{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T02:52:16Z","timestamp":1782528736115,"version":"3.54.5"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,4,19]],"date-time":"2024-04-19T00:00:00Z","timestamp":1713484800000},"content-version":"am","delay-in-days":293,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K09518"],"award-info":[{"award-number":["21K09518"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.physbeh.2023.114199","type":"journal-article","created":{"date-parts":[[2023,4,14]],"date-time":"2023-04-14T23:40:21Z","timestamp":1681515621000},"page":"114199","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"special_numbering":"C","title":["New discoveries on the interaction between testosterone and oxytocin in male rats \u2015 Testosterone-mediated effects of oxytocin in the prevention of obesity"],"prefix":"10.1016","volume":"266","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7706-7762","authenticated-orcid":false,"given":"Shota","family":"Yamamoto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Arakaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Noguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asuka","family":"Takeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maimi","family":"Uchishiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhei","family":"Kamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayuka","family":"Mineda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masafumi","family":"Kon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako","family":"Kawakita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riyo","family":"Kinouchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuo","family":"Shinohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Iwasa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2023.114199_bib0017","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.maturitas.2011.12.016","article-title":"Sex hormones, appetite and eating behavior in women","volume":"71","author":"Hirschberg","year":"2012","journal-title":"Maturitas"},{"key":"10.1016\/j.physbeh.2023.114199_bib0015","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1210\/jcem-69-4-776","article-title":"Increases in body density during treatment of men with idiopathic hypothalamic hypogonadism","volume":"69","author":"Finkelstein","year":"1989","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.physbeh.2023.114199_bib0005","first-page":"74A","article-title":"Testosterone increases lean body mass, mass size and strength in hypogonadal men","volume":"42","author":"Bhasin","year":"1994","journal-title":"Clin. Res."},{"key":"10.1016\/j.physbeh.2023.114199_bib0036","first-page":"1092","article-title":"The effect of testosterone supplementation in the aging male","volume":"75","author":"Tenover","year":"1992","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.physbeh.2023.114199_bib0040","first-page":"1028","article-title":"Body composition and muscle strength in healthy men receiving testosterone enanthate for contraception","volume":"77","author":"Young","year":"1993","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.physbeh.2023.114199_bib0007","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.lfs.2006.01.035","article-title":"Orchiectomized Fischer 344 male rat models body composition in hypogonadal state","volume":"79","author":"Borst","year":"2006","journal-title":"Life Sci."},{"issue":"6","key":"10.1016\/j.physbeh.2023.114199_bib0030","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/0091-3057(82)90048-X","article-title":"Testosterone affects food intake and body weight of weanling male rats","volume":"16","author":"Nunez","year":"1982","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2023.114199_bib0029","doi-asserted-by":"crossref","unstructured":"Nikolaenko, L., Jia, Y., Wang, C., Diaz-Arjonilla, M., Yee, J.K., French, S.W., Liu, P.Y., Laurel, S., Chong, C., Lee, K., Lue, Y., Lee, W.N.P., Swerdloff, R.S., 2014. Testosterone replacement ameliorates nonalcoholic fatty liver disease in castrated male rats. 155, 417\u2013428. 10.1210\/en.2013-1648.","DOI":"10.1210\/en.2013-1648"},{"issue":"4","key":"10.1016\/j.physbeh.2023.114199_bib0027","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/j.1550-8528.1993.tb00618.x","article-title":"Androgen treatment of abdominally obese men","volume":"1","author":"M\u00e5rin","year":"1993","journal-title":"Obes. Res."},{"key":"10.1016\/j.physbeh.2023.114199_bib0001","first-page":"35","article-title":"Testosterone replacement alters the cell size in visceral fat but not in subcutaneous fat in hypogonadal aged male rats as a late-onset hypogonadism animal model","volume":"7","author":"Abdelhamed","year":"2015","journal-title":"Res. Rep. Urol."