{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:49:32Z","timestamp":1777632572026,"version":"3.51.4"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010624","name":"Karab\u00fck \u00dcniversitesi","doi-asserted-by":"publisher","award":["23-DS-107"],"award-info":[{"award-number":["23-DS-107"]}],"id":[{"id":"10.13039\/501100010624","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010624","name":"Karab\u00fck \u00dcniversitesi","doi-asserted-by":"publisher","award":["2023\/3\/7"],"award-info":[{"award-number":["2023\/3\/7"]}],"id":[{"id":"10.13039\/501100010624","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002657","name":"Istanbul \u00dcniversitesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002657","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology & Behavior"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.physbeh.2024.114601","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T20:40:24Z","timestamp":1717447224000},"page":"114601","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Intracerebroventricular prokineticin 2 infusion may play a role on the hypothalamus-pituitary-thyroid axis and energy metabolism"],"prefix":"10.1016","volume":"283","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0248-3483","authenticated-orcid":false,"given":"Umit","family":"Yilmaz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevser","family":"Tanbek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2024.114601_bib0001","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev.physiol.62.1.439","article-title":"The mechanism of action of thyroid hormones","volume":"62","author":"Zhang","year":"2000","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.physbeh.2024.114601_bib0002","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1152\/physrev.2001.81.3.1097","article-title":"Physiological and molecular basis of thyroid hormone action","volume":"81","author":"Yen","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.physbeh.2024.114601_bib0003","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1677\/jme.0.0260067","article-title":"Thyroid hormone action in mitochondria","volume":"26","author":"Wrutniak-Cabello","year":"2001","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.physbeh.2024.114601_bib0004","doi-asserted-by":"crossref","first-page":"5493","DOI":"10.1038\/ncomms6493","article-title":"Berberine activates thermogenesis in white and brown adipose tissue","volume":"5","author":"Zhang","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.physbeh.2024.114601_bib0005","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/ncb2740","article-title":"Bi-directional interconversion of brite and white adipocytes","volume":"15","author":"Rosenwald","year":"2013","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.physbeh.2024.114601_bib0006","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nrendo.2013.204","article-title":"Adipose tissue browning and metabolic health","volume":"10","author":"Bartelt","year":"2014","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.physbeh.2024.114601_bib0007","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1038\/ijo.2016.55","article-title":"Alterations in energy expenditure in Roux-en-Y gastric bypass rats persist at thermoneutrality","volume":"40","author":"Abegg","year":"2016","journal-title":"Int. J. Obes. (Lond)"},{"key":"10.1016\/j.physbeh.2024.114601_bib0008","doi-asserted-by":"crossref","first-page":"18168","DOI":"10.1016\/S0021-9258(19)81340-6","article-title":"Triiodothyronine amplifies norepinephrine stimulation of uncoupling protein gene transcription by a mechanism not requiring protein synthesis","volume":"263","author":"Bianco","year":"1988","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.physbeh.2024.114601_bib0009","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.1210\/endo.136.8.7628361","article-title":"Thyroid hormone and norepinephrine signaling in brown adipose tissue. II: Differential effects of thyroid hormone on beta 3-adrenergic receptors in brown and white adipose tissue","volume":"136","author":"Rubio","year":"1995","journal-title":"Endocrinology"},{"key":"10.1016\/j.physbeh.2024.114601_bib0010","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1016\/j.celrep.2019.05.054","article-title":"Thyroid-Hormone-Induced Browning of White Adipose Tissue Does Not Contribute to Thermogenesis and Glucose Consumption","volume":"27","author":"Johann","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.physbeh.2024.114601_bib0011","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.molmed.2013.04.004","article-title":"Energy balance regulation by thyroid hormones at central level","volume":"19","author":"Lopez","year":"2013","journal-title":"Trends. Mol. Med."},{"key":"10.1016\/j.physbeh.2024.114601_bib0012","article-title":"Browning of white adipose tissue: lessons from experimental models","volume":"31","author":"Bargut","year":"2017","journal-title":"Horm. Mol. Biol. Clin. Investig."},{"key":"10.1016\/j.physbeh.2024.114601_bib0013","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0092-8674(00)80611-X","article-title":"Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1","volume":"98","author":"Wu","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.physbeh.2024.114601_bib0014","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1042\/bst0290803","article-title":"Mechanism of uncoupling protein action","volume":"29","author":"Garlid","year":"2001","journal-title":"Biochem. Soc. Trans."