{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:40:57Z","timestamp":1786995657611,"version":"build-2736575974"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,3]],"date-time":"2021-05-03T00:00:00Z","timestamp":1620000000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008349","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.physbeh.2021.113435","type":"journal-article","created":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T03:05:44Z","timestamp":1619665544000},"page":"113435","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Hypoglycemia attenuates acute amylin-induced reduction of food intake in male rats"],"prefix":"10.1016","volume":"237","author":[{"given":"Miriam","family":"Honegger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Lutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina N.","family":"Boyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2021.113435_bib0001","series-title":"Advances in Pharmacology","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S1054-3589(05)52004-0","article-title":"Amylin and the integrated control of nutrient influx","author":"Young","year":"2005"},{"issue":"3","key":"10.1016\/j.physbeh.2021.113435_bib0002","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1124\/pr.115.010629","article-title":"Amylin: pharmacology, physiology, and clinical potential","volume":"67","author":"Hay","year":"2015","journal-title":"Pharmacol Rev"},{"issue":"1","key":"10.1016\/j.physbeh.2021.113435_bib0003","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2337\/diab.47.1.93","article-title":"Hypoglycemia overrides amylin-mediated regulation of gastric emptying in rats","volume":"47","author":"Gedulin","year":"1998","journal-title":"Diabetes"},{"issue":"3","key":"10.1016\/j.physbeh.2021.113435_bib0004","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.regpep.2006.06.004","article-title":"Role of endogenous amylin in glucagon secretion and gastric emptying in rats demonstrated with the selective antagonist, AC187","volume":"137","author":"Gedulin","year":"2006","journal-title":"Regul. Pept."},{"issue":"1","key":"10.1016\/j.physbeh.2021.113435_bib0005","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0026-0495(97)90170-0","article-title":"Dose-response for glucagonostatic effect of amylin in rats","volume":"46","author":"Gedulin","year":"1997","journal-title":"Metabolism"},{"issue":"3","key":"10.1016\/j.physbeh.2021.113435_bib0006","doi-asserted-by":"crossref","first-page":"R340","DOI":"10.1152\/ajpregu.00380.2011","article-title":"Involvement of the extracellular signal-regulated kinase 1\/2 signaling pathway in amylin's eating inhibitory effect","volume":"302","author":"Potes","year":"2012","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"7","key":"10.1016\/j.physbeh.2021.113435_bib0007","doi-asserted-by":"crossref","first-page":"3055","DOI":"10.1111\/ejn.12672","article-title":"The role of the area postrema in the anorectic effects of amylin and salmon calcitonin: behavioral and neuronal phenotyping","volume":"40","author":"Braegger","year":"2014","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.physbeh.2021.113435_bib0008","first-page":"26","article-title":"Area postrem (AP)-lesions block the regulation of gastric emptying by amylin","volume":"10","author":"Edwards","year":"1998","journal-title":"Neurogastroenterol Motil"},{"issue":"2","key":"10.1016\/j.physbeh.2021.113435_bib0009","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0304-3940(02)00482-2","article-title":"Amylin and glucose co-activate area postrema neurons of the rat","volume":"328","author":"Riediger","year":"2002","journal-title":"Neurosci Lett"},{"issue":"4","key":"10.1016\/j.physbeh.2021.113435_bib0010","doi-asserted-by":"crossref","first-page":"R856","DOI":"10.1152\/ajpregu.00179.2018","article-title":"Rodent models of leptin receptor deficiency are less sensitive to amylin","volume":"315","author":"Duffy","year":"2018","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"8","key":"10.1016\/j.physbeh.2021.113435_bib0011","doi-asserted-by":"crossref","first-page":"2866","DOI":"10.2337\/db13-1600","article-title":"Activation of hindbrain neurons is mediated by portal-mesenteric vein glucosensors during slow-onset hypoglycemia","volume":"63","author":"Bohland","year":"2014","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.physbeh.2021.113435_bib0012","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/dmrr.419","article-title":"Pramlintide reduces postprandial glucose excursions when added to insulin lispro in subjects with type 2 diabetes: a dose-timing study","volume":"20","author":"Maggs","year":"2004","journal-title":"Diabetes Metab Res Rev"},{"issue":"14","key":"10.1016\/j.physbeh.2021.113435_bib0013","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.2174\/1381612013397357","article-title":"Amylin replacement with pramlintide as an adjunct to insulin therapy in type 1 and type 2 diabetes mellitus: a physiological approach toward improved metabolic control","volume":"7","author":"Weyer","year":"2001","journal-title":"Curr Pharm Des"},{"issue":"6","key":"10.1016\/j.physbeh.2021.113435_bib0014","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/0031-9384(95)02067-5","article-title":"Amylin