{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T20:59:48Z","timestamp":1774558788462,"version":"3.50.1"},"reference-count":116,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.physbeh.2022.114000","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T12:16:06Z","timestamp":1666095366000},"page":"114000","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Investigating a role of orexin and \u2018cocaine- and amphetamine-regulated transcript\u2019 in the nucleus accumbens shell in binge eating of male rats and the relationship with impulsivity"],"prefix":"10.1016","volume":"257","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1106-4398","authenticated-orcid":false,"given":"Julia","family":"Schuller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Koch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2022.114000_bib0001","series-title":"Diagnostic and Statistical Manual of Mental Disorders","year":"2013"},{"key":"10.1016\/j.physbeh.2022.114000_bib0002","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pharmthera.2017.08.002","article-title":"Binge-eating disorder: clinical and therapeutic advances","volume":"182","author":"Hutson","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.physbeh.2022.114000_bib0003","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1097\/YCO.0000000000000278","article-title":"Epidemiology of eating disorders in Europe","volume":"29","author":"Keski-Rahkonen","year":"2016","journal-title":"Curr. Opin. Psychiatry"},{"key":"10.1016\/j.physbeh.2022.114000_bib0004","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.mcna.2019.02.003","article-title":"Update on binge eating disorder","volume":"103","author":"Guerdjikova","year":"2019","journal-title":"Med. Clin. North Am."},{"key":"10.1016\/j.physbeh.2022.114000_bib0005","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.psc.2017.01.003","article-title":"Binge eating disorder","volume":"40","author":"Guerdjikova","year":"2017","journal-title":"Psychiatr. Clin. North Am."},{"key":"10.1016\/j.physbeh.2022.114000_bib0006","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.biopsych.2006.03.040","article-title":"The prevalence and correlates of eating disorders in the national comorbidity survey replication","volume":"61","author":"Hudson","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.physbeh.2022.114000_bib0007","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.psc.2019.01.010","article-title":"Medical complications of binge eating disorder","volume":"42","author":"Wassenaar","year":"2019","journal-title":"Psychiatr. Clin. North Am."},{"key":"10.1016\/j.physbeh.2022.114000_bib0008","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s12888-016-0840-7","article-title":"Treatment-seeking patients with binge-eating disorder in the Swedish national registers: clinical course and psychiatric comorbidity","volume":"16","author":"Welch","year":"2016","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.physbeh.2022.114000_bib0009","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1097\/YCO.0000000000000641","article-title":"Review of the burden of eating disorders: mortality, disability, costs, quality of life, and family burden","volume":"33","author":"van Hoeken","year":"2020","journal-title":"Curr. Opin. Psychiatry"},{"key":"10.1016\/j.physbeh.2022.114000_bib0010","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/S2215-0366(21)00040-7","article-title":"The hidden burden of eating disorders: an extension of estimates from the Global Burden of Disease Study 2019","volume":"8","author":"Santomauro","year":"2021","journal-title":"The Lancet Psychiatry"},{"key":"10.1016\/j.physbeh.2022.114000_bib0011","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.biopsych.2012.11.020","article-title":"The prevalence and correlates of binge eating disorder in the world health organization world mental health surveys","volume":"73","author":"Kessler","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.physbeh.2022.114000_bib0012","doi-asserted-by":"crossref","unstructured":"J. Treasure, Eating disorders, Medicine (Baltimore). 44 (2016) 672\u2013678. 10.1016\/J.MPMED.2016.08.001.","DOI":"10.1016\/j.mpmed.2016.08.001"},{"key":"10.1016\/j.physbeh.2022.114000_bib0013","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1002\/eat.22409","article-title":"Incidence and weight trajectories of binge eating disorder among young women in the community","volume":"48","author":"Mustelin","year":"2015","journal-title":"Int. J. Eat. Disord."},{"key":"10.1016\/j.physbeh.2022.114000_bib0014","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.comppsych.2006.08.002","article-title":"Prevalence and correlates of binge eating disorder in a community sample","volume":"48","author":"Grucza","year":"2007","journal-title":"Compr. Psychiatry"},{"key":"10.1016\/j.physbeh.2022.114000_bib0015","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1002\/eat.20599","article-title":"DSM-IV psychiatric disorder comorbidity and its correlates in binge eating disorder","volume":"42","author":"Grilo","year":"2009","journal-title":"Int. J. Eat. Disord."