},{"key":"10.1016\/j.physbeh.2024.114601_bib0015","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.freeradbiomed.2007.08.011","article-title":"Mitochondrial uncoupling proteins\u2013what is their physiological role?","volume":"43","author":"Echtay","year":"2007","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.physbeh.2024.114601_bib0016","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1016\/j.celrep.2013.10.044","article-title":"UCP1 in brite\/beige adipose tissue mitochondria is functionally thermogenic","volume":"5","author":"Shabalina","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.physbeh.2024.114601_bib0017","doi-asserted-by":"crossref","first-page":"C463","DOI":"10.1152\/ajpcell.00010.2011","article-title":"Triiodothyronine induces UCP-1 expression and mitochondrial biogenesis in human adipocytes","volume":"302","author":"Lee","year":"2012","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.physbeh.2024.114601_bib0018","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0092-8674(00)81410-5","article-title":"A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis","volume":"92","author":"Puigserver","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.physbeh.2024.114601_bib0019","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1007\/s11033-024-09604-4","article-title":"Intracerebroventricular PROK2 infusion could increase the secretion of male reproductive hormones by stimulating the HPG axis","volume":"51","author":"Yilmaz","year":"2024","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.physbeh.2024.114601_bib0020","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1210\/jc.2007-2654","article-title":"Mutations in prokineticin 2 and prokineticin receptor 2 genes in human gonadotrophin-releasing hormone deficiency: molecular genetics and clinical spectrum","volume":"93","author":"Cole","year":"2008","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.physbeh.2024.114601_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamem.2020.183549","article-title":"Analysis of role of aromatic residues in extracellular loop 2 of Prokineticin receptor 2 in ligand binding probed with genetically encoded photo-crosslinkers","volume":"1863","author":"Fullone","year":"2021","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.physbeh.2024.114601_bib0022","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.biochi.2021.04.009","article-title":"Pleiotropic effects of prokineticin 2 in the control of energy metabolism","volume":"186","author":"Magnan","year":"2021","journal-title":"Biochimie"},{"key":"10.1016\/j.physbeh.2024.114601_bib0023","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/417405a","article-title":"Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus","volume":"417","author":"Cheng","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.physbeh.2024.114601_bib0024","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2337\/db09-1198","article-title":"Prokineticin 2 is a hypothalamic neuropeptide that potently inhibits food intake","volume":"59","author":"Gardiner","year":"2010","journal-title":"Diabetes"},{"key":"10.1016\/j.physbeh.2024.114601_bib0025","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1476-5381.2012.02191.x","article-title":"Peripheral administration of prokineticin 2 potently reduces food intake and body weight in mice via the brainstem","volume":"168","author":"Beale","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.physbeh.2024.114601_bib0026","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.regpep.2012.08.003","article-title":"Prokineticin 2 is involved in the thermoregulation and energy expenditure","volume":"179","author":"Zhou","year":"2012","journal-title":"Regul. Pept."},{"key":"10.1016\/j.physbeh.2024.114601_bib0027","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1469-7793.2000.00003.x","article-title":"Mitochondrial uncoupling proteins: from mitochondria to the regulation of energy balance","volume":"1","author":"Ricquier","year":"2000","journal-title":"J Physiol 529 Pt"},{"key":"10.1016\/j.physbeh.2024.114601_bib0028","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1056\/NEJMoa0810780","article-title":"Identification and importance of brown adipose tissue in adult humans","volume":"360","author":"Cypess","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.physbeh.2024.114601_bib0029","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1056\/NEJMoa0808718","article-title":"Cold-activated brown adipose tissue in healthy men","volume":"360","author":"van Marken Lichtenbelt","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.physbeh.2024.114601_bib0030","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1056\/NEJMoa0808949","article-title":"Functional brown adipose tissue in healthy adults","volume":"360","author":"Virtanen","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.physbeh.2024.114601_bib0031","first-page":"1","article-title":"Effect of Thyroid Hormones on Adipose Tissue Flexibility","volume":"10","author":"Volke","year":"2021","journal-title":"Eur. Thyroid. J."},{"key":"10.1016\/j.physbeh.2024.114601_bib0032","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1159\/000531567","article-title":"Melatonin Attenuates Cerebral Ischemia\/Reperfusion Injury through Inducing Autophagy","volume":"113","author":"Yilmaz","year":"2023","journal-title":"Neuroendocrinology."