{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T13:34:45Z","timestamp":1788269685298,"version":"build-2803163510"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology & Behavior"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.physbeh.2022.113710","type":"journal-article","created":{"date-parts":[[2022,1,20]],"date-time":"2022-01-20T11:02:57Z","timestamp":1642676577000},"page":"113710","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Involvement of Hippocampal Astrocytic Connexin-43 in Morphine dependence"],"prefix":"10.1016","volume":"247","author":[{"given":"Mahgol","family":"Darvishmolla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soomaayeh","family":"Heysieattalab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negin","family":"Saeedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narges","family":"Hosseinmardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahyar","family":"Janahmadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.physbeh.2022.113710_bib0001","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1101\/lm.042192.116","article-title":"Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addiction","volume":"23","author":"Kutlu","year":"2016","journal-title":"Learn Mem."},{"key":"10.1016\/j.physbeh.2022.113710_bib0002","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.physbeh.2018.04.003","article-title":"Hippocampal glial cells modulate morphine-induced behavioral responses","volume":"191","author":"Seyedaghamiri","year":"2018","journal-title":"Physiol. Behav."},{"issue":"1","key":"10.1016\/j.physbeh.2022.113710_bib0003","doi-asserted-by":"crossref","first-page":"76","DOI":"10.2174\/1874473710902010076","article-title":"The role of glial cells in drug abuse","volume":"2","author":"Miguel-Hidalgo","year":"2009","journal-title":"Curr. Drug Abuse Rev."},{"key":"10.1016\/j.physbeh.2022.113710_bib0004","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.coph.2015.11.010","article-title":"Novel insights into gliotransmitters","volume":"26","author":"Petrelli","year":"2016","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.physbeh.2022.113710_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-319-40764-7_1","article-title":"Glial cells and integrity of the nervous system","volume":"949","author":"von Bernhardi","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"issue":"4","key":"10.1016\/j.physbeh.2022.113710_bib0006","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.neuropharm.2009.06.031","article-title":"Tripartite synapses: roles for astrocytic purines in the control of synaptic physiology and behavior","volume":"57","author":"Halassa","year":"2009","journal-title":"Neuropharmacology"},{"issue":"2","key":"10.1016\/j.physbeh.2022.113710_bib0007","doi-asserted-by":"crossref","first-page":"120","DOI":"10.5607\/en.2018.27.2.120","article-title":"Expression of \u00b5-opioid receptor in CA1 hippocampal astrocytes","volume":"27","author":"Nam","year":"2018","journal-title":"Exp. Neurobiol."},{"issue":"5","key":"10.1016\/j.physbeh.2022.113710_bib0008","doi-asserted-by":"crossref","first-page":"3328","DOI":"10.1523\/JNEUROSCI.15-05-03328.1995","article-title":"Distribution and targeting of a mu-opioid receptor (MOR1) in brain and spinal cord","volume":"15","author":"Arvidsson","year":"1995","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.physbeh.2022.113710_bib0009","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a020420","article-title":"Astrogliosis","volume":"7","author":"Sofroniew","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"issue":"9","key":"10.1016\/j.physbeh.2022.113710_bib0010","doi-asserted-by":"crossref","first-page":"645","DOI":"10.14348\/molcells.2016.0137","article-title":"Brain reward circuits in morphine addiction","volume":"39","author":"Kim","year":"2016","journal-title":"Mol. Cells"},{"key":"10.1016\/j.physbeh.2022.113710_bib0011","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1146\/annurev.neuro.29.051605.113009","article-title":"Neural mechanisms of addiction: the role of reward-related learning and memory","volume":"29","author":"Hyman","year":"2006","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.physbeh.2022.113710_bib0012","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3389\/fnins.2015.00404","article-title":"Glutamatergic transmission in drug reward: implications for drug addiction","volume":"9","author":"D'Souza","year":"2015","journal-title":"Front. Neurosci."},{"issue":"8","key":"10.1016\/j.physbeh.2022.113710_bib0013","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nrn2515","article-title":"The glutamate homeostasis hypothesis of addiction","volume":"10","author":"Kalivas","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"issue":"3","key":"10.1016\/j.physbeh.2022.113710_bib0014","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1007\/s11064-016-2137-0","article-title":"Glutamate and brain glutaminases in drug addiction","volume":"42","author":"M\u00e1rquez","year":"2017","journal-title":"Neurochem. Res."