{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T09:43:00Z","timestamp":1792143780765,"version":"4.4.0"},"reference-count":219,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["304650\/2016-1"],"award-info":[{"award-number":["304650\/2016-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["401842\/2018-5"],"award-info":[{"award-number":["401842\/2018-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["88887.192493\/2018-00"],"award-info":[{"award-number":["88887.192493\/2018-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e Inova\u00e7\u00e3o de Santa Catarina","award":["TO2018TR1196"],"award-info":[{"award-number":["TO2018TR1196"]}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/01139-0"],"award-info":[{"award-number":["2016\/01139-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011893","name":"Pan American Health Organization","doi-asserted-by":"publisher","award":["SCON2018-00402"],"award-info":[{"award-number":["SCON2018-00402"]}],"id":[{"id":"10.13039\/100011893","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.physbeh.2019.03.009","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T12:00:42Z","timestamp":1552392042000},"page":"309-323","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Epigenetic modifications induced by exercise: Drug-free intervention to improve cognitive deficits associated with obesity"],"prefix":"10.1016","volume":"204","author":[{"given":"Leonardo","family":"Barros","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuany","family":"Eichwald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Francisco","family":"Solano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora","family":"Scheffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Augusto","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana M.","family":"Gaspar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4255-3589","authenticated-orcid":false,"given":"Alexandra","family":"Latini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2019.03.009_bb0005","series-title":"Obesity and Overweight","first-page":"1","author":"WHO","year":"2018"},{"key":"10.1016\/j.physbeh.2019.03.009_bb0010","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/j.1467-789X.2011.00920.x","article-title":"A review of the association between obesity and cognitive function across the lifespan: implications for novel approaches to prevention and treatment","volume":"12","author":"Smith","year":"2011","journal-title":"Obes. Rev."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0015","doi-asserted-by":"crossref","first-page":"8889","DOI":"10.1523\/JNEUROSCI.0789-18.2018","article-title":"Microglia Play an Active Role in Obesity-Associated Cognitive Decline","volume":"38","author":"Cope","year":"2018","journal-title":"J Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0020","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.biopsych.2009.02.013","article-title":"Meta-analysis of alzheimer\u2019s disease risk with obesity, diabetes, and related disorders","volume":"67","author":"Profenno","year":"2010","journal-title":"Biol. Psychiatry."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0025","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1749-6632.2012.06785.x","article-title":"Physical activity in obesity and metabolic syndrome","volume":"1281","author":"Strasser","year":"2013","journal-title":"Ann N Y Acad Sci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0030","series-title":"Physical Activity Guidelines for Americans","author":"U.S. Department of Health and Human Services","year":"2018"},{"key":"10.1016\/j.physbeh.2019.03.009_bb0035","first-page":"1","article-title":"A tennis-based health program for middle-aged men who are at risk for heart disease","volume":"3","author":"Rosa","year":"2017","journal-title":"Integr. Obes. Diabetes"},{"key":"10.1016\/j.physbeh.2019.03.009_bb0040","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/j.2040-4603.2013.tb00485.x","article-title":"The influence of exercise on cognitive abilities","volume":"3","author":"Gomez-Pinilla","year":"2013","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0045","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1016\/j.neuroscience.2009.01.057","article-title":"The effect of acute treadmill walking on cognitive control and academic achievement in preadolescent children","volume":"159","author":"Hillman","year":"2009","journal-title":"Neuroscience."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0050","doi-asserted-by":"crossref","first-page":"2255","DOI":"10.1016\/S0140-6736(15)60461-5","article-title":"A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): a randomised controlled trial","volume":"385","author":"Ngandu","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.physbeh.2019.03.009_bb0055","series-title":"The Combined Effects of Physical Exercise Training and Detraining on Adiponectin in Overweight and Obese Children","first-page":"145","volume":"2","author":"Jeon","year":"2013"},{"key":"10.1016\/j.physbeh.2019.03.009_bb0060","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.celrep.2018.03.059","article-title":"RNA-dependent intergenerational inheritance of enhanced synaptic plasticity after environmental enrichment","volume":"23","author":"Benito","year":"2018","journal-title":"Cell Rep."},{"issue":"2012","key":"10.1016\/j.physbeh.2019.03.009_bb0065","first-page":"10","article-title":"The epigenotype","volume":"41","author":"Waddington","year":"1942","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0070","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s12033-009-9216-2","article-title":"DNA methylation: an introduction to the biology and the disease-associated changes of a promising biomarker","volume":"44","author":"Tost","year":"2010","journal-title":"Mol. Biotechnol."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mrfmmm.2008.03.002","article-title":"Epigenetic drivers and genetic passengers on the road to cancer","volume":"642","author":"Sawan","year":"2008","journal-title":"Mutat. Res."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0080","first-page":"631","article-title":"The role of mammalian DNA methyltransferases in the regulation of gene expression","volume":"10","author":"Turek-Plewa","year":"2005","journal-title":"Cell. Mol. Biol. Lett."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0085","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00018-002-8420-z","article-title":"DNA methylation and the regulation of gene transcription","volume":"59","author":"Attwood","year":"2002","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0090","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1016\/j.chembiol.2009.06.002","article-title":"Oxygenase catalyzed 5-methylcytosine hydroxylation","volume":"16","author":"Loenarz","year":"2009","journal-title":"Chem. Biol."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0095","doi-asserted-by":"crossref","first-page":"13669","DOI":"10.1074\/jbc.C113.464800","article-title":"Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine","volume":"288","author":"Minor","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0100","first-page":"334","article-title":"Replication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryos","volume":"80","author":"Inoue","year":"2011","journal-title":"Science"},{"key":"10.1016\/j.physbeh.2019.03.009_bb0105","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1126\/science.1210597","article-title":"Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine","volume":"333","author":"Ito","year":"2011","journal-title":"Science."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0110","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1126\/science.1210944","article-title":"Tet-mediated Formation of 5-Carb","volume":"333","author":"He","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.physbeh.2019.03.009_bb0115","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2007.02.005","article-title":"Chromatin modifications and their function","volume":"128","author":"Kouzarides","year":"2007","journal-title":"Cell."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0120","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1016\/j.bbamcr.2008.07.018","article-title":"Nuclear architecture and gene regulation","volume":"1783","author":"Fedorova","year":"2008","journal-title":"Biochim. Biophys. Acta - Mol. Cell Res."