},{"key":"10.1016\/j.physbeh.2022.114000_bib0016","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.appet.2016.11.032","article-title":"Prevalence and correlates of binge eating disorder related features in the community","volume":"109","author":"Mustelin","year":"2017","journal-title":"Appetite"},{"key":"10.1016\/j.physbeh.2022.114000_bib0017","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.3390\/nu9111170","article-title":"Food-related impulsivity in obesity and binge eating disorder\u2014a systematic update of the evidence","volume":"9","author":"Giel","year":"2017","journal-title":"Nutrients"},{"key":"10.1016\/j.physbeh.2022.114000_bib0018","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1017\/S1092852920001674","article-title":"General impulsivity in binge-eating disorder","volume":"26","author":"Boswell","year":"2021","journal-title":"CNS Spectr."},{"key":"10.1016\/j.physbeh.2022.114000_bib0019","first-page":"1","article-title":"From passive overeating to \u201cfood addiction\u201d: a spectrum of compulsion and severity","author":"Davis","year":"2013","journal-title":"ISRN Obes."},{"key":"10.1016\/j.physbeh.2022.114000_bib0020","doi-asserted-by":"crossref","first-page":"8225","DOI":"10.1038\/s41598-021-87231-w","article-title":"Food-related impulsivity assessed by longitudinal laboratory tasks is reduced in patients with binge eating disorder in a randomized controlled trial","volume":"11","author":"Schag","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.physbeh.2022.114000_bib0021","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1002\/eat.20441","article-title":"Test meal intake in obese binge eaters in relation to impulsivity and compulsivity","volume":"40","author":"Galanti","year":"2007","journal-title":"Int. J. Eat. Disord."},{"key":"10.1016\/j.physbeh.2022.114000_bib0022","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1371\/journal.pone.0076542","article-title":"Impulsivity in binge eating disorder: food cues elicit increased reward responses and disinhibition","volume":"8","author":"Schag","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.physbeh.2022.114000_bib0023","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/ijo.2014.99","article-title":"Attentional impulsivity in binge eating disorder modulates response inhibition performance and frontal brain networks","volume":"39","author":"Hege","year":"2015","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.physbeh.2022.114000_bib0024","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.appet.2004.04.006","article-title":"Impulsivity and test meal intake in obese binge eating women","volume":"43","author":"Nasser","year":"2004","journal-title":"Appetite"},{"key":"10.1016\/j.physbeh.2022.114000_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.paid.2019.109538","article-title":"Which came first? Exploring the reciprocal relations between impulsivity and binge eating","volume":"151","author":"Mushquash","year":"2019","journal-title":"Pers. Individ. Dif."},{"key":"10.1016\/j.physbeh.2022.114000_bib0026","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.neuron.2011.01.020","article-title":"Impulsivity, compulsivity, and top-down cognitive control","volume":"69","author":"Dalley","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.physbeh.2022.114000_bib0027","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.appet.2015.10.025","article-title":"Slowing down and taking a second look: inhibitory deficits associated with binge eating are not food-specific","volume":"96","author":"Manasse","year":"2016","journal-title":"Appetite"},{"key":"10.1016\/j.physbeh.2022.114000_bib0028","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/13651501.2019.1687724","article-title":"Neurocognitive findings in young adults with binge eating disorder","volume":"24","author":"Grant","year":"2020","journal-title":"Int. J. Psychiatry Clin. Pract."},{"key":"10.1016\/j.physbeh.2022.114000_bib0029","first-page":"1448","article-title":"Nutritional and neuropsychological profile of the executive functions on binge eating disorder in obese adults","volume":"34","author":"C\u00f3rdova","year":"2017","journal-title":"Nutr. Hosp."},{"key":"10.1016\/j.physbeh.2022.114000_bib0030","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.appet.2011.04.023","article-title":"Cognitive deficits in obese persons with and without binge eating disorder. Investigation using a mental flexibility task","volume":"57","author":"Mobbs","year":"2011","journal-title":"Appetite"},{"key":"10.1016\/j.physbeh.2022.114000_bib0031","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1002\/eat.22260","article-title":"General and food-specific inhibitory deficits in binge eating disorder","volume":"47","author":"Svaldi","year":"2014","journal-title":"Int. J. Eat. Disord."},{"key":"10.1016\/j.physbeh.2022.114000_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2021.102679","article-title":"Diminished prefrontal cortex activation in patients with binge eating disorder associates with trait impulsivity and improves after impulsivity-focused treatment based on a randomized controlled IMPULS trial","volume":"30","author":"Veit","year":"2021","journal-title":"NeuroImage Clin."