{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T19:31:15Z","timestamp":1785526275596,"version":"3.56.0"},"reference-count":130,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004784","name":"Novartis Foundation for Medical-Biological Research","doi-asserted-by":"publisher","award":["18A040"],"award-info":[{"award-number":["18A040"]}],"id":[{"id":"10.13039\/501100004784","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Swiss National Science Foundation","doi-asserted-by":"publisher","award":["PZ00P3_174120"],"award-info":[{"award-number":["PZ00P3_174120"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006390","name":"Universit\u00e9 de Lausanne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006390","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019180","name":"HORIZON EUROPE European Research Council","doi-asserted-by":"publisher","award":["948196"],"award-info":[{"award-number":["948196"]}],"id":[{"id":"10.13039\/100019180","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.physbeh.2025.114917","type":"journal-article","created":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T08:44:31Z","timestamp":1744361071000},"page":"114917","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Tanycytes in the nexus of hypothalamic inflammation, appetite control, and obesity"],"prefix":"10.1016","volume":"296","author":[{"given":"Rafik","family":"Dali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0021-0422","authenticated-orcid":false,"given":"Fanny","family":"Langlet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2025.114917_bib0001","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3810\/pgm.2009.11.2074","article-title":"The medical risks of obesity","volume":"121","author":"Pi-Sunyer","year":"2009","journal-title":"Postgrad. Med."},{"key":"10.1016\/j.physbeh.2025.114917_bib0002","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/01.hjr.0000114707.27531.48","article-title":"International Obesity Task Force, The obesity epidemic, metabolic syndrome and future prevention strategies","volume":"11","author":"James","year":"2004","journal-title":"Eur. J. Cardiovasc. Prev. Rehabil."},{"key":"10.1016\/j.physbeh.2025.114917_bib0003","first-page":"1571","article-title":"The importance of gene\u2013environment interactions in human obesity","volume":"130","author":"Reddon","year":"2016","journal-title":"Clin. Neurosci. Res."},{"key":"10.1016\/j.physbeh.2025.114917_bib0004","first-page":"e1435","article-title":"The interplay of genetics and environmental factors in the development of obesity","volume":"9","author":"Sheikh","year":"2017","journal-title":"Cureus"},{"key":"10.1016\/j.physbeh.2025.114917_bib0005","article-title":"Hypothalamic obesity: from basic mechanisms to clinical perspectives","author":"Argente","year":"2024","journal-title":"Lancet Diabetes Endocrinol."},{"key":"10.1016\/j.physbeh.2025.114917_bib0006","doi-asserted-by":"crossref","first-page":"448","DOI":"10.2741\/s37","article-title":"The central nervous system at the core of the regulation of energy homeostasis","volume":"1","author":"Luquet","year":"2009","journal-title":"Front. Biosci."},{"key":"10.1016\/j.physbeh.2025.114917_bib0007","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1210\/endrev\/bnab025","article-title":"Arcuate nucleus-dependent regulation of metabolism\u2014pathways to obesity and diabetes mellitus","volume":"43","author":"Jais","year":"2022","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.physbeh.2025.114917_bib0008","doi-asserted-by":"crossref","first-page":"e216","DOI":"10.1038\/emm.2016.4","article-title":"Emerging role of the brain in the homeostatic regulation of energy and glucose metabolism","volume":"48","author":"Roh","year":"2016","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.physbeh.2025.114917_bib0009","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1172\/JCI88878","article-title":"Hypothalamic inflammation in obesity and metabolic disease","volume":"127","author":"Jais","year":"2017","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.physbeh.2025.114917_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s44324-024-00026-1","article-title":"Hypothalamic neuronal-glial crosstalk in metabolic disease","volume":"2","author":"Nguyen","year":"2024","journal-title":"npj Metab. Health Dis."},{"key":"10.1016\/j.physbeh.2025.114917_bib0011","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/MED.0000000000000182","article-title":"Hypothalamic inflammation and gliosis in obesity","volume":"22","author":"Dorfman","year":"2015","journal-title":"Curr. Opin. Endocrinol. Diabetes Obes."},{"key":"10.1016\/j.physbeh.2025.114917_bib0012","doi-asserted-by":"crossref","first-page":"eabl7398","DOI":"10.1126\/science.abl7398","article-title":"Integrative neurocircuits that control metabolism and food intake","volume":"381","author":"Br\u00fcning","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.physbeh.2025.114917_bib0013","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1242\/dmm.026609","article-title":"Hypothalamic circuits regulating appetite and energy homeostasis: pathways to obesity","volume":"10","author":"Timper","year":"2017","journal-title":"Dis. Models Mech."