{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T10:32:00Z","timestamp":1785148320758,"version":"3.55.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T00:00:00Z","timestamp":1657843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014440","name":"Espa\u00f1a Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PSI 2017\u201383023"],"award-info":[{"award-number":["PSI 2017\u201383023"]}],"id":[{"id":"10.13039\/100014440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["MCIN\/ AEI\/10.13039\/501100011033"],"award-info":[{"award-number":["MCIN\/ AEI\/10.13039\/501100011033"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["PID2020\u2013118945RB-I00"],"award-info":[{"award-number":["PID2020\u2013118945RB-I00"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology & Behavior"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.physbeh.2022.113916","type":"journal-article","created":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T03:15:36Z","timestamp":1657941336000},"page":"113916","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Intermittent voluntary wheel running promotes resilience to the negative consequences of repeated social defeat in mice"],"prefix":"10.1016","volume":"254","author":[{"given":"C.","family":"Calpe-L\u00f3pez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.A.","family":"Mart\u00ednez-Caballero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.P.","family":"Garc\u00eda-Pardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1935-6619","authenticated-orcid":false,"given":"M.A.","family":"Aguilar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.physbeh.2022.113916_bib0001","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1080\/08964289.2016.1170661","article-title":"Adapting to stress: understanding the neurobiology of resilience","volume":"43","author":"Os\u00f3rio","year":"2017","journal-title":"Behav. Med."},{"key":"10.1016\/j.physbeh.2022.113916_bib0002","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.pnpbp.2015.06.006","article-title":"Long-term effects of repeated social stress on the conditioned place preference induced by MDMA in mice","volume":"63","author":"Garc\u00eda-Pardo","year":"2015","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.physbeh.2022.113916_bib0003","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/adb.12184","article-title":"Social defeat in adolescent mice increases vulnerability to alcohol consumption","volume":"21","author":"Rodriguez-Arias","year":"2016","journal-title":"Addict. Biol."},{"issue":"4","key":"10.1016\/j.physbeh.2022.113916_bib0004","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s002130100858","article-title":"Repeated social-defeat stress, cocaine or morphine. Effects on behavioral sensitization and intravenous cocaine self-administration \u2018Binges\u2019","volume":"158","author":"Covington","year":"2001","journal-title":"Psychopharmacology (Berl.)"},{"issue":"7","key":"10.1016\/j.physbeh.2022.113916_bib0005","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1177\/0269881120965952","article-title":"Cannabidiol prevents priming-and stress-induced reinstatement of the conditioned place preference induced by cocaine in mice","volume":"35","author":"Calpe-L\u00f3pez","year":"2021","journal-title":"J. Psychopharmacol."},{"issue":"40","key":"10.1016\/j.physbeh.2022.113916_bib0006","doi-asserted-by":"crossref","first-page":"7009","DOI":"10.2174\/138161281940131209124708","article-title":"Impact of social stress in addiction to psychostimulants: what we know from animal models","volume":"19","author":"Aguilar","year":"2013","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.physbeh.2022.113916_bib0007","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3389\/fnbeh.2019.00278","article-title":"Behavioral traits associated with resilience to the effects of repeated social defeat on cocaine-induced conditioned place preference in mice","volume":"13","author":"Calpe-L\u00f3pez","year":"2020","journal-title":"Front. Behav. Neurosci."},{"issue":"1","key":"10.1016\/j.physbeh.2022.113916_bib0008","doi-asserted-by":"crossref","first-page":"e7830","DOI":"10.1590\/1414-431x20187830","article-title":"Voluntary wheel running: patterns and physiological effects in mice","volume":"52","author":"Manzanares","year":"2018","journal-title":"Braz. J. Med. Biol. Res."},{"key":"10.1016\/j.physbeh.2022.113916_bib0009","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.bbr.2016.06.049","article-title":"Parameters for abolishing conditioned place preference for cocaine from running and environmental enrichment in male C57BL\/6\u00a0J mice","volume":"312","author":"Mustroph","year":"2016","journal-title":"Behav. Brain Res."