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Behav."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0370","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ejphar.2003.09.047","article-title":"Basal and feeding-evoked dopamine release in the rat nucleus accumbens is depressed by leptin","volume":"482","author":"Krugel","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0375","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/0361-9230(79)90108-4","article-title":"Striatal dopamine release is altered by glucose and insulin during push-pull perfusion of the rat's caudate nucleus","volume":"4","author":"McCaleb","year":"1979","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0380","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1016\/j.peptides.2005.04.025","article-title":"Ghrelin induces feeding in the mesolimbic reward pathway between the ventral tegmental area and the nucleus accumbens","volume":"26","author":"Naleid","year":"2005","journal-title":"Peptides."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0385","doi-asserted-by":"crossref","first-page":"3229","DOI":"10.1172\/JCI29867","article-title":"Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite","volume":"116","author":"Abizaid","year":"2006","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0390","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.neuropharm.2013.06.004","article-title":"Divergent circuitry underlying food reward and intake effects of ghrelin: dopaminergic VTA-accumbens projection mediates ghrelin's effect on food reward but not food intake","volume":"73","author":"Skibicka","year":"2013","journal-title":"Neuropharmacology."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0395","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1369-1600.2010.00294.x","article-title":"Role of ghrelin in food reward: impact of ghrelin on sucrose self-administration and mesolimbic dopamine and acetylcholine receptor gene expression","volume":"17","author":"Skibicka","year":"2012","journal-title":"Addict. Biol."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0400","doi-asserted-by":"crossref","first-page":"4905","DOI":"10.1523\/JNEUROSCI.4404-13.2014","article-title":"Ghrelin acts as an interface between physiological state and phasic dopamine signaling","volume":"34","author":"Cone","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0405","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/jnc.13080","article-title":"Ghrelin regulates phasic dopamine and nucleus accumbens signaling evoked by food-predictive stimuli","volume":"133","author":"Cone","year":"2015","journal-title":"J. Neurochem."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0410","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.cobeha.2016.02.005","article-title":"GLP-1 influences food and drug reward","volume":"9","author":"Hayes","year":"2016","journal-title":"Curr. Opin. Behav. Sci."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0415","article-title":"Gut-brain axis and addictive disorders: a review with focus on alcohol and drugs of abuse","author":"Jerlhag","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0420","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1152\/physrev.00034.2006","article-title":"The physiology of glucagon-like peptide 1","volume":"87","author":"Holst","year":"2007","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0425","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1053\/j.gastro.2007.03.054","article-title":"Biology of incretins: GLP-1 and GIP","volume":"132","author":"Baggio","year":"2007","journal-title":"Gastroenterology."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0430","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0306-4522(96)00434-4","article-title":"Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem","volume":"77","author":"Larsen","year":"1997","journal-title":"Neuroscience."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0435","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1002\/jnr.490160110","article-title":"Cellular localization of proglucagon\/glucagon-like peptide I messenger RNAs in rat brain","volume":"16","author":"Han","year":"1986","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0440","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/(SICI)1096-9861(19990111)403:2<261::AID-CNE8>3.0.CO;2-5","article-title":"Distribution of pre-pro-glucagon and glucagon-like peptide-1 receptor messenger RNAs in the rat central nervous system","volume":"403","author":"Merchenthaler","year":"1999","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0445","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.brainres.2010.03.059","article-title":"Ascending projections from the caudal visceral nucleus of the solitary tract to brain regions involved in food intake and energy expenditure","volume":"1350","author":"Rinaman","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0450","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.2337\/diab.44.9.1126","article-title":"Both subcutaneously and intravenously administered glucagon-like peptide I are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects","volume":"44","author":"Deacon","year":"1995","journal-title":"Diabetes."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0455","first-page":"952","article-title":"Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo","volume":"80","author":"Deacon","year":"1995","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0460","doi-asserted-by":"crossref","first-page":"3585","DOI":"10.1210\/endo.136.8.7628397","article-title":"Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IV","volume":"136","author":"Kieffer","year":"1995","journal-title":"Endocrinology."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0465","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0167-0115(99)00089-0","article-title":"Dipeptidyl-peptidase IV (CD26)--role in the inactivation of regulatory peptides","volume":"85","author":"Mentlein","year":"1999","journal-title":"Regul. Pept."