},{"key":"10.1016\/j.physbeh.2025.114917_bib0014","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cell.2015.02.023","article-title":"Neural control of energy balance: translating circuits to therapies","volume":"161","author":"Gautron","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.physbeh.2025.114917_bib0015","doi-asserted-by":"crossref","DOI":"10.3389\/fnana.2015.00040","article-title":"Whole-brain mapping of the direct inputs and axonal projections of POMC and AgRP neurons","volume":"9","author":"Wang","year":"2015","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.physbeh.2025.114917_bib0016","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1002\/cne.23355","article-title":"Tanycyte-like cells form a blood-cerebrospinal fluid barrier in the circumventricular organs of the mouse brain","volume":"521","author":"Langlet","year":"2013","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.physbeh.2025.114917_bib0017","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/cne.22273","article-title":"Differential distribution of tight junction proteins suggests a role for tanycytes in blood-hypothalamus barrier regulation in the adult mouse brain","volume":"518","author":"Mullier","year":"2010","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.physbeh.2025.114917_bib0018","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.cmet.2013.03.004","article-title":"Tanycytic VEGF-A boosts blood-hypothalamus barrier plasticity and access of metabolic signals to the arcuate nucleus in response to fasting","volume":"17","author":"Langlet","year":"2013","journal-title":"Cell Metab."},{"key":"10.1016\/j.physbeh.2025.114917_bib0019","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1073\/pnas.1212137110","article-title":"Rapid sensing of circulating ghrelin by hypothalamic appetite-modifying neurons","volume":"110","author":"Schaeffer","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.physbeh.2025.114917_bib0020","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1038\/s42255-022-00657-y","article-title":"HypoMap\u2014A unified single-cell gene expression atlas of the murine hypothalamus","volume":"4","author":"Steuernagel","year":"2022","journal-title":"Nat. Metab."},{"key":"10.1016\/j.physbeh.2025.114917_bib0021","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/s41593-018-0286-y","article-title":"Role of astrocytes, microglia, and tanycytes in brain control of systemic metabolism","volume":"22","author":"Garc\u00eda-C\u00e1ceres","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.physbeh.2025.114917_bib0022","doi-asserted-by":"crossref","first-page":"R59","DOI":"10.1530\/JME-16-0182","article-title":"Glial cells and energy balance","volume":"58","author":"Argente-Ariz\u00f3n","year":"2017","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.physbeh.2025.114917_bib0023","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s00125-016-4181-3","article-title":"Glia: silent partners in energy homeostasis and obesity pathogenesis","volume":"60","author":"Douglass","year":"2017","journal-title":"Diabetologia"},{"key":"10.1016\/j.physbeh.2025.114917_bib0024","doi-asserted-by":"crossref","first-page":"286","DOI":"10.3389\/fendo.2019.00286","article-title":"Tanycyte gene expression dynamics in the regulation of energy homeostasis","volume":"10","author":"Langlet","year":"2019","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.physbeh.2025.114917_bib0025","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/s42255-022-00610-z","article-title":"Glial cells as integrators of peripheral and central signals in the regulation of energy homeostasis","volume":"4","author":"Nampoothiri","year":"2022","journal-title":"Nat. Metab."},{"key":"10.1016\/j.physbeh.2025.114917_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109362","article-title":"Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence","volume":"36","author":"Kohnke","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.physbeh.2025.114917_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2023.114108","article-title":"Tanycyte, the neuron whisperer","volume":"263","author":"Dali","year":"2023","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2025.114917_bib0028","doi-asserted-by":"crossref","first-page":"4109","DOI":"10.1210\/en.2010-0336","article-title":"Minireview: inflammation and obesity pathogenesis: the hypothalamus heats up","volume":"151","author":"Thaler","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.physbeh.2025.114917_bib0029","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1038\/ijo.2011.56","article-title":"Altered hypothalamic function in diet-induced obesity","volume":"35","author":"Velloso","year":"2011","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.physbeh.2025.114917_bib0030","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1172\/JCI59660","article-title":"Obesity is associated with hypothalamic injury in rodents and humans","volume":"122","author":"Thaler","year":"2012","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.physbeh.2025.114917_bib0031","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/glia.23882","article-title":"Dietary fat exacerbates postprandial hypothalamic inflammation