},{"issue":"9","key":"10.1016\/j.physbeh.2022.113916_bib0010","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1038\/s41386-018-0103-z","article-title":"Voluntary wheel running promotes resilience to chronic social defeat stress in mice: a role for nucleus accumbens DeltaFosB","volume":"43","author":"Mul","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.physbeh.2022.113916_bib0011","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3389\/fnins.2019.00256","article-title":"Voluntary wheel running reverses deficits in social behavior induced by chronic social defeat stress in mice: involvement of the dopamine system","volume":"13","author":"Zhang","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.physbeh.2022.113916_bib0012","doi-asserted-by":"crossref","DOI":"10.1016\/j.drugalcdep.2020.108004","article-title":"Voluntary wheel running protects against the increase in ethanol consumption induced by social stress in mice","volume":"212","author":"Reguilon","year":"2020","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.physbeh.2022.113916_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/S0924-977X(97)00051-5","article-title":"Effects of risperidone and SCH 23390 on isolation-induced aggression in male mice","volume":"8","author":"Rodr\u00edguez-Arias","year":"1998","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.physbeh.2022.113916_bib0014","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.bbr.2018.12.025","article-title":"Role of N-methyl-D-aspartate receptors in the long-term effects of repeated social defeat stress on the rewarding and psychomotor properties of cocaine in mice","volume":"361","author":"Garc\u00eda-Pardo","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2022.113916_bib0015","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1126\/science.7199758","article-title":"Opioid-like analgesia in defeated mice","volume":"215","author":"Miczek","year":"1982","journal-title":"Science"},{"key":"10.1016\/j.physbeh.2022.113916_bib0016","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s00213-006-0345-z","article-title":"Social stress is as effective as physical stress in reinstating morphine-induced place preference in mice","volume":"185","author":"Ribeiro Do Couto","year":"2006","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.physbeh.2022.113916_bib0017","series-title":"Psychopharmacology","first-page":"687","article-title":"Drug effects on social behaviors","author":"Brain","year":"1989"},{"issue":"13","key":"10.1016\/j.physbeh.2022.113916_bib0018","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1007\/s00213-017-4612-y","article-title":"Repeated social defeat and the rewarding effects of cocaine in adult and adolescent mice: dopamine transcription factors, proBDNF signaling pathways, and the TrkB receptor in the mesolimbic system","volume":"234","author":"Montagud-Romero","year":"2017","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.physbeh.2022.113916_bib0019","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0091-3057(95)00138-M","article-title":"Factor analysis of spatiotemporal and ethological measures in the murine plus-maze test of anxiety","volume":"52","author":"Rodgers","year":"1995","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2022.113916_bib0020","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0149-7634(96)00058-9","article-title":"Anxiety, defence and the elevated plus-maze","volume":"21","author":"Rodgers","year":"1997","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.physbeh.2022.113916_bib0021","doi-asserted-by":"crossref","first-page":"S101","DOI":"10.1590\/1516-4446-2013-1139","article-title":"Animal models of anxiety disorders and stress","volume":"35","author":"Campos","year":"2013","journal-title":"Braz. J. Psychiatry"},{"key":"10.1016\/j.physbeh.2022.113916_bib0022","doi-asserted-by":"crossref","first-page":"e78317","DOI":"10.1371\/journal.pone.0078317","article-title":"Enhancement of behavioral sensitization, anxiety-like behavior, and hippocampal and frontal cortical CREB levels following cocaine abstinence in mice exposed to cocaine during adolescence","volume":"8","author":"Valzachi","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.physbeh.2022.113916_bib0023","doi-asserted-by":"crossref","first-page":"364","DOI":"10.3389\/fnbeh.2015.00364","article-title":"Ethological evaluation of the effects of social defeat stress in mice: beyond the social interaction ratio","volume":"9","author":"Henriques-Alves","year":"2016","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.physbeh.2022.113916_bib0024","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.cell.2007.09.018","article-title":"Molecular adaptations underlying susceptibility and resistance to social defeat in brain reward regions","volume":"131","author":"Krishnan","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.physbeh.2022.113916_bib0025","series-title":"Mood and Anxiety Related Phenotypes in Mice. Neuromethods","first-page":"21","article-title":"Analysis of grooming behavior and its utility in studying animal stress, anxiety and depression","author":"Smolinsky","year":"2009"},{"key":"10.1016\/j.physbeh.2022.113916_bib0026","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3109\/07853891003769957","article-title":"Rodent models in depression research: classical strategies and new directions","volume":"42","author":"Pollak","year":"2010","journal-title":"Ann. Med."