{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:23:44Z","timestamp":1777375424052,"version":"3.51.4"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.physbeh.2020.113293","type":"journal-article","created":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T16:59:52Z","timestamp":1608137992000},"page":"113293","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["Prenatal hypoxia predisposes vascular functional and structural changes associated with oxidative stress damage and depressive behavior in adult offspring male rats"],"prefix":"10.1016","volume":"230","author":[{"given":"Thain\u00e1 Ferraz Gon\u00e7alves","family":"da Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Graziele Freitas","family":"de Bem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiane Aguiar","family":"da Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izabelle Barcellos","family":"Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo de Andrade","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dayane Teixeira","family":"Ognibene","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Rito-Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana Alencar","family":"Cavalheira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina Pereira","family":"da Concei\u00e7\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos Rochedo","family":"Ferraz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela Castro","family":"Resende","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2020.113293_bib0001","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2017.00016","article-title":"Understanding the full spectrum of organ injury following intrapartum asphyxia","volume":"5","author":"LaRosa","year":"2017","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.physbeh.2020.113293_bib0002","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/pr.2017.260","article-title":"Future perspectives of cell therapy for neonatal hypoxic\u2013ischemic encephalopathy","volume":"83","author":"Nabetani","year":"2018","journal-title":"Pediatr. Res"},{"key":"10.1016\/j.physbeh.2020.113293_bib0003","first-page":"179","article-title":"Protective effects of histone deacetylase inhibition by Scriptaid on brain injury in neonatal rat models of cerebral ischemia and hypoxia","volume":"13","author":"Meng","year":"2020","journal-title":"Int. J. Clin. Exp. Pathol"},{"key":"10.1016\/j.physbeh.2020.113293_bib0004","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.expneurol.2011.10.014","article-title":"Maternal hypertension during pregnancy modifies the response of the immature brain to hypoxia\u2013ischemia: sequential MRI and behavioral investigations","volume":"233","author":"Letourneur","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.physbeh.2020.113293_bib0005","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1079\/PNS2005417","article-title":"Fetal origins of insulin resistance and obesity","volume":"64","author":"Stocker","year":"2005","journal-title":"Proc. Nutr. Soc"},{"key":"10.1016\/j.physbeh.2020.113293_bib0006","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1017\/thg.2018.65","article-title":"Fetal origins of mental disorders? an answer based on mendelian randomization","volume":"21","author":"Arafat","year":"2018","journal-title":"Twin Res Hum Genet"},{"key":"10.1016\/j.physbeh.2020.113293_bib0007","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-030937","article-title":"Mutaba\u2019ah\u2014Mother and Child Health Study: protocol for a prospective cohort study investigating the maternal and early life determinants of infant, child, adolescent and maternal health in the United Arab Emirates","volume":"9","author":"Al Haddad","year":"2019","journal-title":"BMJ Open"},{"key":"10.1016\/j.physbeh.2020.113293_bib0008","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jad.2012.02.008","article-title":"Low plasma levels of l-arginine, impaired intraplatelet nitric oxide and platelet hyperaggregability: implications for cardiovascular disease in depressive patients","volume":"140","author":"Pinto","year":"2012","journal-title":"J Affect Disord"},{"key":"10.1016\/j.physbeh.2020.113293_bib0009","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1007\/s00213-017-4712-8","article-title":"Decreased serum l-arginine and l-citrulline levels in major depression","volume":"234","author":"Hess","year":"2017","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.physbeh.2020.113293_bib0010","series-title":"Mental Health and Older Adults., Mental Health and Older Adults","year":"2015"},{"key":"10.1016\/j.physbeh.2020.113293_bib0011","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S0022-3476(95)70174-5","article-title":"Multiple organ involvement in perinatal asphyxia","volume":"127","author":"Mart\u00edn-Ancel","year":"1995","journal-title":"J. Pediatr."