involving glial fibrillary acidic protein-positive cells and microglia in male mice","volume":"69","author":"Cansell","year":"2021","journal-title":"Glia"},{"key":"10.1016\/j.physbeh.2025.114917_bib0032","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.physbeh.2011.01.010","article-title":"Consumption of a high-fat diet induces central insulin resistance independent of adiposity","volume":"103","author":"Clegg","year":"2011","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2025.114917_bib0033","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.cmet.2017.05.015","article-title":"Microglial inflammatory signaling orchestrates the hypothalamic immune response to dietary excess and mediates obesity susceptibility","volume":"26","author":"Valdearcos","year":"2017","journal-title":"Cell Metab."},{"key":"10.1016\/j.physbeh.2025.114917_bib0034","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.bbi.2013.09.011","article-title":"The effects of dietary saturated fat on basal hypothalamic neuroinflammation in rats","volume":"36","author":"Maric","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.physbeh.2025.114917_bib0035","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1523\/JNEUROSCI.2760-08.2009","article-title":"Saturated fatty acids produce an inflammatory response predominantly through the activation of TLR4 signaling in hypothalamus: implications for the pathogenesis of obesity","volume":"29","author":"Milanski","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.physbeh.2025.114917_bib0036","doi-asserted-by":"crossref","first-page":"E1003","DOI":"10.1152\/ajpendo.90377.2008","article-title":"Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet","volume":"296","author":"Posey","year":"2009","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.physbeh.2025.114917_bib0037","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.celrep.2014.10.045","article-title":"Distinct roles for JNK and IKK activation in agouti-related peptide neurons in the development of obesity and insulin resistance","volume":"9","author":"Tsaousidou","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.physbeh.2025.114917_bib0038","doi-asserted-by":"crossref","first-page":"9047","DOI":"10.1074\/jbc.275.12.9047","article-title":"The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)","volume":"275","author":"Aguirre","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.physbeh.2025.114917_bib0039","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.cmet.2009.08.013","article-title":"MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity","volume":"10","author":"Kleinridders","year":"2009","journal-title":"Cell Metab."},{"key":"10.1016\/j.physbeh.2025.114917_bib0040","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1111\/nyas.12855","article-title":"The complex contribution of chemokines to neuroinflammation: switching from beneficial to detrimental effects","volume":"1351","author":"Thuc","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.physbeh.2025.114917_bib0041","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cell.2008.07.043","article-title":"Hypothalamic IKK\u03b2\/NF-\u03baB and ER stress link overnutrition to energy imbalance and obesity","volume":"135","author":"Zhang","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.physbeh.2025.114917_bib0042","doi-asserted-by":"crossref","first-page":"4192","DOI":"10.1210\/en.2004-1520","article-title":"Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus","volume":"146","author":"De Souza","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.physbeh.2025.114917_bib0043","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1038\/s42255-024-01079-8","article-title":"Obesity-induced inflammation: connecting the periphery to the brain","volume":"6","author":"Thuc","year":"2024","journal-title":"Nat. Metab."},{"key":"10.1016\/j.physbeh.2025.114917_bib0044","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev-immunol-031210-101322","article-title":"Inflammatory mechanisms in obesity","volume":"29","author":"Gregor","year":"2011","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.physbeh.2025.114917_bib0045","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1186\/s12974-019-1607-0","article-title":"Cellular source of hypothalamic macrophage accumulation in diet-induced obesity","volume":"16","author":"Lee","year":"2019","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.physbeh.2025.114917_bib0046","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.celrep.2018.09.070","article-title":"hypothalamic macrophage inducible nitric oxide synthase mediates obesity-associated hypothalamic inflammation","volume":"25","author":"Lee","year":"2018","journal-title":"Cell Rep."