},{"issue":"1","key":"10.1016\/j.physbeh.2023.114199_bib0034","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0006-291X(02)02774-2","article-title":"Late onset of obesity in male androgen receptor-deficient (AR KO) mice","volume":"300","author":"Sato","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.physbeh.2023.114199_bib0013","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/S0021-9258(18)49238-1","article-title":"The sequence of amino acids in oxytocin, with a proposal for the structure of oxytocin","volume":"205","author":"Du Vigneaud","year":"1953","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.physbeh.2023.114199_bib0003","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3389\/fendo.2015.00119","article-title":"Chronic oxytocin administration as a treatment against impaired leptin signaling or leptin resistance in obesity","volume":"6","author":"Altirriba","year":"2015","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.physbeh.2023.114199_bib0022","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.1210\/en.2012-2206","article-title":"Oxytocin receptor in the hypothalamus is sufficient to rescue normal thermoregulatory function in male oxytocin receptor knockout mice","volume":"154","author":"Kasahara","year":"2013","journal-title":"Endocrinology"},{"key":"10.1016\/j.physbeh.2023.114199_bib0012","doi-asserted-by":"crossref","first-page":"e25565","DOI":"10.1371\/journal.pone.0025565","article-title":"Mechanisms of the anti-obesity effects of oxytocin in diet-induced obese rats","volume":"6","author":"Deblon","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.physbeh.2023.114199_bib0025","doi-asserted-by":"crossref","first-page":"8599","DOI":"10.1038\/s41598-017-09318-7","article-title":"Impact of sex, fatdistribution and initial body weight on oxytocin's body weight regulation","volume":"7","author":"Maejima","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.physbeh.2023.114199_bib0026","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1159\/000489263","article-title":"The anorexigenic neural pathways of oxytocin and their clinical implication","volume":"107","author":"Maejima","year":"2018","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.physbeh.2023.114199_bib0031","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0196-9781(91)90176-P","article-title":"Oxytocin and an oxytocin agonist administered centrally decrease food intake in rats","volume":"12","author":"Olson","year":"1991","journal-title":"Peptides"},{"key":"10.1016\/j.physbeh.2023.114199_bib0032","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1210\/en.2017-00200","article-title":"Effects of endogenous oxytocin receptor signaling in nucleus tractus solitarius on satiation-mediated feeding and thermogenic control in male rats","volume":"158","author":"Ong","year":"2017","journal-title":"Endocrinology"},{"key":"10.1016\/j.physbeh.2023.114199_bib0033","doi-asserted-by":"crossref","first-page":"R357","DOI":"10.1152\/ajpregu.00169.2017","article-title":"Chronic hindbrain administration of oxytocin is sufficient to elicit weight loss in diet-induced obese rats","volume":"313","author":"Roberts","year":"2017","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.physbeh.2023.114199_bib0006","doi-asserted-by":"crossref","first-page":"R431","DOI":"10.1152\/ajpregu.00441.2014","article-title":"Chronic oxytocin administration inhibits food intake, increases energy expenditure, and produces weight loss in fructose-fed obese rhesus monkeys","volume":"308","author":"Blevins","year":"2015","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.physbeh.2023.114199_bib0024","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1002\/oby.21069","article-title":"Oxytocin reduces caloric intake in men","volume":"23","author":"Lawson","year":"2015","journal-title":"Obesity"},{"key":"10.1016\/j.physbeh.2023.114199_bib0037","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1038\/ijo.2016.149","article-title":"Oxytocin's inhibitory effect on food intake is stronger in obese than normal-weight men","volume":"40","author":"Thienel","year":"2016","journal-title":"Int. J. Obes."},{"issue":"12","key":"10.1016\/j.physbeh.2023.114199_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111380","article-title":"An oxytocinergic neural pathway that stimulates thermogenic and cardiac sympathetic outflow","volume":"40","author":"Fukushima","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.physbeh.2023.114199_bib0019","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.npep.2019.03.002","article-title":"Oxytocin treatment reduced food intake and body fat and ameliorated obesity in ovariectomized female rats","volume":"75","author":"Iwasa","year":"2019","journal-title":"Neuropeptide"},{"issue":"2","key":"10.1016\/j.physbeh.2023.114199_bib0023","first-page":"30","article-title":"The effects of orchidectomy and testosterone replacement therapy on plasma and brain oxytocin in normal rats","volume":"13","author":"Kirilov","year":"1987","journal-title":"Acta Physiol. Pharmacol. Bulg"},{"issue":"2","key":"10.1016\/j.physbeh.2023.114199_bib0038","first-page":"260","article-title":"Plasma vasopressin and oxytocin levels in intact goats and in castrated goats given testosterone","volume":"117","author":"Thornton","year":"1988","journal-title":"Acta Endocrinol. (Copenh)"},{"issue":"15","key":"10.1016\/j.physbeh.2023.114199_bib0039","doi-asserted-by":"crossref","first-page":"8207","DOI":"10.3390\/ijms23158207","article-title":"Changes in endogenous oxytocin levels and the effects of exogenous oxytocin administration on body weight changes and food intake in polycystic ovary syndrome model rats","volume":"23","author":"Yamamoto","year":"2022","journal-title":"Int. J. Mol. Sci. Int. J. Mol. Sci."