{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T11:25:01Z","timestamp":1773141901431,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.physbeh.2018.06.014","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T11:32:35Z","timestamp":1528803155000},"page":"246-251","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["The effect of intracerebroventricular allopregnanolone on depressive-like behaviors of rats selectively bred for high and low immobility in the forced swim test"],"prefix":"10.1016","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4146-0057","authenticated-orcid":false,"given":"Felipe Borges","family":"Almeida","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan Rios","family":"Fonseca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00fabia","family":"Heidrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maur\u00edcio Sch\u00fcler","family":"Nin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena Maria Tannhauser","family":"Barros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2018.06.014_bb0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069637","article-title":"The epidemiological modelling of major depressive disorder: application for the Global Burden of Disease Study 2010","volume":"8","author":"Ferrari","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.physbeh.2018.06.014_bb0010","series-title":"Depression and Other Common Mental Disorders: Global Health Estimates","author":"WHO","year":"2017"},{"key":"10.1016\/j.physbeh.2018.06.014_bb0015","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1176\/appi.ajp.157.10.1552","article-title":"Genetic epidemiology of major depression: review and meta-analysis","volume":"157","author":"Sullivan","year":"2000","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.physbeh.2018.06.014_bb0020","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jad.2014.01.014","article-title":"A meta-analysis of the risk of major affective disorder in relatives of individuals affected by major depressive disorder or bipolar disorder","volume":"158","author":"Wilde","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0025","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1176\/ajp.2006.163.11.1905","article-title":"Acute and longer-term outcomes in depressed outpatients requiring one or several treatment steps: a STAR*D report","volume":"163","author":"Rush","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.physbeh.2018.06.014_bb0030","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.neubiorev.2012.10.005","article-title":"Neurosteroids, stress and depression: potential therapeutic opportunities","volume":"37","author":"Zorumski","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2018.01.036","article-title":"GABAA receptor: positive and negative allosteric modulators","author":"Olsen","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.physbeh.2018.06.014_bb0040","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.pharmthera.2007.03.011","article-title":"Neurosteroid binding sites on GABA(a) receptors","volume":"116","author":"Hosie","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0045","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.1096\/fasebj.6.6.1347506","article-title":"Neuroactive steroids","volume":"6","author":"Paul","year":"1992","journal-title":"FASEB J."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0050","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1346-8138.2002.tb00200.x","article-title":"Depression circumstantially related to the administration of finasteride for androgenetic alopecia","volume":"29","author":"Altomare","year":"2002","journal-title":"J. Dermatol."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0055","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1472-6904-6-7","article-title":"Mualeki, A. Finasteride induced depression: a prospective study","volume":"6","author":"Rahimi-Ardabili","year":"2006","journal-title":"BMC Clin. Pharmacol."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0060","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.4088\/JCP.12m07887","article-title":"Depressive symptoms and suicidal thoughts among former users of finasteride with persistent sexual side effects","volume":"73","author":"Irwig","year":"2012","journal-title":"J. Clin. Psychiatr."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0065","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.pbb.2007.05.017","article-title":"Inhibition of progesterone metabolism mimics the effect of progesterone withdrawal on forced swim test immobility","volume":"87","author":"Beckley","year":"2007","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0070","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1176\/ajp.155.7.910","article-title":"Effects of antidepressant treatment on neuroactive steroids in major depression","volume":"155","author":"Romeo","year":"1998","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.physbeh.2018.06.014_bb0075","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0006-3223(98)00328-X","article-title":"Concentrations of 3 alpha-reduced neuroactive steroids and their precursors in plasma of patients with major depression and after clinical recovery","volume":"45","author":"Strohle","year":"1999","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.physbeh.2018.06.014_bb0080","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1073\/pnas.95.6.3239","article-title":"Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine","volume":"95","author":"Uzunova","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(03)02577-0","article-title":"Region-specific dysregulation of allopregnanolone brain content in the olfactory bulbectomized rat model of depression","volume":"976","author":"Uzunova","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0090","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neuropharm.2017.06.023","article-title":"Overexpression of the 18 kDa translocator protein (TSPO) in the hippocampal dentate gyrus produced anxiolytic and antidepressant-like behavioural effects","volume":"125","author":"Li","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.physbeh.2018.06.014_bb0095","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.coph.2008.12.006","article-title":"SSRIs act as selective brain steroidogenic stimulants (SBSSs) at low doses that are inactive on 5-HT reuptake","volume":"9","author":"Pinna","year":"2009","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0100","doi-asserted-by":"crossref","first-page":"13512","DOI":"10.1073\/pnas.96.23.13512","article-title":"Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes","volume":"96","author":"Griffin","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0105","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0924-977X(03)00015-4","article-title":"Brain neurosteroid changes after paroxetine administration in mice","volume":"13","author":"Nechmad","year":"2003","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0110","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0091-3057(00)00300-2","article-title":"Antidepressant-like effect of the neurosteroid 3alpha-hydroxy-5alpha-pregnan-20-one in mice forced swim test","volume":"67","author":"Khisti","year":"2000","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0115","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1002\/hipo.20824","article-title":"Infusions of allopregnanolone into the hippocampus and amygdala, but not into the nucleus accumbens and medial prefrontal cortex, produce antidepressant effects on the learned helplessness rats","volume":"21","author":"Shirayama","year":"2011","journal-title":"Hippocampus"},{"key":"10.1016\/j.physbeh.2018.06.014_bb0120","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1177\/0269881107081525","article-title":"Antidepressant effect and changes of GABAA receptor gamma2 subunit mRNA after hippocampal