},{"key":"10.1016\/j.physbeh.2025.114917_bib0047","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/s12974-022-02519-6","article-title":"Perivascular macrophages in high-fat diet-induced hypothalamic inflammation","volume":"19","author":"Mendes","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.physbeh.2025.114917_bib0048","doi-asserted-by":"crossref","first-page":"e5045","DOI":"10.1371\/journal.pone.0005045","article-title":"High-fat diet induces apoptosis of hypothalamic neurons","volume":"4","author":"Moraes","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.physbeh.2025.114917_bib0049","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.tem.2012.11.003","article-title":"Neuroinflammation and neurodegeneration in overnutrition-induced diseases","volume":"24","author":"Cai","year":"2013","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.physbeh.2025.114917_bib0050","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/jnc.14662","article-title":"Injury to hypothalamic Sim1 neurons is a common feature of obesity by exposure to high-fat diet in male and female mice","volume":"149","author":"Nyamugenda","year":"2019","journal-title":"J. Neurochem."},{"key":"10.1016\/j.physbeh.2025.114917_bib0051","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.100977","article-title":"High-fat diet induces time-dependent synaptic plasticity of the lateral hypothalamus","volume":"36","author":"Linehan","year":"2020","journal-title":"Mol. Metab."},{"key":"10.1016\/j.physbeh.2025.114917_bib0052","doi-asserted-by":"crossref","first-page":"14875","DOI":"10.1073\/pnas.1004282107","article-title":"Synaptic input organization of the melanocortin system predicts diet-induced hypothalamic reactive gliosis and obesity","volume":"107","author":"Horvath","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.physbeh.2025.114917_bib0053","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.molmet.2012.08.004","article-title":"High calorie diet triggers hypothalamic angiopathy","volume":"1","author":"Yi","year":"2012","journal-title":"Mol. Metab."},{"key":"10.1016\/j.physbeh.2025.114917_bib0054","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3233\/JAD-2010-091414","article-title":"The effects of a high-energy diet on hippocampal function and blood-brain barrier integrity in the rat","volume":"21","author":"Kanoski","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.physbeh.2025.114917_bib0055","doi-asserted-by":"crossref","first-page":"E1122","DOI":"10.1152\/ajpendo.00006.2010","article-title":"Cultured hypothalamic neurons are resistant to inflammation and insulin resistance induced by saturated fatty acids","volume":"298","author":"Choi","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.physbeh.2025.114917_bib0056","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1016\/j.neuron.2022.10.020","article-title":"Microglia states and nomenclature: a field at its crossroads","volume":"110","author":"Paolicelli","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.physbeh.2025.114917_bib0057","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev-immunol-051116-052358","article-title":"Microglia function in the central nervous system during health and neurodegeneration","volume":"35","author":"Colonna","year":"2017","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.physbeh.2025.114917_bib0058","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1002\/glia.22580","article-title":"Hormones and diet, but not body weight, control hypothalamic microglial activity","volume":"62","author":"Gao","year":"2014","journal-title":"Glia"},{"key":"10.1016\/j.physbeh.2025.114917_bib0059","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.mce.2016.05.015","article-title":"Diet-induced cellular neuroinflammation in the hypothalamus: mechanistic insights from investigation of neurons and microglia","volume":"438","author":"Tran","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.physbeh.2025.114917_bib0060","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1016\/j.celrep.2014.11.018","article-title":"microglia dictate the impact of saturated fat consumption on hypothalamic inflammation and neuronal function","volume":"9","author":"Valdearcos","year":"2014","journal-title":"Cell Rep."},{"key":"10.1016\/j.physbeh.2025.114917_bib0061","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1002\/jlb.63.6.740","article-title":"Melanocortin peptides inhibit production of proinflammatory cytokines and nitric oxide by activated microglia","volume":"63","author":"Delgado","year":"1998","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.physbeh.2025.114917_bib0062","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1017\/S0007114511002868","article-title":"Saturated fatty acids activate microglia via toll-like receptor 4\/NF-\u03baB signalling","volume":"107","author":"Wang","year":"2012","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.physbeh.2025.114917_bib0063","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s00401-016-1595-4","article-title":"High-fat diet-induced brain region-specific phenotypic spectrum of CNS resident microglia","volume":"132","author":"Baufeld","year":"2016","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.physbeh.2025.114917_bib0064","doi-asserted-by":"crossref","first-page":"908","DOI":"10.2337\/db16-0586","article-title":"Inhibiting microglia expansion prevents diet-induced hypothalamic and peripheral inflammation","volume":"66","author":"Andr\u00e9","year":"2017","journal-title":"Diabetes"},{"key":"10.1016\/j.physbeh.2025.114917_bib0065","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/j.cmet.2023.07.008","article-title":"Obesity-associated microglial inflammatory activation