},{"issue":"1\u20132","key":"10.1016\/j.physbeh.2022.113710_bib0015","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neulet.2005.01.071","article-title":"Morphine modulates glutamate release in the hippocampal CA1 area in mice","volume":"381","author":"Guo","year":"2005","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.physbeh.2022.113710_bib0016","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.neuroscience.2005.02.020","article-title":"Time-dependent changes in extracellular glutamate in the rat dorsolateral striatum following a single cocaine injection","volume":"133","author":"McKee","year":"2005","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.physbeh.2022.113710_bib0017","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/s002130000456","article-title":"Ventral pallidal extracellular fluid levels of dopamine, serotonin, gamma amino butyric acid, and glutamate during cocaine self-administration in rats","volume":"150","author":"Sizemore","year":"2000","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.physbeh.2022.113710_bib0018","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fpsyt.2015.00001","article-title":"Enhanced extracellular glutamate and dopamine in the ventral pallidum of alcohol-preferring AA and alcohol-avoiding ANA rats after morphine","volume":"6","author":"Kemppainen","year":"2015","journal-title":"Front. Psychiatry"},{"issue":"2","key":"10.1016\/j.physbeh.2022.113710_bib0019","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.brainres.2003.10.008","article-title":"Increasing of intrathecal CSF excitatory amino acids concentration following morphine challenge in morphine-tolerant rats","volume":"995","author":"Wen","year":"2004","journal-title":"Brain Res."},{"issue":"10","key":"10.1016\/j.physbeh.2022.113710_bib0020","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1038\/aps.2009.130","article-title":"Glutamate receptors in the dorsal hippocampus mediate the acquisition, but not the expression, of conditioned place aversion induced by acute morphine withdrawal in rats","volume":"30","author":"Hou","year":"2009","journal-title":"Acta Pharmacol. Sin."},{"issue":"2","key":"10.1016\/j.physbeh.2022.113710_bib0021","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/BF00967978","article-title":"Neurotransmitter uptake in various brain regions of chronically morphinized rats","volume":"11","author":"R\u00f6nnb\u00e4ck","year":"1986","journal-title":"Neurochem. Res."},{"issue":"9","key":"10.1016\/j.physbeh.2022.113710_bib0022","doi-asserted-by":"crossref","first-page":"e2323","DOI":"10.1002\/brb3.2323","article-title":"The role of hippocampal glial glutamate transporter (GLT-1) in morphine-induced behavioral responses","volume":"11","author":"Saeedi","year":"2021","journal-title":"Brain Behav."},{"issue":"12","key":"10.1016\/j.physbeh.2022.113710_bib0023","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1007\/s11064-015-1622-1","article-title":"Glutamate release","volume":"40","author":"Hackett","year":"2015","journal-title":"Neurochem. Res."},{"issue":"1\u20132","key":"10.1016\/j.physbeh.2022.113710_bib0024","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.neuint.2007.06.005","article-title":"Mechanisms of glutamate release from astrocytes","volume":"52","author":"Malarkey","year":"2008","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.physbeh.2022.113710_bib0025","doi-asserted-by":"crossref","first-page":"102","DOI":"10.3389\/fendo.2013.00102","article-title":"Astrocytic control of biosynthesis and turnover of the neurotransmitters glutamate and GABA","volume":"4","author":"Schousboe","year":"2013","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"1","key":"10.1016\/j.physbeh.2022.113710_bib0026","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.cell.2012.09.005","article-title":"TREK-1 and Best1 channels mediate fast and slow glutamate release in astrocytes upon GPCR activation","volume":"151","author":"Woo","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.physbeh.2022.113710_bib0027","doi-asserted-by":"crossref","first-page":"319","DOI":"10.3389\/fncel.2018.00319","article-title":"Activation of astrocytic \u03bc-opioid receptor elicits fast glutamate release through TREK-1-containing K2P channel in hippocampal astrocytes","volume":"12","author":"Woo","year":"2018","journal-title":"Front. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.physbeh.2022.113710_bib0028","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.bcp.2007.06.039","article-title":"Glutamatergic substrates of drug addiction and alcoholism","volume":"75","author":"Gass","year":"2008","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.physbeh.2022.113710_bib0029","first-page":"20","article-title":"Morphine treatment enhances extracellular ATP enzymolysis and adenosine generation in rat astrocytes","volume":"63","author":"Liu","year":"2011","journal-title":"Sheng Li Xue Bao"},{"issue":"4","key":"10.1016\/j.physbeh.2022.113710_bib0030","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0091-3057(96)00393-0","article-title":"Effect of adenosine receptor agonists and antagonists on the expression of opiate withdrawal in rats","volume":"57","author":"Salem","year":"1997","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"2","key":"10.1016\/j.physbeh.2022.113710_bib0031","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00210-003-0773-9","article-title":"Interactive role of adenosine and dopamine in the opiate withdrawal syndrome","volume":"368","author":"Stella","year":"2003","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"issue":"4","key":"10.1016\/j.physbeh.2022.113710_bib0032","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1358\/dnp.2005.18.4.908657","article-title":"Cross-talk between adenosine and opioid receptors","volume":"18","author":"Peart","year":"2005","journal-title":"Drug News Perspect."