},{"key":"10.1016\/j.physbeh.2022.113916_bib0027","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.neubiorev.2005.03.009","article-title":"The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice","volume":"29","author":"Cryan","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.physbeh.2022.113916_bib0028","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s002130050475","article-title":"Individual differences in response to imipramine in the mouse tail suspension test","volume":"134","author":"Vaugeois","year":"1997","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.physbeh.2022.113916_bib0029","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.pnpbp.2007.02.012","article-title":"Effect of memantine and CNQX in the acquisition, expression and reinstatement of cocaine-induced conditioned place preference","volume":"31","author":"Maldonado","year":"2007","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.physbeh.2022.113916_bib0030","first-page":"469","article-title":"The influence of social stress on the reinforcing effect of ecstasy under the conditioned place preference paradigm: the role played by age, dose and type of stress","volume":"65","author":"Garc\u00eda-Pardo","year":"2017","journal-title":"Rev. Neurol."},{"key":"10.1016\/j.physbeh.2022.113916_bib0031","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.yhbeh.2017.10.007","article-title":"Consequences of continuous social defeat stress on anxiety- and depressive-like behaviors and ethanol reward in mice","volume":"97","author":"Macedo","year":"2018","journal-title":"Horm. Behav."},{"issue":"3","key":"10.1016\/j.physbeh.2022.113916_bib0032","doi-asserted-by":"crossref","first-page":"247","DOI":"10.3109\/10253890.2014.910650","article-title":"Social defeat stress induces a depression-like phenotype in adolescent male c57BL\/6 mice","volume":"17","author":"Iniguez","year":"2014","journal-title":"Stress"},{"issue":"12","key":"10.1016\/j.physbeh.2022.113916_bib0033","doi-asserted-by":"crossref","first-page":"pyw080","DOI":"10.1093\/ijnp\/pyw080","article-title":"Antidepressant effects of (+)-MK-801 and (-)-MK-801 in the social defeat stress model","volume":"19","author":"Yang","year":"2016","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.physbeh.2022.113916_bib0034","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0173182","article-title":"Indomethacin counteracts the effects of chronic social defeat stress on emotional but not recognition memory in mice","volume":"12","author":"Duque","year":"2017","journal-title":"PLoS ONE"},{"issue":"4","key":"10.1016\/j.physbeh.2022.113916_bib0035","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/s41386-018-0295-2","article-title":"A diet enriched with curcumin promotes resilience to chronic social defeat stress","volume":"44","author":"Aubry","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.physbeh.2022.113916_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynstr.2019.100170","article-title":"Branched-chain amino acids mediate resilience to chronic social defeat stress by activating BDNF\/TRKB signaling","volume":"11","author":"Nasrallah","year":"2019","journal-title":"Neurobiol. Stress"},{"key":"10.1016\/j.physbeh.2022.113916_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117669","article-title":"Ginsenoside Rg1 ameliorates chronic social defeat stress-induced depressive-like behaviors and hippocampal neuroinflammation","volume":"252","author":"Jiang","year":"2020","journal-title":"Life Sci"},{"issue":"3","key":"10.1016\/j.physbeh.2022.113916_bib0038","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1037\/bne0000418","article-title":"Chronic social defeat stress mouse model: current view on its behavioral deficits and modifications","volume":"135","author":"Wang","year":"2021","journal-title":"Behav. Neurosci."},{"issue":"1","key":"10.1016\/j.physbeh.2022.113916_bib0039","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12974-022-02400-6","article-title":"Edaravone ameliorates depressive and anxiety-like behaviors via Sirt1\/Nrf2\/HO-1\/Gpx4 pathway","volume":"19","author":"Dang","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"7","key":"10.1016\/j.physbeh.2022.113916_bib0040","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1210\/en.2003-0097","article-title":"Effects of long-term voluntary exercise on the mouse hypothalamic-pituitary-adrenocortical axis","volume":"144","author":"Droste","year":"2003","journal-title":"Endocrinology"},{"issue":"3","key":"10.1016\/j.physbeh.2022.113916_bib0041","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/hipo.20634","article-title":"Voluntary exercise induces anxiety-like behavior in