{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T22:51:51Z","timestamp":1776725511938,"version":"3.51.2"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology & Behavior"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.physbeh.2019.03.018","type":"journal-article","created":{"date-parts":[[2019,5,7]],"date-time":"2019-05-07T13:38:48Z","timestamp":1557236328000},"page":"139-150","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["The combination of swimming and curcumin consumption may improve spatial memory recovery after binge ethanol drinking"],"prefix":"10.1016","volume":"207","author":[{"given":"Foad","family":"Feizolahi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad-Ali","family":"Azarbayjani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Nasehi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maghsoud","family":"Peeri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad-Reza","family":"Zarrindast","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2019.03.018_bb0005","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s00213-008-1294-5","article-title":"Alcohol-induced retrograde memory impairment in rats: prevention by caffeine","volume":"201","author":"Spinetta","year":"2008","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.physbeh.2019.03.018_bb0010","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.pbb.2009.04.018","article-title":"Impulsivity, frontal lobes and risk for addiction","volume":"93","author":"Crews","year":"2009","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0015","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.biopsych.2011.04.006","article-title":"Unique brain areas associated with abstinence control are damaged in multiply detoxified alcoholics","volume":"70","author":"Duka","year":"2011","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.physbeh.2019.03.018_bb0020","first-page":"14","article-title":"C., prevention. Vital signs: binge drinking prevalence, frequency, and intensity among adults - United States, 2010","volume":"61","author":"Centers for Disease","year":"2012","journal-title":"MMWR Morb. Mortal. Wkly Rep."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0025","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1111\/j.1530-0277.2011.01527.x","article-title":"Adolescent binge drinking linked to abnormal spatial working memory brain activation: differential gender effects","volume":"35","author":"Squeglia","year":"2011","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0030","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.alcohol.2008.05.002","article-title":"Intermittent binge alcohol exposure during the periadolescent period induces spatial working memory deficits in young adult rats","volume":"42","author":"Schulteis","year":"2008","journal-title":"Alcohol"},{"key":"10.1016\/j.physbeh.2019.03.018_bb0035","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1111\/j.1530-0277.1995.tb01598.x","article-title":"Longitudinal changes in magnetic resonance imaging brain volumes in abstinent and relapsed alcoholics","volume":"19","author":"Pfefferbaum","year":"1995","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0040","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1093\/alcalc\/agg020","article-title":"MR volumetry during acute alcohol withdrawal and abstinence: a descriptive study","volume":"38","author":"Agartz","year":"2003","journal-title":"Alcohol Alcohol."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0045","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.neuroimage.2006.10.015","article-title":"Deformation-based morphometry of brain changes in alcohol dependence and abstinence","volume":"34","author":"Cardenas","year":"2007","journal-title":"NeuroImage"},{"key":"10.1016\/j.physbeh.2019.03.018_bb0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076644","article-title":"Exercise enhances hippocampal recovery following binge ethanol exposure","volume":"8","author":"Maynard","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.physbeh.2019.03.018_bb0055","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0006-8993(96)00273-9","article-title":"Physical activity increases mRNA for brain-derived neurotrophic factor and nerve growth factor in rat brain","volume":"726","author":"Neeper","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0060","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0169-328X(98)00222-8","article-title":"Exercise-induced regulation of brain-derived neurotrophic factor (BDNF) transcripts in the rat hippocampus","volume":"61","author":"Oliff","year":"1998","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0006-8993(97)00375-2","article-title":"Physical exercise induces FGF-2 and its mRNA in the hippocampus","volume":"764","author":"Gomez-Pinilla","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0070","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/729827","article-title":"The impacts of swimming exercise on hippocampal expression of neurotrophic factors in rats exposed to chronic unpredictable mild stress","volume":"2014","author":"Jiang","year":"2014","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0075","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.1021\/jf025506a","article-title":"Improved HPLC method for the determination of curcumin, demethoxycurcumin, and