{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:53:08Z","timestamp":1791503588098,"version":"4.3.4"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.physbeh.2019.112762","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T02:20:24Z","timestamp":1574907624000},"page":"112762","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Modulation of hippocampal TLR4\/BDNF signal pathway using probiotics is a step closer towards treating cognitive impairment in NASH model"],"prefix":"10.1016","volume":"214","author":[{"given":"Safaa K.","family":"Mohammed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yosra M.","family":"Magdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia AA.","family":"El-Waseef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enas S.","family":"Nabih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Hamouda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omnyah A.","family":"El-kharashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2019.112762_bib0001","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nature08821","article-title":"A human gut microbial gene catalog established by metagenomic sequencing","volume":"464","author":"Qin","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.physbeh.2019.112762_bib0002","first-page":"1","article-title":"Influence of functional food components on gut health","volume":"30","author":"Wan","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.physbeh.2019.112762_bib0003","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nri3608","article-title":"Intestinal epithelial cells: regulators of barrier function and immune homeostasis","volume":"14","author":"Peterson","year":"2014","journal-title":"Nat. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.physbeh.2019.112762_bib0004","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/MPG.0b013e318284abb5","article-title":"Microbiome gut liver axis: a mini-review on their influences on obesity and obesity related liver disease","volume":"56","author":"Vajro","year":"2013","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"10.1016\/j.physbeh.2019.112762_bib0005","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1053\/jhep.2003.50182","article-title":"Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells","volume":"37","author":"Paik","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.physbeh.2019.112762_bib0006","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s12944-016-0278-4","article-title":"The role of gut microbiota in the development of obesity and diabetes","volume":"15","author":"Baothman","year":"2016","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.physbeh.2019.112762_bib0007","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0079-6123(09)17509-X","article-title":"Toll-like receptors in the CNS: implications for neurodegeneration and repair","volume":"175","author":"Van Noort","year":"2009","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.physbeh.2019.112762_bib0008","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3389\/fnagi.2014.00171","article-title":"Systemic inflammation, blood-brain barrier vulnerability and cognitive\/noncognitive symptoms in Alzheimer disease: relevance to pathogenesis and therapy","volume":"6","author":"Takeda","year":"2014","journal-title":"Front Aging Neurosci."},{"key":"10.1016\/j.physbeh.2019.112762_bib0009","doi-asserted-by":"crossref","first-page":"827","DOI":"10.3233\/JAD-2009-1115","article-title":"Nitrosamine exposure causes insulin resistance diseases: relevance to type 2 diabetes mellitus, non-alcoholic steato-hepatitis, and Alzheimer's disease","volume":"17","author":"Tong","year":"2009","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.physbeh.2019.112762_bib0010","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1111\/liv.12483","article-title":"Readiness for behaviour change in non-alcoholic fatty liver disease: implications for multidisciplinary care models","volume":"35","author":"Stewart","year":"2015","journal-title":"Liver Int."},{"issue":"6","key":"10.1016\/j.physbeh.2019.112762_bib0011","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1079\/BJN20051428","article-title":"Should yoghurt cultures be considered probiotic?","volume":"93","author":"Guarner","year":"2005","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.physbeh.2019.112762_bib0012","doi-asserted-by":"crossref","first-page":"2057","DOI":"10.2337\/diacare.27.8.2057","article-title":"Approach to the pathogenesis and treatment of nonalcoholic steatohepatitis","volume":"27","author":"Medina","year":"2004","journal-title":"Diabet. Care"},{"key":"10.1016\/j.physbeh.2019.112762_bib0013","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/B978-0-12-374420-3.00043-7","article-title":"Degradation of phenolic compounds found in olive products by LP EMCC-1039 strains","author":"Landete","year":"2010","journal-title":"Olives Olive Oil Health and Dis. Prevent."},{"key":"10.1016\/j.physbeh.2019.112762_bib0014","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.anaerobe.2014.03.003","article-title":"Lactobacillus pentosus var. Plantarum C29 ameliorates memory impairment and inflammaging in a D-galactose-induced accelerated aging mouse model","volume":"27","author":"Woo","year":"2014","journal-title":"Anaerobe"},{"key":"10.1016\/j.physbeh.2019.112762_bib0015","unstructured":"Reynolds J. and Farinha M. (2005). Counting bacteria. Richland College, editor. 