{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T14:58:19Z","timestamp":1777906699417,"version":"3.51.4"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013795","name":"Fujian Medical University","doi-asserted-by":"publisher","award":["2018001"],"award-info":[{"award-number":["2018001"]}],"id":[{"id":"10.13039\/501100013795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018623","name":"Quanzhou City Science and Technology Program","doi-asserted-by":"publisher","award":["2022NS068"],"award-info":[{"award-number":["2022NS068"]}],"id":[{"id":"10.13039\/501100018623","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.physbeh.2025.114864","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T11:42:21Z","timestamp":1740570141000},"page":"114864","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Therapeutic effects of amisulpride in male schizophrenics: Role of short-chain fatty acids and gene expression changes"],"prefix":"10.1016","volume":"294","author":[{"given":"Saizheng","family":"Weng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinchi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongqiao","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5767-3041","authenticated-orcid":false,"given":"Chih-Yuan","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"17","key":"10.1016\/j.physbeh.2025.114864_bib0001","doi-asserted-by":"crossref","first-page":"5040","DOI":"10.3390\/jcm11175040","article-title":"Schizophrenia: a narrative review of etiopathogenetic, diagnostic and treatment aspects","volume":"11","author":"Orsolini","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.physbeh.2025.114864_bib0002","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.schres.2020.02.010","article-title":"The role of the gut microbiome in the development of schizophrenia","volume":"234","author":"Kelly","year":"2021","journal-title":"Schizophr. Res"},{"key":"10.1016\/j.physbeh.2025.114864_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2024.105561","article-title":"Probiotic, prebiotic, synbiotic and fermented food supplementation in psychiatric disorders: a systematic review of clinical trials","volume":"158","author":"Ribera","year":"2024","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1","key":"10.1016\/j.physbeh.2025.114864_bib0004","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2147\/tcrm.2007.3.1.3","article-title":"The use of amisulpride in the treatment of acute psychosis","volume":"3","author":"Nuss","year":"2007","journal-title":"Ther. Clin. Risk. Manage"},{"key":"10.1016\/j.physbeh.2025.114864_bib0005","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.2147\/NDT.S140905","article-title":"Effectiveness of amisulpride in Chinese patients with predominantly negative symptoms of schizophrenia: a subanalysis of the ESCAPE study","volume":"13","author":"Liang","year":"2017","journal-title":"Neuropsychiatr. Dis. Treat."},{"issue":"3","key":"10.1016\/j.physbeh.2025.114864_bib0006","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00213-004-1826-6","article-title":"Prolactinemia is uncoupled from central D2\/D3 dopamine receptor occupancy in amisulpride treated patients","volume":"175","author":"Bressan","year":"2004","journal-title":"Psychopharmacology. (Berl)"},{"key":"10.1016\/j.physbeh.2025.114864_bib0007","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/4262094","article-title":"Analysis of gut microbiota in patients with exacerbated symptoms of schizophrenia following therapy with amisulpride: a pilot study","volume":"2022","author":"Zheng","year":"2022","journal-title":"Behav. Neurol."},{"key":"10.1016\/j.physbeh.2025.114864_bib0008","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.bbi.2019.06.039","article-title":"Altered gut microbiota and mucosal immunity in patients with schizophrenia","volume":"85","author":"Xu","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.physbeh.2025.114864_bib0009","article-title":"The regulatory effects of second-generation antipsychotics on lipid metabolism: potential mechanisms mediated by the gut microbiota and therapeutic implications","volume":"14","author":"Chen","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"2","key":"10.1016\/j.physbeh.2025.114864_bib0010","doi-asserted-by":"crossref","first-page":"eaau8317","DOI":"10.1126\/sciadv.aau8317","article-title":"The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice","volume":"5","author":"Zheng","year":"2019","journal-title":"Sci. Adv."