},{"key":"10.1016\/j.physbeh.2022.114000_bib0033","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1002\/oby.20068","article-title":"Divergent neural substrates of inhibitory control in binge eating disorder relative to other manifestations of obesity","volume":"21","author":"Balodis","year":"2013","journal-title":"Obesity (Silver Spring)"},{"key":"10.1016\/j.physbeh.2022.114000_bib0034","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/brainsci11010019","article-title":"Evidence of fNIRS-based prefrontal cortex hypoactivity in obesity and binge-eating disorder","volume":"11","author":"R\u00f6sch","year":"2020","journal-title":"Brain Sci"},{"key":"10.1016\/j.physbeh.2022.114000_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.beproc.2016.08.011","article-title":"Delay discounting predicts binge-eating in Wistar rats","volume":"132","author":"Cano","year":"2016","journal-title":"Behav. Processes."},{"key":"10.1016\/j.physbeh.2022.114000_bib0036","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1177\/0269881117691672","article-title":"Investigation of impulsivity in binge-eating rats in a delay-discounting task and its prevention by the D-amphetamine prodrug, lisdexamfetamine","volume":"31","author":"Vickers","year":"2017","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.physbeh.2022.114000_bib0037","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1038\/s41386-019-0394-8","article-title":"Convergent neural connectivity in motor impulsivity and high-fat food binge-like eating in male Sprague-Dawley rats","volume":"44","author":"Anastasio","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.physbeh.2022.114000_bib0038","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1159\/000354599","article-title":"Effect of BMI and binge eating on food reward and energy intake: further evidence for a binge eating subtype of obesity","volume":"6","author":"Dalton","year":"2013","journal-title":"Obes. Facts"},{"key":"10.1016\/j.physbeh.2022.114000_bib0039","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/eat.22171","article-title":"Hedonic hunger and binge eating among women with eating disorders","volume":"47","author":"Witt","year":"2014","journal-title":"Int. J. Eat. Disord."},{"key":"10.1016\/j.physbeh.2022.114000_bib0040","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.physbeh.2018.02.011","article-title":"Homeostatic and non-homeostatic controls of feeding behavior: distinct vs. common neural systems","volume":"193","author":"Liu","year":"2018","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2022.114000_bib0041","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1111\/jnc.15328","article-title":"Orexins (hypocretins): the intersection between homeostatic and hedonic feeding","volume":"157","author":"Muthmainah","year":"2021","journal-title":"J. Neurochem."},{"key":"10.1016\/j.physbeh.2022.114000_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2021.170534","article-title":"Demystifying functional role of cocaine- and amphetamine-related transcript (CART) peptide in control of energy homeostasis: a twenty-five year expedition","volume":"140","author":"Singh","year":"2021","journal-title":"Peptides"},{"key":"10.1016\/j.physbeh.2022.114000_bib0043","doi-asserted-by":"crossref","first-page":"11777","DOI":"10.1523\/JNEUROSCI.2329-05.2005","article-title":"Hedonic hot spot in nucleus accumbens shell: where do mu-opioids cause increased hedonic impact of sweetness?","volume":"25","author":"Peci\u00f1a","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.physbeh.2022.114000_bib0044","first-page":"500","article-title":"Hedonic hot spots in the brain","volume":"12","author":"Peci\u00f1a","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2022.114000_bib0045","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/s41366-018-0133-y","article-title":"Reward-representing D1-type neurons in the medial shell of the accumbens nucleus regulate palatable food intake","volume":"43","author":"Durst","year":"2019","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.physbeh.2022.114000_bib0046","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.neuron.2011.02.016","article-title":"Reward mechanisms in obesity: new insights and future directions","volume":"69","author":"Kenny","year":"2011","journal-title":"Neuron"},{"key":"10.1016\/j.physbeh.2022.114000_bib0047","doi-asserted-by":"crossref","unstructured":"D.C. Castro, R.A. Terry, K.C. Berridge, Orexin in Rostral Hotspot of Nucleus Accumbens Enhances Sucrose \u2018Liking\u2019 and Intake but Scopolamine in Caudal Shell Shifts \u2018Liking\u2019 Toward \u2018Disgust\u2019 and \u2018Fear,\u2019 Neuropsychopharmacology. 41 (2016) 2101\u20132111. 10.1038\/npp.2016.10.","DOI":"10.1038\/npp.2016.10"},{"key":"10.1016\/j.physbeh.2022.114000_bib0048","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.peptides.2003.12.014","article-title":"Functional opioid pathways are necessary for hypocretin-1 (orexin-A)-induced feeding","volume":"25","author":"Sweet","year":"2004","journal-title":"Peptides"},{"key":"10.1016\/j.physbeh.2022.114000_bib0049","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.neuroscience.2005.03.023","article-title":"Cocaine- and amphetamine-regulated transcript in the nucleus accumbens participates in the regulation of feeding behavior in rats","volume":"133","author":"Yang","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2022.114000_bib0050","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/npp.2017.158","article-title":"Effects of suvorexant, a dual orexin\/hypocretin receptor antagonist, on impulsive behavior associated with cocaine","volume":"43","author":"Gentile","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.physbeh.2022.114000_bib0051","doi-asserted-by":"crossref","first-page":"E1648","DOI":"10.1073\/pnas.1315542111","article-title":"Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area","volume":"111","author":"Muschamp","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.physbeh.2022.114000_bib0052","unstructured":"J. Schuller, M. Koch, Blockade of the orexin 1-receptors and ..