{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:56:22Z","timestamp":1791636982581,"version":"4.3.4"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology & Behavior"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.physbeh.2022.113777","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T12:49:15Z","timestamp":1646743755000},"page":"113777","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Floralozone improves cognitive impairment in vascular dementia rats via regulation of TRPM2 and NMDAR signaling pathway"],"prefix":"10.1016","volume":"249","author":[{"given":"Ya-ling","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-hua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mo-li","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan-huan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-rui","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.physbeh.2022.113777_bib0001","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1111\/j.1745-7254.2005.00042.x","article-title":"Protective effects of cariporide on endothelial dysfunction induced by high glucose","volume":"26","author":"Wang","year":"2005","journal-title":"Acta pharmacologica Sinica"},{"key":"10.1016\/j.physbeh.2022.113777_bib0002","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.2147\/NDT.S197032","article-title":"Vascular cognitive impairment: pathophysiological mechanisms, insights into structural basis, and perspectives in specific treatments","volume":"15","author":"Parfenov","year":"2019","journal-title":"Neuropsychiatric disease and treatment"},{"key":"10.1016\/j.physbeh.2022.113777_bib0003","article-title":"Vascular Cognitive Impairment (VCI)","author":"Rundek","year":"2021","journal-title":"Neurotherapeutics: the journal of the American Society for Experimental NeuroTherapeutics"},{"issue":"8","key":"10.1016\/j.physbeh.2022.113777_bib0004","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.3390\/ijms21082977","article-title":"Update on the Neurobiology of Vascular Cognitive Impairment: From Lab to Clinic","volume":"21","author":"Vinciguerra","year":"2020","journal-title":"International journal of molecular sciences"},{"issue":"4","key":"10.1016\/j.physbeh.2022.113777_bib0005","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.neuron.2013.10.008","article-title":"The pathobiology of vascular dementia","volume":"80","author":"Iadecola","year":"2013","journal-title":"Neuron"},{"issue":"10004","key":"10.1016\/j.physbeh.2022.113777_bib0006","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/S0140-6736(15)00463-8","article-title":"Vascular dementia","volume":"386","author":"O'Brien","year":"2015","journal-title":"Lancet (London, England)"},{"issue":"8","key":"10.1016\/j.physbeh.2022.113777_bib0007","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1161\/ATVBAHA.119.311908","article-title":"Epidemiology of Vascular Dementia","volume":"39","author":"Wolters","year":"2019","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"issue":"9","key":"10.1016\/j.physbeh.2022.113777_bib0008","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1038\/aps.2014.57","article-title":"Alzheimer's disease progression model based on integrated biomarkers and clinical measures","volume":"35","author":"Qiu","year":"2014","journal-title":"Acta pharmacologica Sinica"},{"issue":"3","key":"10.1016\/j.physbeh.2022.113777_bib0009","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jalz.2017.09.007","article-title":"Progress toward standardized diagnosis of vascular cognitive impairment: Guidelines from the Vascular Impairment of Cognition Classification Consensus Study","volume":"14","author":"Skrobot","year":"2018","journal-title":"Alzheimer's & dementia: the journal of the Alzheimer's Association"},{"key":"10.1016\/j.physbeh.2022.113777_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2020.117069","article-title":"Mouse nerve growth factor promotes neurological recovery in patients with acute intracerebral hemorrhage: A proof-of-concept study","volume":"418","author":"An","year":"2020","journal-title":"Journal of the neurological sciences"},{"issue":"2","key":"10.1016\/j.physbeh.2022.113777_bib0011","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.neuroscience.2009.04.065","article-title":"Edaravone attenuates white matter lesions through endothelial protection in a rat chronic hypoperfusion model","volume":"162","author":"Ueno","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2022.113777_bib0012","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.brainres.2009.11.080","article-title":"Changes in pro-oxidant and antioxidant enzyme levels during cerebral hypoperfusion