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1756-6606-5-14","article-title":"The molecular biology of memory: cAMP, PKA, CRE, CREB-1, CREB-2, and CPEB","volume":"5","author":"Kandel","year":"2012","journal-title":"Mol. Brain."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnmol.2015.00046","article-title":"A new perspective on the role of the CREB family of transcription factors in memory consolidation via adult hippocampal neurogenesis","volume":"8","author":"Ortega-Mart\u00ednez","year":"2015","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0135","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/jcb.20179","article-title":"Regulation of histone deacetylase activities","volume":"93","author":"Sengupta","year":"2004","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0140","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1868-7083-4-5","article-title":"Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors","volume":"4","author":"Delcuve","year":"2012","journal-title":"Clin. Epigenetics."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0145","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/47412","article-title":"The language of covalent histone modifications","volume":"403","author":"Strahl","year":"2000","journal-title":"Nature."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0150","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.molcel.2012.11.006","article-title":"Histone lysine methylation dynamics: establishment, regulation, and biological impact","volume":"48","author":"Black","year":"2012","journal-title":"Mol. Cell."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0155","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/nrm1761","article-title":"The diverse functions of histone lysine methylation","volume":"6","author":"Martin","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0160","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/35020506","article-title":"Regulation of chromatin structure by site-specific histone H3 methyltransferases","volume":"406","author":"Rea","year":"2000","journal-title":"Nature."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0165","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nature07756","article-title":"Small RNAs in transcriptional gene silencing and genome defence","volume":"457","author":"Moazed","year":"2009","journal-title":"Nature."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0170","doi-asserted-by":"crossref","first-page":"5949","DOI":"10.1242\/jcs.01487","article-title":"Biogenesis of small nuclear RNPs","volume":"117","author":"Kiss","year":"2004","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0175","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nrg2504","article-title":"Small silencing RNAs: an expanding universe","volume":"10","author":"Zamore","year":"2009","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0180","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.molcel.2011.08.018","article-title":"Molecular mechanisms of long noncoding RNAs","volume":"43","author":"Wang","year":"2011","journal-title":"Mol. Cell."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0185","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev-biochem-051410-092902","article-title":"Genome regulation by long noncoding RNAs","volume":"81","author":"Rinn","year":"2012","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0190","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.neuron.2004.06.002","article-title":"CBP histone acetyltransferase activity is a critical component of memory consolidation","volume":"42","author":"Korzus","year":"2004","journal-title":"Neuron."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0195","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.tins.2008.03.005","article-title":"Chromatin and nuclear architecture in the nervous system","volume":"31","author":"Takizawa","year":"2008","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0200","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1042\/BJ20110293","article-title":"Tetrahydrobiopterin: biochemistry and pathophysiology","volume":"438","author":"Werner","year":"2011","journal-title":"Biochem. J."},{"issue":"Pt 1","key":"10.1016\/j.physbeh.2019.03.009_bb0205","first-page":"1","article-title":"Tetrahydrobiopterin biosynthesis, regeneration and functions","volume":"347","author":"Thony","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0210","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/jb\/mvp042","article-title":"Expression analysis of the Aldo-keto reductases involved in the novel biosynthetic pathway of tetrahydrobiopterin in human and mouse tissues","volume":"146","author":"Hirakawa","year":"2009","journal-title":"J. Biochem."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0215","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1002\/(SICI)1097-4644(19971001)67:1<24::AID-JCB3>3.0.CO;2-Y","article-title":"Distinct roles for Sp1 and E2F sites in the growth\/cell cycle regulation of the DHFR promoter","volume":"67","author":"Jensen","year":"1997","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0220","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1016\/S0021-9258(17)43186-3","article-title":"The functional human dihydrofolate reductase gene","volume":"259","author":"Chen","year":"1984","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0225","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.1093\/jn\/133.8.2650","article-title":"Multivitamin supplements are inversely associated with risk of myocardial infarction in men and women\u2014Stockholm Heart Epidemiology Program (SHEEP)","volume":"133","author":"Holmquist","year":"2003","journal-title":"J. Nutr."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0230","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/nrc1144","article-title":"Chemoprevention of colon cancer by calcium, vitamin D and folate: molecular mechanisms","volume":"3","author":"Lamprecht","year":"2003","journal-title":"Nat. Rev. Cancer."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0235","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1136\/adc.51.12.944","article-title":"Vitamin dificiencies and neural tube defects","volume":"51","author":"Smithells","year":"1976","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0240","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1136\/bmj.282.6275.1509","article-title":"Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects","volume":"282","author":"Laurence","year":"1981","journal-title":"BMJ."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0245","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.pain.2008.10.023","article-title":"Polymorphisms in the GTP cyclohydrolase gene (GCH1) are associated with ratings of capsaicin pain","volume":"141","author":"Campbell","year":"2009","journal-title":"Pain."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0250","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/s41586-018-0701-2","article-title":"The metabolite BH4 controls T cell proliferation in autoimmunity and cancer","volume":"563","author":"Cronin","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.physbeh.2019.03.009_bb0255","doi-asserted-by":"crossref","first-page":"2671","DOI":"10.2353\/ajpath.2010.100025","article-title":"Roles of tetrahydrobiopterin in promoting tumor angiogenesis","volume":"177","author":"Chen","year":"2010","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0260","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0387-7604(00)00144-3","article-title":"Alterations of tetrahydrobiopterin biosynthesis and pteridine levels in mouse tissues during growth and aging","volume":"22","author":"Yoshida","year":"2000","journal-title":"Brain Dev."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0265","doi-asserted-by":"crossref","first-page":"3040","DOI":"10.1089\/ars.2013.5566","article-title":"Tetrahydrobiopterin in cardiovascular health and disease","volume":"20","author":"Bendall","year":"2014","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0270","doi-asserted-by":"crossref","first-page":"3924","DOI":"10.1016\/j.febslet.2014.09.004","article-title":"Disturbed biopterin and folate metabolism in the Qdpr -deficient mouse","volume":"588","author":"Xu","year":"2014","journal-title":"FEBS Lett."