{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:53:13Z","timestamp":1791503593570,"version":"4.3.4"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.physbeh.2021.113411","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T21:29:11Z","timestamp":1617226151000},"page":"113411","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["Saccharomyces boulardii ameliorates gut dysbiosis associated cognitive decline"],"prefix":"10.1016","volume":"236","author":[{"given":"Suparna","family":"Roy Sarkar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Papiya","family":"Mitra Mazumder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaberi","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Sarkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Adhikary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunal","family":"Mukhopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sugato","family":"Banerjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9356","key":"10.1016\/j.physbeh.2021.113411_bib0001","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/S0140-6736(03)12489-0","article-title":"Gut flora in health and disease","volume":"361","author":"Guarner","year":"2003","journal-title":"Lancet"},{"issue":"9","key":"10.1016\/j.physbeh.2021.113411_bib0002","first-page":"560","article-title":"Gut bacteria in health and disease","volume":"9","author":"Quigley","year":"2013","journal-title":"Gastroenterol Hepatol"},{"issue":"6","key":"10.1016\/j.physbeh.2021.113411_bib0003","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1053\/j.gastro.2009.01.075","article-title":"The relationship between intestinal microbiota and the central nervous system in normal gastrointestinal function and disease","volume":"136","author":"Collins","year":"2009","journal-title":"Gastroenterology"},{"issue":"34","key":"10.1016\/j.physbeh.2021.113411_bib0004","doi-asserted-by":"crossref","first-page":"13780","DOI":"10.1073\/pnas.0706625104","article-title":"Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases","volume":"104","author":"Frank","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"4","key":"10.1016\/j.physbeh.2021.113411_bib0005","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1177\/1756283X13482996","article-title":"Role of the gut microbiota in health and chronic gastrointestinal disease: understanding a hidden metabolic organ","volume":"6","author":"Guinane","year":"2013","journal-title":"Ther Adv Gastroenterol"},{"issue":"1","key":"10.1016\/j.physbeh.2021.113411_bib0006","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbi.2009.05.058","article-title":"Mood and gut feelings","volume":"24","author":"Forsythe","year":"2009","journal-title":"Brain Behav. Immun"},{"key":"10.1016\/j.physbeh.2021.113411_bib0007","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jneuroim.2019.01.004","article-title":"Gut microbiota in neurodegenerative disorders","volume":"328","author":"Roy Sarkar","year":"2019","journal-title":"J. Neuroimmunol."},{"issue":"1","key":"10.1016\/j.physbeh.2021.113411_bib0008","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/gbb.12109","article-title":"Microbial genes, brain & behaviour\u2013epigenetic regulation of the gut\u2013brain axis","volume":"13","author":"Stilling","year":"2014","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.physbeh.2021.113411_bib0009","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.bbi.2016.02.020","article-title":"Cognitive impairment by antibiotic-induced gut dysbiosis: analysis of gut microbiota-brain communication","volume":"56","author":"Fr\u00f6hlich","year":"2016","journal-title":"Brain Behav Immun"},{"issue":"10","key":"10.1016\/j.physbeh.2021.113411_bib0010","doi-asserted-by":"crossref","first-page":"4726","DOI":"10.1128\/IAI.00319-08","article-title":"Antibiotic-induced perturbations of the intestinal microbiota alter host susceptibility to enteric infection","volume":"76","author":"Sekirov","year":"2008","journal-title":"Infect. Immun."},{"issue":"5","key":"10.1016\/j.physbeh.2021.113411_bib0011","doi-asserted-by":"crossref","first-page":"707","DOI":"10.3920\/BM2014.0177","article-title":"Lactobacillus fermentum NS9 restores the antibiotic induced physiological and psychological abnormalities in rats","volume":"6","author":"Wang","year":"2015","journal-title":"Benef Microbes"},{"key":"10.1016\/j.physbeh.2021.113411_bib0012","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.bbi.2015.04.004","article-title":"Gut microbiota depletion from early adolescence in mice: implications for brain and behaviour","volume":"48","author":"Desbonnet","year":"2015","journal-title":"Brain Behav. Immun."},{"issue":"9","key":"10.1016\/j.physbeh.2021.113411_bib0013","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/j.celrep.2016.04.074","article-title":"Ly6Chi monocytes provide a link between antibiotic-induced changes in gut microbiota and adult hippocampal neurogenesis","volume":"15","author":"M\u00f6hle","year":"2016","journal-title":"Cell Rep"},{"key":"10.1016\/j.physbeh.2021.113411_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2020.577390","article-title":"Probiotics protect against gut dysbiosis associated decline in learning and memory","volume":"348","author":"Roy Sarkar","year":"2020","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.physbeh.2021.113411_bib0015","article-title":"Yeasts as probiotics: mechanisms, outcomes, and future potential","volume":"103333","author":"Sen","year":"2020","journal-title":"Fungal Genet. Biol."