in rats","volume":"1321","author":"Mracsko","year":"2010","journal-title":"Brain research"},{"issue":"5","key":"10.1016\/j.physbeh.2022.113777_bib0013","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1093\/abbs\/gmw024","article-title":"The effect of Scutellaria baicalensis stem-leaf flavonoids on spatial learning and memory in chronic cerebral ischemia-induced vascular dementia of rats","volume":"48","author":"Cao","year":"2016","journal-title":"Acta biochimica et biophysica Sinica"},{"key":"10.1016\/j.physbeh.2022.113777_bib0014","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.expneurol.2015.05.006","article-title":"Models and mechanisms of vascular dementia","volume":"272","author":"Venkat","year":"2015","journal-title":"Experimental neurology"},{"issue":"4","key":"10.1016\/j.physbeh.2022.113777_bib0015","doi-asserted-by":"crossref","first-page":"342","DOI":"10.2174\/156720211798120981","article-title":"Cognitive impairment with vascular impairment and degeneration","volume":"8","author":"Pluta","year":"2011","journal-title":"Current neurovascular research"},{"issue":"6","key":"10.1016\/j.physbeh.2022.113777_bib0016","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1089\/jmf.2010.0125","article-title":"Antinociceptive action and redox properties of citronellal, an essential oil present in lemongrass","volume":"14","author":"Quintans-Junior","year":"2011","journal-title":"Journal of medicinal food"},{"issue":"5","key":"10.1016\/j.physbeh.2022.113777_bib0017","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/ffj.3165","article-title":"Major bio-activities and mechanism of action of essential oils and their components","volume":"28","author":"Sad","year":"2013","journal-title":"Flavour Fragrance J"},{"issue":"9-10","key":"10.1016\/j.physbeh.2022.113777_bib0018","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1159\/000504758","article-title":"Floralozone Ameliorated Atherosclerosis in Experimental Atherosclerotic Rats Involved with Sphingosine 1-Phosphate 1 Enhancement","volume":"105","author":"Yang","year":"2020","journal-title":"Pharmacology"},{"issue":"3","key":"10.1016\/j.physbeh.2022.113777_bib0019","doi-asserted-by":"crossref","first-page":"441","DOI":"10.4103\/1673-5374.245467","article-title":"Essential oils and functional herbs for healthy aging","volume":"14","author":"Agatonovic-Kustrin","year":"2019","journal-title":"Neural regeneration research"},{"issue":"3","key":"10.1016\/j.physbeh.2022.113777_bib0020","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.ceca.2011.04.006","article-title":"Roles of TRPM2 in oxidative stress","volume":"50","author":"Takahashi","year":"2011","journal-title":"Cell calcium"},{"issue":"2","key":"10.1016\/j.physbeh.2022.113777_bib0021","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/jnc.14970","article-title":"Regulation of NMDA glutamate receptor functions by the GluN2 subunits","volume":"154","author":"Vieira","year":"2020","journal-title":"Journal of neurochemistry"},{"issue":"12","key":"10.1016\/j.physbeh.2022.113777_bib0022","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1007\/s007020100019","article-title":"Chronic cerebral hypoperfusion in the rat enhances age-related deficits in spatial memory","volume":"108","author":"Sopala","year":"2001","journal-title":"Journal of neural transmission (Vienna, Austria: 1996)"},{"issue":"2","key":"10.1016\/j.physbeh.2022.113777_bib0023","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0197-4580(00)00125-1","article-title":"The role of cerebral ischemia in Alzheimer's disease","volume":"21","author":"Kalaria","year":"2000","journal-title":"Neurobiology of aging"},{"issue":"1","key":"10.1016\/j.physbeh.2022.113777_bib0024","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.brainresrev.2007.01.003","article-title":"Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases","volume":"54","author":"Farkas","year":"2007","journal-title":"Brain Research Reviews"},{"issue":"5","key":"10.1016\/j.physbeh.2022.113777_bib0025","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1007\/s12035-016-9915-1","article-title":"Molecular Mechanisms of Vascular Dementia: What Can Be Learned from Animal Models of Chronic Cerebral Hypoperfusion?","volume":"54","author":"Du","year":"2017","journal-title":"Molecular neurobiology"},{"key":"10.1016\/j.physbeh.2022.113777_bib0026","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neulet.2016.04.047","article-title":"Neuroprotective and memory enhancing effects of auraptene in a rat model of vascular dementia: Experimental study and histopathological evaluation","volume":"623","author":"Ghanbarabadi","year":"2016","journal-title":"Neuroscience