},{"issue":"11","key":"10.1016\/j.physbeh.2025.114864_bib0011","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1038\/s41380-019-0475-4","article-title":"Transplantation of microbiota from drug-free patients with schizophrenia causes schizophrenia-like abnormal behaviors and dysregulated kynurenine metabolism in mice","volume":"25","author":"Zhu","year":"2020","journal-title":"Mol. Psychiat."},{"key":"10.1016\/j.physbeh.2025.114864_bib0012","article-title":"Intestinal permeability and low-grade chronic inflammation in schizophrenia: a multicentre study on biomarkers. Rationale, objectives, protocol and preliminary results","author":"Anmella","year":"2023","journal-title":"Span. J. Psychiat. Ment. Heal."},{"issue":"5","key":"10.1016\/j.physbeh.2025.114864_bib0013","doi-asserted-by":"crossref","first-page":"e02133","DOI":"10.1002\/brb3.2133","article-title":"Maternal immune activation alters adult behavior, intestinal integrity, gut microbiota and the gut inflammation","volume":"11","author":"Li","year":"2021","journal-title":"Brain Behav"},{"key":"10.1016\/j.physbeh.2025.114864_bib0014","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jpsychires.2023.07.042","article-title":"Altered levels of fecal short-chain fatty acids are associated with subclinical inflammation and worse cognitive performance in patients with schizophrenia","volume":"165","author":"Kowalski","year":"2023","journal-title":"J. Psychiatr. Res."},{"issue":"2","key":"10.1016\/j.physbeh.2025.114864_bib0015","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1093\/schbul\/sbad171","article-title":"Toll-like receptor mRNA levels in schizophrenia: association with complement factors and cingulate gyrus cortical thinning","volume":"50","author":"Weickert","year":"2024","journal-title":"Schizophr. Bull."},{"issue":"Suppl 2","key":"10.1016\/j.physbeh.2025.114864_bib0016","first-page":"114","article-title":"Peripheral blood mononuclear cell-related biomarkers in schizophrenia","volume":"35","author":"Astafeva","year":"2023","journal-title":"Psychiatr. Danub."},{"issue":"1","key":"10.1016\/j.physbeh.2025.114864_bib0017","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41398-022-02229-w","article-title":"Diagnostic model development for schizophrenia based on peripheral blood mononuclear cell subtype-specific expression of metabolic markers","volume":"12","author":"Zaki","year":"2022","journal-title":"Transl. Psychiat"},{"issue":"1","key":"10.1016\/j.physbeh.2025.114864_bib0018","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12951-021-00915-3","article-title":"Melatonin alleviates titanium nanoparticles induced osteolysis via activation of butyrate\/GPR109A signaling pathway","volume":"19","author":"Wu","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.physbeh.2025.114864_bib0019","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9877053","article-title":"Disturbances of the gut microbiota, sleep architecture, and mTOR signaling pathway in patients with severe obstructive sleep apnea-associated hypertension","volume":"2021","author":"Ko","year":"2021","journal-title":"Int. J. Hypertens."},{"issue":"1","key":"10.1016\/j.physbeh.2025.114864_bib0020","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.immuni.2013.12.007","article-title":"Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis","volume":"40","author":"Singh","year":"2014","journal-title":"Immunity."},{"issue":"7","key":"10.1016\/j.physbeh.2025.114864_bib0021","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/nn.4030","article-title":"Host microbiota constantly control maturation and function of microglia in the CNS","volume":"18","author":"Erny","year":"2015","journal-title":"Nat. Neurosci."},{"issue":"10","key":"10.1016\/j.physbeh.2025.114864_bib0022","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/nrd2681","article-title":"Therapeutic application of histone deacetylase inhibitors for central nervous system disorders","volume":"7","author":"Kazantsev","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.physbeh.2025.114864_bib0023","doi-asserted-by":"crossref","first-page":"RP86823","DOI":"10.7554\/eLife.86823","article-title":"Plasticity of gene expression in the nervous system by exposure to environmental odorants that inhibit HDACs","volume":"12","author":"Haga-Yamanaka","year":"2024","journal-title":"Elife"},{"issue":"11","key":"10.1016\/j.physbeh.2025.114864_bib0024","doi-asserted-by":"crossref","first-page":"3707","DOI":"10.3390\/jcm9113707","article-title":"The differences between gluten sensitivity, intestinal biomarkers and immune biomarkers in patients with first-episode and chronic schizophrenia","volume":"9","author":"Dzikowski","year":"2020","journal-title":"J. Clin. Med."