{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:57:58Z","timestamp":1781870278476,"version":"3.54.5"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.physbeh.2023.114311","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T11:22:34Z","timestamp":1690888954000},"page":"114311","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Similar functional roles of the Orexin-1 and Orexin-2 receptors within the dentate gyrus area of the hippocampus in the stress-induced antinociceptive responses in the acute pain model in the rat"],"prefix":"10.1016","volume":"270","author":[{"given":"Parisa Sadat","family":"Panahi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sogol","family":"Esmaili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohadeseh","family":"Ghalandari-Shamami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Mousavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Haghparast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"15","key":"10.1016\/j.physbeh.2023.114311_bib0001","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1016\/j.bmcl.2015.05.012","article-title":"Recent trends in orexin research\u20142010 to 2015","volume":"25","author":"Boss","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"17","key":"10.1016\/j.physbeh.2023.114311_bib0002","doi-asserted-by":"crossref","first-page":"4761","DOI":"10.1016\/j.bmcl.2013.06.057","article-title":"Selective orexin receptor antagonists","volume":"23","author":"Lebold","year":"2013","journal-title":"Bioorg. Med. Chem. Lett."},{"issue":"1","key":"10.1016\/j.physbeh.2023.114311_bib0003","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1002\/cne.1190","article-title":"Differential expression of orexin receptors 1 and 2 in the rat brain","volume":"435","author":"Marcus","year":"2001","journal-title":"J. Comp. Neurol."},{"issue":"1","key":"10.1016\/j.physbeh.2023.114311_bib0004","first-page":"47","article-title":"Role of Orexin-A receptors within the Locus Coeruleus in the antinociception induced by microinjection of carbachol into the lateral hypothalamus","volume":"15","author":"Safari","year":"2011","journal-title":"Physiol. Pharmacol."},{"issue":"45","key":"10.1016\/j.physbeh.2023.114311_bib0005","doi-asserted-by":"crossref","first-page":"E10740","DOI":"10.1073\/pnas.1808622115","article-title":"Activation of orexin system facilitates anesthesia emergence and pain control","volume":"115","author":"Zhou","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.physbeh.2023.114311_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2019.112595","article-title":"Role of orexin receptors within the dentate gyrus of the hippocampus in antinociception induced by chemical stimulation of the lateral hypothalamus in the tail-flick test as a model of acute pain in rats","volume":"209","author":"Brojeni","year":"2019","journal-title":"Physiol. Behav."},{"issue":"3","key":"10.1016\/j.physbeh.2023.114311_bib0007","first-page":"395","article-title":"Assesment of orexin receptor 1 in stress attenuated nociceptive behaviours in formalin test","volume":"15","author":"Sofiabad","year":"2011","journal-title":"Physiol. Pharmacol."},{"issue":"2","key":"10.1016\/j.physbeh.2023.114311_bib0008","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/sj.bjp.0704851","article-title":"Analgesic effect of intrathecally administered orexin-A in the rat formalin test and in the rat hot plate test","volume":"137","author":"Yamamoto","year":"2002","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.physbeh.2023.114311_bib0009","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.biopha.2017.03.053","article-title":"A review of the role of orexin system in pain modulation","volume":"90","author":"Razavi","year":"2017","journal-title":"Biomed. Pharmacother."},{"issue":"2","key":"10.1016\/j.physbeh.2023.114311_bib0010","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.pbb.2012.08.007","article-title":"Antagonism of orexin-1 receptors attenuates swim-and restraint stress-induced antinociceptive behaviors in formalin test","volume":"103","author":"Heidari-Oranjaghi","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2023.114311_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2020.170401","article-title":"Role of orexin receptors within the dentate gyrus in antinociception induced by chemical stimulation of the lateral hypothalamus in an animal model of inflammatory pain","volume":"134","author":"Rasouli","year":"2020","journal-title":"Peptides"},{"issue":"1","key":"10.1016\/j.physbeh.2023.114311_bib0012","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/0304-3959(92)90195-H","article-title":"Analgesia produced by lidocaine microinjection into the dentate gyms","volume":"49","author":"McKenna","year":"1992","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.physbeh.2023.114311_bib0013","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1006\/exnr.2001.7777","article-title":"Blocking NMDA receptors in the hippocampal dentate gyrus with AP5 produces analgesia in the formalin pain test","volume":"172","author":"McKenna","year":"2001","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.physbeh.2023.114311_bib0014","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/cne.902400104","article-title":"An analysis of the origins of the cholinergic and noncholinergic septal projections to the hippocampal formation of the rat","volume":"240","author":"Amaral","year":"1985","journal-title":"J. Comp. Neurol."},{"issue":"1","key":"10.1016\/j.physbeh.2023.114311_bib0015","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0091-3057(02)00964-4","article-title":"Delayed stress-induced antinociceptive effect of nitric oxide synthase inhibition in the dentate gyrus of rats","volume":"74","author":"Echeverry","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"5","key":"10.1016\/j.physbeh.2023.114311_bib0016","doi-asserted-by":"crossref","DOI":"10.1007\/s12264-009-0905-4","article-title":"Roles of the hippocampal formation in pain information processing","volume":"25","author":"Liu","year":"2009","journal-title":"Neurosci. Bull."