letters"},{"issue":"10","key":"10.1016\/j.physbeh.2022.113777_bib0027","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1161\/STROKEAHA.119.026652","article-title":"Validity and Reliability of Neurological Scores in Mice Exposed to Middle Cerebral Artery Occlusion","volume":"50","author":"Bieber","year":"2019","journal-title":"Stroke"},{"issue":"4","key":"10.1016\/j.physbeh.2022.113777_bib0028","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1080\/03610738108259823","article-title":"Age-related differences in behavior across the life span of the C57BL\/6J mouse","volume":"7","author":"Dean","year":"1981","journal-title":"Experimental aging research"},{"issue":"2","key":"10.1016\/j.physbeh.2022.113777_bib0029","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nprot.2006.116","article-title":"Morris water maze: procedures for assessing spatial and related forms of learning and memory","volume":"1","author":"Vorhees","year":"2006","journal-title":"Nature protocols"},{"issue":"4","key":"10.1016\/j.physbeh.2022.113777_bib0030","doi-asserted-by":"crossref","first-page":"3290","DOI":"10.1007\/s12035-017-0568-5","article-title":"Erythropoietin Rescues Memory Impairment in a Rat Model of Chronic Cerebral Hypoperfusion via the EPO-R\/JAK2\/STAT5\/PI3K\/Akt\/GSK-3\u03b2 Pathway","volume":"55","author":"Ma","year":"2018","journal-title":"Molecular neurobiology"},{"issue":"3","key":"10.1016\/j.physbeh.2022.113777_bib0031","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1248\/bpb.b16-00567","article-title":"Cinepazide Maleate Improves Cognitive Function and Protects Hippocampal Neurons in Diabetic Rats with Chronic Cerebral Hypoperfusion","volume":"40","author":"Li","year":"2017","journal-title":"Biological & pharmaceutical bulletin"},{"key":"10.1016\/j.physbeh.2022.113777_bib0032","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3389\/fphar.2017.00002","article-title":"\u03b2-Caryophyllene\/Hydroxypropyl-\u03b2-Cyclodextrin Inclusion Complex Improves Cognitive Deficits in Rats with Vascular Dementia through the Cannabinoid Receptor Type 2 -Mediated Pathway","volume":"8","author":"Lou","year":"2017","journal-title":"Frontiers in pharmacology"},{"key":"10.1016\/j.physbeh.2022.113777_bib0033","unstructured":"Sun, B., He, Y., Pei, Y., Zhang, C., Zhang, X., & Yang, Z. (2017). Zhonghua wei zhong bing ji jiu yi xue, 29(3), 211\u2013215. 10.3760\/cma.j.issn.2095-4352.2017.03.004."},{"issue":"3","key":"10.1016\/j.physbeh.2022.113777_bib0034","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1539\/joh.14-0226-OA","article-title":"Subchronic exposure to arsenic induces apoptosis in the hippocampus of the mouse brains through the Bcl-2\/Bax pathway","volume":"57","author":"Wang","year":"2015","journal-title":"Journal of occupational health"},{"issue":"1","key":"10.1016\/j.physbeh.2022.113777_bib0035","doi-asserted-by":"crossref","first-page":"4","DOI":"10.5414\/NP301087","article-title":"Clinical Neuropathology image 1-2018: Golgi silver staining, the black reaction","volume":"37","author":"Mariotto","year":"2018","journal-title":"Clinical neuropathology"},{"issue":"33","key":"10.1016\/j.physbeh.2022.113777_bib0036","doi-asserted-by":"crossref","first-page":"52729","DOI":"10.18632\/oncotarget.10400","article-title":"Activation of activator protein 2 alpha by aspirin alleviates atherosclerotic plaque growth and instability in vivo","volume":"7","author":"Yang","year":"2016","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.physbeh.2022.113777_bib0037","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/nm.2711","article-title":"Activation of AMP-activated protein kinase \u03b12 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo","volume":"18","author":"Wang","year":"2012","journal-title":"Nature medicine"},{"key":"10.1016\/j.physbeh.2022.113777_bib0038","first-page":"16","article-title":"Citronellal ameliorates doxorubicin-induced hepatotoxicity via anti-oxidative stress, apoptosis, and angiogenesis in rats","author":"Liu","year":"2020","journal-title":"Journal of Biochemical and Molecular Toxicology"},{"issue":"1-2","key":"10.1016\/j.physbeh.2022.113777_bib0039","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.jns.2014.09.021","article-title":"Effects of donepezil, an acetylcholinesterase inhibitor, on neurogenesis in a rat model of vascular dementia","volume":"347","author":"Kwon","year":"2014","journal-title":"Journal of the neurological sciences"},{"issue":"8","key":"10.1016\/j.physbeh.2022.113777_bib0040","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1038\/aps.2016.17","article-title":"Polygalasaponin XXXII, a triterpenoid