{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T08:01:01Z","timestamp":1770537661167,"version":"3.49.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"am","delay-in-days":297,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DEB-1655362"],"award-info":[{"award-number":["DEB-1655362"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["IOS-1121273"],"award-info":[{"award-number":["IOS-1121273"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK114978"],"award-info":[{"award-number":["DK114978"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK119498"],"award-info":[{"award-number":["DK119498"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005188","name":"Tobacco-Related Disease Research Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014576","name":"Office of the President, University of California","doi-asserted-by":"publisher","award":["T29KT0232"],"award-info":[{"award-number":["T29KT0232"]}],"id":[{"id":"10.13039\/100014576","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology & Behavior"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.physbeh.2021.113675","type":"journal-article","created":{"date-parts":[[2021,12,18]],"date-time":"2021-12-18T01:53:21Z","timestamp":1639792401000},"page":"113675","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Effects of Selective Breeding, Voluntary Exercise, and Sex on Endocannabinoid Levels in the Mouse Small-Intestinal Epithelium"],"prefix":"10.1016","volume":"245","author":[{"given":"Margaret P.","family":"Schmill","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zoe","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donovan A.","family":"Argueta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas V.","family":"DiPatrizio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Theodore","family":"Garland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2021.113675_bib0001","doi-asserted-by":"crossref","unstructured":"Z. Thompson, D. Argueta, T. Garland Jr., N. DiPatrizio, Circulating levels of endocannabinoids respond acutely to voluntary exercise, are altered in mice selectively bred for high voluntary wheel running, and differ between the sexes, Physiology & Behavior. 170 (2017) 141\u2013150. 10.1016\/j.physbeh.2016.11.041.","DOI":"10.1016\/j.physbeh.2016.11.041"},{"key":"10.1016\/j.physbeh.2021.113675_bib0002","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1096\/fj.13-227587","article-title":"Endocannabinoid signaling in the gut mediates preference for dietary unsaturated fats","volume":"27","author":"DiPatrizio","year":"2013","journal-title":"The FASEB Journal"},{"key":"10.1016\/j.physbeh.2021.113675_bib0003","doi-asserted-by":"crossref","first-page":"R805","DOI":"10.1152\/ajpregu.00239.2015","article-title":"Fasting stimulates 2-AG biosynthesis in the small intestine: Role of cholinergic pathways","volume":"309","author":"DiPatrizio","year":"2015","journal-title":"American Journal of Physiology-Regulatory, Integrative and Comparative Physiology"},{"key":"10.1016\/j.physbeh.2021.113675_bib0004","doi-asserted-by":"crossref","unstructured":"N.V. DiPatrizio, Endocannabinoids in the Gut, Cannabis and Cannabinoid Research. 1 (2016) 67\u201377. 10.1089\/can.2016.0001.","DOI":"10.1089\/can.2016.0001"},{"key":"10.1016\/j.physbeh.2021.113675_bib0005","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.3390\/nu13041214","article-title":"Endocannabinoids and the gut-brain control of food intake and obesity","volume":"13","author":"DiPatrizio","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.physbeh.2021.113675_bib0006","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.physbeh.2016.12.044","article-title":"Peripheral endocannabinoid signaling controls hyperphagia in western diet-induced obesity","volume":"171","author":"Argueta","year":"2017","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.physbeh.2021.113675_bib0007","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.3390\/nu12092874","article-title":"Cannabinoid CB1 receptors in the intestinal epithelium are required for acute Western-diet preferences in mice","volume":"12","author":"Avalos","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.physbeh.2021.113675_bib0008","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.2337\/diabetes.54.10.2838","article-title":"Activation