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0275","doi-asserted-by":"crossref","first-page":"5821","DOI":"10.1074\/jbc.RA118.002180","article-title":"Deletion of the neural tube defect\u2013associated gene Mthfd1l disrupts one-carbon and central energy metabolism in mouse embryos","volume":"293","author":"Bryant","year":"2018","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0280","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1016\/j.cell.2018.09.041","article-title":"Mitochondrial one-carbon pathway supports cytosolic folate integrity in cancer cells","volume":"175","author":"Zheng","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.physbeh.2019.03.009_bb0285","doi-asserted-by":"crossref","first-page":"28128","DOI":"10.1074\/jbc.M109.041483","article-title":"Critical role for tetrahydrobiopterin recycling by dihydrofolate reductase in regulation of endothelial nitric-oxide synthase coupling","volume":"284","author":"Crabtree","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0290","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1002\/bdra.23511","article-title":"Determining the association between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and genomic DNA methylation level: A meta-analysis","volume":"106","author":"Wang","year":"2016","journal-title":"Birth Defects Res. Part A Clin. Mol. Teratol."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0295","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1096\/fasebj.10.4.8647346","article-title":"S-Adenosylmethionine and methylation","volume":"10","author":"Chiang","year":"1996","journal-title":"FASEB J."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0300","doi-asserted-by":"crossref","first-page":"H2167","DOI":"10.1152\/ajpheart.00935.2001","article-title":"Interaction of 5-methyltetrahydrofolate and tetrahydrobiopterin on endothelial function","volume":"282","author":"Hyndman","year":"2002","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0305","first-page":"216","article-title":"The methylation, neurotransmitter, and antioxidant connections between folate and depression","volume":"13","author":"Miller","year":"2008","journal-title":"Altern. Med. Rev."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0310","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1161\/01.RES.86.11.1129","article-title":"Folic acid reverts dysfunction of endothelial nitric oxide synthase","volume":"9","author":"Stroes","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0315","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1080\/15592294.2016.1229730","article-title":"Epigenetic loss of putative tumor suppressor SFRP3 correlates with poor prognosis of lung adenocarcinoma patients","volume":"13","author":"Schlensog","year":"2016","journal-title":"Epigenetics."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0320","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.4161\/epi.25865","article-title":"Identification of concordant epigenetic changes in brain and peripheral blood leukocytes Distinctive patterns of DNA methylation associated with Parkinson disease","volume":"8","author":"Masliah","year":"2013","journal-title":"Epigenetics."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0325","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neurobiolaging.2016.07.008","article-title":"Increased DNA methylation near TREM2 is consistently seen in the superior temporal gyrus in Alzheimer\u2019s disease brain","volume":"47","author":"Smith","year":"2016","journal-title":"Neurobiol. Aging."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0330","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nature13163","article-title":"REST and stress resistance in ageing and Alzheimer\u2019s disease","volume":"507","author":"Lu","year":"2014","journal-title":"Nature."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0335","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1741-7015-8-87","article-title":"Obesity related methylation changes in DNA of peripheral blood leukocytes","volume":"8","author":"Wang","year":"2010","journal-title":"BMC Med."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0340","doi-asserted-by":"crossref","first-page":"76","DOI":"10.4161\/epi.6.1.13391","article-title":"Global methylation profles in DNA from different blood cell types","volume":"6","author":"Wu","year":"2011","journal-title":"Epigenetics."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0345","doi-asserted-by":"crossref","first-page":"623","DOI":"10.4161\/epi.6.5.15335","article-title":"Significant differences in global genomic DNA methylation by gender and race\/ethnicity in peripheral blood","volume":"6","author":"Zhang","year":"2011","journal-title":"Epigenetics."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0350","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1017\/S0029665111003302","article-title":"Nutritional influences on epigenetics and age-related disease, in: Proc","volume":"71","author":"Park","year":"2012","journal-title":"Nutr. Soc."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0355","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1038\/s41598-019-38587-7","article-title":"Association between DNA methylation in obesity-related genes and body mass index percentile in adolescents","volume":"9","author":"He","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0360","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1007\/s12035-018-1175-9","article-title":"Chronic metabolic derangement-induced cognitive deficits and neurotoxicity are associated with rest inactivation","volume":"56","author":"Remor","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0365","doi-asserted-by":"crossref","first-page":"46311","DOI":"10.1038\/srep46311","article-title":"Genome-wide methylation analysis identifies specific epigenetic marks in severely obese children","volume":"7","author":"Fradin","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0370","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1016\/S0140-6736(13)62674-4","article-title":"DNA methylation and body-mass index: a genome-wide analysis","volume":"383","author":"Dick","year":"2014","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.physbeh.2019.03.009_bb0375","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pgen.1002543","article-title":"An Alu element\u2013associated hypermethylation variant of the POMC gene is associated with childhood obesity","volume":"8","author":"Kuehnen","year":"2012","journal-title":"PLoS Genet."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0380","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/j.celrep.2013.03.018","article-title":"Weight loss after gastric bypass surgery in human obesity remodels promoter methylation","volume":"3","author":"Barres","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0385","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.2337\/db13-0671","article-title":"PGC1\u03b1 promoter methylation in blood at 5-7 years predicts adiposity from 9 to 14 years (EarlyBird 50)","volume":"63","author":"Clarke-Harris","year":"2014","journal-title":"Diabetes."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0390","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nature13163","article-title":"REST and stress resistance in ageing and Alzheimer disease","volume":"507","author":"Lu","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.physbeh.2019.03.009_bb0395","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/ijo.2012.8","article-title":"Promoter methylation of serotonin transporter gene is associated with obesity measures: A monozygotic twin study","volume":"37","author":"Zhao","year":"2013","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0400","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1111\/j.1365-2265.2012.04453.x","article-title":"An unbalanced maternal diet in pregnancy associates with offspring epigenetic changes in genes controlling glucocorticoid action and foetal growth","volume":"77","author":"Drake","year":"2012","journal-title":"Clin. Endocrinol. (Oxf)."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0405","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1868-7083-4-21","article-title":"DNA methylation of the IGF2\/H19 imprinting control region and adiposity distribution in young adults","volume":"4","author":"Huang","year":"2012","journal-title":"Clin. Epigenetics."