{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T16:08:59Z","timestamp":1776355739559,"version":"3.51.2"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["217854"],"award-info":[{"award-number":["217854"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.physbeh.2018.06.033","type":"journal-article","created":{"date-parts":[[2018,7,17]],"date-time":"2018-07-17T15:16:15Z","timestamp":1531840575000},"page":"560-567","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Influence of sex and estrous cycle on blood glucose levels, body weight gain, and depressive-like behavior in streptozotocin-induced diabetic rats"],"prefix":"10.1016","volume":"194","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6994-7599","authenticated-orcid":false,"given":"Daniela","family":"Rebolledo-Solleiro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1283-8911","authenticated-orcid":false,"given":"Alonso","family":"Fern\u00e1ndez-Guasti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2018.06.033_bb0005","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.psyneuen.2010.09.004","article-title":"A high-fat diet exacerbates depressive-like behavior in the flinders sensitive line (FSL) rat, a genetic model of depression","volume":"36","author":"Abildgaard","year":"2011","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0010","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1196\/annals.1372.016","article-title":"Diabetic patients: psychological aspects","volume":"1084","author":"Adili","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0015","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0031-9384(91)90232-D","article-title":"Sex differences in behavioral despair: relationships between behavioral despair and open field activity","volume":"49","author":"Alonso","year":"1991","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0020","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.2337\/diacare.24.6.1069","article-title":"The prevalence of comorbid depression in adults with diabetes: a meta-analysis","volume":"24","author":"Anderson","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0025","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.pnpbp.2006.12.006","article-title":"Gender differences of acute and chronic administration of dehydroepiandrosterone in rats submitted to the forced swimming test","volume":"31","author":"Andrade","year":"2007","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0030","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.physbeh.2010.02.002","article-title":"Sex-dependent antidepressant effects of lower doses of progesterone in rats","volume":"99","author":"Andrade","year":"2010","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0035","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1089\/109662003772519976","article-title":"Antidepressant activity of quercetin, a bioflavonoid, in streptozotocin-induced diabetic mice","volume":"6","author":"Anjaneyulu","year":"2003","journal-title":"J. Med. Food"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0040","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.pharep.2016.12.004","article-title":"Telmisartan attenuates diabetes induced depression in rats","volume":"69","author":"Aswar","year":"2017","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0045","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1097\/GME.0000000000000435","article-title":"Differential role of estrogen receptor modulators in depression-like behavior and memory impairment in rats with postmenopausal diabetes","volume":"22","author":"Bansal","year":"2015","journal-title":"Menopause"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0050","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0149-7634(98)00029-3","article-title":"Ethopharmacology of imipramine in the forced-swimming test: gender differences","volume":"23","author":"Barros","year":"1998","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0055","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2337\/diab.40.2.217","article-title":"Altered behavior and neurochemistry during short-term insulin withdrawal in streptozocin-induced diabetic rats","volume":"40","author":"Bellush","year":"1991","journal-title":"Diabetes"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0060","first-page":"R87","article-title":"Metabolic and neurochemical profiles in insulin-treated diabetic rats","volume":"266","author":"Bellush","year":"1994","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0065","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.2337\/diab.45.9.1259","article-title":"Place learning and hippocampal synaptic plasticity in streptozotocininduced diabetic rats","volume":"45","author":"Biessels","year":"1996","journal-title":"Diabetes"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(02)01486-3","article-title":"Ageing and diabetes: implications for brain function","volume":"441","author":"Biessels","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0075","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.physbeh.2013.05.012","article-title":"Factors influencing behavior in the forced swim test","volume":"118","author":"Bogdanova","year":"2013","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0080","doi-asserted-by":"crossref","first-page":"571","DOI":"10.2466\/pr0.1977.41.2.571","article-title":"Open-field behavior as a function of age, sex and repeated trials","volume":"41","author":"Bond","year":"1977","journal-title":"Psychol. Rep."