},{"issue":"13","key":"10.1016\/j.physbeh.2025.114864_bib0025","doi-asserted-by":"crossref","first-page":"5341","DOI":"10.1007\/s00253-021-11406-8","article-title":"Research progress on toll-like receptor signal transduction and its roles in antimicrobial immune responses","volume":"105","author":"Xia","year":"2021","journal-title":"Appl. Microbiol. Biotechnol."},{"issue":"4","key":"10.1016\/j.physbeh.2025.114864_bib0026","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1124\/dmd.31.4.421","article-title":"Effects of prototypical microsomal enzyme inducers on cytochrome P450 expression in cultured human hepatocytes","volume":"31","author":"Madan","year":"2003","journal-title":"Drug Metab. Dispos."},{"issue":"4","key":"10.1016\/j.physbeh.2025.114864_bib0027","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s00213-023-06511-7","article-title":"Behavioral and transcriptional effects of repeated electroconvulsive seizures in the neonatal MK-801-treated rat model of schizophrenia","volume":"241","author":"Lee","year":"2024","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.physbeh.2025.114864_bib0028","doi-asserted-by":"crossref","first-page":"6734","DOI":"10.1038\/ncomms7734","article-title":"Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome","volume":"6","author":"Macia","year":"2015","journal-title":"Nat. Commun."},{"issue":"8","key":"10.1016\/j.physbeh.2025.114864_bib0029","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41575-019-0157-3","article-title":"The role of short-chain fatty acids in microbiota-gut-brain communication","volume":"16","author":"Dalile","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"7","key":"10.1016\/j.physbeh.2025.114864_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0276-5","article-title":"Acetate attenuates inflammasome activation through GPR43-mediated Ca2+-dependent NLRP3 ubiquitination","volume":"51","author":"Xu","year":"2019","journal-title":"Exp. Mol. Med."},{"issue":"20","key":"10.1016\/j.physbeh.2025.114864_bib0031","doi-asserted-by":"crossref","first-page":"4391","DOI":"10.3390\/nu15204391","article-title":"The gut-brain axis in schizophrenia: the implications of the gut microbiome and SCFA production","volume":"15","author":"Ju","year":"2023","journal-title":"Nutrients"},{"issue":"4","key":"10.1016\/j.physbeh.2025.114864_bib0032","doi-asserted-by":"crossref","first-page":"930","DOI":"10.3390\/nu15040930","article-title":"Neuroprotective effects of sodium butyrate by restoring gut microbiota and inhibiting TLR4 signaling in mice with MPTP-induced Parkinson's disease","volume":"15","author":"Guo","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.physbeh.2025.114864_bib0033","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.schres.2019.10.013","article-title":"Adolescent social functioning in offspring at high risk for schizophrenia spectrum disorders in the finnish adoptive family study of schizophrenia","volume":"215","author":"Tikkanen","year":"2020","journal-title":"Schizophr. Res"},{"issue":"16","key":"10.1016\/j.physbeh.2025.114864_bib0034","doi-asserted-by":"crossref","first-page":"8710","DOI":"10.3390\/ijms22168710","article-title":"Inhibition of BET proteins during adolescence affects prefrontal cortical development: relevance to schizophrenia","volume":"22","author":"Bilecki","year":"2021","journal-title":"Int. J. Mol. Sci"},{"issue":"1","key":"10.1016\/j.physbeh.2025.114864_bib0035","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.biopsych.2020.11.014","article-title":"Relationship between serum NMDA receptor antibodies and response to antipsychotic treatment in first-episode psychosis","volume":"90","author":"Pollak","year":"2021","journal-title":"Biol. Psychiat."},{"issue":"7","key":"10.1016\/j.physbeh.2025.114864_bib0036","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.cell.2013.11.024","article-title":"Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders","volume":"155","author":"Hsiao","year":"2013","journal-title":"Cell"}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938425000654?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938425000654?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:21:55Z","timestamp":1777641715000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938425000654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":36,"alternative-id":["S0031938425000654"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2025.114864","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic effects of amisulpride in male schizophrenics: Role of short-chain fatty acids and gene expression changes","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2025.114864","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"114864"}}