},{"key":"10.1016\/j.physbeh.2023.114199_bib0011","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1523\/JNEUROSCI.14-03-01789.1994","article-title":"Sex differences in the effects of testosterone and its metabolites on vasopressin messenger RNA levels in the bed nucleus of the stria terminalis of rats","volume":"14","author":"De Vries","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.physbeh.2023.114199_bib0018","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.steroids.2017.08.014","article-title":"The effects of chronic testosterone administration on body weight, food intake, and fat weight were age-dependent","volume":"127","author":"Iwasa","year":"2017","journal-title":"Steroids"},{"key":"10.1016\/j.physbeh.2023.114199_bib0014","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1056\/NEJMra041536","article-title":"Polycystic ovary syndrome","volume":"352","author":"Ehrmann","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.physbeh.2023.114199_bib0028","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/humupd\/dmq001","article-title":"Impaired glucose tolerance, type 2 diabetes and mettabolic syndrome inpolycystic ovary syndrome: a systematic review and meta-analysis","volume":"16","author":"Moran","year":"2010","journal-title":"Hum. Reprod. Update."},{"key":"10.1016\/j.physbeh.2023.114199_bib0021","doi-asserted-by":"crossref","first-page":"e12416","DOI":"10.1002\/rmb2.12416","article-title":"A novel PCOS rat model and an evaluation of its reproductive, metabolic, and behavioral phenotype","volume":"21","author":"Kamada","year":"2021","journal-title":"Reprod. Med. Biol."},{"key":"10.1016\/j.physbeh.2023.114199_bib0020","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1080\/09513590.2019.1631276","article-title":"The effects of chronic oxytocin administration on body weight and food intake in DHT-induced PCOS model rats","volume":"36","author":"Iwasa","year":"2020","journal-title":"Gynecol. Endocrinol."},{"issue":"3","key":"10.1016\/j.physbeh.2023.114199_bib0009","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1385\/ENDO:22:3:203","article-title":"Modulatory role of testosterone in plasma leptin turnover in rats","volume":"22","author":"Castrogiovanni","year":"2003","journal-title":"Endocrine"},{"key":"10.1016\/j.physbeh.2023.114199_bib0002","doi-asserted-by":"crossref","first-page":"9S","DOI":"10.1038\/oby.2006.276","article-title":"Metabolic actions of adipocyte hormones: focus on adiponectin","volume":"14","author":"Ahima","year":"2006","journal-title":"Obesity."},{"issue":"3","key":"10.1016\/j.physbeh.2023.114199_bib0008","doi-asserted-by":"crossref","first-page":"E527","DOI":"10.1152\/ajpendo.00110.2003","article-title":"Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans","volume":"285","author":"Bruun","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.physbeh.2023.114199_bib0035","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/s12944-020-01364-x","article-title":"Oxytocin reduces adipose tissue inflammation in obese mice","volume":"19","author":"Szeto","year":"2020","journal-title":"Lipids Health Dis."},{"key":"10.1016\/j.physbeh.2023.114199_bib0010","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s40618-016-0480-2","article-title":"Testosterone supplementation and body composition: results from a meta-analysis of observational studies","volume":"39","author":"Corona","year":"2016","journal-title":"J. Endocrinol. Invest."}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938423001245?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938423001245?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T01:12:37Z","timestamp":1736385157000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938423001245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":39,"alternative-id":["S0031938423001245"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2023.114199","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"New discoveries on the interaction between testosterone and oxytocin in male rats \u2015 Testosterone-mediated effects of oxytocin in the prevention of obesity","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2023.114199","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114199"}}