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0085","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/BF00176837","article-title":"Is the forced swimming test a suitable model for revealing antidepressant activity?","volume":"94","author":"Borsini","year":"1988","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0090","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1055\/s-0031-1280129","article-title":"Effects of insulin and St. John's wort treatments on anxiety, locomotory activity, depression, and active learning parameters of streptozotocin-diabetic rats","volume":"77","author":"Can","year":"2011","journal-title":"Planta Med."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0095","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0006-3223(03)00236-1","article-title":"Influence of estradiol, stress, and 5-HT2A agonist treatment on brain-derived neurotrophic factor expression in female rats","volume":"54","author":"Cavus","year":"2003","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0100","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.1001\/archinte.160.21.3278","article-title":"Depression and diabetes: impact of depressive symptoms on adherence, function, and costs","volume":"160","author":"Ciechanowski","year":"2000","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0105","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/0278-5846(95)00266-9","article-title":"An early lesion of the lateral septal nuclei produces changes in the forced swim test depending on gender","volume":"19","author":"Contreras","year":"1995","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0110","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0014-2999(01)01628-4","article-title":"Noradrenergic lesions differentially alter the antidepressant-like effects of reboxetine in a modified forced swim test","volume":"436","author":"Cryan","year":"2002","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0115","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2174\/1573399811666150223123053","article-title":"Major depressive disorder and diabetes: does serotonin bridge the gap?","volume":"11","author":"De Long","year":"2015","journal-title":"Curr. Diabetes Rev."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0120","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.bbr.2013.10.011","article-title":"Increased oxidative stress in prefrontal cortex and hippocampus is related to depressive-like behavior in streptozotocin-diabetic rats","volume":"258","author":"de Morais","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0125","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/BF02246053","article-title":"Blockade of the antidepressant-like effects of 8-OH-DPAT, buspirone and desipramine in the rat forced swim test by 5HT1A receptor antagonists","volume":"119","author":"Detke","year":"1995","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0130","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/0166-4328(96)00067-8","article-title":"Detection of serotonergic and noradrenergic antidepressants in the rat forced swimming test: the effects of water depth","volume":"73","author":"Detke","year":"1996","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0135","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1037\/1064-1297.5.2.107","article-title":"Acute and chronic antidepressant drug treatment in the rat forced swimming test model of depression","volume":"5","author":"Detke","year":"1997","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0140","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.mcna.2006.04.001","article-title":"Disease-focused or integrated treatment: diabetes and depression","volume":"90","author":"Egede","year":"2006","journal-title":"Med. Clin. North Am."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0145","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1139\/cjpp-2014-0560","article-title":"Antidepressant-like effect of simvastatin in diabetic rats","volume":"93","author":"Elbatsh","year":"2015","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0150","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1139\/cjpp-2014-0281","article-title":"Anti-depressant effect of hesperidin in diabetic rats","volume":"92","author":"El-Marasy","year":"2014","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0155","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1038\/sj.npp.1300097","article-title":"Antidepressant-like effect of different estrogenic compounds in the forced swimming test","volume":"28","author":"Estrada-Camarena","year":"2003","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0160","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.psyneuen.2006.05.001","article-title":"A facilitating antidepressant-like actions of estrogens are mediated by 5-HT1A and estrogen receptors in the rat forced swimming test","volume":"31","author":"Estrada-Camarena","year":"2006","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0165","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/sj.npp.1300821","article-title":"B participation of the 5-HT1A receptor in the antidepressant-like effect of estrogens in the forced swimming test","volume":"31","author":"Estrada-Camarena","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0170","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/FBP.0b013e32833db7e9","article-title":"Antidepressant effects of estrogens: a basic approximation","volume":"21","author":"Estrada-Camarena","year":"2010","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0175","first-page":"561","article-title":"The aqueous extract of portulaca oleracea ameliorates neurobehavioral dysfunction and hyperglycemia related to streptozotocin-diabetes induced in ovariectomized rats","volume":"15","author":"Fatemi Tabatabaei","year":"2016","journal-title":"Iran J. Pharm. Res."