{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T23:44:35Z","timestamp":1786405475411,"version":"build-2736575974"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T00:00:00Z","timestamp":1619481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.physbeh.2021.113432","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T07:12:29Z","timestamp":1619161949000},"page":"113432","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Implication of the social function of excessive self-grooming behavior in BTBR T+ltpr3tf\/J mice as an idiopathic model of autism"],"prefix":"10.1016","volume":"237","author":[{"given":"Hiroyuki","family":"Arakawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2021.113432_bib0001","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1007\/s10803-011-1284-z","article-title":"Evidence-based behavioral interventions for repetitive behaviors in autism","volume":"42","author":"Boyd","year":"2012","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.physbeh.2021.113432_bib0002","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.gene.2012.01.020","article-title":"Integrative gene network analysis provides novel regulatory relationships, genetic contributions and susceptible targets in autism spectrum disorders","volume":"496","author":"Lee","year":"2012","journal-title":"Gene"},{"key":"10.1016\/j.physbeh.2021.113432_bib0003","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2020.592408","article-title":"From multisensory assessment to functional interpretation of social behavioral phenotype in transgenic mouse models for autism spectrum disorders","volume":"11","author":"Arakawa","year":"2020","journal-title":"Front. Psychiatry"},{"issue":"4","key":"10.1016\/j.physbeh.2021.113432_bib0004","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00401-017-1736-4","article-title":"Autism spectrum disorder: neuropathology and animal models","volume":"134","author":"Varghese","year":"2017","journal-title":"Acts Neuropathol"},{"issue":"1","key":"10.1016\/j.physbeh.2021.113432_bib0005","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.neubiorev.2011.06.008","article-title":"BTBR T+tf\/J mice: autism-relevant behaviors and reduced fractone-associated heparan sulfate","volume":"36","author":"Blanchard","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.physbeh.2021.113432_bib0006","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1601-183X.2007.00330.x","article-title":"Autism-like behavioral phenotypes in, BTBR T+tf\/J mice","volume":"7","author":"McFarlane","year":"2008","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.physbeh.2021.113432_bib0007","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bbr.2012.07.021","article-title":"The BTBR T+ tf\/J mouse model for autism spectrum disorders- in search of biomarkers","volume":"251","author":"Meyza","year":"2013","journal-title":"Behav. Brain Res."},{"issue":"5","key":"10.1016\/j.physbeh.2021.113432_bib0008","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/j.1601-183X.2004.00071.x","article-title":"Automated apparatus for quantitation of social approach behaviors in mice","volume":"3","author":"Nadler","year":"2004","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.physbeh.2021.113432_bib0009","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1038\/npp.2009.201","article-title":"Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP","volume":"35","author":"Silverman","year":"2010","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"10.1016\/j.physbeh.2021.113432_bib0010","doi-asserted-by":"crossref","first-page":"e61829","DOI":"10.1371\/journal.pone.0061829","article-title":"Quantitative trait loci for interhemispheric commissure development and social behaviors in the BTBR T+tf\/J mouse model of autism","volume":"8","author":"Jones-Davis","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.physbeh.2021.113432_bib0011","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1111\/j.1460-9568.2009.06714.x","article-title":"Postnatal lesion evidence against a primary role for the corpus callosum in mouse sociability","volume":"29","author":"Yang","year":"2009","journal-title":"Eur. J. Neurosci."},{"issue":"1","key":"10.1016\/j.physbeh.2021.113432_bib0012","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bbr.2006.09.007","article-title":"Assessing autism-like behavior in mice: variations in social interactions among inbred strains","volume":"176","author":"Bolivar","year":"2007","journal-title":"Behav. Brain Res."