bisdemethoxycurcumin","volume":"50","author":"Jayaprakasha","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0080","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1089\/jmf.2009.1278","article-title":"Curcumin exerts neuroprotective effects against homocysteine intracerebroventricular injection-induced cognitive impairment and oxidative stress in rat brain","volume":"13","author":"Ataie","year":"2010","journal-title":"J. Med. Food"},{"key":"10.1016\/j.physbeh.2019.03.018_bb0085","doi-asserted-by":"crossref","first-page":"3350","DOI":"10.1021\/jf0734931","article-title":"Antioxidant and iron-binding properties of curcumin, capsaicin, and S-allylcysteine reduce oxidative stress in rat brain homogenate","volume":"56","author":"Dairam","year":"2008","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0090","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1007\/s10753-011-9350-4","article-title":"A novel synthetic mono-carbonyl analogue of curcumin, A13, exhibits anti-inflammatory effects in vivo by inhibition of inflammatory mediators","volume":"35","author":"Wang","year":"2012","journal-title":"Inflammation"},{"key":"10.1016\/j.physbeh.2019.03.018_bb0095","first-page":"481","article-title":"Combined effects of curcumin and vitamin C to protect endothelial dysfunction in the iris tissue of STZ-induced diabetic rats","volume":"35","author":"Patumraj","year":"2006","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0100","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s10522-013-9422-y","article-title":"Curcumin improves spatial memory and decreases oxidative damage in aged female rats","volume":"14","author":"Belviranli","year":"2013","journal-title":"Biogerontology"},{"key":"10.1016\/j.physbeh.2019.03.018_bb0105","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1046\/j.1471-4159.2002.01214.x","article-title":"Binge ethanol exposure decreases neurogenesis in adult rat hippocampus","volume":"83","author":"Nixon","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0110","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.pnpbp.2012.08.017","article-title":"NMDA GluN2B receptors involved in the antidepressant effects of curcumin in the forced swim test","volume":"40","author":"Zhang","year":"2013","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.physbeh.2019.03.018_bb0115","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.neuroscience.2015.11.023","article-title":"Role of dorsal hippocampal orexin-1 receptors in memory restoration induced by morphine sensitization phenomenon","volume":"312","author":"Alijanpour","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2019.03.018_bb0120","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1111\/j.1360-0443.2010.03351.x","article-title":"Alcohol and depression","volume":"106","author":"Boden","year":"2011","journal-title":"Addiction"},{"key":"10.1016\/j.physbeh.2019.03.018_bb0125","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.pscychresns.2005.05.008","article-title":"Reduced hippocampal volume among adolescents with alcohol use disorders without psychiatric comorbidity","volume":"139","author":"Nagel","year":"2005","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0130","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0091-3057(02)00715-3","article-title":"Cognitive deficits and CNS damage after a 4-day binge ethanol exposure in rats","volume":"72","author":"Obernier","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0135","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1097\/01.ALC.0000052581.46630.C5","article-title":"Neural stem cells and alcohol","volume":"27","author":"Crews","year":"2003","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0140","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/npp.2008.90","article-title":"Abstinence following alcohol drinking produces depression-like behavior and reduced hippocampal neurogenesis in mice","volume":"34","author":"Stevenson","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.physbeh.2019.03.018_bb0145","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.nlm.2010.09.006","article-title":"Reversibility of object recognition but not spatial memory impairment following binge-like alcohol exposure in rats","volume":"94","author":"Cippitelli","year":"2010","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0150","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.conb.2004.03.001","article-title":"Functional significance of adult neurogenesis","volume":"14","author":"Kempermann","year":"2004","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0155","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1038\/nn.2185","article-title":"Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain","volume":"11","author":"Imayoshi","year":"2008","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0160","doi-asserted-by":"crossref","first-page":"239","DOI":"10.5483\/BMBRep.2009.42.5.239","article-title":"Adult hippocampal neurogenesis and related neurotrophic factors","volume":"42","author":"Lee","year":"2009","journal-title":"BMB Rep."