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0470","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.cmet.2011.02.001","article-title":"Intracellular signals mediating the food intake-suppressive effects of hindbrain glucagon-like peptide-1 receptor activation","volume":"13","author":"Hayes","year":"2011","journal-title":"Cell Metab."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0475","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1210\/endo.140.3.6550","article-title":"Pancreatic glucagon-like peptide-1 receptor couples to multiple G proteins and activates mitogen-activated protein kinase pathways in Chinese hamster ovary cells","volume":"140","author":"Montrose-Rafizadeh","year":"1999","journal-title":"Endocrinology."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0480","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0167-4838(00)00270-3","article-title":"Different domains in the third intracellular loop of the GLP-1 receptor are responsible for Galpha(s) and Galpha(i)\/Galpha(o) activation","volume":"1546","author":"Hallbrink","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.physbeh.2019.03.026_bb0485","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1042\/BST20150244","article-title":"The complexity of signalling mediated by the glucagon-like peptide-1 receptor","volume":"44","author":"Fletcher","year":"2016","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0490","doi-asserted-by":"crossref","first-page":"E751","DOI":"10.1152\/ajpendo.00367.2013","article-title":"Hindbrain GLP-1 receptor-mediated suppression of food intake requires a PI3K-dependent decrease in phosphorylation of membrane-bound Akt","volume":"305","author":"Rupprecht","year":"2013","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0495","first-page":"R1541","article-title":"Glucagon-like peptide-1 promotes satiety and reduces food intake in patients with diabetes mellitus type 2","volume":"276","author":"Gutzwiller","year":"1999","journal-title":"Am. J. Phys."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0500","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1136\/gut.44.1.81","article-title":"Glucagon-like peptide-1: a potent regulator of food intake in humans","volume":"44","author":"Gutzwiller","year":"1999","journal-title":"Gut."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0505","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/379069a0","article-title":"A role for glucagon-like peptide-1 in the central regulation of feeding","volume":"379","author":"Turton","year":"1996","journal-title":"Nature."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0510","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1523\/JNEUROSCI.2212-10.2011","article-title":"Hyperphagia and increased fat accumulation in two models of chronic CNS glucagon-like peptide-1 loss of function","volume":"31","author":"Barrera","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0515","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.physbeh.2010.02.029","article-title":"Role of the glucagon-like-peptide-1 receptor in the control of energy balance","volume":"100","author":"Hayes","year":"2010","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0520","doi-asserted-by":"crossref","first-page":"3103","DOI":"10.1210\/en.2011-0174","article-title":"Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4","volume":"152","author":"Kanoski","year":"2011","journal-title":"Endocrinology."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0525","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1210\/en.2008-1221","article-title":"Intrameal hepatic portal and intraperitoneal infusions of glucagon-like peptide-1 reduce spontaneous meal size in the rat via different mechanisms","volume":"150","author":"Ruttimann","year":"2009","journal-title":"Endocrinology."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0530","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/nrendo.2009.48","article-title":"Incretin-based therapies for type 2 diabetes mellitus","volume":"5","author":"Lovshin","year":"2009","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0535","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1172\/JCI72434","article-title":"Neuronal GLP1R mediates liraglutide's anorectic but not glucose-lowering effect","volume":"124","author":"Sisley","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0540","doi-asserted-by":"crossref","first-page":"4473","DOI":"10.1172\/JCI75276","article-title":"The arcuate nucleus mediates GLP-1 receptor agonist liraglutide-dependent weight loss","volume":"124","author":"Secher","year":"2014","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0545","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/HCR.0000000000000112","article-title":"Treatment of obesity in 2015","volume":"35","author":"Shukla","year":"2015","journal-title":"J. Cardiopulm. Rehabil. Prevent."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0550","first-page":"E1367","article-title":"The food intake-suppressive effects of glucagon-like peptide-1 receptor signaling in the ventral tegmental area are mediated by AMPA\/kainate receptors. American journal of physiology","volume":"305","author":"Mietlicki-Baase","year":"2013","journal-title":"Endocrinol. Metab."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0555","doi-asserted-by":"crossref","first-page":"14453","DOI":"10.1523\/JNEUROSCI.3262-11.2011","article-title":"Glucagon-like peptide 1 receptors in nucleus accumbens affect food intake","volume":"31","author":"Dossat","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0560","first-page":"R1427","article-title":"Peptides that regulate food intake: glucagon-like peptide 1-(7-36) amide acts at lateral and medial hypothalamic sites to suppress feeding in rats","volume":"284","author":"Schick","year":"2003","journal-title":"Am. J. Phys. Regul. Integr. Comp. Phys."