},{"issue":"2","key":"10.1016\/j.physbeh.2021.113432_bib0013","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.bbr.2010.10.033","article-title":"A novel social proximity test suggests patterns of social avoidance and gaze aversion-like behavior in BTBR T+tf\/J mice","volume":"217","author":"Defensor","year":"2011","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.physbeh.2021.113432_bib0014","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.bbr.2006.07.030","article-title":"Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains","volume":"176","author":"Moy","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2021.113432_bib0015","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.neuroscience.2020.02.002","article-title":"Somatosensorimotor and odor modification, along with serotonergic Processes underlying the social deficits in BTBR T+ Itpr3 tf\/J and BALB\/cJ mouse models of autism","volume":"445","author":"Arakawa","year":"2020","journal-title":"Neurosci"},{"issue":"5","key":"10.1016\/j.physbeh.2021.113432_bib0016","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/brb3.273","article-title":"Validation of operant social motivation paradigms using BTBR T+tf\/J and C57BL\/6 J inbred mouse strains","volume":"4","author":"Martin","year":"2014","journal-title":"Brain Behav"},{"key":"10.1016\/j.physbeh.2021.113432_bib0017","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1111\/j.1601-183X.2010.00659.x","article-title":"Motor and cognitive stereotypies in the BTBR T+tf\/J mouse model of autism","volume":"10","author":"Pearson","year":"2011","journal-title":"Genes Brain Behav"},{"key":"10.1016\/j.physbeh.2021.113432_bib0018","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.bbr.2010.06.025","article-title":"Expression of social behaviors of C57BL\/6 J versus BTBR inbred mouse strains in the visible burrow system","volume":"214","author":"Pobbe","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2021.113432_bib0019","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.bbr.2011.10.032","article-title":"Differences in BTBR T+ tf\/J and C57BL\/6 J mice on probabilistic reversal learning and stereotyped behaviors","volume":"227","author":"Amodeo","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2021.113432_bib0020","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.physbeh.2013.03.006","article-title":"Low home cage social behaviors in BTBR T+ tf\/J mice during juvenile development","volume":"114","author":"Babineau","year":"2013","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2021.113432_bib0021","doi-asserted-by":"crossref","first-page":"e62189","DOI":"10.1371\/journal.pone.0062189","article-title":"The BTBR mouse model of autism spectrum disorders has learning and attentional impairments and alterations in acetylcholine and kynurenic acid in prefrontal cortex","volume":"8","author":"McTighe","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.physbeh.2021.113432_bib0022","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/aur.1298","article-title":"Effects of environmental enrichment on repetitive behaviors in the BTBR T+ tf\/J mouse model of autism","volume":"6","author":"Reynolds","year":"2013","journal-title":"Autism Res"},{"key":"10.1016\/j.physbeh.2021.113432_bib0023","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3389\/fnsyn.2014.00017","article-title":"Oxotremorine treatment reduces repetitive behaviors in BTBR T+ tf\/J mice","volume":"6","author":"Amodeo","year":"2014","journal-title":"Front Synaptic Neurosci"},{"issue":"1","key":"10.1016\/j.physbeh.2021.113432_bib0024","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.bbr.2012.04.040","article-title":"Absence of social conditioned place preference in BTBR T=ft\/J mice: relevance for social motivation testing in rodent models of autism","volume":"233","author":"Pearson","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2021.113432_bib0025","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.ijdevneu.2007.09.008","article-title":"Social deficits in BTBR T+tf\/J mice are unchanged by cross-fostering with C57BL\/6 J mothers","volume":"25","author":"Yang","year":"2007","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.physbeh.2021.113432_bib0026","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0166-4328(02)00111-0","article-title":"Evidence for a relationship between cage stereotypies and behavioural disinhibition in laboratory rodents","volume":"136","author":"Garner","year":"2002","journal-title":"Behav. Brain Res."},{"issue":"3","key":"10.1016\/j.physbeh.2021.113432_bib0027","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1152\/physrev.1992.72.3.825","article-title":"Ethology and neurobiology of grooming behaivor","volume":"72","author":"Spruijt","year":"1992","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.physbeh.2021.113432_bib0028","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ejphar.2004.11.054","article-title":"Mouse grooming microstructure is a reliable anxiety marker bidirectionally sensitive to GABAergic drugs","volume":"508","author":"Kalueff","year":"2005","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.physbeh.2021.113432_bib0029","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/j.1749-6632.1988.tb38613.x","article-title":"The effects of anxiolytics and other agents on rat grooming behavior","volume":"525","author":"Moody","year":"1988","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.physbeh.2021.113432_bib0030","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0197-4580(87)90011-X","article-title":"Behavioral