},{"key":"10.1016\/j.physbeh.2021.113411_bib0016","doi-asserted-by":"crossref","first-page":"237","DOI":"10.2147\/CEG.S85574","article-title":"Saccharomyces boulardii CNCM I-745 supports regeneration of the intestinal microbiota after diarrheic dysbiosis\u2013a review","volume":"8","author":"Mor\u00e9","year":"2015","journal-title":"Clin Exp Gastroenterol"},{"key":"10.1016\/j.physbeh.2021.113411_bib0017","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1203\/00006450-199410000-00019","article-title":"Saccharomyces boulardii enhances rat intestinal enzyme expression by endoluminal release of polyamines","volume":"36","author":"Buts","year":"1994","journal-title":"Pediatr Res"},{"key":"10.1016\/j.physbeh.2021.113411_bib0018","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000007757","article-title":"Application of the colon-simulation technique for studying the effects of Saccharomyces boulardii on basic parameters of porcine cecal microbial metabolism disturbed by clindamycin","volume":"61","author":"Breves","year":"2000","journal-title":"Digestion"},{"key":"10.1016\/j.physbeh.2021.113411_bib0019","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1007\/s12032-008-9128-1","article-title":"The effect of Saccharomyces boulardii on reducing irinotecan-induced intestinal mucositis and diarrhea","volume":"26","author":"Sezer","year":"2009","journal-title":"Med Oncol"},{"key":"10.1016\/j.physbeh.2021.113411_bib0020","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0192-0561(86)90106-2","article-title":"Immunopharmacological effects of Saccharomyces boulardii in healthy human volunteers","volume":"8","author":"Caetano","year":"1986","journal-title":"Int. J. Immunopharmacol."},{"key":"10.1016\/j.physbeh.2021.113411_bib0021","doi-asserted-by":"crossref","first-page":"5990","DOI":"10.1128\/AEM.00233-06","article-title":"Molecular monitoring of the fecal microbiota of healthy human subjects during administration of lactulose and Saccharomyces boulardii","volume":"72","author":"Vanhoutte","year":"2006","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.physbeh.2021.113411_bib0022","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.femsre.2004.01.003","article-title":"Antagonistic activities of Lactobacilli and Bifidobacteria against microbial pathogens","volume":"28","author":"Servin","year":"2004","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.physbeh.2021.113411_bib0023","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1097\/MEG.0000000000000094","article-title":"Cytokine and clinical response to Saccharomyces boulardii therapy in diarrhea-dominant irritable bowel syndrome: a randomized trial","volume":"26","author":"Abbas","year":"2014","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"10.1016\/j.physbeh.2021.113411_bib0024","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.3389\/fmicb.2018.01948","article-title":"Structural and functional alterations in the microbial community and immunological consequences in a mouse model of antibiotic-induced dysbiosis","volume":"9","author":"Shi","year":"2018","journal-title":"Front Microbiol"},{"key":"10.1016\/j.physbeh.2021.113411_bib0025","doi-asserted-by":"crossref","first-page":"27","DOI":"10.4103\/0976-0105.177703","article-title":"A simple practice guide for dose conversion between animals and human","volume":"7","author":"Nair","year":"2016","journal-title":"J Basic Clin Pharm"},{"issue":"4","key":"10.1016\/j.physbeh.2021.113411_bib0026","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"22","key":"10.1016\/j.physbeh.2021.113411_bib0027","first-page":"e1088","article-title":"Elevated plus maze for mice","author":"Komada","year":"2008","journal-title":"JoVE-J Vis Exp"},{"issue":"3","key":"10.1016\/j.physbeh.2021.113411_bib0028","first-page":"91","article-title":"Various animal models to check learning and memory-A review","volume":"4","author":"Gupta","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.physbeh.2021.113411_bib0029","first-page":"1","article-title":"Evidence for a role of brain serotonergic neurotransmission in avoidance learning","volume":"544","author":"Ogren","year":"1985","journal-title":"Acta Physiol. Scand. Suppl."},{"issue":"2","key":"10.1016\/j.physbeh.2021.113411_bib0030","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10339-011-0430-z","article-title":"The novel object recognition memory: neurobiology, test procedure, and its modifications","volume":"13","author":"Antunes","year":"2012","journal-title":"Cogn. Process."