{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T15:20:21Z","timestamp":1774452021495,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T00:00:00Z","timestamp":1563840000000},"content-version":"vor","delay-in-days":295,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"CAPES\/PROEX, FAPESP","award":["05\/00096-1"],"award-info":[{"award-number":["05\/00096-1"]}]},{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","award":["07\/06549-3"],"award-info":[{"award-number":["07\/06549-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["304215\/2016-3"],"award-info":[{"award-number":["304215\/2016-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.physbeh.2018.07.003","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T22:12:39Z","timestamp":1531174359000},"page":"538-544","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Restricted lesions of the ventrolateral or dorsal columns of the periaqueductal gray promotes distinct effects on tonic immobility and defensive analgesia in guinea pigs"],"prefix":"10.1016","volume":"194","author":[{"given":"Eveline Bis","family":"Vieira-Rasteli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna Balbino","family":"de Paula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yara Bezerra","family":"de Paiva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norberto Cysne","family":"Coimbra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christie Ramos Andrade","family":"Leite-Panissi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2018.07.003_bb0005","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1017\/S0140525X0000491X","article-title":"A perceptual-defensive-recuperative model of fear and pain","volume":"3","author":"Bolles","year":"1980","journal-title":"Behav. Brain Sci."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0010","series-title":"Handbook of Clinical and Experimental Hypnosis","first-page":"550","article-title":"Comparative aspects of hypnosis","author":"Ratner","year":"1967"},{"key":"10.1016\/j.physbeh.2018.07.003_bb0015","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1146\/annurev.ps.39.020188.000355","article-title":"Ethoexperimental approaches of the biology of emotion","volume":"39","author":"Blanchard","year":"1988","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0020","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0166-4328(93)90159-N","article-title":"GABAergic nigro-collicular pathways modulate the defensive behavior elicited by midbrain tectum stimulation","volume":"59","author":"Coimbra","year":"1993","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0025","series-title":"The Neuropsychology of Anxiety: An Enquiry into the Functions of the Septo-Hippocampal System","author":"Gray","year":"1982"},{"key":"10.1016\/j.physbeh.2018.07.003_bb0030","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/0006-8993(90)91692-A","article-title":"Flight and immobility evoked by excitatory amino acid microinjection within distinct parts of the sub-tentorial midbrain periaqueductal gray of the cat","volume":"520","author":"Zhang","year":"1990","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0035","first-page":"315","article-title":"Critical role for \"affective neuroscience\" in resolving what is basic about basic emotions","volume":"3","author":"Panksepp","year":"1990","journal-title":"Psychol. Rev."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0040","first-page":"33","article-title":"Das subkortikale zentrum der affectiven abwerreaktion","volume":"1","author":"Hess","year":"1943","journal-title":"Helv. Physiol. Pharmacol. Acta."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0045","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/B978-0-12-512504-8.50011-1","article-title":"Neurophysiologic studies of the immobility reflex (\u201cAnimal hypnosis\u201d)","volume":"4","author":"Klemm","year":"1971","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0050","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1590\/S0100-879X2001000200013","article-title":"Endogenous opiate analgesia induced by tonic immobility in guinea pigs","volume":"34","author":"Leite-Panissi","year":"2001","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0055","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.yhbeh.2016.12.002","article-title":"Effect of melatonin injection into the periaqueductal gray on antinociception and tonic immobility in male rats","volume":"89","author":"Miranda-P\u00e1ez","year":"2017","journal-title":"Horm. Behav."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0060","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0166-4328(93)90030-T","article-title":"The parabrachial region, a possible substrate shared by the systems that modulate pain and tonic immobility","volume":"56","author":"Menescal-de-Oliveira","year":"1993","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0065","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0006-8993(98)00669-6","article-title":"Immobility and flight associated with antinociception produced by activation of the ventral and lateral\/dorsal regions of the rat periaqueductal gray","volume":"804","author":"Morgan","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0070","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.pbb.2016.01.002","article-title":"Involvement of opioid and GABA systems in the ventrolateral periaqueductal gray on analgesia associated with tonic immobility","volume":"142","author":"Miranda-P\u00e1ez","year":"2016","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"10","key":"10.1016\/j.physbeh.2018.07.003_bb0075","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1590\/S0100-879X2004001000018","article-title":"Cholinergic-opioidergic