},{"issue":"1","key":"10.1016\/j.physbeh.2022.113710_bib0033","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0014-2999(98)00724-9","article-title":"Adenosine kinase inhibitors attenuate opiate withdrawal via adenosine receptor activation","volume":"362","author":"Kaplan","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.physbeh.2022.113710_bib0034","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3389\/fphys.2014.00193","article-title":"Hemichannels: new roles in astroglial function","volume":"5","author":"Orellana","year":"2014","journal-title":"Front. Physiol."},{"issue":"21","key":"10.1016\/j.physbeh.2022.113710_bib0035","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1242\/jcs.200667","article-title":"Role of connexin 43 in different forms of intercellular communication - gap junctions, extracellular vesicles and tunnelling nanotubes","volume":"130","author":"Ribeiro-Rodrigues","year":"2017","journal-title":"J. Cell. Sci."},{"issue":"8","key":"10.1016\/j.physbeh.2022.113710_bib0036","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1111\/cns.12244","article-title":"A novel role of spinal astrocytic connexin 43: mediating morphine antinociceptive tolerance by activation of NMDA receptors and inhibition of glutamate transporter-1 in rats","volume":"20","author":"Shen","year":"2014","journal-title":"CNS Neurosci. Ther."},{"issue":"1654","key":"10.1016\/j.physbeh.2022.113710_bib0037","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2013.0596","article-title":"Astroglial connexin 43 sustains glutamatergic synaptic efficacy","volume":"369","author":"Chever","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.physbeh.2022.113710_bib0038","series-title":"The Rat Brain in Stereotaxic Coordinates: Hard Cover Edition","author":"Paxinos","year":"2006"},{"issue":"21","key":"10.1016\/j.physbeh.2022.113710_bib0039","doi-asserted-by":"crossref","first-page":"8520","DOI":"10.1523\/JNEUROSCI.17-21-08520.1997","article-title":"Opposite modulation of opiate withdrawal behaviors on microinfusion of a protein kinase A inhibitor versus activator into the locus coeruleus or periaqueductal gray","volume":"17","author":"Punch","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.physbeh.2022.113710_bib0040","article-title":"Spinal Cx43 mediates chronic morphine antinociceptive tolerance through JNK pathway in rats","volume":"3","author":"SHEN","year":"2013","journal-title":"Chinese Pharmacol. Bull."},{"key":"10.1016\/j.physbeh.2022.113710_bib0041","doi-asserted-by":"crossref","first-page":"306","DOI":"10.3389\/fncel.2014.00306","article-title":"The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes","volume":"8","author":"Abudara","year":"2014","journal-title":"Front. Cell. Neurosci."},{"issue":"3","key":"10.1016\/j.physbeh.2022.113710_bib0042","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/S0022-3565(25)31261-9","article-title":"Development and maintenance of morphine tolerance and dependence in the rat by scheduled access to morphine drinking solutions","volume":"205","author":"Gellert","year":"1978","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.physbeh.2022.113710_bib0043","doi-asserted-by":"crossref","first-page":"288","DOI":"10.3389\/fncel.2016.00288","article-title":"Inhibition of connexin43 hemichannels impairs spatial short-term memory without affecting spatial working memory","volume":"10","author":"Walrave","year":"2016","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.physbeh.2022.113710_bib0044","article-title":"Hippocampal involvement in the pharmacologic induction of withdrawal-like behaviors","author":"Isaacson","year":"1981","journal-title":"Fed. Proc."},{"issue":"3","key":"10.1016\/j.physbeh.2022.113710_bib0045","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0304-3940(00)01352-5","article-title":"Inhibition of the amygdala and hippocampal calcium\/calmodulin-dependent protein kinase II attenuates the dependence and relapse to morphine differently in rats","volume":"291","author":"Lu","year":"2000","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.physbeh.2022.113710_bib0046","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0304-3940(81)90030-6","article-title":"Anatomical correlates of morphine-withdrawal syndrome: differential participation of structures located within the limbic system and striatum","volume":"23","author":"Tremblay","year":"1981","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.physbeh.2022.113710_bib0047","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.brainresbull.2018.04.006","article-title":"Glial cells modulate hippocampal synaptic plasticity in morphine dependent rats","volume":"140","author":"Elahi-Mahani","year":"2018","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.physbeh.2022.113710_bib0048","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.neuroscience.2011.06.067","article-title":"Astroglial