of the peripheral endocannabinoid system in human obesity","volume":"54","author":"Engeli","year":"2005","journal-title":"Diabetes"},{"key":"10.1016\/j.physbeh.2021.113675_bib0009","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1038\/sj.ijo.0803539","article-title":"Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men","volume":"31","author":"C\u00f4t\u00e9","year":"2007","journal-title":"International Journal of Obesity"},{"key":"10.1016\/j.physbeh.2021.113675_bib0010","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1476-5381.2009.00183.x","article-title":"Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re-feeding","volume":"158","author":"Izzo","year":"2009","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.physbeh.2021.113675_bib0011","doi-asserted-by":"crossref","first-page":"e42399","DOI":"10.1371\/journal.pone.0042399","article-title":"Endocannabinoids measurement in human saliva as potential biomarker of obesity","volume":"7","author":"Matias","year":"2012","journal-title":"PLOS ONE"},{"key":"10.1016\/j.physbeh.2021.113675_bib0012","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0205021","article-title":"Impact of maternal western diet-induced obesity on offspring mortality and peripheral endocannabinoid system in mice","volume":"13","author":"Perez","year":"2018","journal-title":"PLOS ONE"},{"key":"10.1016\/j.physbeh.2021.113675_bib0013","doi-asserted-by":"crossref","unstructured":"R.W. Alberca, L. de M. Oliveira, A.C.C.C. Branco, N.Z. Pereira, M.N. Sato, Obesity as a risk factor for COVID-19: An overview, Critical Reviews in Food Science and Nutrition. (2020) 1\u201315. 10.1080\/10408398.2020.1775546.","DOI":"10.1080\/10408398.2020.1775546"},{"key":"10.1016\/j.physbeh.2021.113675_bib0014","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1002\/oby.22818","article-title":"Obesity and its implications for Covid-19 mortality","volume":"28","author":"Dietz","year":"2020","journal-title":"Obesity"},{"key":"10.1016\/j.physbeh.2021.113675_bib0015","doi-asserted-by":"crossref","first-page":"12904","DOI":"10.1073\/pnas.1104675108","article-title":"Endocannabinoid signal in the gut controls dietary fat intake","volume":"108","author":"DiPatrizio","year":"2011","journal-title":"PNAS"},{"key":"10.1016\/j.physbeh.2021.113675_bib0016","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2019.00704","article-title":"Cannabinoid CB1 receptors inhibit gut-brain satiation signaling in diet-induced obesity","volume":"10","author":"Argueta","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.physbeh.2021.113675_bib0017","doi-asserted-by":"crossref","unstructured":"T. Garland Jr., H. Schutz, M.A. Chappell, B.K. Keeney, T.H. Meek, L.E. Copes, W. Acosta, C. Drenowatz, R.C. Maciel, G. van Dijk, C.M. Kotz, J.C. Eisenmann, The biological control of voluntary exercise, spontaneous physical activity and daily energy expenditure in relation to obesity: Human and rodent perspectives, Journal of Experimental Biology. 214 (2011) 206\u2013229. 10.1242\/jeb.048397.","DOI":"10.1242\/jeb.048397"},{"key":"10.1016\/j.physbeh.2021.113675_bib0018","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1136\/bjsm.2004.011718","article-title":"Endocannabinoids and exercise","volume":"38","author":"Dietrich","year":"2004","journal-title":"British Journal of Sports Medicine"},{"key":"10.1016\/j.physbeh.2021.113675_bib0019","doi-asserted-by":"crossref","unstructured":"B.K. Keeney, D.A. Raichlen, T.H. Meek, R.S. Wijeratne, K.M. Middleton, G.L. Gerdeman, T. Garland Jr., Differential response to a selective cannabinoid receptor antagonist (SR141716: rimonabant) in female mice from lines selectively bred for high voluntary wheel-running behaviour, Behavioural Pharmacology. 19 (2008) 812. 10.1097\/FBP.0b013e32831c3b6b.","DOI":"10.1097\/FBP.0b013e32831c3b6b"},{"key":"10.1016\/j.physbeh.2021.113675_bib0020","doi-asserted-by":"crossref","unstructured":"B.K. Keeney, T.H. Meek, K.M. Middleton, L.F. Holness, T. Garland Jr., Sex differences in cannabinoid receptor-1 (CB1) pharmacology in mice selectively bred for high voluntary wheel-running behavior, Pharmacology Biochemistry and Behavior. 