saponin from Polygalae Radix, attenuates scopolamine-induced cognitive impairments in mice","volume":"37","author":"Zhou","year":"2016","journal-title":"Acta pharmacologica Sinica"},{"key":"10.1016\/j.physbeh.2022.113777_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2019.146512","article-title":"Metabolic profiling deciphering the potential targets of Yi-Gan San against vascular dementia in rat","volume":"1727","author":"Liao","year":"2020","journal-title":"Brain research"},{"issue":"39","key":"10.1016\/j.physbeh.2022.113777_bib0042","doi-asserted-by":"crossref","first-page":"10141","DOI":"10.1523\/JNEUROSCI.1054-16.2016","article-title":"Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice","volume":"36","author":"Lane-Donovan","year":"2016","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"2","key":"10.1016\/j.physbeh.2022.113777_bib0043","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/cercor\/bht239","article-title":"Spatial olfactory learning contributes to place field formation in the hippocampus","volume":"25","author":"Zhang","year":"2015","journal-title":"Cerebral cortex (New York, N.Y.: 1991)"},{"issue":"3","key":"10.1016\/j.physbeh.2022.113777_bib0044","first-page":"114","article-title":"Impact of Several Types of Stresses on Short-term Memory and Apoptosis in the Hippocampus of Rats","volume":"17","author":"Kim","year":"2013","journal-title":"International neurology journal"},{"issue":"7","key":"10.1016\/j.physbeh.2022.113777_bib0045","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/S1474-4422(02)00190-4","article-title":"Subcortical ischaemic vascular dementia","volume":"1","author":"Roman","year":"2002","journal-title":"The Lancet. Neurology"},{"key":"10.1016\/j.physbeh.2022.113777_bib0046","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.expneurol.2018.12.005","article-title":"Treadmill exercise ameliorates focal cerebral ischemia\/reperfusion-induced neurological deficit by promoting dendritic modification and synaptic plasticity via upregulating caveolin-1\/VEGF signaling pathways","volume":"313","author":"Xie","year":"2019","journal-title":"Experimental neurology"},{"issue":"1","key":"10.1016\/j.physbeh.2022.113777_bib0047","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004031","article-title":"The formation of multi-synaptic connections by the interaction of synaptic and structural plasticity and their functional consequences","volume":"11","author":"Fauth","year":"2015","journal-title":"PLoS computational biology"},{"issue":"6","key":"10.1016\/j.physbeh.2022.113777_bib0048","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1101\/pdb.prot087486","article-title":"Two-Photon Imaging of Natural Structural Plasticity in Mice during and after Ischemia","volume":"2015","author":"Murphy","year":"2015","journal-title":"Cold Spring Harbor protocols"},{"issue":"1","key":"10.1016\/j.physbeh.2022.113777_bib0049","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3390\/ijms21010120","article-title":"The Potential Role of MicroRNA-124 in Cerebral Ischemia Injury","volume":"21","author":"Liu","year":"2019","journal-title":"International journal of molecular sciences"},{"issue":"13","key":"10.1016\/j.physbeh.2022.113777_bib0050","first-page":"5923","article-title":"Nodal mitigates cerebral ischemia-reperfusion injury via inhibiting oxidative stress and inflammation","volume":"23","author":"Cui","year":"2019","journal-title":"European review for medical and pharmacological sciences"},{"issue":"Pt B","key":"10.1016\/j.physbeh.2022.113777_bib0051","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.neuropharm.2017.11.011","article-title":"Oxidative stress and DNA damage after cerebral ischemia: Potential therapeutic targets to repair the genome and improve stroke recovery","volume":"134","author":"Li","year":"2018","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.physbeh.2022.113777_bib0052","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3736\/jcim20040114","article-title":"Zhong xi yi jie he xue bao =","volume":"2","author":"Cao","year":"2004","journal-title":"Journal of Chinese integrative medicine"},{"issue":"6","key":"10.1016\/j.physbeh.2022.113777_bib0053","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.brainresbull.2010.09.007","article-title":"Effect of pentylenetetrazole and sound stimulation induced single and repeated convulsive seizures on the MDA, GSH and NO levels, and SOD activities in rat liver and kidney tissues","volume":"83","author":"Dillioglugil","year":"2010","journal-title":"Brain research bulletin"},{"issue":"5","key":"10.1016\/j.physbeh.2022.113777_bib0054","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1159\/000087825","article-title":"Effects