},{"issue":"2","key":"10.1016\/j.physbeh.2021.113411_bib0031","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.bbr.2009.12.036","article-title":"One-trial object recognition in rats and mice: methodological and theoretical issues","volume":"215","author":"Ennaceur","year":"2010","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.physbeh.2021.113411_bib0032","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.nlm.2004.03.005","article-title":"On the delay-dependent involvement of the hippocampus in object recognition memory","volume":"82","author":"Hammond","year":"2004","journal-title":"Neurobiol Learn Mem"},{"issue":"6","key":"10.1016\/j.physbeh.2021.113411_bib0033","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/sj.npp.1301256","article-title":"The allosteric potentiation of nicotinic acetylcholine receptors by galantamine ameliorates the cognitive dysfunction in beta amyloid 25\u201335 icv-injected mice: involvement of dopaminergic systems","volume":"32","author":"Wang","year":"2007","journal-title":"Neuropsychopharmacol"},{"key":"10.1016\/j.physbeh.2021.113411_bib0034","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jim.2014.12.015","article-title":"Methods to determine intestinal permeability and bacterial translocation during liver disease","volume":"421","author":"Wang","year":"2015","journal-title":"J Immunol Methods"},{"issue":"2","key":"10.1016\/j.physbeh.2021.113411_bib0035","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"issue":"1\u20132","key":"10.1016\/j.physbeh.2021.113411_bib0036","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF01969102","article-title":"Relationship between arachidonic acid metabolism, myeloperoxidase activity and leukocyte infiltration in a rat model of inflammatory bowel disease","volume":"25","author":"Boughton-Smith","year":"1988","journal-title":"Agents Actions"},{"issue":"3","key":"10.1016\/j.physbeh.2021.113411_bib0037","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0003-9861(62)90321-1","article-title":"Myeloperoxidase of the leucocyte of normal human blood. I. Content and localization","volume":"96","author":"Schultz","year":"1962","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.physbeh.2021.113411_bib0038","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1084\/jem.20122220","article-title":"Diverse novel functions of neutrophils in immunity, inflammation, and beyond","volume":"210","author":"Mocsai","year":"2013","journal-title":"J Exp Med"},{"issue":"1","key":"10.1016\/j.physbeh.2021.113411_bib0039","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-018-1284-4","article-title":"The role of neutrophil granule proteins in neuroinflammation and Alzheimer's disease","volume":"15","author":"Stock","year":"2018","journal-title":"J. Neuroinflammation."},{"issue":"7","key":"10.1016\/j.physbeh.2021.113411_bib0040","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067976","article-title":"Measuring myeloperoxidase activity in biological samples","volume":"8","author":"Pulli","year":"2013","journal-title":"PLoS ONE"},{"issue":"5","key":"10.1016\/j.physbeh.2021.113411_bib0041","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.bbadis.2011.10.003","article-title":"Elevation of glutathione as a therapeutic strategy in Alzheimer disease","volume":"1822","author":"Pocernich","year":"2012","journal-title":"Biochim. Biophys. Acta (BBA)-Mol Basis Dis"},{"issue":"1","key":"10.1016\/j.physbeh.2021.113411_bib0042","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0304-4165(79)90289-7","article-title":"Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver","volume":"582","author":"Moron","year":"1979","journal-title":"BBA-Gen. Subjects"},{"issue":"3","key":"10.1016\/j.physbeh.2021.113411_bib0043","first-page":"265","article-title":"Biochemical and in-vivo antioxidant parameters for evaluation of memory enhancing activity","volume":"6","author":"Ameen","year":"2016","journal-title":"Int. J. Pharm. Chem. Biol. Sci."},{"issue":"2","key":"10.1016\/j.physbeh.2021.113411_bib0044","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/ng0298-159","article-title":"A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase","volume":"18","author":"Melov","year":"1998","journal-title":"Nat. Genet."},{"issue":"4","key":"10.1016\/j.physbeh.2021.113411_bib0045","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/jnr.22582","article-title":"Involvement of interleukin-1 in lipopolysaccaride-induced microglial activation and learning and memory deficits","volume":"89","author":"Tanaka","year":"2011","journal-title":"J Neurosci Res"},{"key":"10.1016\/j.physbeh.2021.113411_bib0046","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/1357-4310(96)88772-7","article-title":"Monocyte chemoattractant protein 1: a potential regulator of monocyte recruitment in inflammatory disease","volume":"2","author":"Rollins","year":"1996","journal-title":"Mol. Med. Today"},{"key":"10.1016\/j.physbeh.2021.113411_bib0047","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1038\/84209","article-title":"Chemokines and disease","volume":"2","author":"Gerard","year":"2001","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.physbeh.2021.113411_bib0048","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.pharep.2019.03.012","article-title":"Minocycline reverses diabetes-associated cognitive impairment in rats","volume":"71","author":"Mehta","year":"2019","journal-title":"Pharmacol Rep"},{"issue":"10","key":"10.1016\/j.physbeh.2021.113411_bib0049","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1093\/jn\/126.10.2519","article-title":"Milk growth factors enriched from cheese whey ameliorate intestinal damage by methotrexate when administered orally to rats","volume":"126","author":"Howarth","year":"1996","journal-title":"J. Nutr."