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Biobehav. Rev"},{"key":"10.1016\/j.physbeh.2020.112965_bib0098","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.psychres.2017.01.012","article-title":"Physical exercise ameliorates mood disorder-like behavior on high fat diet-induced obesity in mice","volume":"250","author":"Park","year":"2017","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.physbeh.2020.112965_bib0099","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ynstr.2018.05.005","article-title":"Effects of high fat or high sucrose diet on behavioral-response to social defeat stress in mice","volume":"9","author":"Eudave","year":"2018","journal-title":"Neurobiol. Stress"},{"key":"10.1016\/j.physbeh.2020.112965_bib0100","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1111\/bph.13343","article-title":"High-fat diet-induced metabolic disorders impairs 5-HT function and anxiety-like behavior in mice","volume":"173","author":"Zemdegs","year":"2016","journal-title":"Br. J. 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