interaction in the central amygdala induces antinociception in the guinea pig","author":"Leite-Panissi","year":"2004","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0080","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0006-8993(88)91465-5","article-title":"Integrated defense reaction elicited by excitatory amino acid microinjection in the midbrain periaqueductal gray region of the unrestrained cat","volume":"439","author":"Bandler","year":"1988","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0085","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev.ne.07.030184.001521","article-title":"Endogenous pain control systems: brainstem spinal pathways and endorphin circuitry","volume":"7","author":"Basbaum","year":"1984","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0090","series-title":"The Midbrain Periaqueductal Gray Matter Functional, Anatomical and Neurochemical Organization","first-page":"101","article-title":"Interactions between descending pathways from the dorsal and ventrolateral periaqueductal gray matter in the rat","author":"Lovick","year":"1991"},{"key":"10.1016\/j.physbeh.2018.07.003_bb0095","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0006-8993(79)90830-8","article-title":"Role of the periaqueductal gray in vocal expression of emotion","volume":"167","author":"J\u00fcrgens","year":"1979","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0100","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/B978-0-444-63274-6.00020-5","article-title":"The periaqueductal gray controls brainstem emotional systems including respiration","volume":"209","author":"Holstege","year":"2014","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0105","series-title":"The Midbrain Periaqueductal Gray Matter: Functional, Anatomical and Neurochemical Organization","first-page":"175","article-title":"Midbrain periaqueductal gray control of defensive behavior in the cat and the rat","author":"Bandler","year":"1991"},{"key":"10.1016\/j.physbeh.2018.07.003_bb0110","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/S0149-7634(99)00038-X","article-title":"Neurochemical mechanisms of the defensive behavior in the dorsal midbrain","volume":"23","author":"Brand\u00e3o","year":"1999","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0115","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0361-9230(03)00031-5","article-title":"The cholinergic stimulation of the central amygdala modifying the tonic immobility response and antinociception in guinea pigs depends on the ventrolateral periaqueductal gray","volume":"60","author":"Leite-Panissi","year":"2003","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0120","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0361-9230(99)00192-6","article-title":"Ventrolateral periaqueductal gray matter and the control of tonic immobility","volume":"150","author":"Monassi","year":"1999","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0125","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0031-9384(97)00134-0","article-title":"Involvement of the cholinergic system and periaqueductal gray matter in the modulation of tonic immobility in guinea pigs","volume":"62","author":"Monassi","year":"1997","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0130","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.bbr.2010.07.013","article-title":"Functional mapping of the periaqueductal gray matter involved in organizing tonic immobility behavior in guinea pigs","volume":"216","author":"Vieira-Rasteli","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0135","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S1569-9048(02)00116-7","article-title":"Chemical lesions of the nucleus isthmi increase the hypoxic and hypercarbic drive to breathing of toads","volume":"133","author":"Gargaglioni","year":"2002","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0140","series-title":"Stereotaktischer Hirnatlas Vom Meerschweinchen","author":"R\u00f6ssner","year":"1965"},{"key":"10.1016\/j.physbeh.2018.07.003_bb0145","series-title":"The rat brain in stereotaxic coordinate, The new coronal set","author":"Paxinos","year":"2005"},{"key":"10.1016\/j.physbeh.2018.07.003_bb0150","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/BF00228745","article-title":"The periaqueductal gray in the cat projects to lamina VIII and the medial part of lamina VII throughout the length of the spinal cord","author":"Mouton","year":"1994","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0155","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.biopsych.2009.08.025","article-title":"Antidepressant-like effects of medial prefrontal cortex deep brain stimulation in rats","volume":"67","author":"Hamani","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.physbeh.2018.07.003_bb0160","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.expneurol.2007.09.015","article-title":"Neuroanatomical changes in the adult rat brain after neonatal lesion of the medial prefrontal cortex","volume":"209","author":"Klein","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0165","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/jcbfm.1992.138","article-title":"Plasticity in the rat hippocampal formation following ibotenic acid lesion of the septal region: a quantitative [14C]deoxyglucose and acetylcholinesterase study","volume":"12","author":"Schulz","year":"1992","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0170","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0165-3806(94)00158-V","article-title":"Rapid serotonergic fiber sprouting in response to ibotenic acid lesion in the striatum and hippocampus","volume":"84","author":"Zhou","year":"1995","journal-title":"Dev. Brain Res."