},{"key":"10.1016\/j.physbeh.2020.113293_bib0012","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/PCC.0000000000001068","article-title":"The severity of hypoxic-ischemic encephalopathy correlates with multiple organ dysfunction in the hypothermia era","volume":"18","author":"Alsina","year":"2017","journal-title":"Pediatr. Crit Care Med"},{"key":"10.1016\/j.physbeh.2020.113293_bib0013","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1161\/ATVBAHA.108.181644","article-title":"Vascular responses to hypoxia and ischemia","volume":"30","author":"Semenza","year":"2010","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.physbeh.2020.113293_bib0014","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3389\/fped.2020.00068","article-title":"Getting an early start in understanding perinatal asphyxia impact on the cardiovascular system","volume":"8","author":"Popescu","year":"2020","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.physbeh.2020.113293_bib0015","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/j.1440-1681.2012.05746.x","article-title":"Early life programming of cardiometabolic disease in the Western Australian pregnancy cohort (Raine) study","volume":"39","author":"Huang","year":"2012","journal-title":"Clin. Exp. Pharmacol. Physiol"},{"key":"10.1016\/j.physbeh.2020.113293_bib0016","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/s41440-018-0181-7","article-title":"Prenatal hypoxia affected endothelium-dependent vasodilation in mesenteric arteries of aged offspring via increased oxidative stress","volume":"42","author":"Chen","year":"2019","journal-title":"Hypertens. Res"},{"key":"10.1016\/j.physbeh.2020.113293_bib0017","doi-asserted-by":"crossref","first-page":"e108","DOI":"10.1161\/ATVBAHA.117.309813","article-title":"Endothelial functions","volume":"37","author":"Godo","year":"2017","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.physbeh.2020.113293_bib0018","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.atherosclerosis.2016.03.007","article-title":"Vascular endothelium - Gatekeeper of vessel health","volume":"248","author":"Cahill","year":"2016","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.physbeh.2020.113293_bib0019","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s11906-010-0118-2","article-title":"Endothelium-derived vasoactive factors and hypertension: possible roles in pathogenesis and as treatment targets","volume":"12","author":"F\u00e9l\u00e9tou","year":"2010","journal-title":"Curr Hypertens Rep"},{"key":"10.1016\/j.physbeh.2020.113293_bib0020","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1007\/s12272-019-01180-7","article-title":"Therapeutic targets for endothelial dysfunction in vascular diseases","volume":"42","author":"Huynh","year":"2019","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.physbeh.2020.113293_bib0021","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1159\/000487727","article-title":"Chronic Prenatal hypoxia down-regulated bk Channel \u03921 subunits in mesenteric artery smooth muscle cells of the offspring","volume":"45","author":"Liu","year":"2018","journal-title":"Cell Physiol. Biochem"},{"key":"10.1016\/j.physbeh.2020.113293_bib0022","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1113\/jphysiol.2005.084889","article-title":"Effects of maternal hypoxia or nutrient restriction during pregnancy on endothelial function in adult male rat offspring","volume":"565","author":"Williams","year":"2005","journal-title":"J. Physiol. (Lond.)."},{"key":"10.1016\/j.physbeh.2020.113293_bib0023","doi-asserted-by":"crossref","first-page":"H674","DOI":"10.1152\/ajpheart.00191.2005","article-title":"Increased myogenic tone in 7-month-old adult male but not female offspring from rat dams exposed to hypoxia during pregnancy","volume":"289","author":"Hemmings","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.physbeh.2020.113293_bib0024","doi-asserted-by":"crossref","first-page":"e31017","DOI":"10.1371\/journal.pone.0031017","article-title":"Developmental programming of cardiovascular dysfunction by prenatal hypoxia and oxidative stress","volume":"7","author":"Giussani","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.physbeh.2020.113293_bib0025","first-page":"977","article-title":"Atheroprotective effects of antioxidants through inhibition of mitogen-activated protein kinases","volume":"25","author":"Kyaw","year":"2004","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.physbeh.2020.113293_bib0026","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.atherosclerosis.2011.04.023","article-title":"Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models","volume":"218","author":"Kleemann","year":"2011","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.physbeh.2020.113293_bib0027","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.pbb.2013.04.004","article-title":"Prenatal hypoxia, habituation memory and oxidative stress","volume":"107","author":"Sab","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2020.113293_bib0028","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/0014-2999(78)90118-8","article-title":"Behavioural despair in rats: a new model sensitive to antidepressant treatments","volume":"47","author":"Porsolt","year":"1978","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.physbeh.2020.113293_bib0029","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.nutres.2020.05.006","article-title":"A\u00e7a\u00ed seed extract prevents the renin-angiotensin system activation, oxidative stress and inflammation in white adipose tissue of high-fat diet\u2013fed mice","volume":"79","author":"Santos","year":"2020","journal-title":"Nutr. Res."},{"key":"10.1016\/j.physbeh.2020.113293_bib0030","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1590\/S0100-879X1998000900017","article-title":"Role of non-nitric oxide non-prostaglandin endothelium-derived relaxing factor(s) in bradykinin vasodilation","volume":"31","author":"Resende","year":"1998","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.physbeh.2020.113293_bib0031","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1007\/s00210-012-0798-z","article-title":"Euterpe oleracea Mart.