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0410","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1038\/ijo.2014.213","article-title":"Epigenetic patterns in successful weight loss maintainers: a pilot study","volume":"39","author":"Huang","year":"2015","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0415","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.5114\/aoms.2015.56342","article-title":"Brain-derived neurotrophic factor and its clinical Implications","volume":"11","author":"Bathina","year":"2015","journal-title":"Arch. Med. Sci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0420","doi-asserted-by":"crossref","first-page":"12660","DOI":"10.1074\/jbc.M008104200","article-title":"Biosynthesis and post-translational processing of the precursor to brain-derived neurotrophic factor","volume":"276","author":"Mowla","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0425","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1080\/1028415X.2016.1180859","article-title":"Investigation of brain-derived neurotrophic factor (BDNF) gene expression in hypothalamus of obese rats: Modulation by omega-3 fatty acids","volume":"20","author":"Abdel-Maksoud","year":"2017","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0430","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12031-014-0461-x","article-title":"Histone deacetylase inhibitor, trichostatin a, improves learning and memory in high-fat diet-induced cognitive deficits in mice","volume":"56","author":"Sharma","year":"2015","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0435","series-title":"Higher Brain BDNF Gene Expression is Associated with Slower Cognitive Decline in Older Adults","first-page":"735","volume":"86","author":"Buchman","year":"2016"},{"key":"10.1016\/j.physbeh.2019.03.009_bb0440","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1093\/embo-reports\/kvf053","article-title":"Histone acetylation: A switch between repressive and permissive chromatin. Second in review on chromatin dynamics","volume":"3","author":"Eberharter","year":"2002","journal-title":"EMBO Rep"},{"key":"10.1016\/j.physbeh.2019.03.009_bb0445","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/nature01648","article-title":"A nucleosomal function for I\u03baB kinase-\u03b1 in NF-\u03baB-dependent gene expression","volume":"423","author":"Strahl","year":"2003","journal-title":"Nature."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0450","first-page":"1","article-title":"For researchers on obesity: historical review of extra body weight definitions","volume":"2016","author":"Komaroff","year":"2016","journal-title":"J. Obes."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0455","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1146\/annurev.pathol.4.110807.092250","article-title":"Mammalian sirtuins: Biological insights and disease relevance","volume":"5","author":"Haigis","year":"2010","journal-title":"Annu. Rev. Pathol. Mech. Dis."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0460","doi-asserted-by":"crossref","first-page":"2913","DOI":"10.1101\/gad.1467506","article-title":"Mammalian sirtuins - Emerging roles in physiology, aging, and calorie restriction","volume":"20","author":"Haigis","year":"2006","journal-title":"Genes Dev."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0465","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.jhep.2013.07.027","article-title":"Adipose tissue and liver expression of SIRT1, 3, and 6 increase after extensive weight loss in morbid obesity","volume":"59","author":"Moschen","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0470","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/j.1365-2362.2008.01998.x","article-title":"Sirtuin gene expression in human mononuclear cells is modulated by caloric restriction","volume":"38","author":"Crujeiras","year":"2008","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0475","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1038\/ijo.2008.78","article-title":"Low Sirt1 expression, which is upregulated by fasting, in human adipose tissue from obese women","volume":"32","author":"Pedersen","year":"2008","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0480","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.diabres.2013.07.002","article-title":"Association between low SIRT1 expression in visceral and subcutaneous adipose tissues and metabolic abnormalities in women with obesity and type 2 diabetes","volume":"101","author":"Song","year":"2013","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0485","first-page":"497","article-title":"Influence of age and physical exercise on Sirtuin activity in humans","volume":"27","author":"Villanova","year":"2013","journal-title":"J Biol Regul Homeost Agents."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0490","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1038\/ijo.2016.131","article-title":"SIRT1 and SIRT7 expression in adipose tissues of obese and normal-weight individuals is regulated by microRNAs but not by methylation status","volume":"40","author":"Kurylowicz","year":"2016","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0495","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1210\/jc.2015-3095","article-title":"Obesity is associated with low nad+\/sirt pathway expression in adipose tissue of BMI-discordant monozygotic twins","volume":"101","author":"Jukarainen","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0500","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nrm3293","article-title":"Sirtuins as regulators of metabolism and healthspan","volume":"13","author":"Houtkooper","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0505","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.bbrc.2018.06.073","article-title":"Tissue distribution, subcellular localization, and enzymatic activity analysis of human SIRT5 isoforms","volume":"5","author":"Du","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0510","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1080\/10409238.2018.1458071","article-title":"Functions of the sirtuin deacylase SIRT5 in normal physiology and pathobiology","volume":"53","author":"Kumar","year":"2018","journal-title":"Crit. Rev. Biochem. Mol. Biol."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0515","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.molmet.2016.09.011","article-title":"Impaired histone deacetylases 5 and 6 expression mimics the effects of obesity and hypoxia on adipocyte function","volume":"5","author":"Bricambert","year":"2016","journal-title":"Mol. Metab."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0520","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1172\/JCI85963","article-title":"HDAC6-mediated acetylation of lipid droplet-binding protein CIDEC regulates fat-induced lipid storage","volume":"127","author":"Li","year":"2017","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0525","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1093\/embo-reports\/kve230","article-title":"Non-coding RNAs: The architects of eukaryotic complexity","volume":"2","author":"Mattick","year":"2001","journal-title":"EMBO Rep."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0530","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1007\/s00018-016-2169-2","article-title":"Long noncoding RNAs in regulating adipogenesis: New RNAs shed lights on obesity","volume":"73","author":"Wei","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0535","doi-asserted-by":"crossref","first-page":"3093","DOI":"10.1002\/stem.235","article-title":"miR-21 regulates adipogenic differentiation through the modulation of TGF-\u03b2 signaling in mesenchymal stem cells derived from human adipose tissue","volume":"27","author":"Kim","year":"2009","journal-title":"Stem Cells"},{"key":"10.1016\/j.physbeh.2019.03.009_bb0540","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1002\/stem.1603","article-title":"MicroRNA-26 family is required for human adipogenesis and drives characteristics of brown adipocytes","volume":"32","author":"Karbiener","year":"2014","journal-title":"Stem Cells."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0545","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.cmet.2013.06.004","article-title":"MicroRNAs and metabolism crosstalk in energy homeostasis","volume":"18","author":"Dumortier","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0550","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000444677","article-title":"Functional significance and predictive value of MicroRNAs in pediatric obesity: tiny molecules with huge impact?","volume":"86","author":"Fischer-Posovszky","year":"2016","journal-title":"Horm. Res. Paediatr."