2005; 1\u201310."},{"key":"10.1016\/j.physbeh.2019.112762_bib0016","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.biopha.2016.10.098","article-title":"Potential involvement of JNK1 repression in the hepatic effect of sitagliptin and metformin in rats subjected to high fat diet and chronic mild distress","volume":"85","author":"Magdy","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.physbeh.2019.112762_bib0017","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.tice.2019.07.010","article-title":"Involvement of TLR4\/ CXCL9\/ PREX-2 pathway in the development of hepatocellular carcinoma (HCC) and the promising role of early administration of LP EMCC-1039 in Wistar rats","volume":"60","author":"Elshaer","year":"2019","journal-title":"Tissue Cell"},{"issue":"2","key":"10.1016\/j.physbeh.2019.112762_bib0018","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1017\/S0954422410000168","article-title":"High-fat diet-induced obesity in animal models","volume":"23","author":"Hariri","year":"2010","journal-title":"Nutr. Res. Rev."},{"issue":"1","key":"10.1016\/j.physbeh.2019.112762_bib0019","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1038\/nprot.2006.205","article-title":"Object recognition in rats and mice: a one-trial non-matching-to-sample learning task to study \u2018recognition memory\u2019","author":"Bevins","year":"2006","journal-title":"Nat. Protocols."},{"issue":"4","key":"10.1016\/j.physbeh.2019.112762_bib0020","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00210-018-1466-8","article-title":"Metformin potentiates cognitive and antidepressant effects of fluoxetine in rats exposed to chronic restraint stress and high fat diet: potential involvement of hippocampal c-Jun repression","volume":"391","author":"Khedr","year":"2018","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"issue":"17","key":"10.1016\/j.physbeh.2019.112762_bib0021","doi-asserted-by":"crossref","first-page":"7809","DOI":"10.1523\/JNEUROSCI.22-17-07809.2002","article-title":"Conceptual, spatial, and cue learning in the Morris water maze in fast or slow kindling rats: attention deficit comorbidity","volume":"22","author":"Anisman","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.physbeh.2019.112762_bib0022","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"key":"10.1016\/j.physbeh.2019.112762_bib0023","doi-asserted-by":"crossref","first-page":"586","DOI":"10.4236\/jbbs.2015.513056","article-title":"Nutritional supplement attenuates unpredictable chronic mild stress-induced memory deficits in mice","volume":"5","author":"Umukoro","year":"2015","journal-title":"J. Behav. Brain Sci"},{"issue":"1\u20132","key":"10.1016\/j.physbeh.2019.112762_bib0024","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jneuroim.2009.11.010","article-title":"Cognitive impairment following high fat diet consumption","volume":"219","author":"Pistell","year":"2010","journal-title":"J. Neuroimmunol."},{"issue":"8","key":"10.1016\/j.physbeh.2019.112762_bib0025","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.3390\/nu4081095","article-title":"Diet-induced dysbiosis of the intestinal microbiota and the effects on immunity and disease","volume":"4","author":"Brown","year":"2012","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.physbeh.2019.112762_bib0026","doi-asserted-by":"crossref","first-page":"e59470","DOI":"10.1371\/journal.pone.0059470","article-title":"Supplementation of Lactobacillus curvatus HY7601 and Lp EMCC-1039KY1032 in diet-induced obese mice is associated with gut microbial changes and reduction in obesity","volume":"8","author":"Park","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.physbeh.2019.112762_bib0027","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.3390\/nu9111220","article-title":"Nonalcoholic fatty liver disease is exacerbated in high-fat diet-fed gnotobiotic mice by colonization with the gut microbiota from patients with nonalcoholic steatohepatitis","volume":"9","author":"Chiu","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.physbeh.2019.112762_bib0028","article-title":"The effects of two Lp EMCC-1039 strains on rat lipid metabolism receiving a high fat diet","volume":"2013","author":"Salaj","year":"2013","journal-title":"Sci. World J.."},{"issue":"1","key":"10.1016\/j.physbeh.2019.112762_bib0029","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1258\/002367707779399518","article-title":"Anthropometrical parameters and markers of obesity in rats","volume":"41","author":"Novelli","year":"2007","journal-title":"Lab. Anim."},{"issue":"27","key":"10.1016\/j.physbeh.2019.112762_bib0030","doi-asserted-by":"crossref","first-page":"3394","DOI":"10.3748\/wjg.v16.i27.3394","article-title":"Effects of four Bifidobacteria on obesity in high-fat diet induced rats","volume":"16","author":"Yin","year":"2010","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.physbeh.2019.112762_bib0031","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1039\/C4FO00549J","article-title":"LP EMCC-1039NCU116 improves liver function, oxidative stress and lipid metabolism in rats with high fat diet induced non-alcoholic fatty liver disease","volume":"5","author":"Li","year":"2014","journal-title":"Food Funct."