-derived polyphenols prevent endothelial dysfunction and vascular structural changes in renovascular hypertensive rats: role of oxidative stress, Naunyn-Schmiedeberg\u2019s","volume":"385","author":"da Costa","year":"2012","journal-title":"Arch. Pharmacol"},{"key":"10.1016\/j.physbeh.2020.113293_bib0032","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/288373a0","article-title":"The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine","volume":"288","author":"Furchgott","year":"1980","journal-title":"Nature"},{"key":"10.1016\/j.physbeh.2020.113293_bib0033","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/9780470110539.ch5","article-title":"Assays for superoxide dismutase","volume":"32","author":"Bannister","year":"1987","journal-title":"Methods Biochem Anal"},{"key":"10.1016\/j.physbeh.2020.113293_bib0034","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0076-6879(84)05016-3","article-title":"Catalase in vitro","volume":"105","author":"Aebi","year":"1984","journal-title":"Meth. Enzymol."},{"key":"10.1016\/j.physbeh.2020.113293_bib0035","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0076-6879(84)05015-1","article-title":"Assays of glutathione peroxidase","volume":"105","author":"Floh\u00e9","year":"1984","journal-title":"Meth. Enzymol."},{"key":"10.1016\/j.physbeh.2020.113293_bib0036","first-page":"429","article-title":"Prenatal stress, anxiety and depression: a mechanism involving CRH peptide family","volume":"35","author":"Fan","year":"2014","journal-title":"Neuro Endocrinol. Lett."},{"key":"10.1016\/j.physbeh.2020.113293_bib0037","first-page":"493","article-title":"Mechanism of synergistic action following co-treatment with pramipexole and fluoxetine or sertraline in the forced swimming test in rats","volume":"58","author":"Rog\u00f3z","year":"2006","journal-title":"Pharmacol. Rep"},{"key":"10.1016\/j.physbeh.2020.113293_bib0038","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.bbr.2006.03.016","article-title":"Models of anxiety: responses of rats to novelty in an open space and an enclosed space","volume":"171","author":"Ennaceur","year":"2006","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2020.113293_bib0039","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.bbr.2008.06.007","article-title":"Integrating the open field, elevated plus maze and light\/dark box to assess different types of emotional behaviors in one single trial","volume":"193","author":"Ramos","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2020.113293_bib0040","doi-asserted-by":"crossref","first-page":"e01028","DOI":"10.1002\/brb3.1028","article-title":"Gunn rats with glial activation in the hippocampus show prolonged immobility time in the forced swimming test and tail suspension test","volume":"8","author":"Arauchi","year":"2018","journal-title":"Brain Behav"},{"key":"10.1016\/j.physbeh.2020.113293_bib0041","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1159\/000047125","article-title":"Prenatal influence of ischemia-hypoxia-induced intrauterine growth retardation on brain development and behavioral activity in rats","volume":"80","author":"Tashima","year":"2001","journal-title":"Biol. Neonate."},{"key":"10.1016\/j.physbeh.2020.113293_bib0042","first-page":"92","article-title":"Long-term prenatal hypoxia alters maturation of brain catecholaminergic systems and motor behavior in rats: catecholamines","volume":"54","author":"Perrin","year":"2004","journal-title":"Behav Prenat Hypoxia Synapse"},{"key":"10.1016\/j.physbeh.2020.113293_bib0043","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuroscience.2017.07.051","article-title":"Differential effects of neonatal SSRI treatments on hypoxia-induced behavioral changes in male and female offspring","volume":"360","author":"Nagano","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2020.113293_bib0044","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.brainresbull.2017.09.009","article-title":"Enriched environment combined with fluoxetine ameliorates depression-like behaviors and hippocampal SYP expression in a rat CUS model","volume":"135","author":"Liu","year":"2017","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.physbeh.2020.113293_bib0045","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.ijdevneu.2011.02.010","article-title":"Mild musculoskeletal and locomotor alterations in adult rats with white matter injury following prenatal ischemia","volume":"29","author":"Delcour","year":"2011","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.physbeh.2020.113293_bib0046","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0892-0362(93)90051-O","article-title":"Altered adult sexual behavior in the male rat following chronic prenatal hypoxia","volume":"15","author":"Hermans","year":"1993","journal-title":"Neurotoxicol Teratol"},{"key":"10.1016\/j.physbeh.2020.113293_bib0047","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.nbd.2004.10.024","article-title":"Developmental changes induced by graded prenatal systemic hypoxic-ischemic insults in rats","volume":"18","author":"Robinson","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.physbeh.2020.113293_bib0048","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0959-4388(99)80016-6","article-title":"Maternal care and the development of stress responses","volume":"9","author":"Francis","year":"1999","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.physbeh.2020.113293_bib0049","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143397","article-title":"Nitric