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0555","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1530\/EJE-14-0867","article-title":"Elevated circulating microRNA-122 is associated with obesity and insulin resistance in young adults","volume":"172","author":"Wang","year":"2015","journal-title":"Eur. J. Endocrinol."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0560","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/jc.2012-1996","article-title":"Circulating miRNA profiles in patients with metabolic syndrome","volume":"97","author":"Karolina","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0565","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1423-0127-20-72","article-title":"Circulating microRNAs have a sex-specific association with metabolic syndrome","volume":"20","author":"Wang","year":"2013","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0570","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/jc.2015-2872","article-title":"Altered circulating miRNA expression profile in pregestational and gestational obesity","volume":"100","author":"Carreras-Badosa","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0575","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1373\/clinchem.2012.195776","article-title":"Targeting the circulating microRNA signature of obesity","volume":"59","author":"Ortega","year":"2013","journal-title":"Clin. Chem."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0580","doi-asserted-by":"crossref","first-page":"347","DOI":"10.2337\/db16-0731","article-title":"Circulating MicroRNA-122 is associated with the risk of new-onset metabolic syndrome and type 2 diabetes","volume":"66","author":"Willeit","year":"2017","journal-title":"Diabetes."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0585","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.metabol.2017.09.006","article-title":"Change in circulating microRNA profile of obese children indicates future risk of adult diabetes","volume":"78","author":"Cui","year":"2018","journal-title":"Metabolism."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0590","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004699","article-title":"MicroRNA expression in human omental and subcutaneous adipose tissue","volume":"4","author":"Kl\u00f6ting","year":"2009","journal-title":"PLoS One."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0595","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1161\/CIRCRESAHA.110.226357","article-title":"Plasma MicroRNA profiling reveals loss of endothelial MiR-126 and other MicroRNAs in type 2 diabetes","volume":"107","author":"Zampetaki","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0600","doi-asserted-by":"crossref","first-page":"E846","DOI":"10.1210\/jc.2010-2701","article-title":"Differential miRNA expression in omental adipose tissue and in the circulation of obese patients identifies novel metabolic biomarkers","volume":"96","author":"Heneghan","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0605","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuron.2014.05.041","article-title":"Alzheimer\u2019s disease genetics: From the bench to the clinic","volume":"83","author":"Karch","year":"2014","journal-title":"Neuron."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0610","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/tp.2012.55","article-title":"Epigenetic modifications in frontal cortex from Alzheimer\u2019s disease and bipolar disorder patients","volume":"2","author":"Rao","year":"2012","journal-title":"Transl. Psychiatry."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0615","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3233\/JAD-170007","article-title":"DNA methylation and tag SNPs of the BDNF gene in conversion of amnestic mild cognitive impairment into alzheimer\u2019s disease: A cross-sectional cohort study","volume":"58","author":"Xie","year":"2017","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0620","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0006617","article-title":"Epigenetic differences in cortical neurons from a pair of monozygotic twins discordant for Alzheimer\u2019s disease","volume":"4","author":"Mastroeni","year":"2009","journal-title":"PLoS One."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0625","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1016\/j.neurobiolaging.2013.02.021","article-title":"Consistent decrease in global DNA methylation and hydroxymethylation in the hippocampus of Alzheimer\u2019s disease patients","volume":"34","author":"Chouliaras","year":"2013","journal-title":"Neurobiol. Aging."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0630","doi-asserted-by":"crossref","first-page":"571","DOI":"10.3233\/JAD-2012-111223","article-title":"Genome-wide DNA methylation differences between late-onset alzheimer\u2019s disease and cognitively normal controls in human frontal cortex","volume":"29","author":"Bakulski","year":"2012","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0635","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrn.2016.7","article-title":"TREM2 variants: New keys to decipher Alzheimer disease pathogenesis","volume":"17","author":"Colonna","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0640","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.neuron.2017.02.042","article-title":"Elucidating the role of TREM2 in alzheimer\u2019s disease","volume":"94","author":"Ulrich","year":"2017","journal-title":"Neuron."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0645","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0000895","article-title":"DNA methylation in the human cerebral cortex is dynamically regulated throughout the life span and involves differentiated neurons","volume":"2","author":"Siegmund","year":"2007","journal-title":"PLoS One."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0650","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/BF02736773","article-title":"Hypomethylation of the amyloid precursor protein gene in the brain of an alzheimer\u2019s disease patient","volume":"6","author":"West","year":"1995","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0655","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.neulet.2016.11.018","article-title":"Association of OPRK1 and OPRM1 methylation with mild cognitive impairment in Xinjiang Han and Uygur populations","volume":"636","author":"Liu","year":"2017","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0660","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.ando.2016.02.008","article-title":"Association between DNA methylation of SORL1 5\u2032-flanking region and mild cognitive impairment in type 2 diabetes mellitus","volume":"77","author":"Yu","year":"2016","journal-title":"Ann. Endocrinol. (Paris)."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0665","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.neuint.2012.07.014","article-title":"SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer\u2019s Disease","volume":"61","author":"Furuya","year":"2012","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0670","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1002\/pmic.201200010","article-title":"Targeted proteomics for quantification of histone acetylation in Alzheimer\u2019s disease","volume":"12","author":"Zhang","year":"2012","journal-title":"Proteomics."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0675","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1007\/s00401-003-0684-3","article-title":"Ectopic localization of phosphorylated histone H3 in Alzheimer\u2019s disease: a mitotic catastrophe?","volume":"105","author":"Ogawa","year":"2003","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0680","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/nature10849","article-title":"An epigenetic blockade of cognitive functions in the neurodegenerating brain","volume":"483","author":"Gr\u00e4ff","year":"2012","journal-title":"Nature."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0685","article-title":"Sirtuin1: a promising serum protein marker for early detection of alzheimer\u2019s disease","volume":"8","author":"Kumar","year":"2013","journal-title":"PLoS One."