101 (2012) 528\u2013537. 10.1016\/j.pbb.2012.02.017.","DOI":"10.1016\/j.pbb.2012.02.017"},{"key":"10.1016\/j.physbeh.2021.113675_bib0021","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1242\/jeb.063677","article-title":"Wired to run: Exercise-induced endocannabinoid signaling in humans and cursorial mammals with implications for the \u2018runner's high","volume":"215","author":"Raichlen","year":"2012","journal-title":"Journal of Experimental Biology"},{"key":"10.1016\/j.physbeh.2021.113675_bib0022","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/s00421-012-2495-5","article-title":"Exercise-induced endocannabinoid signaling is modulated by intensity","volume":"113","author":"Raichlen","year":"2013","journal-title":"Eur J Appl Physiol"},{"key":"10.1016\/j.physbeh.2021.113675_bib0023","doi-asserted-by":"crossref","first-page":"13105","DOI":"10.1073\/pnas.1514996112","article-title":"A runner's high depends on cannabinoid receptors in mice","volume":"112","author":"Fuss","year":"2015","journal-title":"PNAS"},{"key":"10.1016\/j.physbeh.2021.113675_bib0024","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1249\/TJX.0000000000000046","article-title":"Endocannabinoid and mood responses to exercise in adults with varying activity levels","volume":"2","author":"Brellenthin","year":"2017","journal-title":"Translational Journal of the American College of Sports Medicine"},{"key":"10.1016\/j.physbeh.2021.113675_bib0025","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/pm\/pnx058","article-title":"Endocannabinoid and opioid system interactions in exercise-induced hypoalgesia","volume":"19","author":"Crombie","year":"2018","journal-title":"Pain Med"},{"key":"10.1016\/j.physbeh.2021.113675_bib0026","doi-asserted-by":"crossref","unstructured":"J.G. Swallow, P.A. Carter, T. Garland Jr., Artificial selection for increased wheel-running behavior in house mice, Behavior Genetics. 28 (1998) 227\u2013237.","DOI":"10.1023\/A:1021479331779"},{"key":"10.1016\/j.physbeh.2021.113675_bib0027","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1074\/jbc.M607809200","article-title":"Food intake regulates oleoylethanolamide formation and degradation in the proximal small intestine","volume":"282","author":"Fu","year":"2007","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.physbeh.2021.113675_bib0028","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.tem.2013.03.001","article-title":"A fatty gut feeling","volume":"24","author":"Piomelli","year":"2013","journal-title":"Trends in Endocrinology & Metabolism"},{"key":"10.1016\/j.physbeh.2021.113675_bib0029","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.plipres.2017.04.001","article-title":"Oleic acid-derived oleoylethanolamide: A nutritional science perspective","volume":"67","author":"Bowen","year":"2017","journal-title":"Progress in Lipid Research"},{"key":"10.1016\/j.physbeh.2021.113675_bib0030","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.physbeh.2017.02.034","article-title":"Oleoylethanolamide: A fat ally in the fight against obesity","volume":"176","author":"Brown","year":"2017","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.physbeh.2021.113675_bib0031","doi-asserted-by":"crossref","first-page":"100","DOI":"10.3389\/fphys.2014.00100","article-title":"Docosahexaenoyl ethanolamide improves glucose uptake and alters endocannabinoid system gene expression in proliferating and differentiating C2C12 myoblasts","volume":"5","author":"Kim","year":"2014","journal-title":"Front. Physiol."},{"key":"10.1016\/j.physbeh.2021.113675_bib0032","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/bph.12747","article-title":"Inhibition of COX-2-mediated eicosanoid production plays a major role in the anti-inflammatory effects of the endocannabinoid N-docosahexaenoylethanolamine (DHEA) in macrophages","volume":"172","author":"Meijerink","year":"2015","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.physbeh.2021.113675_bib0033","doi-asserted-by":"crossref","first-page":"42584","DOI":"10.1038\/srep42584","article-title":"Transient cannabinoid receptor 2 blockade during immunization heightens intensity and breadth of