paradoxically improves glucose tolerance","volume":"35","author":"Douglass","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.physbeh.2025.114917_bib0066","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2018.00939","article-title":"Interglial crosstalk in obesity-induced hypothalamic inflammation","volume":"12","author":"Rahman","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.physbeh.2025.114917_bib0067","doi-asserted-by":"crossref","first-page":"5243","DOI":"10.3390\/ijms22105243","article-title":"Microglia-neuron crosstalk in obesity: melodious interaction or kiss of death?","volume":"22","author":"L\u00e9on","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.physbeh.2025.114917_bib0068","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.2337\/db13-1495","article-title":"Fractalkine (CX3CL1) is involved in the early activation of hypothalamic inflammation in experimental obesity","volume":"63","author":"Morari","year":"2014","journal-title":"Diabetes"},{"key":"10.1016\/j.physbeh.2025.114917_bib0069","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2020-001492","article-title":"Impaired brain fractalkine-CX3CR1 signaling is implicated in cognitive dysfunction in diet-induced obese mice","volume":"9","author":"Kawamura","year":"2021","journal-title":"BMJ Open Diabetes Res. Care"},{"key":"10.1016\/j.physbeh.2025.114917_bib0070","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-16944-3","article-title":"Brain fractalkine-CX3CR1 signalling is anti-obesity system as anorexigenic and anti-inflammatory actions in diet-induced obese mice","volume":"12","author":"Kawamura","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.physbeh.2025.114917_bib0071","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms14556","article-title":"Sex differences in microglial CX3CR1 signalling determine obesity susceptibility in mice","volume":"8","author":"Dorfman","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.physbeh.2025.114917_bib0072","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3390\/cells14030233","article-title":"Intermittent overconsumption of high fat diet promotes microglial reactivity in the hypothalamus and hindbrain of female rats","volume":"14","author":"Campanile","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.physbeh.2025.114917_bib0073","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.neuroscience.2024.08.034","article-title":"A high-fat diet influences neural stem and progenitor cell environment in the medulla of adult mice","volume":"559","author":"Furube","year":"2024","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2025.114917_bib0074","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bbi.2015.08.023","article-title":"Dietary obesity reversibly induces synaptic stripping by microglia and impairs hippocampal plasticity","volume":"51","author":"Hao","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.physbeh.2025.114917_bib0075","doi-asserted-by":"crossref","first-page":"8889","DOI":"10.1523\/JNEUROSCI.0789-18.2018","article-title":"Microglia play an active role in obesity-associated cognitive decline","volume":"38","author":"Cope","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.physbeh.2025.114917_bib0076","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2023.106164","article-title":"Single-cell RNA sequencing identifies hippocampal microglial dysregulation in diet-induced obesity","volume":"26","author":"Henn","year":"2023","journal-title":"iScience"},{"key":"10.1016\/j.physbeh.2025.114917_bib0077","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1146\/annurev-cellbio-100913-013053","article-title":"Astrocyte regulation of synaptic behavior","volume":"30","author":"Allen","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.physbeh.2025.114917_bib0078","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1002\/glia.20528","article-title":"Activity-dependent regulation of energy metabolism by astrocytes: an update","volume":"55","author":"Pellerin","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.physbeh.2025.114917_bib0079","doi-asserted-by":"crossref","DOI":"10.3389\/fnsyn.2018.00045","article-title":"Astrocyte\u2013neuron networks: a multilane highway of signaling for homeostatic brain function","volume":"10","author":"Mederos","year":"2018","journal-title":"Front. Synaptic Neurosci."},{"key":"10.1016\/j.physbeh.2025.114917_bib0080","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ecl.2012.11.003","article-title":"Hypothalamic astrocytes in obesity","volume":"42","author":"Garc\u00eda-C\u00e1ceres","year":"2013","journal-title":"Endocrinol. Metab. Clin. N. Am."},{"key":"10.1016\/j.physbeh.2025.114917_bib0081","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1002\/glia.24237","article-title":"Diet triggers specific responses of hypothalamic astrocytes in time and region dependent manner","volume":"70","author":"Lutomska","year":"2022","journal-title":"Glia"},{"key":"10.1016\/j.physbeh.2025.114917_bib0082","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s12974-020-01846-w","article-title":"Function of astrocyte MyD88 in high-fat-diet-induced hypothalamic inflammation","volume":"17","author":"Jin","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.physbeh.2025.114917_bib0083","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1038\/nm.3616","article-title":"Obesity- and aging-induced excess of central transforming growth factor-\u03b2 potentiates diabetic development via an RNA stress response","volume":"20","author":"Yan","year":"2014","journal-title":"Nat. Med."