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0165","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a001842","article-title":"Guidance molecules in synapse formation and plasticity","volume":"2","author":"Shen","year":"2010","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0170","doi-asserted-by":"crossref","first-page":"8320","DOI":"10.1523\/JNEUROSCI.4988-05.2006","article-title":"Central and medial amygdaloid brain-derived neurotrophic factor signaling plays a critical role in alcohol-drinking and anxiety-like behaviors","volume":"26","author":"Pandey","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0175","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ijdevneu.2013.04.002","article-title":"Binge alcohol-induced alterations in BDNF and GDNF expression in central extended amygdala and pyriform cortex on infant rats","volume":"31","author":"Balaszczuk","year":"2013","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0180","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.neuroscience.2013.09.031","article-title":"Chronic binge-like alcohol consumption in adolescence causes depression-like symptoms possibly mediated by the effects of BDNF on neurogenesis","volume":"254","author":"Briones","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2019.03.018_bb0185","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.neuroscience.2016.11.041","article-title":"Binge alcohol alters exercise-driven neuroplasticity","volume":"343","author":"Barton","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2019.03.018_bb0190","series-title":"Methods of Behavior Analysis in Neuroscience. Boca Raton (FL)","article-title":"Spatial navigation (water maze) tasks","author":"Terry","year":"2009"},{"key":"10.1016\/j.physbeh.2019.03.018_bb0195","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.biocel.2008.06.010","article-title":"Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases","volume":"41","author":"Aggarwal","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0200","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.lfs.2005.12.007","article-title":"Multiple biological activities of curcumin: a short review","volume":"78","author":"Maheshwari","year":"2006","journal-title":"Life Sci."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0205","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.pnpbp.2013.05.001","article-title":"Curcumin ameliorates memory deficits via neuronal nitric oxide synthase in aged mice","volume":"45","author":"Yu","year":"2013","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.physbeh.2019.03.018_bb0210","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.neulet.2011.02.030","article-title":"Curcumin reverses corticosterone-induced depressive-like behavior and decrease in brain BDNF levels in rats","volume":"493","author":"Huang","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0215","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.brainres.2006.09.009","article-title":"Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB","volume":"1122","author":"Xu","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0220","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bbr.2012.07.019","article-title":"Curcumin produces antidepressant effects via activating MAPK\/ERK-dependent brain-derived neurotrophic factor expression in the amygdala of mice","volume":"235","author":"Zhang","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0225","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.brainres.2007.05.071","article-title":"Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats","volume":"1162","author":"Xu","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0230","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.bbr.2014.05.068","article-title":"Effects of curcumin on learning and memory deficits, BDNF, and ERK protein expression in rats exposed to chronic unpredictable stress","volume":"271","author":"Liu","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0235","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-0-387-46401-5_3","article-title":"Antioxidant and anti-inflammatory properties of curcumin","volume":"595","author":"Menon","year":"2007","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0240","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.brainres.2009.09.027","article-title":"Curcumin is protective against phenytoin-induced cognitive impairment and oxidative stress in rats","volume":"1301","author":"Reeta","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0245","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.euroneuro.2009.02.002","article-title":"Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT)","volume":"19","author":"Ishrat","year":"2009","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0250","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.neuropharm.2009.06.010","article-title":"Curcumin reverses impaired cognition and neuronal plasticity induced by chronic stress","volume":"57","author":"Xu","year":"2009","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.physbeh.2019.03.018_bb0255","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.bcp.2008.12.011","article-title":"Curcumin-induced degradation of PKC delta is associated with enhanced dentate NCAM PSA expression and spatial learning in adult and aged Wistar rats","volume":"77","author":"Conboy","year":"2009","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0260","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1089\/scd.2006.15.165","article-title":"Curcumin-induced histone hypoacetylation enhances caspase-3-dependent glioma cell death and neurogenesis of neural progenitor cells","volume":"15","author":"Kang","year":"2006","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0265","article-title":"Curcumin enhances neurogenesis and cognition in aged rats: implications for transcriptional interactions related to growth and synaptic plasticity","volume":"7","author":"Dong","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.physbeh.2019.03.018_bb0270","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1358\/mf.2007.29.1.1063492","article-title":"Possible neuroprotective mechanisms of curcumin in attenuating 3-nitropropionic acid-induced neurotoxicity","volume":"29","author":"Kumar","year":"2007","journal-title":"Methods Find. Exp. Clin. Pharmacol."