changes in ACTH-(1-24)-induced excessive grooming in aging rats","volume":"8","author":"Spruijt","year":"1987","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.physbeh.2021.113432_bib0031","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1002\/aur.180","article-title":"Absence of preference for social novelty and increased grooming in integrin \u00df3 knockout mice: initial studies and future directions","volume":"4","author":"Carter","year":"2011","journal-title":"Autism Res"},{"issue":"1","key":"10.1016\/j.physbeh.2021.113432_bib0032","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/nrn.2015.8","article-title":"Neurobiology of rodent self-grooming and its value for translational neuroscience","volume":"17","author":"Kalueff","year":"2016","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.physbeh.2021.113432_bib0033","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature06104","article-title":"Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice","volume":"448","author":"Welch","year":"2007","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.physbeh.2021.113432_bib0034","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1038\/nprot.2007.367","article-title":"Analyzing grooming microstructure in neurobehavioral experiments","volume":"2","author":"Kalueff","year":"2007","journal-title":"Nat Protocols"},{"key":"10.1016\/j.physbeh.2021.113432_bib0035","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.pbb.2010.09.012","article-title":"Fluoxetine but not risperidone increases sociability in the BTBR mouse model of autism","volume":"97","author":"Chadman","year":"2011","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2021.113432_bib0036","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/j.1471-4159.2010.07104.x","article-title":"Density and function of central serotonin (5-HT) transporters, 5-HT1A and 5-HT2A receptors and effects of their targeting on, BTBR T+tf\/J mouse social behavior","volume":"116","author":"Gould","year":"2011","journal-title":"J. Neurochem."},{"key":"10.1016\/j.physbeh.2021.113432_bib0037","doi-asserted-by":"crossref","first-page":"00113","DOI":"10.3389\/fnbeh.2020.00113","article-title":"The stage of the estrus cycle is critical for interpretation of female mouse social interaction behavior","author":"Chari","year":"2020","journal-title":"Front. Behav. Neurosci. 2020"},{"key":"10.1016\/j.physbeh.2021.113432_bib0038","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.cell.2014.09.020","article-title":"Oxytocin modulates female sociosexual behavior through a specific class of prefrontal cortical interneurons","volume":"159","author":"Nakajima","year":"2014","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.physbeh.2021.113432_bib0039","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/00008877-200008000-00006","article-title":"Housing conditions and the anxiolytic efficacy of buspirone: the relationship between main and side effects","volume":"11","author":"Haller","year":"2000","journal-title":"Behav. Pharmacol."},{"issue":"1","key":"10.1016\/j.physbeh.2021.113432_bib0040","first-page":"175","article-title":"The effects of buspirone on the behaviour of control and stressed mice","volume":"49","author":"Pokk","year":"1998","journal-title":"J. Physiol. Pharmacol."},{"issue":"2","key":"10.1016\/j.physbeh.2021.113432_bib0041","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1037\/bne0000191","article-title":"Involvement of serotonin and oxytocin in neural mechanism regulating amicable social signal in male mice: implication for impaired recognition of amicable cues in BALB\/c strain","volume":"131","author":"Arakawa","year":"2017","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.physbeh.2021.113432_bib0042","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1352\/0895-8017(2007)112[450:POPNII]2.0.CO;2","article-title":"Predictors of perceived negative impact in mothers of children with autism spectrum disorder","volume":"112","author":"Bishop","year":"2007","journal-title":"Am. J. Ment. Retard."},{"key":"10.1016\/j.physbeh.2021.113432_bib0043","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1037\/a0031721","article-title":"Reduced behavioral flexibility in autism spectrum disorders","volume":"27","author":"D\u2019Cruz","year":"2013","journal-title":"Neuropsychology"},{"key":"10.1016\/j.physbeh.2021.113432_bib0044","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/j.1469-7610.2005.01537.x","article-title":"Investigating the structure of the restricted, repetitive behaviours and interests domain of autism","volume":"47","author":"Szatmari","year":"2006","journal-title":"J. Child Psychol. Psychiatry"},{"issue":"2","key":"10.1016\/j.physbeh.2021.113432_bib0045","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4103\/0019-5545.31597","article-title":"Disability associated with mental