},{"key":"10.1016\/j.physbeh.2025.114917_bib0084","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/glia.21094","article-title":"Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NF\u03baB signaling, MAPK, and Jak1\/Stat1 pathways","volume":"59","author":"Gorina","year":"2011","journal-title":"Glia"},{"key":"10.1016\/j.physbeh.2025.114917_bib0085","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1002\/1873-3468.12691","article-title":"Hypothalamic lipid-laden astrocytes induce microglia migration and activation","volume":"591","author":"Kwon","year":"2017","journal-title":"FEBS Lett."},{"key":"10.1016\/j.physbeh.2025.114917_bib0086","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1002\/glia.22296","article-title":"Microglia are required for astroglial Toll-like receptor 4 response and for optimal TLR2 and TLR3 response","volume":"60","author":"Holm","year":"2012","journal-title":"Glia"},{"key":"10.1016\/j.physbeh.2025.114917_bib0087","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0166-2236(00)01691-X","article-title":"The oligodendrocyte precursor cell in health and disease","volume":"24","author":"Levine","year":"2001","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.physbeh.2025.114917_bib0088","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2023.101690","article-title":"Median eminence myelin continuously turns over in adult mice","volume":"69","author":"Buller","year":"2023","journal-title":"Mol. Metab."},{"key":"10.1016\/j.physbeh.2025.114917_bib0089","doi-asserted-by":"crossref","first-page":"3887","DOI":"10.1038\/s41467-019-11638-3","article-title":"Oligodendrocyte precursor cells present antigen and are cytotoxic targets in inflammatory demyelination","volume":"10","author":"Kirby","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.physbeh.2025.114917_bib0090","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.cmet.2016.04.013","article-title":"Adult NG2-glia are required for median eminence-mediated leptin sensing and body weight control","volume":"23","author":"Djogo","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.physbeh.2025.114917_bib0091","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/s41366-021-00749-x","article-title":"Evidence of association between obesity and lower cerebral myelin content in cognitively unimpaired adults","volume":"45","author":"Bouhrara","year":"2021","journal-title":"Int. J. Obes."},{"key":"10.1016\/j.physbeh.2025.114917_bib0092","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.neuroimage.2015.10.006","article-title":"Specific white matter tissue microstructure changes associated with obesity","volume":"125","author":"Kullmann","year":"2016","journal-title":"Neuroimage"},{"key":"10.1016\/j.physbeh.2025.114917_bib0093","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12868-019-0516-6","article-title":"Chronic exposure to high fat diet triggers myelin disruption and interleukin-33 upregulation in hypothalamus","volume":"20","author":"Huang","year":"2019","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.physbeh.2025.114917_bib0094","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1210\/er.2017-00235","article-title":"The versatile tanycyte: a hypothalamic integrator of reproduction and energy metabolism","volume":"39","author":"Prevot","year":"2018","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.physbeh.2025.114917_bib0095","doi-asserted-by":"crossref","DOI":"10.1152\/ajpregu.00296.2020","article-title":"What is the physiological role of hypothalamic tanycytes in metabolism?","author":"Bolborea","year":"2021","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.physbeh.2025.114917_bib0096","doi-asserted-by":"crossref","first-page":"6604","DOI":"10.1038\/s41467-024-50913-w","article-title":"Fasting induces metabolic switches and spatial redistributions of lipid processing and neuronal interactions in tanycytes","volume":"15","author":"Brunner","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.physbeh.2025.114917_bib0097","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.cmet.2013.12.015","article-title":"Hypothalamic tanycytes are an ERK-gated conduit for leptin into the brain","volume":"19","author":"Balland","year":"2014","journal-title":"Cell Metab."},{"key":"10.1016\/j.physbeh.2025.114917_bib0098","doi-asserted-by":"crossref","DOI":"10.1038\/s42255-021-00432-5","article-title":"Leptin brain entry via a tanycytic LepR-EGFR shuttle controls lipid metabolism and pancreas function","author":"Duquenne","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.physbeh.2025.114917_bib0099","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.molmet.2014.10.003","article-title":"Neonatal overnutrition causes early alterations in the central response to peripheral ghrelin","volume":"4","author":"Collden","year":"2015","journal-title":"Mol. Metab."