodegeneration in major depression and affective spectrum disorders","volume":"35","author":"Gardner","year":"2011","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"8","key":"10.1016\/j.physbeh.2018.04.029_bb0185","doi-asserted-by":"crossref","first-page":"682","DOI":"10.12998\/wjcc.v3.i8.682","article-title":"Depressive symptoms in neurodegenerative diseases","volume":"3","author":"Baquero","year":"2015","journal-title":"World J. Clin. Cases"},{"issue":"7","key":"10.1016\/j.physbeh.2018.04.029_bb0190","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/cdd.2014.47","article-title":"Programmed cell death during neuronal development: the sympathetic neuron model","volume":"21","author":"Kristiansen","year":"2014","journal-title":"Cell Death Differ."},{"issue":"2","key":"10.1016\/j.physbeh.2018.04.029_bb0195","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.pharmthera.2013.01.004","article-title":"GDNF, NGF and BDNF as therapeutic options for neurodegeneration","volume":"138","author":"Allen","year":"2013","journal-title":"Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.physbeh.2018.04.029_bb0200","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a020669","article-title":"Neuronal signaling through endocytosis","volume":"6","author":"Cosker","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"7","key":"10.1016\/j.physbeh.2018.04.029_bb0205","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1002\/dneu.22246","article-title":"The dynein inhibitor Ciliobrevin D inhibits the bidirectional transport of organelles along sensory axons and impairs NGF-mediated regulation of growth cones and axon branches","volume":"75","author":"Sainath","year":"2015","journal-title":"Dev. Neurobiol."},{"issue":"Suppl. 1","key":"10.1016\/j.physbeh.2018.04.029_bb0210","article-title":"Activation of the A2A adenosine receptor modulates the role of kinesin Kif2A in the NGF-mediated differentiation","volume":"23","author":"Chern","year":"2009","journal-title":"FASEB J."},{"issue":"6","key":"10.1016\/j.physbeh.2018.04.029_bb0215","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a011304","article-title":"Mitochondrial trafficking in neurons","volume":"5","author":"Schwarz","year":"2013","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"29","key":"10.1016\/j.physbeh.2018.04.029_bb0220","doi-asserted-by":"crossref","first-page":"11932","DOI":"10.1523\/JNEUROSCI.5425-12.2013","article-title":"Shootin1 acts in concert with KIF20B to promote polarization of migrating neurons","volume":"33","author":"Sapir","year":"2013","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.physbeh.2018.04.029_bb0225","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1083\/jcb.200604160","article-title":"Shootin1: a protein involved in the organization of an asymmetric signal for neuronal polarization","volume":"175","author":"Toriyama","year":"2006","journal-title":"J. Cell Biol."},{"issue":"12","key":"10.1016\/j.physbeh.2018.04.029_bb0230","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1002\/cm.20487","article-title":"Expression of kinesin superfamily genes in cultured hippocampal neurons","volume":"67","author":"Silverman","year":"2010","journal-title":"Cytoskeleton"},{"key":"10.1016\/j.physbeh.2018.04.029_bb0235","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev.neuro.31.061307.090711","article-title":"Role of axonal transport in neurodegenerative diseases","volume":"31","author":"De Vos","year":"2008","journal-title":"Annu. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.physbeh.2018.04.029_bb0240","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.bbamcr.2012.04.007","article-title":"The meaning of mitochondrial movement to a neuron's life","volume":"1833","author":"Lovas","year":"2013","journal-title":"Biochim. et Biophys. Acta (BBA)-Mol. Cell Res."},{"issue":"7","key":"10.1016\/j.physbeh.2018.04.029_bb0245","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1089\/ars.2009.2604","article-title":"Mitochondrial function, morphology, and axonal transport in amyotrophic lateral sclerosis","volume":"11","author":"Magran\u00e9","year":"2009","journal-title":"Antioxid. Redox Signal."},{"issue":"4","key":"10.1016\/j.physbeh.2018.04.029_bb0250","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.neuron.2010.09.039","article-title":"Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease","volume":"68","author":"Hirokawa","year":"2010","journal-title":"Neuron"},{"issue":"11","key":"10.1016\/j.physbeh.2018.04.029_bb0255","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0080136","article-title":"Drosophila growth cones advance by forward translocation of the neuronal cytoskeletal meshwork in vivo","volume":"8","author":"Roossien","year":"2013","journal-title":"PLoS One"},{"issue":"22","key":"10.1016\/j.physbeh.2018.04.029_bb0260","doi-asserted-by":"crossref","first-page":"4399","DOI":"10.1093\/hmg\/ddq363","article-title":"Kinesin-1 transport reductions enhance human tau hyperphosphorylation, aggregation and neurodegeneration in animal models of tauopathies","volume":"19","author":"Falzone","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.physbeh.2018.04.029_bb0265","series-title":"Molecular Cell Biology: Scientific American Books New York","author":"Lodish","year":"1995"},{"issue":"2","key":"10.1016\/j.physbeh.2018.04.029_bb0270","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1083\/jcb.200807155","article-title":"Dynein light chain regulates axonal trafficking and synaptic levels of bassoon","volume":"185","author":"Fejtova","year":"2009","journal-title":"J. Cell Biol."},{"issue":"5","key":"10.1016\/j.physbeh.2018.04.029_bb0275","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1083\/jcb.131.5.1315","article-title":"Axonal transport of mitochondria along microtubules and F-actin in living vertebrate neurons","volume":"131","author":"Morris","year":"1995","journal-title":"J. Cell Biol."}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938418302105?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938418302105?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:03:11Z","timestamp":1758477791000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938418302105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":55,"alternative-id":["S0031938418302105"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2018.04.029","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Axonal transport proteins and depressive like behavior, following Chronic Unpredictable Mild Stress in male rat","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2018.04.029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}