},{"key":"10.1016\/j.physbeh.2024.114601_bib0033","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/13813455.2023.2166964","article-title":"Effects of central FGF21 infusion on the glucose homeostasis in rats (brain-pancreas axis)","author":"Tanbek","year":"2023","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.physbeh.2024.114601_bib0034","doi-asserted-by":"crossref","first-page":"e18246","DOI":"10.1111\/jcmm.18246","article-title":"Intracerebroventricular BDNF infusion may reduce cerebral ischemia\/reperfusion injury by promoting autophagy and suppressing apoptosis","volume":"28","author":"Yilmaz","year":"2024","journal-title":"J. Cell Mol. Med."},{"key":"10.1016\/j.physbeh.2024.114601_bib0035","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s12576-018-0595-7","article-title":"Effects of central FGF21 infusion on the hypothalamus-pituitary-thyroid axis and energy metabolism in rats","volume":"68","author":"Yilmaz","year":"2018","journal-title":"J. Physiol. Sci."},{"key":"10.1016\/j.physbeh.2024.114601_bib0036","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2023.114401","article-title":"Spexin may induce mitochondrial biogenesis in white and brown adipocytes via the hypothalamus-pituitary-thyroid (HPT) axis","volume":"273","author":"Yilmaz","year":"2024","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2024.114601_bib0037","first-page":"163","article-title":"Effects of glucagon as a neurohormone on the central nervous system and glucose homeostasis","volume":"28","author":"Tanbek","year":"2024","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.physbeh.2024.114601_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2022.113727","article-title":"Alpha lipoic acid decreases neuronal damage on brain tissue of STZ-induced diabetic rats","volume":"248","author":"Tanbek","year":"2022","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2024.114601_bib0039","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1097\/MED.0000000000000185","article-title":"Can prokineticin prevent obesity and insulin resistance?","volume":"22","author":"Von Hunolstein","year":"2015","journal-title":"Curr. Opin. Endocrinol. Diabetes. Obes."},{"key":"10.1016\/j.physbeh.2024.114601_bib0040","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3389\/fcvm.2017.00020","article-title":"Prokineticin Is a New Linker between Obesity and Cardiovascular Diseases","volume":"4","author":"Nebigil","year":"2017","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.physbeh.2024.114601_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102814","article-title":"Activation of amygdala prokineticin receptor 2 neurons drives the anorexigenic activity of the neuropeptide PK2","volume":"299","author":"Yin","year":"2023","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.physbeh.2024.114601_bib0042","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.molmet.2019.08.016","article-title":"New roles for prokineticin 2 in feeding behavior, insulin resistance and type 2 diabetes: Studies in mice and humans","volume":"29","author":"Mortreux","year":"2019","journal-title":"Mol. Metab."},{"key":"10.1016\/j.physbeh.2024.114601_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadva.2021.100028","article-title":"The balance of concentration between Prokineticin 2beta and Prokineticin 2 modulates the food intake by STAT3 signaling","volume":"1","author":"Maftei","year":"2021","journal-title":"BBa Adv."},{"key":"10.1016\/j.physbeh.2024.114601_bib0044","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.ijdevneu.2014.02.001","article-title":"Changes in the responsiveness of hypothalamic prokineticin 2 mRNA expression to food deprivation in developing female rats","volume":"34","author":"Iwasa","year":"2014","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.physbeh.2024.114601_bib0045","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/sj.bjp.0705686","article-title":"Bv8, the amphibian homologue of the mammalian prokineticins, modulates ingestive behaviour in rats","volume":"142","author":"Negri","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.physbeh.2024.114601_bib0046","doi-asserted-by":"crossref","first-page":"11615","DOI":"10.1523\/JNEUROSCI.3679-06.2006","article-title":"Attenuated circadian rhythms in mice lacking the prokineticin 2 gene","volume":"26","author":"Li","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.physbeh.2024.114601_bib0047","doi-asserted-by":"crossref","first-page":"R1968","DOI":"10.1152\/ajpregu.00778.2007","article-title":"Loss of prokineticin receptor 2 signaling predisposes mice to torpor","volume":"294","author":"Jethwa","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."}],"container-title":["Physiology & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003193842400146X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003193842400146X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T04:09:51Z","timestamp":1777435791000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S003193842400146X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":47,"alternative-id":["S003193842400146X"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2024.114601","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intracerebroventricular prokineticin 2 infusion may play a role on the hypothalamus-pituitary-thyroid axis and energy metabolism","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2024.114601","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114601"}}