},{"key":"10.1016\/j.physbeh.2019.112762_bib0032","first-page":"1","article-title":"Reduction in serum lipid parameters by incorporation of a native strain of Lp EMCC-1039A7 in MICE","volume":"9","author":"Fazeli","year":"2010","journal-title":"Iran. J. Diabet. Lipid Disord."},{"key":"10.1016\/j.physbeh.2019.112762_bib0033","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.jff.2014.05.002","article-title":"Cholesterol reduction mechanisms and fatty acid composition of cellular membranes of probiotic Lactobacilli and Bifidobacteria","volume":"9","author":"Miremadi","year":"2014","journal-title":"J. Funct. Foods"},{"issue":"1","key":"10.1016\/j.physbeh.2019.112762_bib0034","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004559","article-title":"Implication of gut microbiota in nonalcoholic fatty liver disease","volume":"11","author":"Boursier","year":"2015","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.physbeh.2019.112762_bib0035","doi-asserted-by":"crossref","first-page":"45176","DOI":"10.1038\/srep45176","article-title":"Probiotics may delay the progression of nonalcoholic fatty liver disease by restoring the gut microbiota structure and improving intestinal endotoxemia","volume":"7","author":"Xue","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.physbeh.2019.112762_bib0036","doi-asserted-by":"crossref","first-page":"471","DOI":"10.4103\/pm.pm_279_18","article-title":"LP EMCC-1039 attenuates oxidative stress and liver injury in rats with nonalcoholic steatohepatitis","volume":"14","author":"Werawatganon","year":"2018","journal-title":"Phcog. Mag."},{"key":"10.1016\/j.physbeh.2019.112762_bib0037","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3164\/jcbn.11-38","article-title":"Supplementation with probiotics modifies gut flora and attenuates liver fat accumulation in rat nonalcoholic fatty liver disease model","volume":"50","author":"Xu","year":"2012","journal-title":"J. Clin. Biochem. Nutr."},{"issue":"5","key":"10.1016\/j.physbeh.2019.112762_bib0038","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0063388","article-title":"Butyrate-Producing probiotics reduce nonalcoholic fatty liver disease progression in rats: new insight into the probiotics for the gut-liver axis","volume":"8","author":"Endo","year":"2013","journal-title":"PLoS ONE"},{"issue":"1","key":"10.1016\/j.physbeh.2019.112762_bib0039","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3390\/diseases7010027","article-title":"The therapeutic implications of the gut microbiome and probiotics in patients with NAFLD","volume":"7","author":"Perumpail","year":"2019","journal-title":"Diseases"},{"key":"10.1016\/j.physbeh.2019.112762_bib0040","doi-asserted-by":"crossref","first-page":"794e802","DOI":"10.1016\/j.bbi.2009.02.020","article-title":"Cognitive deficits in interleukin-10 deficient mice after peripheral injection of lipopolysaccharide","volume":"23","author":"Richwine","year":"2009","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.physbeh.2019.112762_bib0041","doi-asserted-by":"crossref","first-page":"133","DOI":"10.5152\/tjg.2014.7886","article-title":"Role of gut microbiota: obesity and NAFLD","volume":"25","author":"Gangarapu","year":"2014","journal-title":"Turk. J. Gastroenterol."},{"issue":"12","key":"10.1016\/j.physbeh.2019.112762_bib0042","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1212\/WNL.0000000000002498","article-title":"Nonalcoholic fatty liver disease is associated with cognitive function in adults","volume":"86","author":"Seo","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.physbeh.2019.112762_bib0043","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11011-011-9269-3","article-title":"Contribution of hyperammonemia and inflammatory factors to cognitive impairment in minimal hepatic encephalopathy","volume":"27","author":"Felipo","year":"2012","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.physbeh.2019.112762_bib0044","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s11427-014-4615-4","article-title":"Ingestion of lactobacillus strain reduces anxiety and improves cognitive function in the hyperammonemia rat","volume":"57","author":"Luo","year":"2014","journal-title":"Sci. China Life Sci."},{"issue":"09","key":"10.1016\/j.physbeh.2019.112762_bib0045","first-page":"012","article-title":"Methionine and choline deficient diet-induced non-alcoholic steatohepatitis in rats: role of melatonin","volume":"7","author":"Amin","year":"2017","journal-title":"J. Appl. Pharm. Sci."}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938419310972?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938419310972?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:10:56Z","timestamp":1758478256000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938419310972"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":45,"alternative-id":["S0031938419310972"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2019.112762","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulation of hippocampal TLR4\/BDNF signal pathway using probiotics is a step closer towards treating cognitive impairment in NASH model","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2019.112762","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112762"}}