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0180","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0091-3057(97)00482-6","article-title":"Modification of the anxiolytic action of 5-HT1A compounds by GABA-benzodiazepine agents in rats","volume":"60","author":"Fernandez-Guasti","year":"1998","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0185","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.pbb.2016.01.011","article-title":"Sex and age differences in the antidepressant-like effect of fluoxetine in the forced swim test","volume":"152","author":"Fernandez-Guasti","year":"2017","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0190","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.2337\/diacare.16.8.1167","article-title":"Prevalence of depression in adults with diabetes. An epidemiological evaluation","volume":"16","author":"Gavard","year":"1993","journal-title":"Diabetes Care"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0195","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0006-8993(97)01511-4","article-title":"Levels of trkA and BDNF mRNA, but not NGF mRNA, fluctuate across the estrous cycle and increase in response to acute hormone replacement","volume":"787","author":"Gibbs","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0200","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1002\/bdrb.20106","article-title":"The rodent estrous cycle: characterization of vaginal cytology and its utility in toxicological studies","volume":"80","author":"Goldman","year":"2007","journal-title":"Birth Defects Res. B Dev. Reprod. Toxicol."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0205","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0091-3057(00)00221-5","article-title":"Ethopharmacology of the antidepressant effect of clonazepam in diabetic rats","volume":"66","author":"Gomez","year":"2000","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0210","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuroscience.2013.12.035","article-title":"Influence of the brain sexual differentiation process on despair and antidepressant-like effect of fluoxetine in the rat forced swim test","volume":"261","author":"Gomez","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0215","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/jnr.24098","article-title":"Quantitative profiling of neurotransmitter abnormalities in brain, cerebrospinal fluid, and serum of experimental diabetic encephalopathy male rat","volume":"96","author":"Han","year":"2018","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0220","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0031-9384(90)90339-6","article-title":"Behavior of streptozotocin-diabetic mice in tests of exploration, locomotion, anxiety, depression and aggression","volume":"48","author":"Hilakivi-Clarke","year":"1990","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0225","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/0091-3057(83)90014-X","article-title":"Sexual dimorphism in rats with respect to locomotor activity and circling behavior","volume":"18","author":"Hyde","year":"1983","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0230","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/sj.mp.4001920","article-title":"Serotonergic vulnerability and depression: assumptions, experimental evidence and implications","volume":"12","author":"Jans","year":"2007","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0235","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1172\/JCI106180","article-title":"Diabetogenic action of streptozotocin: relationship of dose to metabolic response","volume":"48","author":"Junod","year":"1969","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0240","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0306-4522(98)00485-0","article-title":"Hippocampal synaptic plasticity in streptozotocin-diabetic rats: impairment of long-term potentiation and facilitation of long-term depression","volume":"90","author":"Kamal","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0245","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1742-7843.2006.pto_288.x","article-title":"Effect of chromium picolinate on modified forced swimming test in diabetic rats: involvement of serotonergic pathways and potassium channels","volume":"98","author":"Khanam","year":"2006","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0250","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.neuropharm.2015.03.016","article-title":"Forced swim test: what about females?","volume":"99","author":"Kokras","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0255","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00125-006-0537-4","article-title":"Brain-derived neurotrophic factor (BDNF) and type 2 diabetes","volume":"50","author":"Krabbe","year":"2007","journal-title":"Diabetologia"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0260","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature07455","article-title":"The molecular neurobiology of depression","volume":"455","author":"Krishnan","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0265","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/(SICI)1520-7560(199907\/08)15:4<261::AID-DMRR43>3.0.CO;2-Z","article-title":"Glucose transport in brain and retina: implications in the management and complications of diabetes","volume":"15","author":"Kumagai","year":"1999","journal-title":"Diabetes Metab. Res. Rev."