adult C57BL\/6\u00a0J mice correlating with hippocampal neurogenesis","volume":"20","author":"Fuss","year":"2010","journal-title":"Hippocampus"},{"key":"10.1016\/j.physbeh.2022.113916_bib0042","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.physbeh.2018.02.003","article-title":"Voluntary exercise increases resilience to social defeat stress in Syrian hamsters","volume":"188","author":"Kingston","year":"2018","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2022.113916_bib0043","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.physbeh.2014.03.016","article-title":"Moderate treadmill exercise rescues anxiety and depression-like behavior as well as memory impairment in a rat model of posttraumatic stress disorder","volume":"130","author":"Patki","year":"2014","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2022.113916_bib0044","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/ilar\/ilu002","article-title":"Social defeat as an animal model for depression","volume":"55","author":"Hollis","year":"2014","journal-title":"ILAR J"},{"key":"10.1016\/j.physbeh.2022.113916_bib0045","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2021.734054","article-title":"Chronic social defeat during adolescence induces short- and long-term behavioral and neuroendocrine effects in male Swiss-webster mice","volume":"15","author":"Mancha-Gutierrez","year":"2021","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.physbeh.2022.113916_bib0046","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.825522","article-title":"Brief maternal separation inoculates against the effects of social stress on depression-like behavior and cocaine reward in mice","volume":"13","author":"Calpe-L\u00f3pez","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.physbeh.2022.113916_bib0047","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.physbeh.2015.07.024","article-title":"Voluntary exercise and increased food intake after mild chronic stress improve social avoidance behavior in mice","volume":"151","author":"Otsuka","year":"2015","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2022.113916_bib0048","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.neuroscience.2019.12.037","article-title":"Therapeutic and preventive effect of voluntary running wheel exercise on social defeat stress (SDS)-induced depressive-like behavior and chronic pain in mice","volume":"428","author":"Pagliusi","year":"2020","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2022.113916_bib0049","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.pnpbp.2017.04.018","article-title":"Prior treadmill exercise promotes resilience to vicarious trauma in rats","volume":"77","author":"Kochi","year":"2017","journal-title":"Progr. Neuro-psychopharmacol. Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.physbeh.2022.113916_bib0050","doi-asserted-by":"crossref","first-page":"24","DOI":"10.5498\/wjp.v12.i1.24","article-title":"Resilience to the effects of social stress on vulnerability to developing drug addiction","volume":"12","author":"Calpe-L\u00f3pez","year":"2022","journal-title":"World J. Psychiatry"},{"issue":"5","key":"10.1016\/j.physbeh.2022.113916_bib0051","first-page":"242","article-title":"Effects of social stress on ethanol responsivity in adult mice","volume":"6","author":"Garc\u00eda-Pardo","year":"2016","journal-title":"Neuropsychiatry"},{"issue":"2","key":"10.1016\/j.physbeh.2022.113916_bib0052","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1590\/2237-6089-2014-0034","article-title":"Social defeat protocol and relevant biomarkers, implications for stress response physiology, drug abuse, mood disorders and individual stress vulnerability: a systematic review of the last decade","volume":"37","author":"Vasconcelos","year":"2015","journal-title":"Trends Psychiatry Psychother"},{"key":"10.1016\/j.physbeh.2022.113916_bib0053","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/bs.irn.2018.07.005","article-title":"Animal models of the impact of social stress on cocaine use disorders","volume":"140","author":"Vannan","year":"2018","journal-title":"Int. Rev. Neurobiol."},{"issue":"7","key":"10.1016\/j.physbeh.2022.113916_bib0054","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1111\/j.1460-9568.2011.07828.x","article-title":"Wheel running can accelerate or delay extinction of conditioned place preference for cocaine in male C57BL\/6\u00a0J mice, depending on timing of wheel access","volume":"34","author":"Mustroph","year":"2011","journal-title":"Eur. J. Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.physbeh.2022.113916_bib0055","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.drugalcdep.2008.05.006","article-title":"Aerobic exercise decreases the positive-reinforcing effects of cocaine","volume":"98","author":"Smith","year":"2008","journal-title":"Drug Alcohol Depend."