disorders","volume":"48","author":"Chaudhury","year":"2006","journal-title":"Indian J Psychiatry"},{"issue":"9","key":"10.1016\/j.physbeh.2021.113432_bib0046","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1017\/S1092852900023567","article-title":"The mouse who couldn't stop washing: pathologic grooming in animals and humans","volume":"14","author":"Feusner","year":"2009","journal-title":"CNS Spectr"},{"key":"10.1016\/j.physbeh.2021.113432_bib0047","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1749-6632.1988.tb38591.x","article-title":"The development of grooming and its expression in adult animals","volume":"525","author":"Sachs","year":"1988","journal-title":"Ann NY Acad Sci"},{"issue":"9","key":"10.1016\/j.physbeh.2021.113432_bib0048","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1016\/j.neubiorev.2011.03.007","article-title":"From models to mechanisms: odorant communication as a key determinant of social behavior in rodents during illness-associated states","volume":"35","author":"Arakawa","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"2","key":"10.1016\/j.physbeh.2021.113432_bib0049","first-page":"24","article-title":"The role of pheromonal responses in rodent behavior: future directions for the development of laboratory protocols","volume":"52","author":"Bind","year":"2013","journal-title":"J. Am. Assoc. Lab. Anim. Sci."},{"key":"10.1016\/j.physbeh.2021.113432_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neures.2018.02.001","article-title":"Ethological and multi-behavioral analysis of learning and memory performance in laboratory rodent models","volume":"135","author":"Arakawa","year":"2018","journal-title":"Neurosci Res"},{"key":"10.1016\/j.physbeh.2021.113432_bib0051","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1002\/aur.2158","article-title":"Inbred strain preference in the BTBR T+ ltpr3tf\/J mouse model of autism spectrum disorder: does the stranger mouse matter in social approach?","volume":"12","author":"Ryan","year":"2019","journal-title":"Autism Res"},{"issue":"1","key":"10.1016\/j.physbeh.2021.113432_bib0052","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/s41398-019-0558-7","article-title":"Dtbd3 expression regulates compulsive-like and exploratory behaviors in mice","volume":"9","author":"Thompson","year":"2019","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.physbeh.2021.113432_bib0053","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002556","article-title":"Networks of neuronal genes affected by common and rare variants in autism spectrum disorders","volume":"8","author":"Ben-David","year":"2012","journal-title":"PLoS Genet"},{"issue":"1","key":"10.1016\/j.physbeh.2021.113432_bib0054","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/aur.1665","article-title":"Serotonin neuron abnormalities in the BTBR mouse model of autism","volume":"10","author":"Guo","year":"2017","journal-title":"Autism Res"},{"issue":"4","key":"10.1016\/j.physbeh.2021.113432_bib0055","first-page":"22","article-title":"Monoamine depletion studies: implications for antidepressant discontinuation syndrome","volume":"67","author":"Delgado","year":"2006","journal-title":"J. Clin. Psychiatry"},{"issue":"5\u20136","key":"10.1016\/j.physbeh.2021.113432_bib0056","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/j.neuropharm.2011.12.009","article-title":"An effective dietary method for chronic tryptophan depletion in two mouse strains illuminates a role for 5-HT in nesting behaviour","volume":"62","author":"Browne","year":"2012","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.physbeh.2021.113432_bib0057","first-page":"46","article-title":"The biology of tryptophan depletion and mood disorders","volume":"47","author":"Toker","year":"2010","journal-title":"Isr. J. Psychiatry Relat Sci."},{"key":"10.1016\/j.physbeh.2021.113432_bib0058","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuropharm.2014.10.024","article-title":"Acute dietary tryptophan manipulation differentially alters social behavior, brain serotonin and plasma corticosterone in three inbred mouse strain","volume":"90","author":"Zhang","year":"2015","journal-title":"Neuropharmacology"},{"issue":"6","key":"10.1016\/j.physbeh.2021.113432_bib0059","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1179\/147683010X12611460764688","article-title":"Nutritional up-regulation of serotonin paradoxically induces compulsive behavior","volume":"13","author":"Dufour","year":"2010","journal-title":"Nutritional Neurosci"},{"issue":"5","key":"10.1016\/j.physbeh.2021.113432_bib0060","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.biopsych.2008.09.026","article-title":"Chronic reductions in serotonin transporter function prevent 5-HT1B-induced behavioral effects in mice","volume":"65","author":"Shanahan","year":"2009","journal-title":"Biol. Psychiatry"},{"issue":"11","key":"10.1016\/j.physbeh.2021.113432_bib0061","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.biopsych.2011.07.032","article-title":"Essential role for orbitofrontal