antigen-specific antibody responses in young and aged mice","volume":"7","author":"Dotsey","year":"2017","journal-title":"Scientific Reports"},{"key":"10.1016\/j.physbeh.2021.113675_bib0034","first-page":"E141","article-title":"Plasma fatty acid ethanolamides are associated with postprandial triglycerides, ApoCIII, and ApoE in humans consuming a high-fructose corn syrup-sweetened beverage","volume":"5","author":"(Allister) Price","year":"2018","journal-title":"APSselect"},{"key":"10.1016\/j.physbeh.2021.113675_bib0035","unstructured":"T. Garland Jr., Selection experiments: An under-utilized tool in biomechanics and organismal biology, in: V.L. Bels, J.-P. Gasc, A. Casinos (Eds.), Vertebrate Biomechanics and Evolution, BIOS Scientific Publishers Ltd., Oxford, U.K., 2003: pp. 23\u201356."},{"key":"10.1016\/j.physbeh.2021.113675_bib0036","doi-asserted-by":"crossref","unstructured":"E.M. Kolb, S.A. Kelly, K.M. Middleton, L.S. Sermsakdi, M.A. Chappell, T. Garland Jr., Erythropoietin elevates VO2max but not voluntary wheel running in mice, J Exp Biol. 213 (2010) 510\u2013519. 10.1242\/jeb.029074.","DOI":"10.1242\/jeb.029074"},{"key":"10.1016\/j.physbeh.2021.113675_bib0037","doi-asserted-by":"crossref","unstructured":"V. Careau, M.E. Wolak, P.A. Carter, T. Garland Jr., Limits to behavioral evolution: The quantitative genetics of a complex trait under directional selection, Evolution. 67 (2013) 3102\u20133119. 10.1111\/evo.12200.","DOI":"10.1111\/evo.12200"},{"key":"10.1016\/j.physbeh.2021.113675_bib0038","doi-asserted-by":"crossref","unstructured":"P. Koteja, T. Garland Jr., J.K. Sax, J.G. Swallow, P.A. Carter, Behaviour of house mice artificially selected for high levels of voluntary wheel running, Animal Behaviour. 58 (1999) 1307\u20131318. 10.1006\/anbe.1999.1270.","DOI":"10.1006\/anbe.1999.1270"},{"key":"10.1016\/j.physbeh.2021.113675_bib0039","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.699712","article-title":"UPLC-MS\/MS method for analysis of endocannabinoid and related lipid metabolism in mouse mucosal tissue","volume":"12","author":"Wiley","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.physbeh.2021.113675_bib0040","doi-asserted-by":"crossref","unstructured":"J.S. Rhodes, P. Koteja, J.G. Swallow, P.A. Carter, T. Garland Jr., Body temperatures of house mice artificially selected for high voluntary wheel-running behavior: Repeatability and effect of genetic selection, Journal of Thermal Biology. 25 (2000) 391\u2013400. 10.1016\/S0306-4565(99)00112-6.","DOI":"10.1016\/S0306-4565(99)00112-6"},{"key":"10.1016\/j.physbeh.2021.113675_bib0041","doi-asserted-by":"crossref","unstructured":"T. Garland Jr., M.T. Morgan, J.G. Swallow, J.S. Rhodes, I. Girard, J.G. Belter, P.A. Carter, Evolution of a small-muscle polymorphism in lines of house mice selected for high activity levels, Evolution. 56 (2002) 1267\u20131275. 10.1111\/j.0014-3820.2002.tb01437.x.","DOI":"10.1111\/j.0014-3820.2002.tb01437.x"},{"key":"10.1016\/j.physbeh.2021.113675_bib0042","doi-asserted-by":"crossref","unstructured":"S.A. Kelly, T.A. Bell, S.R. Selitsky, R.J. Buus, K. Hua, G.M. Weinstock, T. Garland Jr., F.P.M. de Villena, D. Pomp, A novel intronic single nucleotide polymorphism in the Myosin heavy polypeptide 4 gene is responsible for the mini-muscle phenotype characterized by major reduction in hind-limb muscle mass in mice, Genetics. 195 (2013) 1385\u20131395. 10.1534\/genetics.113.154476.","DOI":"10.1534\/genetics.113.154476"},{"key":"10.1016\/j.physbeh.2021.113675_bib0043","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1017\/S0140525X00077797","article-title":"Insensitivity of the analysis of variance to heredity-environment interaction","volume":"13","author":"Wahlsten","year":"1990","journal-title":"Behavioral and Brain Sciences"},{"key":"10.1016\/j.physbeh.2021.113675_bib0044","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1037\/0033-2909.110.3.587","article-title":"Sample size to detect a planned contrast and a one degree-of-freedom interaction effect","volume":"110","author":"Wahlsten","year":"1991","journal-title":"Psychological Bulletin"},{"key":"10.1016\/j.physbeh.2021.113675_bib0045","doi-asserted-by":"crossref","unstructured":"A.A. Castro, H. Rabitoy, G.C. Claghorn, T. Garland Jr., Rapid and longer-term effects of selective breeding for voluntary exercise behavior on skeletal morphology in house mice, Journal of Anatomy. 