{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T23:38:51Z","timestamp":1779320331070,"version":"3.51.4"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology & Behavior"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.physbeh.2025.114806","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T16:29:55Z","timestamp":1736785795000},"page":"114806","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Acupuncture relieves postoperative pain of mixed hemorrhoids through the P2X7\/ERK axis in dorsal root ganglion"],"prefix":"10.1016","volume":"291","author":[{"given":"Bin","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haijing","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Shu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiqun","family":"Weng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2025.114806_bib0001","volume":"8","author":"De Marco","year":"2021","journal-title":"Lifestyle and risk factors in hemorrhoidal disease"},{"issue":"1","key":"10.1016\/j.physbeh.2025.114806_bib0002","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s13063-023-07175-6","article-title":"Modified ultrasound scalpel haemorrhoidectomy versus conventional haemorrhoidectomy for mixed haemorrhoids: a study protocol for a single-blind randomised controlled trial","volume":"24","author":"Yu","year":"2023","journal-title":"Trials"},{"issue":"5","key":"10.1016\/j.physbeh.2025.114806_bib0003","doi-asserted-by":"crossref","first-page":"253","DOI":"10.4077\/CJP.2013.BAB127","article-title":"Herbal haemorrhoidal cream for haemorrhoids","volume":"56","author":"Gurel","year":"2013","journal-title":"Chin. J. Physiol."},{"issue":"6","key":"10.1016\/j.physbeh.2025.114806_bib0004","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.cgh.2012.12.020","article-title":"The evaluation and treatment of hemorrhoids: a guide for the gastroenterologist","volume":"11","author":"Ganz","year":"2013","journal-title":"Clin. Gastroenterol. Hepatol."},{"issue":"2","key":"10.1016\/j.physbeh.2025.114806_bib0005","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10151-020-02149-1","article-title":"Consensus statement of the Italian society of colorectal surgery (SICCR): management and treatment of hemorrhoidal disease","volume":"24","author":"Gallo","year":"2020","journal-title":"Tech. Coloproctol."},{"key":"10.1016\/j.physbeh.2025.114806_bib0006","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5630487","article-title":"Effectiveness of Mayinglong Musk hemorrhoid ointment on wound healing and complications after internal hemorrhoid ligation and external hemorrhoidectomy","volume":"2022","author":"Lin","year":"2022","journal-title":"Evid. Based. Complement. Alternat. Med."},{"issue":"3","key":"10.1016\/j.physbeh.2025.114806_bib0007","doi-asserted-by":"crossref","first-page":"731","DOI":"10.4240\/wjgs.v16.i3.731","article-title":"Analysis of factors impacting postoperative pain and quality of life in patients with mixed hemorrhoids: a retrospective study","volume":"16","author":"Sun","year":"2024","journal-title":"World J. Gastrointest. Surg."},{"issue":"5","key":"10.1016\/j.physbeh.2025.114806_bib0008","doi-asserted-by":"crossref","first-page":"227","DOI":"10.4082\/kjfm.2014.35.5.227","article-title":"Factors associated with hemorrhoids in korean adults: korean national health and nutrition examination survey","volume":"35","author":"Lee","year":"2014","journal-title":"Korean J. Fam. Med."},{"issue":"8","key":"10.1016\/j.physbeh.2025.114806_bib0009","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1001\/jamasurg.2020.0788","article-title":"Review of American society of colon and rectal surgeons clinical practice guidelines for the management of hemorrhoids","volume":"155","author":"Muldoon","year":"2020","journal-title":"JAMa Surg."},{"issue":"6","key":"10.1016\/j.physbeh.2025.114806_bib0010","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1159\/000320321","article-title":"Evaluation of sclerotherapy with a new sclerosing agent and stapled hemorrhoidopexy for prolapsing internal hemorrhoids: retrospective comparison with hemorrhoidectomy","volume":"27","author":"Tokunaga","year":"2010","journal-title":"Dig. Surg."},{"issue":"4","key":"10.1016\/j.physbeh.2025.114806_bib0011","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1007\/s11605-013-2424-x","article-title":"Circular vs. three-quadrant hemorrhoidectomy for end-stage hemorrhoids: short- and long-term outcomes of a prospective randomized trial","volume":"18","author":"Qarabaki","year":"2014","journal-title":"J. Gastrointest. Surg."