{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T01:57:35Z","timestamp":1780624655013,"version":"3.54.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006087","name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006087","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.physbeh.2022.114054","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T19:43:42Z","timestamp":1670528622000},"page":"114054","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Effect of valproate on sleep patterns disturbed by epilepsy"],"prefix":"10.1016","volume":"259","author":[{"given":"Fructuoso","family":"Ayala-Guerrero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Castro-Dom\u00ednguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik L.","family":"Mateos-Salgado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela","family":"Mexicano-Medina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Alberto","family":"Guti\u00e9rrez-Ch\u00e1vez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2022.114054_bib0001","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/WCO.0000000000000174","article-title":"Redefining epilepsy","volume":"28","author":"Fisher","year":"2015","journal-title":"Curr. Opin. Neurol."},{"key":"10.1016\/j.physbeh.2022.114054_bib0002","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/epi.13709","article-title":"ILAE classification of the epilepsies position paper of the ILAE commission for classification and terminology","volume":"58","author":"Scheffer","year":"2017","journal-title":"Epilepsia"},{"key":"10.1016\/j.physbeh.2022.114054_bib0003","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S0013-4694(96)96028-9","article-title":"Relationship of interictal epileptiform discharges to sleep depth in partial epilepsy","volume":"102","author":"Malow","year":"1997","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.physbeh.2022.114054_bib0004","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/sleep\/25.8.56","article-title":"Relationship of epileptic seizures to sleep stage and sleep depth","volume":"25","author":"Minecan","year":"2002","journal-title":"Sleep"},{"key":"10.1016\/j.physbeh.2022.114054_bib0005","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1528-1167.2007.01400.x","article-title":"The interaction between sleep and epilepsy","volume":"48","author":"Malow","year":"2007","journal-title":"Epilepsia"},{"key":"10.1016\/j.physbeh.2022.114054_bib0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jns.2010.05.003","article-title":"The relationship between sleep and epilepsy: evidence from clinical trials and animal models","volume":"295","author":"Matos","year":"2010","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.physbeh.2022.114054_bib0007","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.eplepsyres.2010.05.006","article-title":"Comorbidity between epilepsy and sleep disorders","volume":"90","author":"Manni","year":"2010","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.physbeh.2022.114054_bib0008","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.yebeh.2018.12.012","article-title":"Effect of gabapentin on sleep patterns disturbed by epilepsy","volume":"92","author":"Ayala-Guerrero","year":"2019","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.physbeh.2022.114054_bib0009","series-title":"Underlying Mechanisms of Epilepsy","first-page":"269","article-title":"Experimental epilepsy models and morphologic alterations of experimental epilepsy models in brain and hippocampus","author":"Akdogan","year":"2011"},{"key":"10.1016\/j.physbeh.2022.114054_bib0010","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.2147\/NDT.S50371","article-title":"Animal models of epilepsy: use and limitations","volume":"10","author":"Kandratavicius","year":"2014","journal-title":"Neuropsychiatr. Dis. Treat"},{"key":"10.1016\/j.physbeh.2022.114054_bib0011","first-page":"1006","article-title":"Effect of generalized seizures on sleep patterns [An animal model]","volume":"2","author":"Ayala-Guerrero","year":"2017","journal-title":"SciTz Neurol. Neurosci."},{"key":"10.1016\/j.physbeh.2022.114054_bib0012","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0031-9384(00)00425-X","article-title":"PTZ-induced seizures in rats: effects of age and strain","volume":"72","author":"Klioueva","year":"2001","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2022.114054_bib0013","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.expneurol.2013.02.019","article-title":"The threshold of pentylenetetrazole-induced convulsive seizures, but not that of nonconvulsive seizures, is controlled by the nitric oxide levels in murine brains","volume":"247","author":"Watanabe","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.physbeh.2022.114054_bib0014","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.brainres.2006.01.078","article-title":"Pentylenetetrazol induced status epilepticus up-regulates the expression of glucose transporter mRNAs but not proteins in the immature rat brain","volume":"1082","author":"Nehlig","year":"2006","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2022.114054_bib0015","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF00437421","article-title":"Differential effects of pentylenetetrazol on REM sleep in naive and cobalt-epileptic rats","volume":"37","author":"Colasanti","year":"1974","journal-title":"Psychopharmacologia"},{"key":"10.1016\/j.physbeh.2022.114054_bib0016","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1517\/14656566.9.2.285","article-title":"Oral valproic acid for epilepsy-long-term experience in therapy and side effects","volume":"9","author":"Gerstner","year":"2008","journal-title":"Expert Opin. Pharmacother."},{"key":"10.1016\/j.physbeh.2022.114054_bib0017","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/479364","article-title":"Molecular and therapeutic potential and toxicity of valproic acid","volume":"2010","author":"Chateauvieux","year":"2010","journal-title":"J. Biomed. Biotechnol."