{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T05:12:25Z","timestamp":1777957945794,"version":"3.51.4"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T00:00:00Z","timestamp":1742601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DC00416"],"award-info":[{"award-number":["DC00416"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology & Behavior"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.physbeh.2025.114889","type":"journal-article","created":{"date-parts":[[2025,3,22]],"date-time":"2025-03-22T17:27:13Z","timestamp":1742664433000},"page":"114889","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Chemogenetic suppression of NST GABA neurons reveals inhibition of behavioral responses to sucrose and quinine"],"prefix":"10.1016","volume":"295","author":[{"given":"B.","family":"Kalyanasundar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Harley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Klimovich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8730-3618","authenticated-orcid":false,"given":"Susan","family":"Travers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2025.114889_bib0001","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1177\/1534582305280031","article-title":"The representation of taste quality in the mammalian nervous system","volume":"4","author":"Spector","year":"2005","journal-title":"Behav. Cogn. Neurosci. Rev."},{"key":"10.1016\/j.physbeh.2025.114889_bib0002","doi-asserted-by":"crossref","DOI":"10.1093\/acrefore\/9780190264086.013.331","article-title":"Anatomical organization and coding in the gustatory system: a functional perspective","author":"Travers","year":"2021","journal-title":"Oxford Res. Encylop. Neurosci."},{"key":"10.1016\/j.physbeh.2025.114889_bib0003","doi-asserted-by":"crossref","unstructured":"Travers, J.B., Travers, S.P. Microcircuitry of the rostral nucleus of the solitary tract. In: Shepherd GM, Grillner S, eds. Handbook of Brain Microcircuits Edition ed: Oxford; 2018.","DOI":"10.1093\/med\/9780190636111.003.0033"},{"key":"10.1016\/j.physbeh.2025.114889_bib0004","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0006-8993(98)01270-0","article-title":"A subpopulation of neurons in the rat rostral nucleus of the solitary tract that project to the parabrachial nucleus express glutamate-like immunoreactivity","volume":"821","author":"Gill","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2025.114889_bib0005","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/0361-9230(88)90202-X","article-title":"Organization of GABA and GABA-transaminase containing neurons in the gustatory zone of the nucleus of the solitary tract","volume":"21","author":"Lasiter","year":"1988","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.physbeh.2025.114889_bib0006","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/0361-9230(93)90040-I","article-title":"GABA-like immunoreactivity in the gustatory zone of the nucleus of the solitary tract in the hamster: light and electron microscopic studies","volume":"30","author":"Davis","year":"1993","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.physbeh.2025.114889_bib0007","doi-asserted-by":"crossref","first-page":"3205","DOI":"10.1152\/jn.00971.2009","article-title":"Properties of GABAergic neurons in the rostral solitary tract nucleus in mice","volume":"103","author":"Wang","year":"2010","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.physbeh.2025.114889_bib0008","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1152\/jn.00711.2012","article-title":"The mu-opioid receptor agonist DAMGO presynaptically suppresses solitary tract-evoked input to neurons in the rostral solitary nucleus","volume":"109","author":"Boxwell","year":"2013","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.physbeh.2025.114889_bib0009","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1152\/jn.00168.2016","article-title":"Inhibitory modulation of optogenetically identified neuron subtypes in the rostral solitary nucleus","volume":"116","author":"Chen","year":"2016","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.physbeh.2025.114889_bib0010","first-page":"9","article-title":"Characteristics and impact of the rNST GABA network on neural and behavioral taste responses","author":"Travers","year":"2022","journal-title":"eNeuro"},{"key":"10.1016\/j.physbeh.2025.114889_bib0011","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1523\/JNEUROSCI.2714-16.2016","article-title":"Excitatory hindbrain-forebrain communication is required for cisplatin-induced anorexia and weight loss","volume":"37","author":"Alhadeff","year":"2017","journal-title":"J. Neurosci. Offic. J. Soc. Neurosci."},{"key":"10.1016\/j.physbeh.2025.114889_bib0012","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1038\/s41598-019-39490-x","article-title":"A hindbrain inhibitory microcircuit mediates vagally-coordinated glucose regulation","volume":"9","author":"Boychuk","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.physbeh.2025.114889_bib0013","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nn.4451","article-title":"HSD2 neurons in the hindbrain drive sodium appetite","volume":"20","author":"Jarvie","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.physbeh.2025.114889_bib0014","doi-asserted-by":"crossref","first-page":"10268","DOI":"10.1038\/ncomms10268","article-title":"Gs-coupled GPCR signalling in AgRP neurons triggers sustained increase in food intake","volume":"7","author":"Nakajima","year":"2016","journal-title":"Nat. Commun."},{"key":"10.1016\/j.physbeh.2025.114889_bib0015","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/nn.4540","article-title":"GLP-1 acts on habenular avoidance circuits to control nicotine intake","volume":"20","author":"Tuesta","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.physbeh.2025.114889_bib0016","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.cell.2020.12.014","article-title":"Top-down control of sweet and bitter taste in the mammalian brain","volume":"184","author":"Jin","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.physbeh.2025.114889_bib0017","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1093\/chemse\/27.5.461","article-title":"A high-throughput screening procedure for identifying mice with aberrant taste and oromotor function","volume":"27","author":"Glendinning","year":"2002","journal-title":"Chem. Senses"},{"key":"10.1016\/j.physbeh.2025.114889_bib0018","first-page":"49","article-title":"TRPM4 and PLCbeta3 contribute to normal behavioral responses to an array of sweeteners and carbohydrates but PLCbeta3 is not needed for taste-driven licking for glucose","author":"Ascencio Gutierrez","year":"2024","journal-title":"Chem. Senses"},{"key":"10.1016\/j.physbeh.2025.114889_bib0019","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1177\/22.12.1077","article-title":"Periodate-lysine-paraformaldehyde fixative. A new fixation for immunoelectron microscopy","volume":"12","author":"McLean","year":"1974","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.physbeh.2025.114889_bib0020","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0196-9781(86)90076-8","article-title":"Use of cryoprotectant to maintain long-term peptide immunoreactivity and tissue morphology","volume":"7","author":"Watson","year":"1986","journal-title":"Peptides."