238 (2021) 720\u2013742. 10.1111\/joa.13341.","DOI":"10.1111\/joa.13341"},{"key":"10.1016\/j.physbeh.2021.113675_bib0046","doi-asserted-by":"crossref","unstructured":"L.E. Copes, H. Schutz, E.M. Dlugosz, W. Acosta, M.A. Chappell, T. Garland Jr., Effects of voluntary exercise on spontaneous physical activity and food consumption in mice: Results from an artificial selection experiment, Physiology & Behavior. 149 (2015) 86\u201394. 10.1016\/j.physbeh.2015.05.025.","DOI":"10.1016\/j.physbeh.2015.05.025"},{"key":"10.1016\/j.physbeh.2021.113675_bib0047","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pharmthera.2009.12.005","article-title":"Cannabinoids and the gut: New developments and emerging concepts","volume":"126","author":"Izzo","year":"2010","journal-title":"Pharmacology & Therapeutics"},{"key":"10.1016\/j.physbeh.2021.113675_bib0048","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1172\/JCI76302","article-title":"Intestinal lipid\u2013derived signals that sense dietary fat","volume":"125","author":"DiPatrizio","year":"2015","journal-title":"J Clin Invest"},{"key":"10.1016\/j.physbeh.2021.113675_bib0049","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.bbi.2019.04.006","article-title":"Altered gut microbiota and endocannabinoid system tone in vitamin D deficiency-mediated chronic pain","volume":"85","author":"Guida","year":"2020","journal-title":"Brain, Behavior, and Immunity"},{"key":"10.1016\/j.physbeh.2021.113675_bib0050","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2165\/00007256-198603050-00003","article-title":"Hormonal alterations due to exercise","volume":"3","author":"Bunt","year":"1986","journal-title":"Sports Medicine"},{"key":"10.1016\/j.physbeh.2021.113675_bib0051","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2165\/00007256-199009030-00004","article-title":"The effect of exercise on the gastrointestinal tract","volume":"9","author":"Moses","year":"1990","journal-title":"Sports Med"},{"key":"10.1016\/j.physbeh.2021.113675_bib0052","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.coph.2006.08.004","article-title":"Importance of the gut\u2013brain axis in the control of glucose homeostasis","volume":"6","author":"Migrenne","year":"2006","journal-title":"Current Opinion in Pharmacology"},{"key":"10.1016\/j.physbeh.2021.113675_bib0053","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2020.165877","article-title":"Cross-talk between gut and brain elicited by physical exercise","volume":"1866","author":"Royes","year":"2020","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease"},{"key":"10.1016\/j.physbeh.2021.113675_bib0054","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1097\/00001756-200312020-00015","article-title":"Exercise activates the endocannabinoid system","volume":"14","author":"Sparling","year":"2003","journal-title":"NeuroReport"},{"key":"10.1016\/j.physbeh.2021.113675_bib0055","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.bbalip.2015.05.006","article-title":"Feeding-induced oleoylethanolamide mobilization is disrupted in the gut of diet-induced obese rodents","volume":"1851","author":"Igarashi","year":"2015","journal-title":"Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids"},{"key":"10.1016\/j.physbeh.2021.113675_bib0056","doi-asserted-by":"crossref","unstructured":"N.M. Templeman, H. Schutz, T. Garland Jr., G.B. McClelland, Do mice bred selectively for high locomotor activity have a greater reliance on lipids to power submaximal aerobic exercise?, American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 303 (2012) R101\u2013R111. 10.1152\/ajpregu.00511.2011.","DOI":"10.1152\/ajpregu.00511.2011"},{"key":"10.1016\/j.physbeh.2021.113675_bib0057","doi-asserted-by":"crossref","unstructured":"E.L. Rezende, M.A. Chappell, F.R. Gomes, J.L. Malisch, T. Garland Jr., Maximal metabolic rates during voluntary exercise, forced exercise, and cold exposure in house mice selectively bred for high wheel-running, Journal of Experimental Biology. 208 (2005) 2447\u20132458. 