\u00a0cocaine- and amphetamine-regulated transcript... in the nucleus accumbens shell alters impulse control in rats, Behav. Brain Res. Submitted for publication."},{"key":"10.1016\/j.physbeh.2022.114000_bib0053","article-title":"Binge eating in rats with limited access to vegetable shortening","volume":"9","author":"Corwin","year":"2006","journal-title":"Curr. Protoc. Neurosci"},{"key":"10.1016\/j.physbeh.2022.114000_bib0054","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1007\/s00213-002-1154-7","article-title":"The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry","volume":"163","author":"Robbins","year":"2002","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.physbeh.2022.114000_bib0055","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1126\/science.1137073","article-title":"Nucleus accumbens D2\/3 receptors predict trait impulsivity and cocaine reinforcement","volume":"315","author":"Dalley","year":"2007","journal-title":"Science"},{"key":"10.1016\/j.physbeh.2022.114000_bib0056","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00213-010-1974-9","article-title":"Trait-like impulsivity does not predict escalation of heroin self-administration in the rat","volume":"212","author":"McNamara","year":"2010","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.physbeh.2022.114000_bib0057","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.physbeh.2022.114000_bib0058","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods."},{"key":"10.1016\/j.physbeh.2022.114000_bib0059","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/mrd.22489","article-title":"The ImageJ ecosystem: an open platform for biomedical image analysis","volume":"82","author":"Schindelin","year":"2015","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.physbeh.2022.114000_bib0060","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.physbeh.2022.114000_bib0061","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/eat.22139","article-title":"Sex differences in binge eating patterns in male and female adult rats","volume":"46","author":"Klump","year":"2013","journal-title":"Int. J. Eat. Disord."},{"key":"10.1016\/j.physbeh.2022.114000_bib0062","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1038\/s41467-022-29903-3","article-title":"An analysis of neuroscience and psychiatry papers published from 2009 to 2019 outlines opportunities for increasing discovery of sex differences","volume":"13","author":"Rechlin","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.physbeh.2022.114000_bib0063","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.bbr.2008.09.021","article-title":"Behavioural characterisation of high impulsivity on the 5-choice serial reaction time task: specific deficits in \u2018waiting\u2019 versus \u2018stopping,\u2019","volume":"196","author":"Robinson","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2022.114000_bib0064","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2020.113260","article-title":"Effects of a high-fat diet on impulsive choice in rats","volume":"229","author":"Garman","year":"2021","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2022.114000_bib0065","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3945\/jn.108.097584","article-title":"Sugar and fat bingeing have notable differences in addictive-like behavior","volume":"79793","author":"Avena","year":"2009","journal-title":"J. Nutr."},{"key":"10.1016\/j.physbeh.2022.114000_bib0066","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.neubiorev.2007.04.019","article-title":"Evidence for sugar addiction: behavioral and neurochemical effects of intermittent, excessive sugar intake","volume":"32","author":"Avena","year":"2008","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.physbeh.2022.114000_bib0067","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.physbeh.2005.07.020","article-title":"Baclofen reduces fat intake under binge-type conditions","volume":"86","author":"Buda-Levin","year":"2005","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2022.114000_bib0068","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1097\/FBP.0b013e328331ba47","article-title":"Baclofen suppresses binge eating of pure fat but not a sugar-rich or sweet\u2013fat diet","volume":"20","author":"Berner","year":"2009","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.physbeh.2022.114000_bib0069","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1097\/FBP.0b013e3283313168","article-title":"Baclofen, raclopride, and naltrexone differentially affect intake of fat and sucrose under limited access conditions","volume":"20","author":"Corwin","year":"2009","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.physbeh.2022.114000_bib0070","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.biopsych.2007.07.011","article-title":"Impulsive choice and impulsive action predict vulnerability to distinct stages of nicotine seeking in rats","volume":"63","author":"Diergaarde","year":"2008","journal-title":"Biol. Psychiatry."