},{"issue":"2","key":"10.1016\/j.physbeh.2025.114806_bib0012","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1097\/DCR.0000000000002323","article-title":"The American society of colon and rectal surgeons clinical practice guidelines for the management of colon cancer","volume":"65","author":"Vogel","year":"2022","journal-title":"Dis. Colon Rectum"},{"issue":"1","key":"10.1016\/j.physbeh.2025.114806_bib0013","doi-asserted-by":"crossref","first-page":"479","DOI":"10.21037\/apm-20-2385","article-title":"Management of intractable pain in patients treated with hemorrhoidectomy for mixed hemorrhoids","volume":"10","author":"Feng","year":"2021","journal-title":"Ann. Palliat. Med."},{"issue":"6","key":"10.1016\/j.physbeh.2025.114806_bib0014","doi-asserted-by":"crossref","first-page":"65","DOI":"10.17116\/kurort20219806265","article-title":"Non-drug technologies in early rehabilitation of patients after hemorrhoidectomy","volume":"98","author":"Kovalev","year":"2021","journal-title":"Vopr. Kurortol. Fizioter. Lech. Fiz. Kult."},{"issue":"3","key":"10.1016\/j.physbeh.2025.114806_bib0015","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.bja.2022.05.029","article-title":"Current approaches to acute postoperative pain management after major abdominal surgery: a narrative review and future directions","volume":"129","author":"Pirie","year":"2022","journal-title":"Br. J. Anaesth."},{"issue":"8","key":"10.1016\/j.physbeh.2025.114806_bib0016","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1007\/s00204-021-03068-2","article-title":"Toxicities of opioid analgesics: respiratory depression, histamine release, hemodynamic changes, hypersensitivity, serotonin toxicity","volume":"95","author":"Baldo","year":"2021","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.physbeh.2025.114806_bib0017","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ctcp.2018.06.013","article-title":"An assessment of methodological quality of systematic reviews of acupuncture and related therapies for cancer-related pain","volume":"32","author":"Anshasi","year":"2018","journal-title":"Complement. Ther. Clin. Pract."},{"issue":"2","key":"10.1016\/j.physbeh.2025.114806_bib0018","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2023-075218","article-title":"Effect of acupuncture on ischaemic stroke in patients with rheumatoid arthritis: a nationwide propensity score-matched study","volume":"14","author":"Huang","year":"2024","journal-title":"BMJ Open."},{"key":"10.1016\/j.physbeh.2025.114806_bib0019","unstructured":"Lin, J.-G., P. Kotha, and Y.-H.J.A.j.o.t.r. Chen, Understandings of acupuncture application and mechanisms. 2022. 14(3): p. 1469."},{"issue":"50","key":"10.1016\/j.physbeh.2025.114806_bib0020","first-page":"e32247","volume":"101","author":"Du","year":"2022","journal-title":"Electroacupuncture for postoperative pain in mixed hemorrhoids: A meta-analysis"},{"issue":"19","key":"10.1016\/j.physbeh.2025.114806_bib0021","doi-asserted-by":"crossref","first-page":"e25948","DOI":"10.1097\/MD.0000000000025948","article-title":"Efficacy and safety of acupoint catgut embedding in treating postoperative pain of mixed hemorrhoids: a randomized controlled trial protocol","volume":"100","author":"Pei","year":"2021","journal-title":"Medicine (Baltimore)"},{"issue":"11","key":"10.1016\/j.physbeh.2025.114806_bib0022","first-page":"2112","volume":"34","author":"Grissa","year":"2016","journal-title":"Acupuncture vs intravenous morphine in the management of acute pain in the ED"},{"issue":"11","key":"10.1016\/j.physbeh.2025.114806_bib0023","doi-asserted-by":"crossref","first-page":"494","DOI":"10.5694\/mja16.00771","article-title":"Acupuncture for analgesia in the emergency department: a multicentre, randomised, equivalence and non-inferiority trial","volume":"206","author":"Cohen","year":"2017","journal-title":"Med. J. Aust."},{"issue":"11","key":"10.1016\/j.physbeh.2025.114806_bib0024","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1007\/s40265-023-01903-7","article-title":"Neuropathic pain and spinal cord injury: management, phenotypes, and biomarkers","volume":"83","author":"Widerstr\u00f6m-Noga","year":"2023","journal-title":"Drugs"},{"issue":"9522","key":"10.1016\/j.physbeh.2025.114806_bib0025","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1016\/S0140-6736(06)68700-X","article-title":"Persistent postsurgical pain: risk factors and prevention","volume":"367","author":"Kehlet","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.physbeh.2025.114806_bib0026","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.bbi.2020.08.015","article-title":"Acupuncture inhibits neuroinflammation and gut microbial dysbiosis in a mouse model of Parkinson's disease","volume":"89","author":"Jang","year":"2020","journal-title":"Brain Behav. Immun."