reaction to delta opioid peptide [D-Ala2, d-Leu5] enkephalin confers neuroprotection against global ischemia in the adult rat hippocampus","volume":"192","author":"Duan","year":"2011","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.physbeh.2022.113710_bib0049","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0896-6273(04)00195-3","article-title":"Differential but complementary mnemonic functions of the hippocampus and subiculum","volume":"42","author":"Deadwyler","year":"2004","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.physbeh.2022.113710_bib0050","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/nrn2614","article-title":"The anatomy of memory: an interactive overview of the parahippocampal\u2013hippocampal network","volume":"10","author":"Van Strien","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"issue":"6","key":"10.1016\/j.physbeh.2022.113710_bib0051","doi-asserted-by":"crossref","first-page":"586","DOI":"10.3390\/cells8060586","article-title":"Opioid-mediated astrocyte\u2013neuron signaling in the nucleus accumbens","volume":"8","author":"Corkrum","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.physbeh.2022.113710_bib0052","first-page":"185","article-title":"Carbenoxolone, a gap junction blocker, enhances antinociceptive effects of morphine in formalin test in mice","volume":"2","author":"Nassiri-Asl","year":"2011","journal-title":"Pharmacologyonline"},{"key":"10.1016\/j.physbeh.2022.113710_bib0053","unstructured":"KHALAFI, A., et\u00a0al., Enhanced expression of hippocampal NMDA receptor subunits in morphine-dependent rats. 2009."},{"issue":"13","key":"10.1016\/j.physbeh.2022.113710_bib0054","doi-asserted-by":"crossref","first-page":"4915","DOI":"10.1523\/JNEUROSCI.21-13-04915.2001","article-title":"Glutamatergic afferents from the hippocampus to the nucleus accumbens regulate activity of ventral tegmental area dopamine neurons","volume":"21","author":"Floresco","year":"2001","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.physbeh.2022.113710_bib0055","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/cne.903130404","article-title":"Distribution of hippocampal CA1 and subicular efferents in the prefrontal cortex of the rat studied by means of anterograde transport of Phaseolus vulgaris-leucoagglutinin","volume":"313","author":"Jay","year":"1991","journal-title":"J. Comp. Neurol."},{"issue":"4","key":"10.1016\/j.physbeh.2022.113710_bib0056","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/0306-4522(93)90048-K","article-title":"GABA and enkephalin projection from the nucleus accumbens and ventral pallidum to the ventral tegmental area","volume":"57","author":"Kalivas","year":"1993","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.physbeh.2022.113710_bib0057","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0006-8993(80)90559-4","article-title":"Nucleus accumbens to globus pallidus GABA projection: electrophysiological and iontophoretic investigations","volume":"188","author":"Jones","year":"1980","journal-title":"Brain Res."},{"issue":"18","key":"10.1016\/j.physbeh.2022.113710_bib0058","doi-asserted-by":"crossref","first-page":"4702","DOI":"10.1523\/JNEUROSCI.5048-07.2008","article-title":"Connexin 43 hemichannels are permeable to ATP","volume":"28","author":"Kang","year":"2008","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.physbeh.2022.113710_bib0059","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nm.4281","article-title":"Blocking microglial pannexin-1 channels alleviates morphine withdrawal in rodents","volume":"23","author":"Burma","year":"2017","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.physbeh.2022.113710_bib0060","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/BF00428791","article-title":"Development of physical dependence on morphine in respect to time and dosage and quantification of the precipitated withdrawal syndrome in rats","volume":"33","author":"Bl\u00e4sig","year":"1973","journal-title":"Psychopharmacologia"},{"issue":"10","key":"10.1016\/j.physbeh.2022.113710_bib0061","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.jpain.2012.06.007","article-title":"Role of P2X7 receptor-mediated IL-18\/IL-18R signaling in morphine tolerance: multiple glial-neuronal dialogues in the rat spinal cord","volume":"13","author":"Chen","year":"2012","journal-title":"J. Pain"},{"issue":"18","key":"10.1016\/j.physbeh.2022.113710_bib0062","doi-asserted-by":"crossref","first-page":"4702","DOI":"10.1523\/JNEUROSCI.5048-07.2008","article-title":"Connexin 43 hemichannels are permeable to ATP","volume":"28","author":"Kang","year":"2008","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.physbeh.2022.113710_bib0063","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1523\/JNEUROSCI.21-06-01983.2001","article-title":"Cell-specific expression of connexins and evidence of restricted gap junctional coupling between glial cells and between neurons","volume":"21","author":"Rash","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.physbeh.2022.113710_bib0064","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3389\/fnmol.2018.00435","article-title":"Synaptic functions of hemichannels and pannexons: a double-edged sword","volume":"11","author":"Abudara","year":"2018","journal-title":"Front. Mol. Neurosci."