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0690","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/nn.3113","article-title":"An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration","volume":"15","author":"Lehmann","year":"2012","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0695","article-title":"Circulating miRNA biomarkers for alzheimer\u2019s disease","volume":"29","author":"Kumar","year":"2013","journal-title":"PLoS One."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0700","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3233\/JAD-2008-14103","article-title":"Identification of miRNA changes in Alzheimer\u2019s disease brain and CSF yields putative biomarkers and insights into disease pathways","volume":"14","author":"Cogswell","year":"2008","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0705","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnmol.2014.00002","article-title":"Increased microRNA-34c abundance in Alzheimer\u2019s disease circulating blood plasma","volume":"7","author":"Bhatnagar","year":"2014","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0710","doi-asserted-by":"crossref","first-page":"694","DOI":"10.3389\/fnins.2018.00694","article-title":"Microarray expression profiles of lncRNAs and mRNAs in postoperative cognitive dysfunction","volume":"12","author":"Zhang","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0715","article-title":"Standardization of exercise intensity and consideration of a dose-response is essential","author":"Gronwald","year":"2019","journal-title":"J. Sport Heal. Sci"},{"key":"10.1016\/j.physbeh.2019.03.009_bb0720","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0210036","article-title":"Dose-response relationship between exercise and cognitive function in older adults with and without cognitive impairment: A systematic review and meta-analysis","volume":"14","author":"Sanders","year":"2019","journal-title":"PLoS One."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0725","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.autrev.2015.09.004","article-title":"The need for differentiating between exercise, physical activity, and training","volume":"15","author":"Budde","year":"2016","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0730","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tins.2007.06.011","article-title":"Exercise builds brain health: key roles of growth factor cascades and inflammation","volume":"30","author":"Cotman","year":"2007","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0735","first-page":"500","article-title":"Exercise training increases size of hippocampus and improves memory","volume":"9","author":"Erickson","year":"2014","journal-title":"ARPN J. Eng. Appl. Sci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0740","first-page":"632","article-title":"Exercise wards off Alzheimer disease by boosting neurogenesis and neuroprotective factors","volume":"14","author":"Ridler","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0745","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7554\/eLife.15092","article-title":"Exercise promotes the expression of brain derived neurotrophic factor (BDNF) through the action of the ketone body \u03b2- hydroxybutyrate","volume":"5","author":"Sleiman","year":"2016","journal-title":"Elife."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0750","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/jnr.20077","article-title":"Exercise Induces BDNF and Synapsin I to Specific Hippocampal Subfields","volume":"76","author":"Vaynman","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0755","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fneur.2017.00188","article-title":"Neuroprotective effects of physical activity: evidence from human and animal studies","volume":"8","author":"Chieffi","year":"2017","journal-title":"Front. Neurol."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0760","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.nlm.2018.05.007","article-title":"Aerobic exercise upregulates the BDNF-Serotonin systems and improves the cognitive function in rats","volume":"155","author":"Pietrelli","year":"2018","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0765","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0036980","article-title":"Identification of combinatorial patterns of post-translational modifications on individual histones in the mouse brain","volume":"7","author":"Tweedie-Cullen","year":"2012","journal-title":"PLoS One."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0770","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.nlm.2007.07.016","article-title":"DNA methylation and histone acetylation work in concert to regulate memory formation and synaptic plasticity","volume":"89","author":"Miller","year":"2008","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0775","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.neuroscience.2010.11.023","article-title":"Nuclear protein phosphatase-1: An epigenetic regulator of fear memory and amygdala long-term potentiation","volume":"173","author":"Koshibu","year":"2011","journal-title":"Neuroscience."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0780","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms1997","article-title":"Dynamic histone marks in the hippocampus and cortex facilitate memory consolidation","volume":"3","author":"Gr\u00e4ff","year":"2012","journal-title":"Nat. Commun."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0785","doi-asserted-by":"crossref","first-page":"509","DOI":"10.4161\/epi.5.6.12224","article-title":"Interplay of bromodomain and histone acetylation in the regulation of p300-dependent genes","volume":"5","author":"Chen","year":"2010","journal-title":"Epigenetics."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0790","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nature07925","article-title":"HDAC2 negatively regulates memory formation and synaptic plasticity","volume":"459","author":"Guan","year":"2009","journal-title":"Nature."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0795","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1086\/429130","article-title":"Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease","volume":"76","author":"Roelfsema","year":"2005","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0800","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1101\/lm.500907","article-title":"Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear","volume":"14","author":"Bredy","year":"2007","journal-title":"Learn. Mem."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0805","doi-asserted-by":"crossref","first-page":"16665","DOI":"10.1073\/pnas.0407581101","article-title":"Transient expansion of synaptically connected dendritic spines upon induction of hippocampal long-term potentiation","volume":"101","author":"Lang","year":"2004","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0810","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1523\/JNEUROSCI.22-05-01532.2002","article-title":"Brain-derived neurotrophic factor induces long-term potentiation in intact adult hippocampus: requirement for ERK activation coupled to CREB and upregulation of Arc synthesis","volume":"22","author":"Ying","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0815","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1101\/lm.54603","article-title":"BDNF and activity-dependent synaptic modulation","volume":"10","author":"Lu","year":"2003","journal-title":"Learn. Mem."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0820","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1046\/j.1471-4159.1997.69010034.x","article-title":"Distribution of brain-derived neurotrophic factor in rats and its changes with development in the brain","volume":"69","author":"Katoh-Semba","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0825","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1017\/S1461145710000738","article-title":"Blood BDNF concentrations reflect brain-tissue BDNF levels across species","volume":"14","author":"Klein","year":"2011","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0830","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/0896-6273(93)90335-O","article-title":"Multiple promoters direct tissue-specific expression of the rat BDNF gene","volume":"10","author":"Timmusk","year":"1993","journal-title":"Neuron."