},{"issue":"3","key":"10.1016\/j.physbeh.2021.113411_bib0050","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1136\/gut.2009.202515","article-title":"Bacterial infection causes stress-induced memory dysfunction in mice","volume":"60","author":"Gareau","year":"2011","journal-title":"Gut"},{"issue":"7","key":"10.1016\/j.physbeh.2021.113411_bib0051","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1073\/pnas.1010529108","article-title":"Normal gut microbiota modulates brain development and behavior","volume":"108","author":"Heijtz","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"4","key":"10.1016\/j.physbeh.2021.113411_bib0052","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1177\/1753425914536450","article-title":"Zinc oxide influences mitogen-activated protein kinase and TGF-\u03b21 signaling pathways, and enhances intestinal barrier integrity in weaned pigs","volume":"21","author":"Song","year":"2015","journal-title":"Innate Immun"},{"issue":"1","key":"10.1016\/j.physbeh.2021.113411_bib0053","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1574-695X.2008.00392.x","article-title":"Bifidobacterium microbiota and parameters of immune function in elderly subjects","volume":"53","author":"Ouwehand","year":"2008","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.physbeh.2021.113411_bib0054","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.bbr.2015.02.044","article-title":"Bifidobacteria modulate cognitive processes in an anxious mouse strain","volume":"287","author":"Savignac","year":"2015","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.physbeh.2021.113411_bib0055","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3389\/fmicb.2016.00185","article-title":"Intestinal short chain fatty acids and their link with diet and human health","volume":"7","author":"R\u00edos-Covi\u00e1n","year":"2016","journal-title":"Front Microbiol"},{"issue":"6","key":"10.1016\/j.physbeh.2021.113411_bib0056","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1053\/j.gastro.2010.06.063","article-title":"Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice","volume":"139","author":"Bercik","year":"2010","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.physbeh.2021.113411_bib0057","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1159\/000116774","article-title":"Role of the brain-gut axis in the pathophysiology of Crohn's disease","volume":"26","author":"Stasi","year":"2008","journal-title":"Dig Dis"},{"issue":"8","key":"10.1016\/j.physbeh.2021.113411_bib0058","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1007\/s12603-019-1240-8","article-title":"Systemic oxidative stress: a key point in neurodegeneration\u2014A review","volume":"23","author":"Leo","year":"2019","journal-title":"J. Nutr. Health Aging"},{"key":"10.1016\/j.physbeh.2021.113411_bib0059","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2147\/CEG.S181590","article-title":"Beneficial effects of Saccharomyces boulardii CNCM I-745 on clinical disorders associated with intestinal barrier disruption","volume":"12","author":"Terciolo","year":"2019","journal-title":"Clin Exp Gastroenterol"},{"issue":"2","key":"10.1016\/j.physbeh.2021.113411_bib0066","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1177\/1756283X11428502","article-title":"Efficacy and safety of the probiotic Saccharomyces boulardii for the prevention and therapy of gastrointestinal disorders","volume":"5","author":"Kelesidis","year":"2012","journal-title":"Therap Adv Gastroenterol"},{"issue":"7","key":"10.1016\/j.physbeh.2021.113411_bib0069","doi-asserted-by":"crossref","first-page":"671","DOI":"10.4161\/cbt.11.7.14896","article-title":"Probiotic factors partially improve parameters of 5-fluorouracil-induced intestinal mucositis in rats","volume":"11","author":"Prisciandaro","year":"2011","journal-title":"Cancer Biol. Ther."},{"issue":"1","key":"10.1016\/j.physbeh.2021.113411_bib0070","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1186\/s12866-019-1610-8","article-title":"Saccharomyces boulardii alleviates ulcerative colitis carcinogenesis in mice by reducing TNF-\u03b1 and IL-6 levels and functions and by rebalancing intestinal microbiota","volume":"19","author":"Wang","year":"2019","journal-title":"BMC Microbiol"},{"issue":"6","key":"10.1016\/j.physbeh.2021.113411_bib0071","first-page":"5652","article-title":"Mechanism and therapeutic effects of Saccharomyces boulardii on experimental colitis in mice","volume":"18","author":"Zhou","year":"2018","journal-title":"Mol Med Rep"}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938421001037?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938421001037?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:16:46Z","timestamp":1758478606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938421001037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":63,"alternative-id":["S0031938421001037"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2021.113411","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Saccharomyces boulardii ameliorates gut dysbiosis associated cognitive decline","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2021.113411","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113411"}}