{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T13:47:11Z","timestamp":1790344031381,"version":"4.1.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.physbeh.2023.114386","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T06:36:08Z","timestamp":1698215768000},"page":"114386","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Environmental interventions reduced repetitive behavior in a mouse model"],"prefix":"10.1016","volume":"273","author":[{"given":"Allison R.","family":"Bechard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"McElderry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2023.114386_bib0001","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s11689-009-9019-6","article-title":"The pathophysiology of restricted repetitive behavior","volume":"1","author":"Lewis","year":"2009","journal-title":"J. Neurodev. Disord."},{"issue":"SS\u20132","key":"10.1016\/j.physbeh.2023.114386_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss7202a1","article-title":"Prevalence and characteristics of autism spectrum disorder among children aged 8 years \u2014 autism and developmental disabilities monitoring network, 11 sites, United States, 2020","volume":"72","author":"Maenner","year":"2023","journal-title":"MMWR Surveill. Summ."},{"key":"10.1016\/j.physbeh.2023.114386_bib0003","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1111\/jcpp.12207","article-title":"Longitudinal patterns of repetitive behavior in toddlers with autism","volume":"55","author":"Wolff","year":"2014","journal-title":"J. Child Psychol. Psychiatry"},{"key":"10.1016\/j.physbeh.2023.114386_bib0004","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1037\/bne0000068","article-title":"Environmental enrichment as a therapy for autism: a clinical trial replication and extension","volume":"129","author":"Woo","year":"2015","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.physbeh.2023.114386_bib0005","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1037\/a0033010","article-title":"Environmental enrichment as an effective treatment for autism: a randomized controlled trial","volume":"127","author":"Woo","year":"2013","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.physbeh.2023.114386_bib0006","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1017\/S096272860001438X","article-title":"Can't stop, won't stop: is stereotypy a reliable animal welfare indicator?","volume":"13","author":"Mason","year":"2004","journal-title":"Anim. Welfare"},{"key":"10.1016\/j.physbeh.2023.114386_bib0007","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/nan.12102","article-title":"Environmental enrichment and brain repair: harnessing the therapeutic effects of cognitive stimulation and physical activity to enhance experience-dependent plasticity","volume":"40","author":"Hannan","year":"2014","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.physbeh.2023.114386_bib0008","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bbr.2015.11.029","article-title":"How does environmental enrichment reduce repetitive motor behaviors? Neuronal activation and dendritic morphology in the indirect basal ganglia pathway of a mouse model","volume":"299","author":"Bechard","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2023.114386_bib0009","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/mrdd.20017","article-title":"Environmental complexity and central nervous system development and function","volume":"10","author":"Lewis","year":"2004","journal-title":"Ment. Retard. Dev. Disabil. Res. Rev."},{"key":"10.1016\/j.physbeh.2023.114386_bib0010","doi-asserted-by":"crossref","first-page":"e12468","DOI":"10.1111\/gbb.12468","article-title":"Subthalamic nucleus pathology contributes to repetitive behavior expression and is reversed by environmental enrichment","volume":"17","author":"Lewis","year":"2018","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.physbeh.2023.114386_bib0011","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.bbr.2010.02.030","article-title":"Indirect basal ganglia pathway mediation of repetitive behavior: attenuation by adenosine receptor agonists","volume":"210","author":"Tanimura","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2023.114386_bib0012","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2020.577858","article-title":"Increased dopamine type 2 gene expression in the dorsal striatum in individuals with autism spectrum disorder suggests alterations in indirect pathway signaling and circuitry","volume":"14","author":"Brandenburg","year":"2020","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.physbeh.2023.114386_bib0013","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3389\/fnana.2011.00059","article-title":"Basal Ganglia disorders associated with imbalances in the striatal striosome and matrix compartments","volume":"5","author":"Crittenden","year":"2011","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.physbeh.2023.114386_bib0014","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1365-2788.2011.01519.x","article-title":"Abnormal repetitive behaviours: shared phenomenology and pathophysiology","volume":"56","author":"Muehlmann","year":"2012","journal-title":"J. Intellect. Disabil. Res."},{"key":"10.1016\/j.physbeh.2023.114386_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2020.112708","article-title":"Pharmacological targeting of striatal indirect pathway neurons improves subthalamic nucleus dysfunction and reduces repetitive behaviors in C58 mice","volume":"391","author":"Muehlmann","year":"2020","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2023.114386_bib0016","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1126\/science.2147780","article-title":"D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons","volume":"250","author":"Gerfen","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.physbeh.2023.114386_bib0017","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3389\/fphar.2018.00243","article-title":"Essential control of the function of the striatopallidal neuron by pre-coupled complexes of adenosine A2A-dopamine D2 receptor heterotetramers and adenylyl cyclase","volume":"9","author":"Ferr\u00e9","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.physbeh.2023.114386_bib0018","first-page":"S19","article-title":"Receptor heteromerization in adenosine A2A receptor signaling: relevance for striatal function and Parkinson's disease","volume":"61","author":"Ferriro Fuxe","year":"2003","journal-title":"Neurology"},{"key":"10.1016\/j.physbeh.2023.114386_bib0019","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1124\/jpet.118.256081","article-title":"Targeting dopamine D2, adenosine A2A, and glutamate mGlu5 receptors to reduce repetitive behaviors in deer mice","volume":"369","author":"Lewis","year":"2019","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.physbeh.2023.114386_bib0020","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0014-2999(94)90438-3","article-title":"Adenosine A2 receptors interact negatively with dopamine D1 and D2 receptors in unilaterally 6-hydroxydopamine-lesioned rats","volume":"251","author":"Morelli","year":"1994","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.physbeh.2023.114386_bib0021","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0014-2999(98)00107-1","article-title":"Differential