},{"key":"10.1016\/j.physbeh.2025.114917_bib0100","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1038\/s42255-021-00499-0","article-title":"Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity","volume":"3","author":"Kumar","year":"2021","journal-title":"Nat. Metab."},{"key":"10.1016\/j.physbeh.2025.114917_bib0101","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1113\/jphysiol.2010.202051","article-title":"ATP-mediated glucosensing by hypothalamic tanycytes","volume":"589","author":"Frayling","year":"2011","journal-title":"J. Physiol."},{"key":"10.1016\/j.physbeh.2025.114917_bib0102","doi-asserted-by":"crossref","DOI":"10.1172\/JCI140521","article-title":"Tanycytic networks mediate energy balance by feeding lactate to glucose-insensitive POMC neurons","author":"Lhomme","year":"2021","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.physbeh.2025.114917_bib0103","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101311","article-title":"Ablation of glucokinase-expressing tanycytes impacts energy balance and increases adiposity in mice","author":"Rohrbach","year":"2021","journal-title":"Mol. Metab."},{"key":"10.1016\/j.physbeh.2025.114917_bib0104","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1919887117","article-title":"Hypothalamic tanycytes generate acute hyperphagia through activation of the arcuate neuronal network","author":"Bolborea","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.physbeh.2025.114917_bib0105","doi-asserted-by":"crossref","first-page":"8049","DOI":"10.3390\/ijms22158049","article-title":"High-fat diet impairs mouse median eminence: a study by transmission and scanning electron microscopy coupled with Raman spectroscopy","volume":"22","author":"Severi","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.physbeh.2025.114917_bib0106","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1111\/cns.14176","article-title":"FGF\/FGFR system in the central nervous system demyelinating disease: recent progress and implications for multiple sclerosis","volume":"29","author":"Zhang","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.physbeh.2025.114917_bib0107","doi-asserted-by":"crossref","first-page":"5000","DOI":"10.1111\/ejn.16473","article-title":"Tanycyte radial morphology and proliferation are influenced by fibroblast growth factor receptor 1 and high-fat diet","volume":"60","author":"Esteve","year":"2024","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.physbeh.2025.114917_bib0108","doi-asserted-by":"crossref","DOI":"10.1111\/jne.12546","article-title":"Functional interleukin-6 receptor-\u03b1 is located in tanycytes at the base of the third ventricle","volume":"29","author":"Anesten","year":"2017","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.physbeh.2025.114917_bib0109","doi-asserted-by":"crossref","first-page":"16199","DOI":"10.1073\/pnas.1306799110","article-title":"Glucagon-like peptide 1 receptor induced suppression of food intake, and body weight is mediated by central IL-1 and IL-6","volume":"110","author":"Shirazi","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.physbeh.2025.114917_bib0110","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jneuroim.2018.04.017","article-title":"TLR4 in circumventricular neural stem cells is a negative regulator for thermogenic pathways in the mouse brain","volume":"331","author":"Muneoka","year":"2019","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.physbeh.2025.114917_bib0111","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.991779","article-title":"Glial functions in the blood-brain communication at the circumventricular organs","volume":"16","author":"Miyata","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.physbeh.2025.114917_bib0112","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1750-3639.1998.tb00189.x","article-title":"The bacterial endotoxin lipopolysaccharide has the ability to target the brain in upregulating its membrane CD14 receptor within specific cellular populations","volume":"8","author":"Lacroix","year":"1998","journal-title":"Brain Pathol."},{"key":"10.1016\/j.physbeh.2025.114917_bib0113","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.1523\/JNEUROSCI.20-09-03456.2000","article-title":"Role of microglial-derived tumor necrosis factor in mediating CD14 transcription and nuclear factor \u03ba B activity in the brain during endotoxemia","volume":"20","author":"Nadeau","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.physbeh.2025.114917_bib0114","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1113\/jphysiol.2003.058834","article-title":"Nuclear translocation of the transcription factor STAT3 in the guinea pig brain during systemic or localized inflammation","volume":"557","author":"Rummel","year":"2004","journal-title":"J. Physiol."