oxide-related biological pathways in patients with major depression","volume":"10","author":"Baranyi","year":"2015","journal-title":"PLoS ONE"},{"key":"10.1016\/j.physbeh.2020.113293_bib0050","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.biopha.2017.10.122","article-title":"Nitric oxide bioavailability dysfunction involves in atherosclerosis","volume":"97","author":"Chen","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.physbeh.2020.113293_bib0051","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12944-017-0594-3","article-title":"The role and function of HDL in patients with diabetes mellitus and the related cardiovascular risk","volume":"16","author":"Femlak","year":"2017","journal-title":"Lipids Health Dis"},{"key":"10.1016\/j.physbeh.2020.113293_bib0052","doi-asserted-by":"crossref","first-page":"R930","DOI":"10.1152\/ajpregu.00641.2009","article-title":"Mechanisms of endothelium-dependent vasodilation in male and female, young and aged offspring born growth restricted","volume":"298","author":"Morton","year":"2010","journal-title":"Am. J. Physiol. Regul IntegrComp. Physiol."},{"key":"10.1016\/j.physbeh.2020.113293_bib0053","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1097\/JGP.0b013e318202bc42","article-title":"Early and late-onset effect of chronic stress on vascular function in mice: a possible model of the impact of depression on vascular disease in aging","volume":"19","author":"Isingrini","year":"2011","journal-title":"Am J Geriatr Psychiatry"},{"key":"10.1016\/j.physbeh.2020.113293_bib0054","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/hr.2016.21","article-title":"Prenatal hypoxia in rats increased blood pressure and sympathetic drive of the adult offspring","volume":"39","author":"Svitok","year":"2016","journal-title":"Hypertens Res"},{"key":"10.1016\/j.physbeh.2020.113293_bib0055","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1097\/PSY.0b013e3181960e7f","article-title":"Plasma levels of matrix metalloproteinase-9 are independently associated with psychosocial factors in a middle-aged normal population","volume":"71","author":"Garvin","year":"2009","journal-title":"Psychosom Med"},{"key":"10.1016\/j.physbeh.2020.113293_bib0056","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.yjmcc.2016.05.012","article-title":"The effects of different angiotensin II type 1 receptor blockers on the regulation of the ACE-AngII-AT1 and ACE2-Ang(1\u20137)-Mas axes in pressure overload-induced cardiac remodeling in male mice","volume":"97","author":"Wang","year":"2016","journal-title":"J. Mol. Cell. Cardiol."},{"key":"10.1016\/j.physbeh.2020.113293_bib0057","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1161\/01.CIR.0000017497.47084.06","article-title":"Hypoxia induces aortic hypertrophic growth, left ventricular dysfunction, and sympathetic hyperinnervation of peripheral arteries in the chick embryo","volume":"105","author":"Rouwet","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.physbeh.2020.113293_bib0058","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1017\/S2040174409990043","article-title":"Cardiac and vascular disease prior to hatching in chick embryos incubated at high altitude","volume":"1","author":"Salinas","year":"2010","journal-title":"J Dev Orig Health Dis"},{"key":"10.1016\/j.physbeh.2020.113293_bib0059","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1161\/CIRCRESAHA.118.313764","article-title":"Oxidative stress contributes to microvascular endothelial dysfunction in men and women with major depressive disorder","volume":"124","author":"Greaney","year":"2019","journal-title":"Circ. Res."},{"key":"10.1016\/j.physbeh.2020.113293_bib0060","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.intimp.2016.02.009","article-title":"Astragaloside IV improves the isoproterenol-induced vascular dysfunction via attenuating eNOS uncoupling-mediated oxidative stress and inhibiting ROS-NF-\u03baB pathways","volume":"33","author":"Xu","year":"2016","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.physbeh.2020.113293_bib0061","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.reprotox.2016.01.001","article-title":"Prenatal hypoxia enhanced angiotensin II-mediated vasoconstriction via increased oxidative signaling in fetal rats","volume":"60","author":"Zhu","year":"2016","journal-title":"Reprod Toxicol"},{"key":"10.1016\/j.physbeh.2020.113293_bib0062","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.atherosclerosis.2018.01.031","article-title":"Quercetin decreases the activity of matrix metalloproteinase-2 and ameliorates vascular remodeling in renovascular hypertension","volume":"270","author":"Pereira","year":"2018","journal-title":"Atherosclerosis"}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938420306077?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938420306077?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:16:43Z","timestamp":1758478603000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938420306077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":62,"alternative-id":["S0031938420306077"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2020.113293","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prenatal hypoxia predisposes vascular functional and structural changes associated with oxidative stress damage and depressive behavior in adult offspring male rats","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2020.113293","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113293"}}