effects of selective adenosine A1 and A2A receptor agonists on dopamine receptor agonist-induced behavioural responses in rats","volume":"347","author":"Rimondini","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.physbeh.2023.114386_bib0022","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3389\/fneur.2019.00119","article-title":"Role of DNA methylation and adenosine in ketogenic diet for pharmacoresistant epilepsy: focus on epileptogenesis and associated comorbidities","volume":"10","author":"Chen","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.physbeh.2023.114386_bib0023","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2174\/157015909789152164","article-title":"Adenosine, ketogenic diet and epilepsy: the emerging therapeutic relationship between metabolism and brain activity","volume":"7","author":"Masino","year":"2009","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.physbeh.2023.114386_bib0024","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jneuroim.2017.08.002","article-title":"Adenosine A2A receptor signaling affects IL-21\/IL-22 cytokines and GATA3\/T-bet transcription factor expression in CD4+ T cells from a BTBR T+ Itpr3tf\/J mouse model of autism","volume":"311","author":"Ahmad","year":"2017","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.physbeh.2023.114386_bib0025","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.jid.2021.07.174","article-title":"Positive allosteric modulation of A2AR alters immune cell responses and ameliorates psoriasis-like dermatitis in mice","volume":"142","author":"Welihinda","year":"2022","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.physbeh.2023.114386_bib0026","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12950-014-0037-0","article-title":"Positive allosteric modulation of the adenosine A2a receptor attenuates inflammation","volume":"11","author":"Welihinda","year":"2014","journal-title":"J. Inflamm. (Lond.)"},{"key":"10.1016\/j.physbeh.2023.114386_bib0027","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.physbeh.2016.10.023","article-title":"Ketogenic diets improve behaviors associated with autism spectrum disorder in a sex-specific manner in the EL mouse","volume":"168","author":"Ruskin","year":"2017","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2023.114386_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2022.113748","article-title":"Benefits of a ketogenic diet on repetitive motor behavior in mice","volume":"422","author":"Brady","year":"2022","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2023.114386_bib0029","article-title":"A ketogenic diet and the treatment of autism spectrum disorder","volume":"9","author":"Li","year":"2021","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.physbeh.2023.114386_bib0030","article-title":"Ketogenic diet and other dietary treatments for epilepsy","volume":"2","author":"Martin","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.physbeh.2023.114386_bib0031","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1172\/JCI57813","article-title":"A ketogenic diet suppresses seizures in mice through adenosine A\u2081 receptors","volume":"121","author":"Masino","year":"2011","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.physbeh.2023.114386_bib0032","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/cns.13779","article-title":"Ketogenic diet ameliorates cognitive impairment and neuroinflammation in a mouse model of Alzheimer's disease","volume":"28","author":"Xu","year":"2022","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.physbeh.2023.114386_bib41","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.anbehav.2010.06.008","article-title":"Middle-aged mice with enrichment resistant stereotypic behaviour show reduced motivation for enrichment","volume":"80","author":"Tilly","year":"2010","journal-title":"Anim Behav"},{"key":"10.1016\/j.physbeh.2023.114386_bib0033","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1002\/dev.21503","article-title":"The development of repetitive motor behaviors in deer mice: effects of environmental enrichment, repeated testing, and differential mediation by indirect basal ganglia pathway activation","volume":"59","author":"Bechard","year":"2017","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.physbeh.2023.114386_bib42","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0168-1591(01)00143-5","article-title":"K.E. Heller. The involvement of dopamine (DA) and serotonin (5-HT) in stress-induced stereotypies in bank voles (Clethrionomys glareolus)","volume":"73","author":"Schoenecker","year":"2001","journal-title":"Appl Anim Behav Sci"},{"key":"10.1016\/j.physbeh.2023.114386_bib0034","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.bbr.2012.07.041","article-title":"Further characterization of repetitive behavior in C58 mice: developmental trajectory and effects of environmental enrichment","volume":"235","author":"Muehlmann","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2023.114386_bib0035","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/dev.10116","article-title":"Environmental enrichment: effects on stereotyped behavior and dendritic morphology","volume":"43","author":"Turner","year":"2003","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.physbeh.2023.114386_bib0040","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.pbb.2019.04.006","article-title":"Reduction of repetitive behavior by co-administration of adenosine receptor agonists in C58 mice","volume":"181","author":"Lewis","year":"2019","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2023.114386_bib0036","first-page":"12","article-title":"Sex-dependent social and repetitive behavior and neurochemical profile in mouse model of autism spectrum disorder","author":"Ferreira","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.physbeh.2023.114386_bib0037","first-page":"407","article-title":"Litter size predicts adult stereotypic behavior in female laboratory mice","volume":"51","author":"Bechard","year":"2012","journal-title":"J. Am. Assoc. Lab. Anim. Sci."},{"key":"10.1016\/j.physbeh.2023.114386_bib0038","unstructured":"CDC 2021. https:\/\/www.cdc.gov\/ncbddd\/autism\/data.html, accessed May 2, 2023."},{"key":"10.1016\/j.physbeh.2023.114386_bib0039","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/WCO.0b013e32835ee548","article-title":"Sex differences in autism spectrum disorders","volume":"26","author":"Werling","year":"2013","journal-title":"Curr. Opin. Neurol."}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938423003116?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938423003116?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T19:42:53Z","timestamp":1736365373000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938423003116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":42,"alternative-id":["S0031938423003116"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2023.114386","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Environmental interventions reduced repetitive behavior in a mouse model","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2023.114386","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114386"}}