},{"key":"10.1016\/j.physbeh.2022.114000_bib0071","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1126\/science.1158136","article-title":"High impulsivity predicts the switch to compulsive cocaine-taking","volume":"320","author":"Belin","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.physbeh.2022.114000_bib0072","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1038\/npp.2014.98","article-title":"High trait impulsivity predicts food addiction-like behavior in the rat","volume":"39","author":"Vel\u00e1zquez-S\u00e1nchez","year":"2014","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.physbeh.2022.114000_bib0073","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2174\/1874473711104030201","article-title":"Binge eating disorder and food addiction","volume":"4","author":"Gearhardt","year":"2011","journal-title":"Curr. Drug Abus. Rev."},{"key":"10.1016\/j.physbeh.2022.114000_bib0074","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1046\/j.0953-816x.2001.01518.x","article-title":"SB-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-A in rats","volume":"13","author":"Rodgers","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.physbeh.2022.114000_bib0075","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0167-0115(00)00199-3","article-title":"A selective orexin-1 receptor antagonist reduces food consumption in male and female rats","volume":"96","author":"Haynes","year":"2000","journal-title":"Regul. Pept."},{"key":"10.1016\/j.physbeh.2022.114000_bib0076","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.brainres.2005.05.045","article-title":"Orexin A in the nucleus accumbens stimulates feeding and locomotor activity","volume":"1050","author":"Thorpe","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2022.114000_bib0077","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0167-0115(01)00358-5","article-title":"Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob\/ob mice","volume":"104","author":"Haynes","year":"2002","journal-title":"Regul. Pept."},{"issue":"1","key":"10.1016\/j.physbeh.2022.114000_bib0078","article-title":"Effect of Orexin A antagonist (SB-334867) infusion into the nucleus accumbens on consummatory behavior and alcohol preference in Wistar rats","volume":"48","author":"Mayannavar","year":"2016","journal-title":"Indian J. Pharmacol."},{"key":"10.1016\/j.physbeh.2022.114000_bib0079","doi-asserted-by":"crossref","first-page":"11075","DOI":"10.1523\/JNEUROSCI.3542-07.2007","article-title":"Orexin signaling in the ventral tegmental area is required for high-fat appetite induced by opioid stimulation of the nucleus accumbens","volume":"27","author":"Zheng","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.physbeh.2022.114000_bib0080","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.bbr.2004.07.012","article-title":"Anorexia and weight loss in male rats 24\u00a0h following single dose treatment with orexin-1 receptor antagonist SB-334867","volume":"157","author":"Ishii","year":"2005","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2022.114000_bib0081","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1016\/j.peptides.2005.03.042","article-title":"Effect of a selective OX1R antagonist on food intake and body weight in two strains of rats that differ in susceptibility to dietary-induced obesity","volume":"26","author":"White","year":"2005","journal-title":"Peptides"},{"key":"10.1016\/j.physbeh.2022.114000_bib0082","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/adb.12339","article-title":"Rev-erb\u03b1 modulates the hypothalamic orexinergic system to influence pleasurable feeding behaviour in mice","volume":"22","author":"Feillet","year":"2017","journal-title":"Addict. Biol."},{"key":"10.1016\/j.physbeh.2022.114000_bib0083","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.neuroscience.2010.02.002","article-title":"The role of orexin-A in food motivation, reward-based feeding behavior and food-induced neuronal activation in rats","volume":"167","author":"Choi","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2022.114000_bib0084","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neuroscience.2020.04.008","article-title":"Hedonic eating: sex differences and characterization of orexin activation and signaling","volume":"436","author":"Buczek","year":"2020","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2022.114000_bib0085","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00213-009-1596-2","article-title":"Systemic and intrabasalis administration of the orexin-1 receptor antagonist, SB-334867, disrupts attentional performance in rats","volume":"206","author":"Boschen","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.physbeh.2022.114000_bib0086","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.bbr.2006.05.028","article-title":"Functional inactivation of orexin 1 receptors in CA1 region impairs acquisition, consolidation and retrieval