decreases meal size in rats","volume":"58","author":"Lutz","year":"1995","journal-title":"Physiol Behav"},{"issue":"6 Pt 2","key":"10.1016\/j.physbeh.2021.113435_bib0015","first-page":"R1654","article-title":"Chronic infusion of islet amyloid polypeptide causes anorexia in rats","volume":"271","author":"Arnelo","year":"1996","journal-title":"Am J Physiol"},{"issue":"6","key":"10.1016\/j.physbeh.2021.113435_bib0016","doi-asserted-by":"crossref","first-page":"E494","DOI":"10.1152\/ajpendo.00199.2014","article-title":"Effects of delayed gastric emptying on postprandial glucose kinetics, insulin sensitivity, and beta-cell function","volume":"307","author":"Hinshaw","year":"2014","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"5","key":"10.1016\/j.physbeh.2021.113435_bib0017","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1210\/jc.2015-3952","article-title":"Effect of pramlintide on postprandial glucose fluxes in type 1 diabetes","volume":"101","author":"Hinshaw","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"10.1016\/j.physbeh.2021.113435_bib0018","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.clinthera.2005.10.009","article-title":"Pramlintide in the treatment of type 1 and type 2 diabetes mellitus","volume":"27","author":"Ryan","year":"2005","journal-title":"Clin Ther"},{"issue":"Suppl 2","key":"10.1016\/j.physbeh.2021.113435_bib0019","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1002\/(SICI)1096-9136(199706)14:2+<S14::AID-DIA398>3.0.CO;2-Q","article-title":"Role of amylin in nutrient intake - animal studies","volume":"14","author":"Young","year":"1997","journal-title":"Diabet Med"},{"key":"10.1016\/j.physbeh.2021.113435_bib0020","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S1054-3589(05)52008-8","article-title":"Inhibition of glucagon secretion","volume":"52","author":"Young","year":"2005","journal-title":"Adv Pharmacol"},{"issue":"5","key":"10.1016\/j.physbeh.2021.113435_bib0021","first-page":"735S","article-title":"Glucose-responsive neurons in the brainstem","volume":"3","author":"Adachi","year":"1995","journal-title":"Obes Res"},{"key":"10.1016\/j.physbeh.2021.113435_bib0022","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.brainres.2010.03.114","article-title":"Identification of central projections from amylin-activated neurons to the lateral hypothalamus","volume":"1334","author":"Potes","year":"2010","journal-title":"Brain Res"},{"issue":"11","key":"10.1016\/j.physbeh.2021.113435_bib0023","doi-asserted-by":"crossref","first-page":"15448","DOI":"10.1096\/fj.202001456RRR","article-title":"Noradrenaline signaling in the LPBN mediates amylin's and salmon calcitonin's hypophagic effect in male rats","volume":"34","author":"Boccia","year":"2020","journal-title":"FASEB J"},{"issue":"6","key":"10.1016\/j.physbeh.2021.113435_bib0024","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.cmet.2014.11.006","article-title":"A parabrachial-hypothalamic cholecystokinin neurocircuit controls counterregulatory responses to hypoglycemia","volume":"20","author":"Garfield","year":"2014","journal-title":"Cell Metab"},{"issue":"3","key":"10.1016\/j.physbeh.2021.113435_bib0025","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.neuron.2018.04.001","article-title":"Different Neuronal Activity Patterns Induce Different Gene Expression Programs","volume":"98","author":"Tyssowski","year":"2018","journal-title":"Neuron,"},{"issue":"1","key":"10.1016\/j.physbeh.2021.113435_bib0026","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1463-1326.2011.01454.x","article-title":"Physiologic action of glucagon on liver glucose metabolism","volume":"13","author":"Ramnanan","year":"2011","journal-title":"Diabetes Obes Metab"},{"issue":"8","key":"10.1016\/j.physbeh.2021.113435_bib0027","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.2337\/diabetes.50.8.1807","article-title":"Effect of physiological hyperinsulinemia on gluconeogenesis in nondiabetic subjects and in type 2 diabetic patients","volume":"50","author":"Gastaldelli","year":"2001","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/j.physbeh.2021.113435_bib0028","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.metabol.2004.04.010","article-title":"Effect of pramlintide on symptom, catecholamine, and glucagon responses to hypoglycemia in healthy subjects","volume":"53","author":"Heise","year":"2004","journal-title":"Metabolism"}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003193842100127X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003193842100127X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:17:37Z","timestamp":1758478657000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S003193842100127X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":28,"alternative-id":["S003193842100127X"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2021.113435","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hypoglycemia attenuates acute amylin-induced reduction of food intake in male rats","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2021.113435","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113435"}}