serotonin 1B receptors in obsessive-compulsive disorder-like behavior and serotonin reuptake inhibitor response in mice","volume":"70","author":"Shanahan","year":"2011","journal-title":"Biol Psychiatry"},{"issue":"3","key":"10.1016\/j.physbeh.2021.113432_bib0062","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s00213-013-2985-0","article-title":"Effects of chronic fluoxetine treatment on serotonin 1B receptor-induced deficits in delayed alternation","volume":"227","author":"Woehrle","year":"2013","journal-title":"Psychopharmacology (Berl)"},{"issue":"8","key":"10.1016\/j.physbeh.2021.113432_bib0063","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/S0028-3908(97)00094-4","article-title":"Comparative behavioural profiles of buspirone and its metabolite 1-(2-pyrimidinyl)-piperazine(1-PP) in the murine elevated plus-maze","volume":"36","author":"Cao","year":"1997","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.physbeh.2021.113432_bib0064","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1016\/S0091-3057(96)00472-8","article-title":"An ethopharmacological analysis of selective activation of 5-HT1A receptors: the mouse 5-HT1A syndrome","volume":"57","author":"Blanchard","year":"1997","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"7","key":"10.1016\/j.physbeh.2021.113432_bib0065","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1177\/0269881120913150","article-title":"Divergent pathways mediate 5-HT1A receptor agonist effects on close social interaction, grooming and aggressive behaviour in mice: exploring the involvement of the oxytocin and vasopressin systems","volume":"34","author":"Tan","year":"2020","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.physbeh.2021.113432_bib0066","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00213-015-4086-8","article-title":"Clinically effective OCD treatment prevents 5-HT1B receptor-induced repetitive behavior and striatal activation","volume":"233","author":"Ho","year":"2016","journal-title":"Psychopharmacology (Berl.)"},{"issue":"8","key":"10.1016\/j.physbeh.2021.113432_bib0067","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1093\/ijnp\/pyaa047","article-title":"Tandospirone, a partial 5-HT1A receptor agonist, administered systemically or into anterior cingulate attenuates repetitive behaviors in Shank3B mice","volume":"23","author":"Dunn","year":"2020","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"6","key":"10.1016\/j.physbeh.2021.113432_bib0068","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/S1734-1140(12)70927-1","article-title":"Drug therapy in autism: a present and future perspective","volume":"64","author":"Kumar","year":"2012","journal-title":"Pharmacol. Rep."},{"issue":"3","key":"10.1016\/j.physbeh.2021.113432_bib0069","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/j.1744-6155.2009.00196.x","article-title":"Review of the evidence for treatment of children with autism with selective serotonin reuptake inhibitors","volume":"14","author":"West","year":"2009","journal-title":"J. Spec. Pediatr. Nurs."},{"issue":"2","key":"10.1016\/j.physbeh.2021.113432_bib0070","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/HRP.0000000000000030","article-title":"Psychopharmacological interventions in autism spectrum disorder","volume":"22","author":"Politte","year":"2014","journal-title":"Harv. Rev. Psychiatry"},{"key":"10.1016\/j.physbeh.2021.113432_bib0071","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.brainresbull.2019.04.026","article-title":"Citalopram attenuates social behavior deficits in the BTBR T+Itpr3tf\/J mouse model of autism","volume":"150","author":"Cai","year":"2019","journal-title":"Brain Res Bull"},{"issue":"2","key":"10.1016\/j.physbeh.2021.113432_bib0072","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/S0022-3565(25)21219-8","article-title":"Chronic fluoxetine induces a gradual desensitization of 5-HT1A receptors: reductions in hypothalamic and midbrain Gi and G(o) proteins and in neuroendocrine responses to a 5-HT1A agonist","volume":"279","author":"Li","year":"1996","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.physbeh.2021.113432_bib0073","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-1-60761-303-9_2","article-title":"Analysis of grooming behavior and its utility in studying animal stress, anxiety, and depression","volume":"42","author":"Smolinsky","year":"2009","journal-title":"Neuromethods"},{"key":"10.1016\/j.physbeh.2021.113432_bib0074","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1111\/gbb.12343","article-title":"5HT2A receptor blockade in dorsomedial striatum reduces repetitive behaviors in BTBR mice","volume":"16","author":"Amodeo","year":"2017","journal-title":"Genes Brain Behav"},{"issue":"1","key":"10.1016\/j.physbeh.2021.113432_bib0075","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bbr.2008.03.020","article-title":"Molecular biology of 5-HT receptors","volume":"195","author":"Hannon","year":"2008","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2021.113432_bib0076","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2020.173076","article-title":"Serotonin 6 receptor blockade reduces repetitive behavior in the BTBR mouse model of autism spectrum disorder","volume":"200","author":"Amodeo","year":"2021","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2021.113432_bib0077","first-page":"eabc1173","article-title":"Cortical and striatal circuits together encode transitions in natural behavior","volume":"6","author":"Sj\u00f6bom","year":"2020","journal-title":"Aci. Adv."