in Morris water maze task","volume":"173","author":"Akbari","year":"2006","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2022.114000_bib0087","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.neuroscience.2019.08.026","article-title":"Sex- and stress-dependent effects on dendritic morphology and spine densities in putative orexin neurons","volume":"418","author":"Grafe","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2022.114000_bib0088","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.1210\/endo.142.8.8299","article-title":"Prepro-orexin and orexin receptor mRNAs are differentially expressed in peripheral tissues of male and female rats","volume":"142","author":"J\u00f6hren","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.physbeh.2022.114000_bib0089","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/S0196-9781(02)00052-9","article-title":"Sexually dimorphic expression of prepro-orexin mRNA in the rat hypothalamus","volume":"23","author":"J\u00f6hren","year":"2002","journal-title":"Peptides"},{"key":"10.1016\/j.physbeh.2022.114000_bib0090","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1210\/en.2002-0030","article-title":"Gonadal steroids differentially regulate the messenger ribonucleic acid expression of pituitary orexin type 1 receptors and adrenal orexin type 2 receptors","volume":"144","author":"J\u00f6hren","year":"2003","journal-title":"Endocrinology"},{"key":"10.1016\/j.physbeh.2022.114000_bib0091","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/s41593-017-0023-y","article-title":"Accumbal D2 cells orchestrate innate risk-avoidance according to orexin signals","volume":"21","author":"Blomeley","year":"2018","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.physbeh.2022.114000_bib0092","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1111\/ejn.12146","article-title":"Dopaminergic and GABA-ergic markers of impulsivity in rats: evidence for anatomical localisation in ventral striatum and prefrontal cortex","volume":"37","author":"Jupp","year":"2013","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.physbeh.2022.114000_bib0093","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1177\/0269881115615107","article-title":"Effects of lisdexamfetamine in a rat model of binge-eating","volume":"29","author":"Vickers","year":"2015","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.physbeh.2022.114000_bib0094","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1038\/npp.2012.48","article-title":"Role of orexin-1 receptor mechanisms on compulsive food consumption in a model of binge eating in female rats","volume":"37","author":"Piccoli","year":"2012","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.physbeh.2022.114000_bib0095","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.bbr.2014.06.049","article-title":"Binge-like consumption of caloric and non-caloric palatable substances in ad libitum-fed C57BL\/6\u00a0J mice: pharmacological and molecular evidence of orexin involvement","volume":"272","author":"Alcaraz-Iborra","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2022.114000_bib0096","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.107993","article-title":"The hypocretin (orexin) system: from a neural circuitry perspective","volume":"167","author":"Li","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.physbeh.2022.114000_bib0097","doi-asserted-by":"crossref","first-page":"3549","DOI":"10.1097\/00001756-200111160-00035","article-title":"Excessive sugar intake alters binding to dopamine and mu-opioid receptors in the brain","volume":"12","author":"Colantuoni","year":"2001","journal-title":"Neuroreport"},{"key":"10.1016\/j.physbeh.2022.114000_bib0098","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0095019","article-title":"A relationship between reduced nucleus accumbens shell and enhanced lateral hypothalamic orexin neuronal activation in long-term fructose bingeing behavior","volume":"9","author":"Rorabaugh","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.physbeh.2022.114000_bib0099","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.pbb.2009.02.002","article-title":"Baclofen, raclopride, and naltrexone differentially affect intake of fat\/sucrose mixtures under limited access conditions","volume":"92","author":"Wong","year":"2009","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2022.114000_bib0100","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.physbeh.2011.04.041","article-title":"Feeding and reward: perspectives from three rat models of binge eating","volume":"104","author":"Corwin","year":"2011","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2022.114000_bib0101","doi-asserted-by":"crossref","first-page":"7122","DOI":"10.1523\/JNEUROSCI.3237-12.2013","article-title":"Amelioration of binge eating by nucleus accumbens shell deep brain stimulation in mice involves D2 receptor modulation","volume":"33","author":"Halpern","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.physbeh.2022.114000_bib0102","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0006-8993(00)03312-6","article-title":"Actions of cocaine- and amphetamine-regulated transcript (CART) peptide on regulation of appetite and hypothalamo-pituitary axes in vitro and in vivo in male