},{"issue":"8","key":"10.1016\/j.physbeh.2022.113916_bib0056","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1007\/s00213-014-3778-9","article-title":"The effects of post-extinction exercise on cocaine-primed and stress-induced reinstatement of cocaine seeking in rats","volume":"232","author":"Ogbonmwan","year":"2015","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.physbeh.2022.113916_bib0057","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.bbr.2019.03.002","article-title":"No evidence that wheel-running exercise impacts cocaine conditioned place preference in male C57BL\/6\u00a0J mice","volume":"365","author":"Lespine","year":"2019","journal-title":"Behav. Brain Res."},{"issue":"2","key":"10.1016\/j.physbeh.2022.113916_bib0058","doi-asserted-by":"crossref","first-page":"e12700","DOI":"10.1111\/gbb.12700","article-title":"Conditioned place preference for cocaine and methylphenidate in female mice from lines selectively bred for high voluntary wheel-running behavior","volume":"20","author":"Schmill","year":"2021","journal-title":"Genes, Brain, Behav"},{"issue":"6","key":"10.1016\/j.physbeh.2022.113916_bib0059","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1007\/s40279-018-0898-0","article-title":"Behavioral and neural evidence of the rewarding value of exercise behaviors: a systematic review","volume":"48","author":"Cheval","year":"2018","journal-title":"Sports Med"},{"key":"10.1016\/j.physbeh.2022.113916_bib0060","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.pnpbp.2016.07.008","article-title":"Role of dopamine neurotransmission in the long-term effects of repeated social defeat on the conditioned rewarding effects of cocaine","volume":"71","author":"Montagud-Romero","year":"2016","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.physbeh.2022.113916_bib0061","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/adb.12301","article-title":"Effects of repeated social defeat on adolescent mice on cocaine-induced CPP and self-administration in adulthood: integrity of the blood-brain barrier","volume":"22","author":"Rodr\u00edguez-Arias","year":"2017","journal-title":"Addict. Biol."},{"key":"10.1016\/j.physbeh.2022.113916_bib0062","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.neuropharm.2013.03.019","article-title":"Reward and aversion in a heterogeneous midbrain dopamine system","volume":"76","author":"Lammel","year":"2014","journal-title":"Neuropharmacology"},{"issue":"15","key":"10.1016\/j.physbeh.2022.113916_bib0063","article-title":"The master neurotransmitter and its implications in chronic stress and mood disorders","volume":"29","author":"Pal","year":"2021","journal-title":"Front. Hum. Neurosci."},{"key":"10.1016\/j.physbeh.2022.113916_bib0064","first-page":"1","article-title":"Dopaminergic and glutamatergic biomarkers disruption in addiction and regulation by exercise: a mini review","author":"Abdullah","year":"2022","journal-title":"Biomarkers"},{"issue":"3","key":"10.1016\/j.physbeh.2022.113916_bib0065","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1093\/icb\/45.3.438","article-title":"Neurobiology of mice selected for high voluntary wheel-running activity","volume":"45","author":"Rhodes","year":"2005","journal-title":"Integr. Comp. Biol."},{"issue":"5","key":"10.1016\/j.physbeh.2022.113916_bib0066","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.cmet.2013.09.008","article-title":"Exercise induces hippocampal BDNF through a PGC-1alpha\/FNDC5 pathway","volume":"18","author":"Wrann","year":"2013","journal-title":"Cell Metab."},{"issue":"13","key":"10.1016\/j.physbeh.2022.113916_bib0067","first-page":"2369","article-title":"Lactate mediates the effects of exercise on learning and memory through SIRT1-dependent activation of hippocampal brain-derived neurotrophic factor (BDNF)","volume":"39","author":"El Hayek","year":"2019","journal-title":"J. Neurosci."},{"issue":"6","key":"10.1016\/j.physbeh.2022.113916_bib0068","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/s41386-019-0313-z","article-title":"Lactate is an antidepressant that mediates resilience to stress by modulating the hippocampal levels and activity of histone deacetylases","volume":"44","author":"Karnib","year":"2019","journal-title":"Neuropsychopharmacology"}],"container-title":["Physiology & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938422002220?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938422002220?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:27:10Z","timestamp":1758479230000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938422002220"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":68,"alternative-id":["S0031938422002220"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2022.113916","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intermittent voluntary wheel running promotes resilience to the negative consequences of repeated social defeat in mice","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2022.113916","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"113916"}}