},{"issue":"11","key":"10.1016\/j.physbeh.2025.114806_bib0027","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.45138","article-title":"Efficacy and safety of auricular acupuncture for depression: a randomized clinical trial","volume":"6","author":"de Oliveira Rodrigues","year":"2023","journal-title":"JAMa Netw. Open"},{"key":"10.1016\/j.physbeh.2025.114806_bib0028","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/6627393","article-title":"Auriculotherapy modulates macrophage polarization to reduce inflammatory response in a rat model of acne","volume":"2023","author":"Zuo","year":"2023","journal-title":"Mediators. Inflamm."},{"issue":"5","key":"10.1016\/j.physbeh.2025.114806_bib0029","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1001\/jamaoncol.2021.0310","article-title":"Effectiveness of electroacupuncture or auricular acupuncture vs usual care for chronic musculoskeletal pain among cancer survivors: the peace randomized clinical trial","volume":"7","author":"Mao","year":"2021","journal-title":"JAMa Oncol."},{"issue":"1","key":"10.1016\/j.physbeh.2025.114806_bib0030","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s10006-023-01140-y","article-title":"Efficacy of auriculotherapy in the control of pain, edema, and trismus following surgical extraction of the lower third molars: a split-mouth, randomized, placebo-controlled, and triple-blind study","volume":"28","author":"Vaira","year":"2024","journal-title":"Oral Maxillofac. Surg."},{"issue":"4","key":"10.1016\/j.physbeh.2025.114806_bib0031","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/j.burns.2014.10.028","article-title":"Interactive effects of acupuncture on pain and distress in major burns: an experiment with rats","volume":"41","author":"Abali","year":"2015","journal-title":"Burns"},{"issue":"18","key":"10.1016\/j.physbeh.2025.114806_bib0032","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1177\/1535370220952342","article-title":"Acupuncture reduces pain in rats with osteoarthritis by inhibiting MCP2\/CCR2 signaling pathway","volume":"245","author":"Li","year":"2020","journal-title":"Exp. Biol. Med. (Maywood)"},{"key":"10.1016\/j.physbeh.2025.114806_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.112095","article-title":"Manual acupuncture ameliorates inflammatory pain by upregulating adenosine A(3) receptor in complete Freund's adjuvant-induced arthritis rats","volume":"133","author":"Xu","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.physbeh.2025.114806_bib0034","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.2147\/JPR.S371399","article-title":"The application of acupuncture therapy for postoperative pain over the past 20 years: a bibliometric analysis","volume":"15","author":"Liu","year":"2022","journal-title":"J. Pain. Res."},{"issue":"49","key":"10.1016\/j.physbeh.2025.114806_bib0035","doi-asserted-by":"crossref","first-page":"e32016","DOI":"10.1097\/MD.0000000000032016","article-title":"Acupuncture for postoperative pain of lumbar disc herniation: a systematic review and meta-analysis","volume":"101","author":"Zhang","year":"2022","journal-title":"Medicine (Baltimore)"},{"issue":"2","key":"10.1016\/j.physbeh.2025.114806_bib0036","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.0517","article-title":"Effectiveness of acupuncture for pain control after cesarean delivery: a randomized clinical trial","volume":"5","author":"Usichenko","year":"2022","journal-title":"JAMa Netw. Open"},{"issue":"6","key":"10.1016\/j.physbeh.2025.114806_bib0037","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/S0254-6272(15)30149-7","article-title":"Effect of direct current pulse stimulating acupoints of JiaJi (T10-13) and Ciliao (BL 32) with Han's Acupoint Nerve Stimulator on labour pain in women: a randomized controlled clinical study","volume":"35","author":"Liu","year":"2015","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.physbeh.2025.114806_bib0038","doi-asserted-by":"crossref","DOI":"10.1016\/j.clinsp.2024.100485","article-title":"Exploration of the mechanism underlying the therapeutic effect of electroacupuncture at chengshan acupoint on post-hemorrhoidectomy anal pain: insights from the mAChRs\/IP3-Ca(2+)-CaM signaling pathway","volume":"79","author":"Song","year":"2024","journal-title":"Clinics (Sao Paulo)"},{"issue":"1","key":"10.1016\/j.physbeh.2025.114806_bib0039","first-page":"68","article-title":"[Comparison of pain thresholds of acupoints on the leg in healthy volunteers]","volume":"38","author":"Wang","year":"2013","journal-title":"Zhen Ci Yan Jiu"},{"issue":"4","key":"10.1016\/j.physbeh.2025.114806_bib0040","first-page":"280","article-title":"Clinical observation on 100 cases of postoperative pain of anal-intestinal diseases treated with vitamin K blocking at changqiang point","volume":"22","author":"Wang","year":"2002","journal-title":"J. Tradit. Chin. Med."