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0175","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0006-8993(84)90916-8","article-title":"Induced homotypic collateral sprouting of serotonergic fibers in hippocampus","volume":"308","author":"Zhou","year":"1984","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0180","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.brainresbull.2006.02.007","article-title":"Serotoninergic activation of the basolateral amygdala and modulation of tonic immobility in guinea pig","volume":"69","author":"Leite-Panissi","year":"2006","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0185","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.brainres.2004.02.061","article-title":"Serotonin 5-HT2 and 5-HT1A receptors in the periaqueductal gray matter differentially modulate tonic immobility in guinea pig","volume":"1009","author":"Monassi","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0190","doi-asserted-by":"crossref","first-page":"108","DOI":"10.2307\/2424542","article-title":"Death feigning by ducks in response to predation by red foxes (Vulpes fulva)","volume":"94","author":"Sargeant","year":"1975","journal-title":"Am. Midbrain Nat."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0195","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0166-2236(94)90047-7","article-title":"Columnar organization in the midbrain periaqueductal gray: modules for emotional expression?","volume":"17","author":"Bandler","year":"1994","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0200","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neuroscience.2004.01.026","article-title":"Organization of single components of defensive behaviors within distinct columns of periaqueductal gray matter of the rat: role of n-methyl-d-aspartic acid glutamate receptors","volume":"125","author":"Bittencourt","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2018.07.003_bb0205","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0006-8993(97)01293-6","article-title":"Local connections between the columns of the periaqueductal gray matter: a case of intrinsic neuromodulation","volume":"784","author":"Jansen","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0210","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/0166-2236(96)89621-4","article-title":"Intrinsic neuromodulation: altering neuronal circuits from within","volume":"19","author":"Katz","year":"1996","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0215","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1037\/0735-7044.98.1.79","article-title":"Shock-induced analgesia on the formalin test: effects of shock severity, naloxone, hypophysectomy, and associative variables","volume":"1","author":"Fanselow","year":"1984","journal-title":"Behav. Neurosci."},{"issue":"1","key":"10.1016\/j.physbeh.2018.07.003_bb0220","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0361-9230(87)90177-8","article-title":"Social conflict analgesia: inhibition of early non-opioid component by diazepam or flumazepil fails to affect appearance of late opioid component","author":"Rodgers","year":"1987","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0225","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1037\/0735-7044.102.2.233","article-title":"Conditional analgesia, defensive freezing, and benzodiazepines","volume":"102","author":"Fanselow","year":"1988","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0230","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0166-4328(84)90202-X","article-title":"Physiological characteristics of pressure immobility. Effect of morphine, naloxone and pain","volume":"12","author":"Carli","year":"1984","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0235","series-title":"The midbrain Periaqueductal Gray Matter: Functional","first-page":"151","article-title":"The midbrain periaqueductal gray as coordinator of action in response to fear and anxiety","author":"Fanselow","year":"1991"},{"key":"10.1016\/j.physbeh.2018.07.003_bb0240","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0006-8993(84)91144-2","article-title":"Fear is not critical to classically conditioned analgesia: the effects of periaqueductal gray lesions and administration of chlordiazepoxide","volume":"298","author":"Kinscheck","year":"1984","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2018.07.003_bb0245","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0304-3959(85)90088-0","article-title":"Ventrolateral medullary lesions block the antinociceptive and cardiovascular responses elicited by stimulating the dorsal periaqueductal grey matter in rats","volume":"21","author":"Lovick","year":"1985","journal-title":"Pain"}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938418304384?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938418304384?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:11:34Z","timestamp":1758478294000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938418304384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":49,"alternative-id":["S0031938418304384"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2018.07.003","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Restricted lesions of the ventrolateral or dorsal columns of the periaqueductal gray promotes distinct effects on tonic immobility and defensive analgesia in guinea pigs","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2018.07.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc.","name":"copyright","label":"Copyright"}]}}