},{"key":"10.1016\/j.physbeh.2025.114917_bib0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.20653","article-title":"Nuclear STAT3 translocation in guinea pig and rat brain endothelium during systemic challenge with lipopolysaccharide and interleukin-6","volume":"491","author":"Rummel","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.physbeh.2025.114917_bib0116","doi-asserted-by":"crossref","first-page":"10985","DOI":"10.1073\/pnas.94.20.10985","article-title":"Induction of inhibitory factor \u03baB\u03b1 mRNA in the central nervous system after peripheral lipopolysaccharide administration: an in situ hybridization histochemistry study in the\u2009rat","volume":"94","author":"Quan","year":"1997","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.physbeh.2025.114917_bib0117","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1210\/en.2013-2018","article-title":"NF\u03baB signaling is essential for the lipopolysaccharide-induced increase of type 2 deiodinase in tanycytes","volume":"155","author":"de Vries","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.physbeh.2025.114917_bib0118","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12974-020-01832-2","article-title":"Microglia depletion fails to abrogate inflammation-induced sickness in mice and rats","volume":"17","author":"Vichaya","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.physbeh.2025.114917_bib0119","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2020.101022","article-title":"NF-\u03baB signaling in tanycytes mediates inflammation-induced anorexia","author":"B\u00f6ttcher","year":"2020","journal-title":"Mol. Metab."},{"key":"10.1016\/j.physbeh.2025.114917_bib0120","doi-asserted-by":"crossref","first-page":"233","DOI":"10.2337\/db21-1072","article-title":"Prostaglandin PGE2 receptor EP4 regulates microglial phagocytosis and increases susceptibility to diet-induced obesity","volume":"72","author":"Niraula","year":"2023","journal-title":"Diabetes"},{"key":"10.1016\/j.physbeh.2025.114917_bib0121","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2019.08.004","article-title":"Tanycytes regulate lipid homeostasis by sensing free fatty acids and signaling to key hypothalamic neuronal populations via FGF21 secretion","author":"Geller","year":"2019","journal-title":"Cell Metab."},{"key":"10.1016\/j.physbeh.2025.114917_bib0122","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110439","article-title":"FGF21 attenuates neurodegeneration through modulating neuroinflammation and oxidant-stress","volume":"129","author":"Kang","year":"2020","journal-title":"Biomed. PharmacOther."},{"key":"10.1016\/j.physbeh.2025.114917_bib0123","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111239","article-title":"Central FGF21 production regulates memory but not peripheral metabolism","volume":"40","author":"Zhou","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.physbeh.2025.114917_bib0124","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111954","article-title":"Tanycytes and hypothalamic FGF21: new players in the metabolic game","volume":"42","author":"Geller","year":"2023","journal-title":"Cell Rep."},{"key":"10.1016\/j.physbeh.2025.114917_bib0125","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/s42255-022-00602-z","article-title":"Prolonged breastfeeding protects from obesity by hypothalamic action of hepatic FGF21","volume":"4","author":"Pena-Leon","year":"2022","journal-title":"Nat. Metab."},{"key":"10.1016\/j.physbeh.2025.114917_bib0126","doi-asserted-by":"crossref","DOI":"10.1038\/srep26830","article-title":"A neuroendocrine role for chemerin in hypothalamic remodelling and photoperiodic control of energy balance","volume":"6","author":"Helfer","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.physbeh.2025.114917_bib0127","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119897","article-title":"Crosstalk of hypothalamic chemerin, histamine, and AMPK in diet-and olanzapine-induced obesity in rats","volume":"284","author":"Samy","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.physbeh.2025.114917_bib0128","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/obr.12009","article-title":"Towards an integrative approach to understanding the role of chemerin in human health and disease","volume":"14","author":"Rourke","year":"2013","journal-title":"Obes. Rev."},{"key":"10.1016\/j.physbeh.2025.114917_bib0129","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1177\/2042018815589088","article-title":"Diet-induced increases in chemerin are attenuated by exercise and mediate the effect of diet on insulin and HOMA-IR","volume":"6","author":"Lloyd","year":"2015","journal-title":"Ther. Adv. Endocrinol. Metab."},{"key":"10.1016\/j.physbeh.2025.114917_bib0130","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s002219900289","article-title":"A second look at the barriers of the medial basal hypothalamus","volume":"132","author":"Peruzzo","year":"2000","journal-title":"Exp. Brain Res."}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938425001180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938425001180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T16:24:07Z","timestamp":1746894247000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938425001180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":130,"alternative-id":["S0031938425001180"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2025.114917","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tanycytes in the nexus of hypothalamic inflammation, appetite control, and obesity","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2025.114917","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"114917"}}