},{"issue":"9169","key":"10.1016\/j.physbeh.2023.114311_bib0017","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1016\/S0140-6736(99)03313-9","article-title":"Acute pain","volume":"353","author":"Carr","year":"1999","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.physbeh.2023.114311_bib0018","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1097\/00001756-200501190-00002","article-title":"Persistent pain and stress activate pain-inhibitory orexin pathways","volume":"16","author":"Watanabe","year":"2005","journal-title":"Neuroreport"},{"issue":"2","key":"10.1016\/j.physbeh.2023.114311_bib0019","first-page":"205","article-title":"The role of hypocretin\/orexin in stress-induced analgesia","volume":"22","author":"Azhdari-Zarmehri","year":"2015","journal-title":"J. Kerman Univ. Med. Sci."},{"key":"10.1016\/j.physbeh.2023.114311_bib0020","series-title":"The Rat Brain in Stereotaxic Coordinates: Hard Cover","author":"George Paxinos","year":"2006"},{"issue":"1\u20132","key":"10.1016\/j.physbeh.2023.114311_bib0021","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0304-3940(95)11546-3","article-title":"Rapid reversible phosphorylation of rat brain tau proteins in response to cold water stress","volume":"191","author":"Korneyev","year":"1995","journal-title":"Neurosci. Lett."},{"issue":"4","key":"10.1016\/j.physbeh.2023.114311_bib0022","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1152\/physrev.1986.66.4.1091","article-title":"Stress-induced analgesia: adaptive pain suppression","volume":"66","author":"Amit","year":"1986","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.physbeh.2023.114311_bib0023","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2021.170679","article-title":"Orexin receptors in the CA1 region of hippocampus modulate the stress-induced antinociceptive responses in an animal model of persistent inflammatory pain","volume":"147","author":"Zareie","year":"2022","journal-title":"Peptides"},{"issue":"1","key":"10.1016\/j.physbeh.2023.114311_bib0024","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0031-9384(95)02073-X","article-title":"Opioid and nonopioid swim stress-induced analgesia: a parametric analysis in mice","volume":"59","author":"Mogil","year":"1996","journal-title":"Physiol. Behav."},{"issue":"10","key":"10.1016\/j.physbeh.2023.114311_bib0025","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1002\/ejp.1840","article-title":"Modulatory role of the orexin system in stress-induced analgesia: involvement of the ventral tegmental area","volume":"25","author":"Askari","year":"2021","journal-title":"Eur. J. Pain"},{"issue":"4","key":"10.1016\/j.physbeh.2023.114311_bib0026","doi-asserted-by":"crossref","DOI":"10.1046\/j.1533-2500.2001.1039_17.x","article-title":"Orexin-A, an hypothalamic peptide with analgesic properties.(SmithKline Beecham Pharmaceuticals, Harlow, Essex, United Kingdom) Pain. 2001; 92: 81\u201390","volume":"1","author":"Bingham","year":"2001","journal-title":"Pain Pract."},{"key":"10.1016\/j.physbeh.2023.114311_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2022.113785","article-title":"Intra-CA1 injection of orexin receptors antagonism attenuates the stress-induced analgesia in a rat acute pain model","volume":"423","author":"Ghalebandi","year":"2022","journal-title":"Behav. Brain Res."},{"issue":"5","key":"10.1016\/j.physbeh.2023.114311_bib0028","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.peptides.2005.01.001","article-title":"Enhanced antinociception by intracerebroventricularly and intrathecally-administered orexin A and B (hypocretin-1 and-2) in mice","volume":"26","author":"Mobarakeh","year":"2005","journal-title":"Peptides"},{"issue":"2","key":"10.1016\/j.physbeh.2023.114311_bib0029","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1113\/jphysiol.2001.013120","article-title":"Hypocretin-2 (orexin-B) modulation of superficial dorsal horn activity in rat","volume":"538","author":"Grudt","year":"2002","journal-title":"J. Physiol. (Lond.)"},{"issue":"41","key":"10.1016\/j.physbeh.2023.114311_bib0030","doi-asserted-by":"crossref","first-page":"14600","DOI":"10.1523\/JNEUROSCI.2671-11.2011","article-title":"Activation of orexin 1 receptors in the periaqueductal gray of male rats leads to antinociception via retrograde endocannabinoid (2-arachidonoylglycerol)-induced disinhibition","volume":"31","author":"Ho","year":"2011","journal-title":"J. Neurosci."},{"issue":"7","key":"10.1016\/j.physbeh.2023.114311_bib0031","first-page":"2471","article-title":"Hypocretin\/orexin and nociceptin\/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia","volume":"118","author":"Xie","year":"2008","journal-title":"J. Clin. Invest."},{"issue":"12","key":"10.1016\/j.physbeh.2023.114311_bib0032","first-page":"54","article-title":"Role of orexin in the tolerance and physical dependence to morphine","volume":"16","author":"Nazemi","year":"2014","journal-title":"J. Babol Univ. Med. Sci."}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938423002366?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938423002366?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:25:53Z","timestamp":1758479153000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938423002366"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":32,"alternative-id":["S0031938423002366"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2023.114311","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Similar functional roles of the Orexin-1 and Orexin-2 receptors within the dentate gyrus area of the hippocampus in the stress-induced antinociceptive responses in the acute pain model in the rat","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2023.114311","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114311"}}