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0565","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0069010","article-title":"The glucagon-like peptide 1 analogue, exendin-4, attenuates the rewarding properties of psychostimulant drugs in mice","volume":"8","author":"Egecioglu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.physbeh.2019.03.026_bb0570","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/mp.2012.141","article-title":"GLP-1 analog attenuates cocaine reward","volume":"18","author":"Graham","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.physbeh.2019.03.026_bb0580","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.physbeh.2015.06.013","article-title":"The glucagon-like peptide 1 (GLP-1) receptor agonist exendin-4 reduces cocaine self-administration in mice","volume":"149","author":"Sorensen","year":"2015","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0585","doi-asserted-by":"crossref","first-page":"3748","DOI":"10.1210\/en.2005-0473","article-title":"Peripheral exendin-4 and peptide YY(3-36) synergistically reduce food intake through different mechanisms in mice","volume":"146","author":"Talsania","year":"2005","journal-title":"Endocrinology."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0590","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1038\/sj.ijo.0803284","article-title":"Antiobesity action of peripheral exenatide (exendin-4) in rodents: effects on food intake, body weight, metabolic status and side-effect measures","volume":"30","author":"Mack","year":"2006","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0595","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1016\/j.neuropharm.2011.12.022","article-title":"The role of nausea in food intake and body weight suppression by peripheral GLP-1 receptor agonists, exendin-4 and liraglutide","volume":"62","author":"Kanoski","year":"2012","journal-title":"Neuropharmacology."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0600","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0140-6736(09)60659-0","article-title":"Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)","volume":"374","author":"Buse","year":"2009","journal-title":"Lancet."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0605","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1038\/s41386-018-0010-3","article-title":"Glucagon-like peptide-1 receptor activation in the ventral tegmental area attenuates cocaine seeking in rats","volume":"43","author":"Hernandez","year":"2018","journal-title":"Neuropsychopharmacology."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0610","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2016.86","article-title":"Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels","volume":"6","author":"Reddy","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.physbeh.2019.03.026_bb0615","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/cne.21983","article-title":"Afferents to the GABAergic tail of the ventral tegmental area in the rat","volume":"513","author":"Kaufling","year":"2009","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0620","doi-asserted-by":"crossref","first-page":"13309","DOI":"10.1523\/JNEUROSCI.2277-12.2012","article-title":"Fos activation of selective afferents to ventral tegmental area during cue-induced reinstatement of cocaine seeking in rats","volume":"32","author":"Mahler","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0625","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1038\/sj.npp.1301552","article-title":"Cannabinoid CB1 receptor antagonists attenuate cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats","volume":"33","author":"Xi","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.physbeh.2019.03.026_bb0630","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1046\/j.1471-4159.1995.64031406.x","article-title":"Effects of arachidonic acid on dopamine synthesis, spontaneous release, and uptake in striatal synaptosomes from the rat","volume":"64","author":"L'Hirondel","year":"1995","journal-title":"J. Neurochem."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0635","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1111\/j.1460-9568.1995.tb00650.x","article-title":"Distribution of GLP-1 binding sites in the rat brain: evidence that exendin-4 is a ligand of brain GLP-1 binding sites","volume":"7","author":"Goke","year":"1995","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0640","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1038\/npp.2015.362","article-title":"Glucagon-like peptide-1 receptor activation in the ventral tegmental area decreases the reinforcing efficacy of cocaine","volume":"41","author":"Schmidt","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.physbeh.2019.03.026_bb0645","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0091-3057(96)00445-5","article-title":"A critique of fixed and progressive ratio schedules used to examine the neural substrates of drug reinforcement","volume":"57","author":"Arnold","year":"1997","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0650","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0165-0270(95)00153-0","article-title":"Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy","volume":"66","author":"Richardson","year":"1996","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.physbeh.2019.03.026_bb0655","doi-asserted-by":"crossref","first-page":"4812","DOI":"10.1523\/JNEUROSCI.6326-11.2012","article-title":"The glucagon-like peptide 1 (GLP-1) analogue, exendin-4, decreases the rewarding value of food: a new role for mesolimbic GLP-1 receptors","volume":"32","author":"Dickson","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0660","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/adb.12583","article-title":"Activation of glucagon-like peptide-1 receptors in the nucleus accumbens attenuates cocaine seeking in rats","volume":"24","author":"Hernandez","year":"2019","journal-title":"Addict. Biol."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0665","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0166-4328(02)00286-3","article-title":"Nucleus accumbens shell and core dopamine: differential role in behavior and addiction","volume":"137","author":"Di Chiara","year":"2002","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2019.03.026_bb0670","doi-asserted-by":"crossref","first-page":"6985","DOI":"10.1523\/JNEUROSCI.0115-14.2014","article-title":"Glucagon-like peptide-1 receptor activation in the nucleus accumbens core suppresses feeding by increasing glutamatergic AMPA\/kainate signaling","volume":"34","author":"Mietlicki-Baase","year":"2014","journal-title":"J. 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