of vitamins E, A and D on MDA, GSH, NO levels and SOD activities in 5\/6 nephrectomized rats","volume":"25","author":"Kir","year":"2005","journal-title":"American journal of nephrology"},{"key":"10.1016\/j.physbeh.2022.113777_bib0055","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2147\/NDT.S338226","article-title":"Comparison of Cognitive Performance and Cardiac Function Between Three Different Rat Models of Vascular Dementia","volume":"18","author":"Wei","year":"2022","journal-title":"Neuropsychiatric disease and treatment"},{"key":"10.1016\/j.physbeh.2022.113777_bib0056","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ejphar.2018.05.015","article-title":"Betulinic acid, a natural PDE inhibitor restores hippocampal cAMP\/cGMP and BDNF, improve cerebral blood flow and recover memory deficits in permanent BCCAO induced vascular dementia in rats","volume":"832","author":"Kaundal","year":"2018","journal-title":"European journal of pharmacology"},{"issue":"10","key":"10.1016\/j.physbeh.2022.113777_bib0057","first-page":"951","article-title":"Role of mouse nerve growth factor in neural recovery following hypoxic-ischemic brain damage","volume":"6","author":"Yin","year":"2013","journal-title":"International journal of clinical and experimental medicine"},{"key":"10.1016\/j.physbeh.2022.113777_bib0058","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.neulet.2017.01.046","article-title":"NGF protects against oxygen and glucose deprivation-induced oxidative stress and apoptosis by up-regulation of HO-1 through MEK\/ERK pathway","volume":"641","author":"Sun","year":"2017","journal-title":"Neuroscience letters"},{"issue":"1","key":"10.1016\/j.physbeh.2022.113777_bib0059","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3390\/pharmaceutics13010025","article-title":"Biodegradable Microcapsules Loaded with Nerve Growth Factor Enable Neurite Guidance and Synapse Formation","volume":"13","author":"Kopach","year":"2020","journal-title":"Pharmaceutics"},{"issue":"15","key":"10.1016\/j.physbeh.2022.113777_bib0060","doi-asserted-by":"crossref","first-page":"4181","DOI":"10.1113\/JP270934","article-title":"TRPM2 protects against tissue damage following oxidative stress and ischaemia-reperfusion","volume":"594","author":"Miller","year":"2016","journal-title":"The Journal of physiology"},{"issue":"6837","key":"10.1016\/j.physbeh.2022.113777_bib0061","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/35079100","article-title":"ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology","volume":"411","author":"Perraud","year":"2001","journal-title":"Nature"},{"issue":"41","key":"10.1016\/j.physbeh.2022.113777_bib0062","doi-asserted-by":"crossref","first-page":"27426","DOI":"10.1074\/jbc.M801049200","article-title":"Identification of pore residues engaged in determining divalent cationic permeation in transient receptor potential melastatin subtype channel 2","volume":"283","author":"Xia","year":"2008","journal-title":"The Journal of biological chemistry"},{"issue":"11","key":"10.1016\/j.physbeh.2022.113777_bib0063","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.4103\/1673-5374.282271","article-title":"Knocking down TRPM2 expression reduces cell injury and NLRP3 inflammasome activation in PC12 cells subjected to oxygen-glucose deprivation","volume":"15","author":"Pan","year":"2020","journal-title":"Neural regeneration research"},{"issue":"11","key":"10.1016\/j.physbeh.2022.113777_bib0064","doi-asserted-by":"crossref","first-page":"3395","DOI":"10.1161\/STROKEAHA.114.005836","article-title":"Transient receptor potential melastatin subfamily member 2 cation channel regulates detrimental immune cell invasion in ischemic stroke","volume":"45","author":"Gelderblom","year":"2014","journal-title":"Stroke"},{"issue":"11","key":"10.1016\/j.physbeh.2022.113777_bib0065","doi-asserted-by":"crossref","first-page":"e1541","DOI":"10.1038\/cddis.2014.494","article-title":"TRPM2 channel deficiency prevents delayed cytosolic Zn2+ accumulation and CA1 pyramidal neuronal death after transient global ischemia","volume":"5","author":"Ye","year":"2014","journal-title":"Cell death & disease"},{"issue":"7","key":"10.1016\/j.physbeh.2022.113777_bib0066","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1517\/14728222.2015.1021781","article-title":"Non-NMDAR neuronal Ca(2+)-permeable channels in delayed neuronal death and as potential therapeutic targets for ischemic brain damage","volume":"19","author":"Li","year":"2015","journal-title":"Expert opinion on therapeutic