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0835","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nbt.2158","article-title":"Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation","volume":"25","author":"Modarresi","year":"2012","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0840","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ygeno.2007.05.004","article-title":"Dissecting the human BDNF locus: Bidirectional transcription, complex splicing, and multiple promoters","volume":"90","author":"Pruunsild","year":"2007","journal-title":"Genomics."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0845","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41398-019-0367-z","article-title":"The lncRNA BDNF-AS is an epigenetic regulator in the human amygdala in early onset alcohol use disorders","volume":"9","author":"Bohnsack","year":"2019","journal-title":"Transl. Psychiatry."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0850","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/jnc.12153","article-title":"Aging is associated with altered inflammatory, arachidonic acid cascade, and synaptic markers, influenced by epigenetic modifications, in the human frontal cortex","volume":"125","author":"Keleshian","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0855","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1001\/archgenpsychiatry.2010.9","article-title":"Increased BDNF promoter methylation in the wernicke area of suicide subjects","volume":"67","author":"Keller","year":"2010","journal-title":"Arch. Gen. Psychiatry."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0860","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nn1659","article-title":"Sustained hippocampal chromatin regulation in a mouse model of depression and antidepressant action","volume":"9","author":"Tsankova","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0865","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.jpsychires.2011.01.013","article-title":"Epigenetic modification of hippocampal Bdnf DNA in adult rats in an animal model of post-traumatic stress disorder","volume":"45","author":"Roth","year":"2011","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0870","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1126\/science.7871435","article-title":"The neuron-restrictive silencer factor (NRSF): A coordinate repressor of multiple neuron-specific genes","volume":"267","author":"Schoenherr","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.physbeh.2019.03.009_bb0875","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","author":"Dunham","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.physbeh.2019.03.009_bb0880","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnins.2012.00059","article-title":"Crosstalk among epigenetic pathways regulates neurogenesis","volume":"6","author":"Jobe","year":"2012","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0885","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.bbi.2016.07.159","article-title":"Running for REST: Physical activity attenuates neuroinflammation in the hippocampus of aged mice","volume":"61","author":"Dallagnol","year":"2017","journal-title":"Brain. Behav. Immun."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0890","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnmol.2017.00128","article-title":"Downregulation of the repressor element 1-Silencing transcription factor (REST) is associated with Akt-mTOR and Wnt-\u03b2-Catenin signaling in prion diseases models","volume":"10","author":"Song","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0895","doi-asserted-by":"crossref","first-page":"12035","DOI":"10.18632\/oncotarget.7640","article-title":"REST alleviates neurotoxic prion peptide-induced synaptic abnormalities, neurofibrillary degeneration and neuronal death partially <i>via<\/i> LRP6-mediated Wnt-&beta;-catenin signaling","volume":"7","author":"Song","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.physbeh.2019.03.009_bb0900","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1002\/ana.24349","article-title":"Protective variant for hippocampal atrophy identified by whole exome sequencing","volume":"77","author":"Nho","year":"2015","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0905","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1523\/JNEUROSCI.18-04-01280.1998","article-title":"Neuronal expression of zinc finger transcription factor REST\/NRSF\/XBR gene","volume":"18","author":"Palm","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0910","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.neures.2009.07.006","article-title":"Alteration of NRSF expression exacerbating 1-methyl-4-phenyl-pyridinium ion-induced cell death of SH-SY5Y cells","volume":"65","author":"Yu","year":"2009","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0915","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.4049\/jimmunol.182.3.1500","article-title":"Methylation status of CpG islands flanking a cAMP response element motif on the protein phosphatase 2Ac alpha promoter determines CREB binding and activity","volume":"182","author":"Sunahori","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0920","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1038\/13165","article-title":"Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes","volume":"2","author":"Huang","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0925","doi-asserted-by":"crossref","first-page":"8680","DOI":"10.1523\/JNEUROSCI.1731-05.2005","article-title":"Exercise enhances learning and hippocampal neurogenesis in aged mice","volume":"25","author":"van Praag","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0930","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1073\/pnas.0911725107","article-title":"Running enhances spatial pattern separation in mice","volume":"107","author":"Creer","year":"2010","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0935","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1111\/j.1460-9568.2010.07508.x","article-title":"Exercise impacts brain-derived neurotrophic factor plasticity by engaging mechanisms of epigenetic regulation","volume":"33","author":"Gomez-Pinilla","year":"2011","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0940","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.ijdevneu.2012.11.002","article-title":"Running-induced epigenetic and gene expression changes in the adolescent brain","volume":"31","author":"Abel","year":"2013","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0945","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.brainres.2005.11.062","article-title":"Exercise differentially regulates synaptic proteins associated to the function of BDNF","volume":"1070","author":"Vaynman","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0950","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1007\/s12031-014-0344-1","article-title":"Spontaneous running wheel improves cognitive functions of mouse associated with miRNA expressional alteration in hippocampus following traumatic brain injury","volume":"54","author":"Bao","year":"2014","journal-title":"J. Mol. Neurosci"},{"key":"10.1016\/j.physbeh.2019.03.009_bb0955","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13041-015-0128-8","article-title":"Impact of voluntary exercise and housing conditions on hippocampal glucocorticoid receptor, miR-124 and anxiety","volume":"8","author":"Pan-Vazquez","year":"2015","journal-title":"Mol. Brain."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0960","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.neulet.2017.11.023","article-title":"Exercise enhances cognitive function and neurotrophin expression in the hippocampus accompanied by changes in epigenetic programming in senescence-accelerated mice","volume":"665","author":"Maejima","year":"2018","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0965","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.nlm.2013.01.007","article-title":"Treadmill exercise induces age-related changes in aversive memory, Neuroinflammatory and epigenetic processes in the rat hippocampus","volume":"101","author":"Lovatel","year":"2013","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0970","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.neuroscience.2015.12.049","article-title":"Swimming exercise ameliorates neurocognitive impairment induced by neonatal exposure to isoflurane and enhances hippocampal histone acetylation in mice","volume":"316","author":"Zhong","year":"2016","journal-title":"Neuroscience."