administration of allopregnanolone in rats","volume":"22","author":"Nin","year":"2008","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0125","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.pbb.2004.11.017","article-title":"Antidepressant-like actions of intra-accumbens infusions of allopregnanolone in ovariectomized Wistar rats","volume":"80","author":"Molina-Hernandez","year":"2005","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0130","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.pbb.2012.09.002","article-title":"The effect of intra-nucleus accumbens administration of allopregnanolone on delta and gamma2 GABA(A) receptor subunit mRNA expression in the hippocampus and on depressive-like and grooming behaviors in rats","volume":"103","author":"Nin","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0135","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/266730a0","article-title":"Depression: a new animal model sensitive to antidepressant treatments","volume":"266","author":"Porsolt","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.physbeh.2018.06.014_bb0140","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/BF02245592","article-title":"Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants","volume":"121","author":"Detke","year":"1995","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.physbeh.2018.06.014_bb0145","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/S0091-3057(98)00011-2","article-title":"Comparison of behavioral effects of moclobemide and deprenyl during forced swimming","volume":"60","author":"Ferigolo","year":"1998","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0150","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1007\/s00213-015-4015-x","article-title":"Brain DNA damage and behavioral changes after repeated intermittent acute ethanol withdrawal by young rats","volume":"232","author":"Costa","year":"2015","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.physbeh.2018.06.014_bb0155","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.physbeh.2018.06.014_bb0160","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0091-3057(98)00075-6","article-title":"Selective breeding of rats for high and low motor activity in a swim test: toward a new animal model of depression","volume":"61","author":"Weiss","year":"1998","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0165","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/sj.mp.4001345","article-title":"Selectively bred Wistar-Kyoto rats: an animal model of depression and hyper-responsiveness to antidepressants","volume":"8","author":"Will","year":"2003","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.physbeh.2018.06.014_bb0170","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/BF02246047","article-title":"Acute immobilization stress reduces (+\/\u2212)DOI-induced 5-HT2A receptor-mediated head shakes in rats","volume":"119","author":"Yamada","year":"1995","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.physbeh.2018.06.014_bb0175","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0149-7634(98)00029-3","article-title":"Ethopharmacology of imipramine in the forced-swimming test: gender differences","volume":"23","author":"Barros","year":"1998","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0180","first-page":"136","article-title":"Effects and mechanisms of 3alpha,5alpha,-THP on emotion, motivation, and reward functions involving Pregnane xenobiotic receptor","volume":"5","author":"Frye","year":"2011","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0185","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.neuropharm.2015.03.016","article-title":"Forced swim test: what about females?","volume":"99","author":"Kokras","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.physbeh.2018.06.014_bb0190","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.physbeh.2010.02.002","article-title":"Sex-dependent antidepressant effects of lower doses of progesterone in rats","volume":"99","author":"Andrade","year":"2010","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0195","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.physbeh.2017.01.020","article-title":"A mixed glucocorticoid\/mineralocorticoid receptor modulator dampens endocrine and hippocampal stress responsivity in male rats","volume":"178","author":"Nguyen","year":"2017","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0200","doi-asserted-by":"crossref","first-page":"12599","DOI":"10.1073\/pnas.93.22.12599","article-title":"Fluoxetine-elicited changes in brain neurosteroid content measured by negative ion mass fragmentography","volume":"93","author":"Uzunov","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0205","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1073\/pnas.0337642100","article-title":"In socially isolated mice, the reversal of brain allopregnanolone down-regulation mediates the anti-aggressive action of fluoxetine","volume":"100","author":"Pinna","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0210","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.2042-7158.1992.tb03638.x","article-title":"A comparative study on desipramine pharmacokinetics in the rat brain after administration of desipramine or imipramine","volume":"44","author":"Daniel","year":"1992","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0215","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/978-1-61779-458-2_7","article-title":"Modeling depression in animal models","volume":"829","author":"Overstreet","year":"2012","journal-title":"Meth. Mol. Biol. (Clifton, N.J.)"},{"key":"10.1016\/j.physbeh.2018.06.014_bb0220","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1001\/jama.2009.1943","article-title":"Antidepressant drug effects and depression severity: a patient-level meta-analysis","volume":"303","author":"Fournier","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.physbeh.2018.06.014_bb0225","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2302\/kjm.41.221","article-title":"\"Swimming-induced head twitching\" in rats in the forced swimming test induced by overcrowding stress: a new marker in the animal model of depression?","volume":"41","author":"Naitoh","year":"1992","journal-title":"Keio J. Med."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0230","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0091-3057(00)00221-5","article-title":"Ethopharmacology of the antidepressant effect of clonazepam in diabetic rats","volume":"66","author":"Gomez","year":"2000","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0235","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.euroneuro.2009.11.009","article-title":"Antidepressants in healthy subjects: what are the psychotropic\/psychological effects?","volume":"20","author":"Serretti","year":"2010","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.physbeh.2018.06.014_bb0240","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0091-3057(98)00076-8","article-title":"Effects of antidepressant drugs on rats bred for low activity in the swim test","volume":"61","author":"West","year":"1998","journal-title":"Pharmacol. Biochem. Behav."}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938418303445?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938418303445?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:06:41Z","timestamp":1758478001000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938418303445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":48,"alternative-id":["S0031938418303445"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2018.06.014","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of intracerebroventricular allopregnanolone on depressive-like behaviors of rats selectively bred for high and low immobility in the forced swim test","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2018.06.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}