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0270","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1007\/s00213-016-4209-x","article-title":"The role of sigma-1 receptor and brain-derived neurotrophic factor in the development of diabetes and comorbid depression in streptozotocin-induced diabetic rats","volume":"233","author":"Lenart","year":"2016","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0275","article-title":"Therapeutic effect of vagus nerve stimulation on depressive-like behavior, hyperglycemia and insulin receptor expression in Zucker fatty rats","volume":"9","author":"Li","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0280","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1097\/00008877-199711000-00010","article-title":"The forced swimming test as a model for core and component behavioral effects of antidepressant drugs","volume":"8","author":"Lucki","year":"1997","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0285","first-page":"113","article-title":"Depression in diabetic patients: the relationship between mood and glycemic control","volume":"19","author":"Lustman","year":"2005","journal-title":"J. Diabetes Complicat."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0290","doi-asserted-by":"crossref","first-page":"710","DOI":"10.2337\/diab.29.9.710","article-title":"Androgen sensitization of streptozotocin-induced diabetes in mice","volume":"29","author":"Maclaren","year":"1980","journal-title":"Diabetes"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0295","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.pbb.2007.09.003","article-title":"Estrogens participate in the antidepressant-like effect of desipramine and fluoxetine in male rats","volume":"88","author":"Martinez-Mota","year":"2008","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0300","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1007\/s00125-006-0221-8","article-title":"Diabetic encephalopathy: a concept in need of a definition","volume":"49","author":"Mijnhout","year":"2006","journal-title":"Diabetologia"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0305","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/sj.npp.1300354","article-title":"Diabetes attenuates the antidepressant-like effect mediated by the activation of 5-HT1A receptor in the mouse tail suspension test","volume":"29","author":"Miyata","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0310","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1007\/s11064-015-1670-6","article-title":"Effect of imipramine, paroxetine, and lithium carbonate on neurobehavioral changes of streptozotocin in rats: impact on glycogen synthase kinase-3 and blood glucose level","volume":"40","author":"Nadeem","year":"2015","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0315","doi-asserted-by":"crossref","first-page":"724","DOI":"10.2337\/diab.31.8.724","article-title":"Induction of insulin-dependent diabetes by streptozotocin. Inhibition by estrogens and potentiation by androgens","volume":"31","author":"Paik","year":"1982","journal-title":"Diabetes"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0320","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.yhbeh.2009.04.008","article-title":"Sex differences in neuroactive steroid levels in the nervous system of diabetic and non-diabetic rats","volume":"57","author":"Pesaresi","year":"2010","journal-title":"Horm. Behav."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0325","doi-asserted-by":"crossref","first-page":"448","DOI":"10.2337\/diacare.22.3.448","article-title":"Persistence of depressive symptoms in diabetic adults","volume":"22","author":"Peyrot","year":"1999","journal-title":"Diabetes Care"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0330","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.bbr.2014.04.049","article-title":"Endotoxaemia resulting from decreased serotonin tranporter (5-HTT) function: a reciprocal risk factor for depression and insulin resistance?","volume":"276","author":"Pomytkin","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0335","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/9780470942390.mo110176","article-title":"Depression-related behavioral tests","volume":"2","author":"Powell","year":"2012","journal-title":"Curr. Protoc. Mouse Biol."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0340","doi-asserted-by":"crossref","first-page":"4","DOI":"10.4103\/0253-7613.150305","article-title":"Diabetes-associated depression: the serotonergic system as a novel multifunctional target","volume":"47","author":"Prabhakar","year":"2015","journal-title":"Indian J. Pharm."