rats","volume":"893","author":"Stanley","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2022.114000_bib0103","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/29993","article-title":"Hypothalamic CART is a new anorectic peptide regulated by leptin","volume":"393","author":"Kristensen","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.physbeh.2022.114000_bib0104","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/(SICI)1098-2396(199808)29:4<293::AID-SYN1>3.0.CO;2-0","article-title":"CART peptides in the central control of feeding and interactions with neuropeptide Y","volume":"29","author":"Lambert","year":"1998","journal-title":"Synapse"},{"key":"10.1016\/j.physbeh.2022.114000_bib0105","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.bbr.2015.05.030","article-title":"Differential expression of CART in feeding and reward circuits in binge eating rat model","volume":"291","author":"Bharne","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2022.114000_bib0106","doi-asserted-by":"crossref","unstructured":"A. Jean, G. Conductier, C. Manrique, C. Bouras, P. Berta, R. Hen, Y. Charnay, J. Bockaert, V. Compan, Anorexia induced by activation of serotonin 5-HT4 receptors is mediated by increases in CART in the nucleus accumbens, Proc. Natl. Acad. Sci. 104 (2007) 16335\u201316340. 10.1073\/pnas.0701471104.","DOI":"10.1073\/pnas.0701471104"},{"key":"10.1016\/j.physbeh.2022.114000_bib0107","first-page":"1313","article-title":"CART neurons in the lateral hypothalamus communicate with the nucleus accumbens shell via glutamatergic neurons in paraventricular thalamic nucleus to modulate reward behavior","volume":"223","author":"Choudhary","year":"2018","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.physbeh.2022.114000_bib0108","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.bbr.2016.09.054","article-title":"The role of neuropeptide CART in the lateral hypothalamic-ventral tegmental area (LH-VTA) circuit in motivation","volume":"317","author":"Somalwar","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2022.114000_bib0109","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.brainres.2004.10.053","article-title":"CART peptide diurnal rhythm in brain and effect of fasting","volume":"1032","author":"Vicentic","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2022.114000_bib0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2019.146595","article-title":"Cocaine- and amphetamine-regulated transcript peptide promotes reward seeking behavior in socially isolated rats","volume":"1728","author":"Somalwar","year":"2020","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2022.114000_bib0111","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/cne.1190","article-title":"Differential expression of orexin receptors 1 and 2 in the rat brain","volume":"435","author":"Marcus","year":"2001","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.physbeh.2022.114000_bib0112","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0014-5793(98)01266-6","article-title":"Distribution of orexin receptor mRNA in the rat brain","volume":"438","author":"Trivedi","year":"1998","journal-title":"FEBS Lett."},{"key":"10.1016\/j.physbeh.2022.114000_bib0113","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0006-8993(99)01336-0","article-title":"Distribution of orexin neurons in the adult rat brain","volume":"827","author":"Nambu","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2022.114000_bib0114","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1046\/j.0953-816x.2001.01859.x","article-title":"Orexin receptor-1 (OX-R1) immunoreactivity in chemically identified neurons of the hypothalamus: focus on orexin targets involved in control of food and water intake","volume":"15","author":"B\u00e4ckberg","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.physbeh.2022.114000_bib0115","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/S0306-4522(01)00033-1","article-title":"Gene expression and protein distribution of the orexin-1 receptor in the rat brain and spinal cord","volume":"103","author":"Hervieu","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2022.114000_bib0116","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jchemneu.2015.03.002","article-title":"Distribution of the orexin-1 receptor (OX1R) in the mouse forebrain and rostral brainstem: a characterisation of OX1R-eGFP mice","volume":"66\u201367","author":"Ch'ng","year":"2015","journal-title":"J. Chem. Neuroanat."}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938422003055?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938422003055?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:24:17Z","timestamp":1758479057000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938422003055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":116,"alternative-id":["S0031938422003055"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2022.114000","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigating a role of orexin and \u2018cocaine- and amphetamine-regulated transcript\u2019 in the nucleus accumbens shell in binge eating of male rats and the relationship with impulsivity","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2022.114000","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114000"}}