},{"key":"10.1016\/j.physbeh.2021.113432_bib0078","doi-asserted-by":"crossref","DOI":"10.1016\/j.crneur.2021.100011","article-title":"Dynamic regulation of oxytocin neuronal circuits in the sequential processes of prosocial behavior in rodent models","author":"Arakawa","year":"2021","journal-title":"Cur. Res. Neurobiol."},{"key":"10.1016\/j.physbeh.2021.113432_bib0079","doi-asserted-by":"crossref","DOI":"10.1038\/s41593-020-0674-y","article-title":"Social touch promotes interfemale communication via activation of parvocellular oxytocin neurons","author":"Tang","year":"2020","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.physbeh.2021.113432_bib0080","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.neuron.2017.06.003","article-title":"Biased oxytocinergic modulation of midbrain dopamine systems","volume":"95","author":"Xiao","year":"2017","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.physbeh.2021.113432_bib0081","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0006-8993(99)01419-5","article-title":"Oxotremorine-induced modifications of the behavioral and neuroendocrine responses to formalin pain in male rats","volume":"830","author":"Capone","year":"1999","journal-title":"Brain Res"},{"key":"10.1016\/j.physbeh.2021.113432_bib0082","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1097\/WNF.0b013e3181d6f7ad","article-title":"Cholinergic abnormalities in autism: is there a rationale for selective nicotinic agonist interventions?","volume":"33","author":"Deutsch","year":"2010","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.physbeh.2021.113432_bib0083","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1176\/appi.ajp.158.7.1058","article-title":"Cholinergic activity in autism: abnormalities in the cerebral cortex and basal forebrain","volume":"158","author":"Perry","year":"2001","journal-title":"Am. J. Psychiatry"},{"issue":"1","key":"10.1016\/j.physbeh.2021.113432_bib0084","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1365-2222.2011.03791.x","article-title":"Basic mechanisms of itch","volume":"42","author":"Potenzieri","year":"2012","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.physbeh.2021.113432_bib0085","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/brain\/awq285","article-title":"Key role of striatal cholinergic interneurons in processes leading to arrest of motor stereotypies","volume":"134","author":"Aliane","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.physbeh.2021.113432_bib0087","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1023\/A:1005596502855","article-title":"Varieties of repetitive behavior in autism: comparisons to mental retardation","volume":"30","author":"Bodfish","year":"2000","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.physbeh.2021.113432_bib0088","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/sj.npp.1300627","article-title":"A placebo-controlled crossover trial of liquid fluoxetine on repet- itive behaviors in childhood and adolescent autism","volume":"30","author":"Hollander","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.physbeh.2021.113432_bib0089","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/npp.2013.274","article-title":"Acetylcholine elevation relieves cognitive rigidity and social deficiency in a mouse model of autism","volume":"39","author":"Karvat","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.physbeh.2021.113432_bib94","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1038\/s41398-019-0558-7","article-title":"Btbd3 expression regulates compulsive-like and exploratory behaviors in mice","volume":"9","author":"Thompson","year":"2019","journal-title":"Transl. Psychiatry"}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938421001244?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938421001244?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:16:47Z","timestamp":1758478607000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938421001244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":89,"alternative-id":["S0031938421001244"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2021.113432","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Implication of the social function of excessive self-grooming behavior in BTBR T+ltpr3tf\/J mice as an idiopathic model of autism","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2021.113432","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113432"}}