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0345","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.physbeh.2013.08.002","article-title":"Role of thirst and visual barriers in the differential behavior displayed by streptozotocin-treated rats in the elevated plus-maze and the open field test","volume":"120","author":"Rebolledo-Solleiro","year":"2013","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0350","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.bbr.2016.06.060","article-title":"Dopamine D1 receptor activity is involved in the increased anxiety levels observed in STZ-induced diabetes in rats","volume":"313","author":"Rebolledo-Solleiro","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0355","series-title":"Organization for the Study of Sex Differences Annual Meeting, Montreal, CA. Poster Session No. 100","article-title":"Streptozotocin-induced diabetes exerts depressive-like behavior in male and naturally cycling female rats. A comparative study","author":"Rebolledo-Solleiro","year":"2017"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0360","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1210\/endo-103-4-1518","article-title":"Sex differences in the multiple-dose streptozotocin model of diabetes","volume":"103","author":"Rossini","year":"1978","journal-title":"Endocrinology"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0365","doi-asserted-by":"crossref","first-page":"651","DOI":"10.2337\/diacare.5.6.651b","article-title":"Oral contraceptives abolish luteal phase exacerbation of hyperglycemia in type I diabetes","volume":"5","author":"Sacerdote","year":"1982","journal-title":"Diabetes Care"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0370","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.physbeh.2010.07.002","article-title":"Neurobehavioral deficits in db\/db diabetic mice","volume":"101","author":"Sharma","year":"2010","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0375","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/ijo.2012.48","article-title":"Diet-induced obesity promotes depressive-like behaviour that is associated with neural adaptations in brain reward circuitry","volume":"37","author":"Sharma","year":"2013","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0380","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ejphar.2004.02.056","article-title":"Insulin, C-peptide, hyperglycemia, and central nervous system complications in diabetes","volume":"490","author":"Sima","year":"2004","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0385","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1124\/jpet.105.093948","article-title":"Differential gender-related vulnerability to depression induction and converging antidepressant responses in rats","volume":"316","author":"Sun","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0390","doi-asserted-by":"crossref","first-page":"537","DOI":"10.33549\/physiolres.930111","article-title":"The mechanism of alloxan and streptozotocin action in \u03b2 cells of the rat pancreas","volume":"50","author":"Szkudelski","year":"2001","journal-title":"Physiol. Res."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0395","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/j.psyneuen.2012.12.008","article-title":"Acute stress further decreases the effect of ovariectoy on immobility behavior and hippocampal cell survival in rats","volume":"38","author":"Vega-Rivera","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0400","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1677\/joe.1.06596","article-title":"Sexual dimorphism in insulin sensitivity and susceptibility to develop diabetes in rats","volume":"190","author":"Vital","year":"2006","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0405","doi-asserted-by":"crossref","first-page":"15196","DOI":"10.1074\/jbc.M115.672857","article-title":"Diabetes impairs Wnt3 protein-induced neurogenesis in olfactory bulbs via glutamate transporter 1 inhibition","volume":"291","author":"Wakabayashi","year":"2016","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0410","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s11011-010-9211-0","article-title":"Protein and lipid oxidative damage in streptozotocin-induced diabetic rats submitted to forced swimming test: the insulin and clonazepam effect","volume":"25","author":"Wayhs","year":"2010","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0415","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1177\/0192623308315665","article-title":"The female rat reproductive cycle: a practical histological guide to staging","volume":"36","author":"Westwood","year":"2008","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.physbeh.2018.06.033_bb0420","doi-asserted-by":"crossref","first-page":"213","DOI":"10.2337\/diacare.15.2.213","article-title":"Alterations in glucose metabolism during menstrual cycle in women with IDDM","volume":"15","author":"Widom","year":"1992","journal-title":"Diabetes Care"},{"key":"10.1016\/j.physbeh.2018.06.033_bb0425","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1210\/en.2011-0004","article-title":"Impaired CNS leptin action is implicated in depression associated with obesity","volume":"152","author":"Yamada","year":"2011","journal-title":"Endocrinology"}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938418303998?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938418303998?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:12:04Z","timestamp":1758478324000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938418303998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":85,"alternative-id":["S0031938418303998"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2018.06.033","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influence of sex and estrous cycle on blood glucose levels, body weight gain, and depressive-like behavior in streptozotocin-induced diabetic rats","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2018.06.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}