},{"key":"10.1016\/j.physbeh.2025.114889_bib0021","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1002\/cne.23069","article-title":"Glial responses after chorda tympani nerve injury","volume":"520","author":"Bartel","year":"2012","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.physbeh.2025.114889_bib0022","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/chemse\/bjw055","article-title":"P2X2 Receptor terminal field demarcates a \"transition zone\" for gustatory and mechanosensory processing in the mouse nucleus tractus solitarius","volume":"41","author":"Breza","year":"2016","journal-title":"Chem. Senses"},{"key":"10.1016\/j.physbeh.2025.114889_bib0023","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1002\/cne.24501","article-title":"Neurons with diverse phenotypes project from the caudal to the rostral nucleus of the solitary tract","volume":"526","author":"Travers","year":"2018","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.physbeh.2025.114889_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2022.147838","article-title":"Perturbation of amygdala\/somatostatin-nucleus of the solitary tract projections reduces sensitivity to quinine in a brief-access test","volume":"1783","author":"Bartonjo","year":"2022","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2025.114889_bib0025","series-title":"AChemS XLV","article-title":"Inhibitory neuron subpopulations in the rNST","author":"Klimovich","year":"2023"},{"key":"10.1016\/j.physbeh.2025.114889_bib0026","doi-asserted-by":"crossref","first-page":"R1085","DOI":"10.1152\/ajpregu.2001.280.4.R1085","article-title":"Muscimol infusions in the brain stem reticular formation reversibly block ingestion in the awake rat","volume":"280","author":"Chen","year":"2001","journal-title":"Am. J. Physiol. Regul. Integr. Compar. Physiol."},{"key":"10.1016\/j.physbeh.2025.114889_bib0027","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s002219900223","article-title":"Medullary reticular formation activity during ingestion and rejection in the awake rat","volume":"130","author":"Travers","year":"2000","journal-title":"Exp. Brain Res."},{"key":"10.1016\/j.physbeh.2025.114889_bib0028","doi-asserted-by":"crossref","first-page":"e13132","DOI":"10.1111\/jne.13132","article-title":"The ins and outs of the caudal nucleus of the solitary tract: an overview of cellular populations and anatomical connections","volume":"34","author":"Holt","year":"2022","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.physbeh.2025.114889_bib0029","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.tins.2018.03.007","article-title":"The parabrachial nucleus: CGRP neurons function as a general alarm","volume":"41","author":"Palmiter","year":"2018","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.physbeh.2025.114889_bib0030","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0006-8993(91)90143-J","article-title":"Intramedullary connections of the rostral nucleus of the solitary tract in the hamster","volume":"557","author":"Beckman","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.physbeh.2025.114889_bib0031","doi-asserted-by":"crossref","first-page":"R1401","DOI":"10.1152\/ajpregu.00536.2011","article-title":"Activation of NPY receptors suppresses excitatory synaptic transmission in a taste-feeding network in the lower brain stem","volume":"302","author":"Chen","year":"2012","journal-title":"Am. J. Physiol. Regul. Integr. Compar. Physiol."},{"key":"10.1016\/j.physbeh.2025.114889_bib0032","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1002\/cne.21213","article-title":"Taste-evoked Fos expression in nitrergic neurons in the nucleus of the solitary tract and reticular formation of the rat","volume":"500","author":"Travers","year":"2007","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.physbeh.2025.114889_bib0033","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0031-9384(24)00191-4","article-title":"Blood glucose selectively affects taste-evoked activity in rat nucleus tractus solitarius","volume":"31","author":"Giza","year":"1983","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2025.114889_bib0034","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/0361-9230(92)90116-F","article-title":"Administration of satiety factors and gustatory responsiveness in the nucleus tractus solitarius of the rat","volume":"28","author":"Giza","year":"1992","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.physbeh.2025.114889_bib0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2023.101833","article-title":"AgRP neuron activity promotes associations between sensory and nutritive signals to guide flavor preference","volume":"78","author":"Nyema","year":"2023","journal-title":"Mol. Metab."},{"key":"10.1016\/j.physbeh.2025.114889_bib0036","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.bbr.2018.11.023","article-title":"Sex differences in hedonic and homeostatic aspects of palatable food motivation","volume":"359","author":"Tapia","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2025.114889_bib0037","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2024.105743","article-title":"Mapping GABAergic projections that mediate feeding","volume":"163","author":"Wang","year":"2024","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.physbeh.2025.114889_bib0038","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/j.cell.2009.04.022","article-title":"Loss of GABAergic signaling by AgRP neurons to the parabrachial nucleus leads to starvation","volume":"137","author":"Wu","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.physbeh.2025.114889_bib0039","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1016\/j.cub.2024.02.074","article-title":"A brainstem to hypothalamic arcuate nucleus GABAergic circuit drives feeding","volume":"34","author":"Martinez de Morentin","year":"2024","journal-title":"Curr. Biol. CB"}],"container-title":["Physiology & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938425000903?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938425000903?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T04:28:44Z","timestamp":1777955324000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938425000903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":39,"alternative-id":["S0031938425000903"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2025.114889","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chemogenetic suppression of NST GABA neurons reveals inhibition of behavioral responses to sucrose and quinine","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2025.114889","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114889"}}