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0975","first-page":"202","article-title":"Spatial memory is improved by aerobic and resistance exercise through divergent molecular mechanisms","volume":"27","author":"Cassilhas","year":"2012","journal-title":"Neuroscience."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0980","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.brainres.2010.09.060","article-title":"Exercise-induced plasticity of AMPA-type glutamate receptor subunits in the rat brain","volume":"1363","author":"Real","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2019.03.009_bb0985","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1126\/science.273.5277.959","article-title":"Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase","volume":"273","author":"Xing","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.physbeh.2019.03.009_bb0990","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/jcbfm.2014.206","article-title":"Lactate transport and signaling in the brain : potential therapeutic targets and roles in body \u2013 brain interaction","volume":"35","author":"Bergersen","year":"2014","journal-title":"J. Cereb. Blood Flow"},{"key":"10.1016\/j.physbeh.2019.03.009_bb0995","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/s41591-018-0275-4","article-title":"Exercise-linked FNDC5\/irisin rescues synaptic plasticity and memory defects in Alzheimer\u2019s models","volume":"25","author":"Lourenco","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.physbeh.2019.03.009_bb1000","series-title":"Exercise induces hippocampal BDNF through a PGC-1\u03b1\/FNDC5 pathway","first-page":"617","volume":"18","author":"Wrann","year":"2013"},{"key":"10.1016\/j.physbeh.2019.03.009_bb1005","series-title":"Interleukin-6 and Neural Stem Cells : More Than Gliogenesis","first-page":"188","volume":"20","author":"Islam","year":"2009"},{"key":"10.1016\/j.physbeh.2019.03.009_bb1010","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.pop.2004.11.008","article-title":"Sports pharmacology and ergogenic aids","volume":"32","author":"Ellender","year":"2005","journal-title":"Prim. Care - Clin. Off. Pract."},{"key":"10.1016\/j.physbeh.2019.03.009_bb1015","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1519\/JSC.0b013e3181660cec","article-title":"Ustainable Evelopment I Ndicators for L and U Se in S Antiago, Chile","volume":"22","author":"S\u00f6kmen","year":"2008","journal-title":"J. Strength Cond. Res. J. Strength Cond. Res."},{"key":"10.1016\/j.physbeh.2019.03.009_bb1020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000350223","article-title":"Caffeine, Exercise and the Brain","volume":"76","author":"Meeusen","year":"2013","journal-title":"Nestle Nutr Inst Work. Ser."},{"key":"10.1016\/j.physbeh.2019.03.009_bb1025","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nn.3623","article-title":"Post-study caffeine administration enhances memory consolidation in humans","volume":"17","author":"Borota","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb1030","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1136\/bjsm.2009.069989","article-title":"BJSM reviews : A \u2013 Z of nutritional supplements : dietary supplements, sports nutrition foods and ergogenic aids for health and performance Part 5","volume":"44","author":"Castell","year":"2010","journal-title":"Br J Sport. Med."},{"key":"10.1016\/j.physbeh.2019.03.009_bb1035","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/aje\/kwh312","article-title":"Coffee Consumption, Gender, and Parkinson\u2019s Disease Mortality in the Cancer Prevention Study II Cohort : The Modifying Effects of Estrogen","volume":"160","author":"Ascherio","year":"2004","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.physbeh.2019.03.009_bb1040","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/sj.ejcn.1602495","article-title":"Coffee consumption is inversely associated with cognitive decline in elderly European men: the FINE Study","volume":"61","author":"van Gelder","year":"2007","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.physbeh.2019.03.009_bb1045","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1001\/jama.283.20.2674","article-title":"Association of Coffee and Caffeine Intake With the Risk of Parkinson Disease","volume":"283","author":"Ross","year":"2000","journal-title":"JAMA."},{"key":"10.1016\/j.physbeh.2019.03.009_bb1050","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/j.foodchem.2012.04.148","article-title":"Crude caffeine reduces memory impairment and amyloid \u03b21-42levels in an Alzheimer\u2019s mouse model","volume":"135","author":"Chu","year":"2012","journal-title":"Food Chem."},{"key":"10.1016\/j.physbeh.2019.03.009_bb1055","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.expneurol.2006.08.008","article-title":"Caffeine and adenosine A2a receptor antagonists prevent \u03b2-amyloid (25-35)-induced cognitive deficits in mice","volume":"203","author":"Dall\u2019Igna","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.physbeh.2019.03.009_bb1060","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.neuroscience.2016.02.035","article-title":"Neuroprotection by caffeine in the MPTP model of parkinson\u2019s disease and its dependence on adenosine A2A receptors","volume":"322","author":"Xu","year":"2016","journal-title":"Neuroscience."},{"key":"10.1016\/j.physbeh.2019.03.009_bb1065","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1471-4159.2009.06349.x","article-title":"Caffeine consumption attenuates neurochemical modifications in the hippocampus of streptozotocin-induced diabetic rats","volume":"111","author":"Duarte","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.physbeh.2019.03.009_bb1070","doi-asserted-by":"crossref","first-page":"71","DOI":"10.2174\/1570159X13666141210215655","article-title":"Caffeine: cognitive and physical performance enhancer or psychoactive drug?","volume":"13","author":"Cappelletti","year":"2015","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.physbeh.2019.03.009_bb1075","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.neuropharm.2018.03.041","article-title":"A novel pharmacological activity of caffeine in the cholinergic system","volume":"135","author":"Fabiani","year":"2018","journal-title":"Neuropharmacology."},{"key":"10.1016\/j.physbeh.2019.03.009_bb1080","doi-asserted-by":"crossref","first-page":"9873","DOI":"10.3390\/ijms14059873","article-title":"Caffeine Inhibits Acetylcholinesterase, But Not Butyrylcholinesterase","volume":"14","author":"Pohanka","year":"2013","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.physbeh.2019.03.009_bb1085","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.bbr.2014.01.051","article-title":"Caffeine neuroprotective effects on 6-OHDA-lesioned rats are mediated by several factors, including pro-inflammatory cytokines and histone deacetylase inhibitions","volume":"264","author":"Machado-Filho","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2019.03.009_bb1090","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1111\/adb.12433","article-title":"Caffeine-mediated BDNF release regulates long-term synaptic plasticity through activation of IRS2 signaling","volume":"22","author":"Lao-Peregr\u00edn","year":"2017","journal-title":"Addict. Biol."},{"key":"10.1016\/j.physbeh.2019.03.009_bb1095","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.ejcb.2017.03.004","article-title":"Incretin hormones regulate microglia oxidative stress, survival and expression of trophic factors","volume":"96","author":"Spielman","year":"2017","journal-title":"Eur. J. Cell Biol."}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938418312137?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938418312137?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:10:14Z","timestamp":1758478214000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938418312137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":219,"alternative-id":["S0031938418312137"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2019.03.009","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenetic modifications induced by exercise: Drug-free intervention to improve cognitive deficits associated with obesity","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2019.03.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}