10.1242\/jeb.01631.","DOI":"10.1242\/jeb.01631"},{"key":"10.1016\/j.physbeh.2021.113675_bib0058","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1016\/j.celrep.2017.01.038","article-title":"Lipidomic adaptations in white and brown adipose tissue in response to exercise demonstrate molecular species-specific remodeling","volume":"18","author":"May","year":"2017","journal-title":"Cell Reports"},{"key":"10.1016\/j.physbeh.2021.113675_bib0059","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3389\/fphys.2019.00026","article-title":"Effect of exercise on fatty acid metabolism and adipokine secretion in adipose tissue","volume":"10","author":"Mika","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.physbeh.2021.113675_bib0060","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.cbpc.2004.07.003","article-title":"Fat to the fire: The regulation of lipid oxidation with exercise and environmental stress","volume":"139","author":"McClelland","year":"2004","journal-title":"Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology"},{"key":"10.1016\/j.physbeh.2021.113675_bib0061","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1152\/ajplegacy.1967.213.4.824","article-title":"Metabolism of free fatty acids and chylomicron triglycerides during exercise in rats","volume":"213","author":"Jones","year":"1967","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.physbeh.2021.113675_bib0062","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1152\/jappl.1982.52.4.815","article-title":"Chylomicron triglyceride metabolism in resting and exercising fed dogs","volume":"52","author":"Terjung","year":"1982","journal-title":"Journal of Applied Physiology"},{"key":"10.1016\/j.physbeh.2021.113675_bib0063","doi-asserted-by":"crossref","first-page":"558S","DOI":"10.1093\/ajcn\/72.2.558S","article-title":"Lipid metabolism during endurance exercise","volume":"72","author":"Horowitz","year":"2000","journal-title":"The American Journal of Clinical Nutrition"},{"key":"10.1016\/j.physbeh.2021.113675_bib0064","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.cell.2018.08.049","article-title":"A neural circuit for gut-induced reward","volume":"175","author":"Han","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.physbeh.2021.113675_bib0065","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1196\/annals.1417.003","article-title":"Dopamine signaling in the dorsal striatum is essential for motivated behaviors: Lessons from dopamine-deficient mice","volume":"1129","author":"Palmiter","year":"2008","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.physbeh.2021.113675_bib0066","first-page":"62","article-title":"Development and function of the midbrain dopamine system: What we know and what we need to, Genes","volume":"15","author":"Bissonette","year":"2016","journal-title":"Brain and Behavior."},{"key":"10.1016\/j.physbeh.2021.113675_bib0067","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.neuropharm.2017.04.033","article-title":"Endocannabinoid modulation of dopamine neurotransmission","volume":"124","author":"Covey","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.physbeh.2021.113675_bib0068","doi-asserted-by":"crossref","unstructured":"T.H. Meek, J.C. Eisenmann, T. Garland Jr., Western diet increases wheel running in mice selectively bred for high voluntary wheel running, Int J Obes. 34 (2010) 960\u2013969. 10.1038\/ijo.2010.25.","DOI":"10.1038\/ijo.2010.25"}],"container-title":["Physiology & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938421003620?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938421003620?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:19:51Z","timestamp":1758478791000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938421003620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":68,"alternative-id":["S0031938421003620"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2021.113675","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of Selective Breeding, Voluntary Exercise, and Sex on Endocannabinoid Levels in the Mouse Small-Intestinal Epithelium","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2021.113675","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113675"}}