},{"issue":"6","key":"10.1016\/j.physbeh.2025.114806_bib0041","first-page":"533","article-title":"[Effect on Postoperative Complications of Mixed Hemorrhoids Treated with Electroacupuncture at Chengshan(BL 57), Dachangshu(BL 25)and Erbai(EX-UE 2)]","volume":"42","author":"Song","year":"2017","journal-title":"Zhen Ci Yan Jiu"},{"issue":"2","key":"10.1016\/j.physbeh.2025.114806_bib0042","first-page":"163","article-title":"Banding hemorrhoids using the O'Regan Disposable Bander. Single center experience","volume":"16","author":"Paikos","year":"2007","journal-title":"J. Gastrointestin. Liver. Dis."},{"key":"10.1016\/j.physbeh.2025.114806_bib0043","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jare.2021.06.007","article-title":"Characteristics of sensory innervation in synovium of rats within different knee osteoarthritis models and the correlation between synovial fibrosis and hyperalgesia","volume":"35","author":"Zhang","year":"2022","journal-title":"J. Adv. Res."},{"issue":"3","key":"10.1016\/j.physbeh.2025.114806_bib0044","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/BF00187257","article-title":"Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant","volume":"93","author":"Willner","year":"1987","journal-title":"Psychopharmacology (Berl)"},{"issue":"1","key":"10.1016\/j.physbeh.2025.114806_bib0045","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1007\/PL00005748","article-title":"Characterization of heat-hyperalgesia in an experimental trigeminal neuropathy in rats","volume":"116","author":"Imamura","year":"1997","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.physbeh.2025.114806_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.mce.2021.111392","article-title":"Let-7e modulates the proliferation and the autophagy of human granulosa cells by suppressing p21 signaling pathway in polycystic ovary syndrome without hyperandrogenism","volume":"535","author":"Li","year":"2021","journal-title":"Mol. Cell. Endocrinol."},{"issue":"3","key":"10.1016\/j.physbeh.2025.114806_bib0047","doi-asserted-by":"crossref","first-page":"e27","DOI":"10.4081\/hpr.2013.932","article-title":"Quality of life in chronic disease patients","volume":"1","author":"Megari","year":"2013","journal-title":"Health Psychol. Res."},{"issue":"11","key":"10.1016\/j.physbeh.2025.114806_bib0048","first-page":"792","article-title":"[Observation on therapeutic effect of electroacupuncture at Chengshan (BL 57) and Changqiang (GV 1) on hemorrhoidal pain]","volume":"28","author":"Li","year":"2008","journal-title":"Zhongguo Zhen. Jiu"},{"key":"10.1016\/j.physbeh.2025.114806_bib0049","article-title":"The role of acupuncture in relieving post-hemorrhoidectomy pain: a systematic review of randomized controlled trials","volume":"9","author":"Chen","year":"2022","journal-title":"Front. Surg."},{"issue":"50","key":"10.1016\/j.physbeh.2025.114806_bib0050","doi-asserted-by":"crossref","first-page":"e32247","DOI":"10.1097\/MD.0000000000032247","article-title":"Electroacupuncture for postoperative pain in mixed hemorrhoids: a meta-analysis","volume":"101","author":"Du","year":"2022","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.physbeh.2025.114806_bib0051","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5627550","article-title":"Three acupuncture methods for postoperative pain in mixed hemorrhoids: a systematic review and network meta-analysis","volume":"2022","author":"Ye","year":"2022","journal-title":"Comput. Math. Methods Med."},{"issue":"6","key":"10.1016\/j.physbeh.2025.114806_bib0052","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.joim.2020.08.001","article-title":"Effects of the pestle needle therapy, a type of acupoint stimulation, on post-hemorrhoidectomy pain: a randomized controlled trial","volume":"18","author":"Wang","year":"2020","journal-title":"J. Integr. Med."},{"issue":"7","key":"10.1016\/j.physbeh.2025.114806_bib0053","first-page":"747","article-title":"[Mechanism of acupoint transcutaneous electric stimulation on analgesic anesthesia in the patients undergoing general anesthesia anorectal operation]","volume":"37","author":"Lin","year":"2017","journal-title":"Zhongguo Zhen. Jiu"},{"issue":"3\u20134","key":"10.1016\/j.physbeh.2025.114806_bib0054","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3727\/036012902816026022","article-title":"Increased neuronal nitric oxide synthase expression in the gracile nucleus of brainstem following electroacupuncture given between cutaneous hindlimb acupuncture points BL 64 & BL 65 in rats","volume":"27","author":"Ma","year":"2002","journal-title":"Acupunct. ElectrOther Res."