targets"},{"key":"10.1016\/j.physbeh.2022.113777_bib0067","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1756-6606-4-44","article-title":"Dependence of NMDA\/GSK-3\u03b2 mediated metaplasticity on TRPM2 channels at hippocampal CA3-CA1 synapses","volume":"4","author":"Xie","year":"2011","journal-title":"Molecular brain"},{"issue":"4","key":"10.1016\/j.physbeh.2022.113777_bib0068","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0216162","article-title":"Transcranial Doppler ultrasound in vascular cognitive impairment-no dementia","volume":"14","author":"Vinciguerra","year":"2019","journal-title":"PloS one"},{"issue":"2","key":"10.1016\/j.physbeh.2022.113777_bib0069","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.arr.2011.12.009","article-title":"Cerebrovascular hemodynamics in Alzheimer's disease and vascular dementia: a meta-analysis of transcranial Doppler studies","volume":"11","author":"Sabayan","year":"2012","journal-title":"Ageing research reviews"},{"key":"10.1016\/j.physbeh.2022.113777_bib0070","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.2741\/4459","article-title":"The neurobiology of acetyl-L-carnitine","volume":"21","author":"Traina","year":"2016","journal-title":"Frontiers in bioscience (Landmark edition)"},{"issue":"6","key":"10.1016\/j.physbeh.2022.113777_bib0071","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1007\/s11064-017-2288-7","article-title":"L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain","volume":"42","author":"Ferreira","year":"2017","journal-title":"Neurochemical research"},{"issue":"5","key":"10.1016\/j.physbeh.2022.113777_bib0072","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.3390\/nu12051389","article-title":"Acetyl-L-Carnitine in Dementia and Other Cognitive Disorders: A Critical Update","volume":"12","author":"Pennisi","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.physbeh.2022.113777_bib0073","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fnmol.2016.00010","article-title":"SNARE Protein Syntaxin-1 Colocalizes Closely with NMDA Receptor Subunit NR2B in Postsynaptic Spines in the Hippocampus","volume":"9","author":"Hussain","year":"2016","journal-title":"Frontiers in molecular neuroscience"},{"key":"10.1016\/j.physbeh.2022.113777_bib0074","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.expneurol.2017.06.023","article-title":"Transient receptor potential melastatin 2 channels (TRPM2) mediate neonatal hypoxic-ischemic brain injury in mice","volume":"296","author":"Huang","year":"2017","journal-title":"Experimental neurology"},{"issue":"2","key":"10.1016\/j.physbeh.2022.113777_bib0075","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/ana.410190202","article-title":"Glutamate and the pathophysiology of hypoxic\u2013ischemic brain damage","volume":"19","author":"Rothman","year":"1986","journal-title":"Annals of neurology"},{"issue":"2","key":"10.1016\/j.physbeh.2022.113777_bib0076","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/jnc.12304","article-title":"Deregulation of excitatory neurotransmission underlying synapse failure in Alzheimer's disease","volume":"126","author":"Paula-Lima","year":"2013","journal-title":"Journal of neurochemistry"},{"issue":"10","key":"10.1016\/j.physbeh.2022.113777_bib0077","doi-asserted-by":"crossref","first-page":"2568","DOI":"10.1016\/j.clinph.2021.05.035","article-title":"Diagnostic contribution and therapeutic perspectives of transcranial magnetic stimulation in dementia","volume":"132","author":"Di Lazzaro","year":"2021","journal-title":"Clinical neurophysiology: official journal of the International Federation of Clinical Neurophysiology"},{"key":"10.1016\/j.physbeh.2022.113777_bib0078","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8820881","article-title":"Evaluation and Treatment of Vascular Cognitive Impairment by Transcranial Magnetic Stimulation","volume":"2020","author":"Cantone","year":"2020","journal-title":"Neural plasticity"}],"container-title":["Physiology & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938422000841?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938422000841?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:23:21Z","timestamp":1758479001000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938422000841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":78,"alternative-id":["S0031938422000841"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2022.113777","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Floralozone improves cognitive impairment in vascular dementia rats via regulation of TRPM2 and NMDAR signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2022.113777","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113777"}}