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0275","article-title":"Curcumin improves amyloid beta-peptide (1-42) induced spatial memory deficits through BDNF-ERK Signaling pathway","volume":"10","author":"Zhang","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.physbeh.2019.03.018_bb0280","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1249\/00003677-199401000-00009","article-title":"Physical fitness and cognitive functioning in aging","volume":"22","author":"Chodzko-Zajko","year":"1994","journal-title":"Exerc. Sport Sci. Rev."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0285","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1001\/archinternmed.2009.498","article-title":"Physical activity and incident cognitive impairment in elderly persons: the INVADE study","volume":"170","author":"Etgen","year":"2010","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0290","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1001\/archneurol.2009.297","article-title":"Physical exercise, aging, and mild cognitive impairment: a population-based study","volume":"67","author":"Geda","year":"2010","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0295","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1111\/j.1460-9568.2008.06524.x","article-title":"Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition","volume":"28","author":"Gomez-Pinilla","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0300","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.neuroscience.2004.01.030","article-title":"Voluntary exercise following traumatic brain injury: brain-derived neurotrophic factor upregulation and recovery of function","volume":"125","author":"Griesbach","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2019.03.018_bb0305","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1001\/archneur.58.3.498","article-title":"Physical activity and risk of cognitive impairment and dementia in elderly persons","volume":"58","author":"Laurin","year":"2001","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0310","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0166-2236(02)02143-4","article-title":"Exercise: a behavioral intervention to enhance brain health and plasticity","volume":"25","author":"Cotman","year":"2002","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0315","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.physbeh.2004.10.010","article-title":"Exercise improves biomarkers of health and stress in animals fed ad libitum","volume":"84","author":"Alessio","year":"2005","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0320","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/6368","article-title":"Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus","volume":"2","author":"van Praag","year":"1999","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0325","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neuroscience.2003.09.029","article-title":"Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo","volume":"124","author":"Farmer","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2019.03.018_bb0330","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.neuroscience.2005.03.026","article-title":"Exercise primes a molecular memory for brain-derived neurotrophic factor protein induction in the rat hippocampus","volume":"133","author":"Berchtold","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2019.03.018_bb0335","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1038\/sj.npp.1300514","article-title":"Hippocampal brain-derived neurotrophic factor expression following treatment with reboxetine, citalopram, and physical exercise","volume":"29","author":"Russo-Neustadt","year":"2004","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.physbeh.2019.03.018_bb0340","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1111\/j.1460-9568.2004.03720.x","article-title":"Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition","volume":"20","author":"Vaynman","year":"2004","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0345","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1046\/j.1460-9568.2002.02158.x","article-title":"Differential effects of acute and chronic exercise on plasticity-related genes in the rat hippocampus revealed by microarray","volume":"16","author":"Molteni","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0350","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1006\/nbdi.2001.0427","article-title":"Effects of exercise on gene-expression profile in the rat hippocampus","volume":"8","author":"Tong","year":"2001","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0355","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0306-4522(03)00096-4","article-title":"Exercise induces behavioral recovery and attenuates neurochemical deficits in rodent models of Parkinson's