},{"issue":"6","key":"10.1016\/j.physbeh.2025.114806_bib0055","first-page":"580","article-title":"[Clinical observation of electroacupuncture combined with auricular point sticking therapy for anal pain of mixed hemorrhoid after external excision and internal ligation]","volume":"38","author":"Long","year":"2018","journal-title":"Zhongguo Zhen. Jiu"},{"issue":"4","key":"10.1016\/j.physbeh.2025.114806_bib0056","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1177\/1054773816685745","article-title":"Effect of transcutaneous acupoint electrical stimulation on post-hemorrhoidectomy-associated pain, anxiety, and heart rate variability: a randomized-controlled study","volume":"27","author":"Yeh","year":"2018","journal-title":"Clin. Nurs. Res."},{"issue":"2","key":"10.1016\/j.physbeh.2025.114806_bib0057","first-page":"118","article-title":"Acupuncture relieves pain by inhibiting expression of Cx43 in astrocytes and release of interfe-ron-\u03b3 in neurons of trigeminal spinal nucleus in rats with migraine","volume":"48","author":"Liu","year":"2023","journal-title":"Zhen Ci Yan Jiu"},{"issue":"5","key":"10.1016\/j.physbeh.2025.114806_bib0058","doi-asserted-by":"crossref","first-page":"2606","DOI":"10.1007\/s12035-023-03737-6","article-title":"Acupuncture ameliorates depression-like behaviors through modulating the neuroinflammation mediated by TLR4 signaling pathway in rats exposed to chronic restraint stress","volume":"61","author":"Jiang","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.physbeh.2025.114806_bib0059","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2147\/JPR.S346242","article-title":"Imaging study on acupuncture inhibiting inflammation and bone destruction in knee osteoarthritis induced by monosodium iodoacetate in rat model","volume":"15","author":"Tan","year":"2022","journal-title":"J. Pain. Res."},{"key":"10.1016\/j.physbeh.2025.114806_bib0060","doi-asserted-by":"crossref","DOI":"10.1007\/s11302-024-09985-y","article-title":"The role of purinergic signaling in acupuncture-mediated relief of neuropathic and inflammatory pain","author":"Huo","year":"2024","journal-title":"Purinergic. Signal."},{"issue":"3","key":"10.1016\/j.physbeh.2025.114806_bib0061","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/sj.bjp.0706559","article-title":"Activation of ERK1\/2 by extracellular nucleotides in macrophages is mediated by multiple P2 receptors independently of P2X7-associated pore or channel formation","volume":"147","author":"da Cruz","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.physbeh.2025.114806_bib0062","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pnpbp.2015.02.010","article-title":"ERK1\/2: function, signaling and implication in pain and pain-related anxio-depressive disorders","volume":"60","author":"Borges","year":"2015","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.physbeh.2025.114806_bib0063","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1213\/ANE.0b013e31826f0a4a","article-title":"The effects of electroacupuncture on the extracellular signal-regulated kinase 1\/2\/P2X3 signal pathway in the spinal cord of rats with chronic constriction injury","volume":"116","author":"Yu","year":"2013","journal-title":"Anesth. Analg."},{"issue":"6","key":"10.1016\/j.physbeh.2025.114806_bib0064","doi-asserted-by":"crossref","first-page":"340","DOI":"10.5498\/wjp.v13.i6.340","article-title":"Acupuncture at Back-Shu point improves insomnia by reducing inflammation and inhibiting the ERK\/NF-\u03baB signaling pathway","volume":"13","author":"Zhang","year":"2023","journal-title":"World J. Psychiatry"},{"key":"10.1016\/j.physbeh.2025.114806_bib0065","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1186\/1472-6882-14-285","article-title":"Electroacupuncture mediates extracellular signal-regulated kinase 1\/2 pathways in the spinal cord of rats with inflammatory pain","volume":"14","author":"Fang","year":"2014","journal-title":"BMC. Complement. Altern. Med."}],"container-title":["Physiology & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938425000083?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938425000083?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,24]],"date-time":"2025-02-24T02:32:47Z","timestamp":1740364367000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938425000083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":65,"alternative-id":["S0031938425000083"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2025.114806","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Acupuncture relieves postoperative pain of mixed hemorrhoids through the P2X7\/ERK axis in dorsal root ganglion","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2025.114806","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114806"}}