},{"key":"10.1016\/j.physbeh.2022.114054_bib0018","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/0301-0082(90)90010-E","article-title":"Neurophysiological and biochemical changes evoked by valproic acid in the central nervous system","volume":"34","author":"Cotariu","year":"1990","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.physbeh.2022.114054_bib0019","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/0028-3908(83)90134-X","article-title":"The effects of analogues of valproic acid on seizures induced by pentylenetetrazol and GABA content in brain of mice","volume":"22","author":"Keane","year":"1983","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.physbeh.2022.114054_bib0020","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ejphar.2010.06.041","article-title":"Improvement of pentylenetetrazol-induced learning deficits by valproic acid in the adult zebrafish","volume":"643","author":"Lee","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.physbeh.2022.114054_bib0021","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0028-3908(82)90047-8","article-title":"The relationship between plasma concentration of valproic acid and its anticonvulsant and behavioural effects in the rat","volume":"21","author":"Tulloch","year":"1982","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.physbeh.2022.114054_bib0022","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1111\/j.1471-4159.1990.tb03127.x","article-title":"Decrease in the function of the gamma-aminobutyric acid-coupled chloride channel produced by the repeated administration of pentylenetetrazol to rats","volume":"55","author":"Corda","year":"1990","journal-title":"J. Neurochem."},{"key":"10.1016\/j.physbeh.2022.114054_bib0023","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S0022-3565(24)29466-0","article-title":"Pentylenetetrazol-induced inhibition of recombinant gamma-aminobutyric acid type A (GABA(A)) receptors: mechanism and site of action","volume":"298","author":"Huang","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.physbeh.2022.114054_bib0024","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0920-1211(01)00256-X","article-title":"Differential effects of NMDA antagonists microinjections into the nucleus reticularis pontis caudalis on seizures induced by pentylenetetrazol in the rat","volume":"46","author":"Manjarrez","year":"2001","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.physbeh.2022.114054_bib0025","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/267720a0","article-title":"Pentylenetetrazol and penicillin are selective antagonists of GABA-mediated post-synaptic inhibition in cultured mammalian neurons","volume":"267","author":"Macdonald","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.physbeh.2022.114054_bib0026","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.neulet.2015.06.037","article-title":"Unilateral microinjection of carbenoxolone into the pontis caudalis nucleus inhibits the pentylenetetrazole-induced epileptiform activity in rats","volume":"602","author":"Franco-P\u00e9rez","year":"2015","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.physbeh.2022.114054_bib0027","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1016\/0028-3908(87)90171-7","article-title":"Pentylenetetrazol-induced seizure is not mediated by benzodiazepine receptors in vivo","volume":"26","author":"Hantraye","year":"1987","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.physbeh.2022.114054_bib0028","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0301-0082(02)00013-8","article-title":"Drug interactions at GABA(A) receptors","volume":"67","author":"Korpi","year":"2002","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.physbeh.2022.114054_bib0029","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/01.wnp.0000206877.90232.cb","article-title":"Sleep and epilepsy: what we know, don't know, and need to know","volume":"23","author":"Foldvary-Schaefer","year":"2006","journal-title":"J. Clin. Neurophysiol."},{"key":"10.1016\/j.physbeh.2022.114054_bib0030","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2165\/00003088-198005010-00002","article-title":"Clinical pharmacokinetics of valproic acid","volume":"5","author":"Gugler","year":"1980","journal-title":"Clin. Pharmacokinet"},{"key":"10.1016\/j.physbeh.2022.114054_bib0031","first-page":"1","article-title":"Mechanism of action of valproic acid and its derivatives","volume":"7","author":"Bourin","year":"2020","journal-title":"SOJ Pharm. Pharm. Sci."},{"key":"10.1016\/j.physbeh.2022.114054_bib0032","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2174\/1570159X17666181227165722","article-title":"Valproic acid and epilepsy: from molecular mechanisms to clinical evidences","volume":"17","author":"Romoli","year":"2019","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.physbeh.2022.114054_bib0033","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.coph.2005.11.003","article-title":"The mechanisms of action of gabapentin and pregabalin","volume":"6","author":"Sills","year":"2006","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.physbeh.2022.114054_bib0034","first-page":"480","volume":"24","author":"epilepsia","year":"2013","journal-title":"Rev. Med. Clin."},{"key":"10.1016\/j.physbeh.2022.114054_bib0035","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1038\/nm.2058","article-title":"Enhanced tonic GABAA inhibition in typical absence epilepsy","volume":"15","author":"Cope","year":"2009","journal-title":"Nat. Med."}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938422003584?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938422003584?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:23:18Z","timestamp":1758478998000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938422003584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":35,"alternative-id":["S0031938422003584"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2022.114054","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of valproate on sleep patterns disturbed by epilepsy","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2022.114054","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114054"}}