disease","volume":"119","author":"Tillerson","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2019.03.018_bb0360","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1523\/JNEUROSCI.21-15-05678.2001","article-title":"Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy","volume":"21","author":"Carro","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0365","doi-asserted-by":"crossref","first-page":"13427","DOI":"10.1073\/pnas.96.23.13427","article-title":"Running enhances neurogenesis, learning, and long-term potentiation in mice","volume":"96","author":"van Praag","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0370","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.bbr.2013.03.007","article-title":"Forced and voluntary exercises equally improve spatial learning and memory and hippocampal BDNF levels","volume":"247","author":"Alomari","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0375","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.bbr.2006.10.018","article-title":"The effects of forced exercise on hippocampal plasticity in the rat: a comparison of LTP, spatial- and non-spatial learning","volume":"176","author":"O'Callaghan","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0380","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1590\/S0001-37652008000200008","article-title":"Effects of acute and chronic physical exercise and stress on different types of memory in rats","volume":"80","author":"Mello","year":"2008","journal-title":"An. Acad. Bras. Cienc."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0385","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1002\/hipo.20631","article-title":"Exercise enhances hippocampal-dependent learning in the rat: evidence for a BDNF-related mechanism","volume":"19","author":"Griffin","year":"2009","journal-title":"Hippocampus"},{"key":"10.1016\/j.physbeh.2019.03.018_bb0390","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.nlm.2010.06.006","article-title":"BDNF expression in perirhinal cortex is associated with exercise-induced improvement in object recognition memory","volume":"94","author":"Hopkins","year":"2010","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0395","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.nbd.2009.06.002","article-title":"Effects of voluntary and forced exercise on plaque deposition, hippocampal volume, and behavior in the Tg2576 mouse model of Alzheimer's disease","volume":"35","author":"Yuede","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0400","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.physbeh.2012.02.023","article-title":"A comparison of low- and high-impact forced exercise: effects of training paradigm on learning and memory","volume":"106","author":"Kennard","year":"2012","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0405","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0006-8993(93)91526-X","article-title":"Gender influences outcome of brain injury: progesterone plays a protective role","volume":"607","author":"Roof","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0410","doi-asserted-by":"crossref","first-page":"370","DOI":"10.55782\/ane-2010-1809","article-title":"Effects of chronic forced swim stress on hippocampal brain-derived neutrophic factor (BDNF) and its receptor (TrkB) immunoreactive cells in juvenile and aged rats","volume":"70","author":"Badowska-Szalewska","year":"2010","journal-title":"Acta Neurobiol. Exp. (Wars)"},{"key":"10.1016\/j.physbeh.2019.03.018_bb0415","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/jnr.23322","article-title":"Mechanisms and effects of curcumin on spatial learning and memory improvement in APPswe\/PS1dE9 mice","volume":"92","author":"Wang","year":"2014","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0420","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1089\/jmf.2013.2965","article-title":"Effects of curcumin (Curcuma longa) on learning and spatial memory as well as cell proliferation and neuroblast differentiation in adult and aged mice by upregulating brain-derived neurotrophic factor and CREB signaling","volume":"17","author":"Nam","year":"2014","journal-title":"J. Med. Food"},{"key":"10.1016\/j.physbeh.2019.03.018_bb0425","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.biopha.2016.12.020","article-title":"Curcumin confers neuroprotection against alcohol-induced hippocampal neurodegeneration via CREB-BDNF pathway in rats","volume":"87","author":"Motaghinejad","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.physbeh.2019.03.018_bb0430","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.psyneuen.2016.12.013","article-title":"Role of BDNF val66met polymorphism in modulating exercised-induced emotional memories","volume":"77","author":"Keyan","year":"2017","journal-title":"Psychoneuroendocrinology"}],"container-title":["Physiology & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938418311922?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938418311922?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:08:29Z","timestamp":1758478109000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938418311922"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":86,"alternative-id":["S0031938418311922"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2019.03.018","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The combination of swimming and curcumin consumption may improve spatial memory recovery after binge ethanol drinking","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2019.03.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}