},{"issue":"11","key":"10.1016\/j.physbeh.2022.113710_bib0065","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1002\/glia.23196","article-title":"Subcellular reorganization and altered phosphorylation of the astrocytic gap junction protein connexin43 in human and experimental temporal lobe epilepsy","volume":"65","author":"Deshpande","year":"2017","journal-title":"Glia"},{"key":"10.1016\/j.physbeh.2022.113710_bib0066","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3389\/fphar.2013.00130","article-title":"Managing the complexity of communication: regulation of gap junctions by post-translational modification","volume":"4","author":"Axelsen","year":"2013","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.physbeh.2022.113710_bib0067","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0896-6273(91)90241-Q","article-title":"Gap junctions: new tools, new answers, new questions","volume":"6","author":"Bennett","year":"1991","journal-title":"Neuron"},{"issue":"12","key":"10.1016\/j.physbeh.2022.113710_bib0068","doi-asserted-by":"crossref","first-page":"10482","DOI":"10.1074\/jbc.M109902200","article-title":"Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels","volume":"277","author":"Stout","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.physbeh.2022.113710_bib0069","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-52900-4","article-title":"Blocking connexin43 hemichannels protects mice against tumour necrosis factor-induced inflammatory shock","volume":"9","author":"Delvaeye","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.physbeh.2022.113710_bib0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2016.12.017","article-title":"Astrocytic gap junction blockade markedly increases extracellular potassium without causing seizures in the mouse neocortex","volume":"101","author":"Bazzigaluppi","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.physbeh.2022.113710_bib0071","first-page":"61","article-title":"Effect of potassium channel modulators on morphine withdrawal in mice","volume":"4","author":"Seth","year":"2010","journal-title":"Subst. Abuse"},{"issue":"4","key":"10.1016\/j.physbeh.2022.113710_bib0072","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0031-6997(25)06638-4","article-title":"Electrophysiology of opioids","volume":"35","author":"Duggan","year":"1983","journal-title":"Pharmacol. Rev."},{"issue":"12","key":"10.1016\/j.physbeh.2022.113710_bib0073","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.1523\/JNEUROSCI.5311-10.2011","article-title":"Fast and reversible stimulation of astrocytic glycolysis by K+ and a delayed and persistent effect of glutamate","volume":"31","author":"Bittner","year":"2011","journal-title":"J. Neurosci."},{"issue":"40","key":"10.1016\/j.physbeh.2022.113710_bib0074","doi-asserted-by":"crossref","first-page":"14264","DOI":"10.1523\/JNEUROSCI.2310-11.2011","article-title":"NBCe1 mediates the acute stimulation of astrocytic glycolysis by extracellular K+","volume":"31","author":"Ruminot","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.physbeh.2022.113710_bib0075","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fncel.2019.00082","article-title":"The strategic location of glycogen and lactate: from body energy reserve to brain plasticity","volume":"13","author":"Cal\u00ec","year":"2019","journal-title":"Front. Cell Neurosci."},{"issue":"6228","key":"10.1016\/j.physbeh.2022.113710_bib0076","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1126\/science.aaa1299","article-title":"Epilepsy treatment. Targeting LDH enzymes with a stiripentol analog to treat epilepsy","volume":"347","author":"Sada","year":"2015","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.physbeh.2022.113710_bib0077","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1038\/mp.2015.157","article-title":"Disrupting astrocyte\u2013neuron lactate transfer persistently reduces conditioned responses to cocaine","volume":"21","author":"Boury-Jamot","year":"2016","journal-title":"Mol. Psychiatry"},{"issue":"2","key":"10.1016\/j.physbeh.2022.113710_bib0078","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/s41386-019-0450-4","article-title":"Astrocytes determine conditioned response to morphine via glucocorticoid receptor-dependent regulation of lactate release","volume":"45","author":"Skupio","year":"2020","journal-title":"Neuropsychopharmacology"}],"container-title":["Physiology & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938422000178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938422000178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:20:20Z","timestamp":1758478820000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938422000178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":78,"alternative-id":["S0031938422000178"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2022.113710","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Involvement of Hippocampal Astrocytic Connexin-43 in Morphine dependence","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2022.113710","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113710"}}