{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T11:11:14Z","timestamp":1780571474292,"version":"3.54.1"},"reference-count":89,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005671","name":"Funda\u00e7\u00e3o de Apoio \u00e0 Pesquisa e \u00e0 Inova\u00e7\u00e3o Tecnol\u00f3gica do Estado de Sergipe","doi-asserted-by":"publisher","award":["794017\/2013"],"award-info":[{"award-number":["794017\/2013"]}],"id":[{"id":"10.13039\/501100005671","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100015800","name":"Universidade Federal de Sergipe","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015800","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["408377\/2021-6"],"award-info":[{"award-number":["408377\/2021-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["312863\/2022-5"],"award-info":[{"award-number":["312863\/2022-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["420458\/2023-9"],"award-info":[{"award-number":["420458\/2023-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","award":["310403\/2021-9"],"award-info":[{"award-number":["310403\/2021-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.physbeh.2025.115042","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T17:37:10Z","timestamp":1753724230000},"page":"115042","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Motor impairments and increased GFAP expression in different stages of a progressive model of parkinsonism induced by reserpine"],"prefix":"10.1016","volume":"300","author":[{"given":"Edson R.","family":"Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thassya F.O.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.M.","family":"Bispo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena C.N.M.","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o E.C.","family":"Melo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mylaine S.","family":"Mendon\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katty A.A.L.","family":"Medeiros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra M.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina H.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco Aurelio M.","family":"Freire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Auderlan M.","family":"Gois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9108-7532","authenticated-orcid":false,"given":"Jos\u00e9 R.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2025.115042_bib0001","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1111\/bpa.12538","article-title":"Diversity of astroglial responses across human neurodegenerative disorders and brain aging","volume":"27","author":"Ferrer","year":"2017","journal-title":"Brain Pathol."},{"key":"10.1016\/j.physbeh.2025.115042_bib0002","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2020.573256","article-title":"Protective functions of reactive astrocytes following central nervous system insult","volume":"11","author":"Linnerbauer","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.physbeh.2025.115042_bib0003","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.conb.2018.10.002","article-title":"Glial regulation of synapse maturation and stabilization in the developing nervous system","volume":"54","author":"Van Horn","year":"2019","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.physbeh.2025.115042_bib0004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/ijms21041539","article-title":"Neurons, glia, extracellular matrix and neurovascular unit: a systems biology approach to the complexity of synaptic plasticity in health and disease","volume":"21","author":"De Luca","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.physbeh.2025.115042_bib0005","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/cns.13982","article-title":"Brain energy metabolism: astrocytes in neurodegenerative diseases","volume":"29","author":"Chen","year":"2023","journal-title":"CNS. Neurosci. Ther."},{"key":"10.1016\/j.physbeh.2025.115042_bib0006","article-title":"Astrocytes in human central nervous system diseases: a frontier for new therapies","volume":"8","author":"Verkhratsky","year":"2023","journal-title":"Signal. Transduct. Target. Ther."},{"key":"10.1016\/j.physbeh.2025.115042_bib0007","doi-asserted-by":"crossref","DOI":"10.3390\/biom14030289","article-title":"Astrocytes: the stars in neurodegeneration?","volume":"14","author":"Stoklund Dittlau","year":"2024","journal-title":"Biomolecules."},{"key":"10.1016\/j.physbeh.2025.115042_bib0008","first-page":"1","article-title":"Cellular and molecular pathophysiology of traumatic brain injury: what have we learned so far?","volume":"12","author":"Freire","year":"2023","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.physbeh.2025.115042_bib0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fneur.2018.00860","article-title":"Outside in: unraveling the role of neuroinflammation in the progression of Parkinson\u2019s disease","volume":"9","author":"Troncoso-Escudero","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.physbeh.2025.115042_bib0010","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s00401-018-1944-6","article-title":"The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments","volume":"137","author":"Morganti-Kossmann","year":"2019","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.physbeh.2025.115042_bib0011","doi-asserted-by":"crossref","first-page":"77","DOI":"10.5607\/en.2018.27.2.77","article-title":"Astrocytes, microglia, and Parkinson\u2019s disease","volume":"27","author":"Joe","year":"2018","journal-title":"Exp. Neurobiol."},{"key":"10.1016\/j.physbeh.2025.115042_bib0012","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnana.2010.00146","article-title":"Parkinson\u2019s disease: general features, effects of levodopa treatment and future directions","volume":"4","author":"Freire","year":"2010","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.physbeh.2025.115042_bib0013","doi-asserted-by":"crossref","first-page":"S119","DOI":"10.1016\/j.parkreldis.2015.09.004","article-title":"Non-motor symptoms in Parkinson\u2019s disease","volume":"22","author":"Pfeiffer","year":"2016","journal-title":"Parkinsonism. Relat. Disord."},{"key":"10.1016\/j.physbeh.2025.115042_bib0014","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241914582","article-title":"The involvement of neuroinflammation in the onset and progression of Parkinson\u2019s disease","volume":"24","author":"Jurcau","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.physbeh.2025.115042_bib0015","doi-asserted-by":"crossref","unstructured":"MJ. Armstrong, MD, MSc; MS. Okun M (2020) Diagnosis and treatment of Parkinson disease a review. 323:548\u2013560.","DOI":"10.1001\/jama.2019.22360"},{"key":"10.1016\/j.physbeh.2025.115042_bib0016","first-page":"3","article-title":"Non-motor features of PD","volume":"3","author":"Schapira","year":"2017","journal-title":"J. Parkinsons. Dis."},{"key":"10.1016\/j.physbeh.2025.115042_bib0017","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fneur.2018.00860","article-title":"Outside in: unraveling the role of neuroinflammation in the progression of Parkinson\u2019s disease","volume":"9","author":"Troncoso-Escudero","year":"2018","journal-title":"Front. Neurol."},{"key":"10.1016\/j.physbeh.2025.115042_bib0018","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1177\/1073858417748875","article-title":"Glucocerebrosidase and Parkinson disease: molecular, clinical, and therapeutic implications","volume":"24","author":"Balestrino","year":"2018","journal-title":"Neuroscientist"},{"key":"10.1016\/j.physbeh.2025.115042_bib0019","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.lfs.2019.03.057","article-title":"Parkinson\u2019s disease: mechanisms, translational models and management strategies","volume":"226","author":"Raza","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.physbeh.2025.115042_bib0020","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1111\/j.1476-5381.2011.01426.x","article-title":"Animal models of Parkinson\u2019s disease: a source of novel treatments and clues to the cause of the disease","volume":"164","author":"Duty","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.physbeh.2025.115042_bib0021","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnsys.2023.1242929","article-title":"Basal ganglia for beginners: the basic concepts you need to know and their role in movement control","volume":"17","author":"Rocha","year":"2023","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.physbeh.2025.115042_bib0022","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0896-6273(03)00568-3","article-title":"Parkinson\u2019s disease: mechanisms and models","volume":"39","author":"Dauer","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.physbeh.2025.115042_bib0023","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1515\/revneuro-2016-0068","article-title":"Neurotransmission systems in Parkinson\u2019s disease","volume":"28","author":"Moghaddam","year":"2017","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.physbeh.2025.115042_bib0024","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/bpa.12253","article-title":"Molecular, neurochemical, and behavioral hallmarks of Reserpine as a model for Parkinson\u2019s Disease: new perspectives to a long-standing model","volume":"25","author":"Le\u00e3o","year":"2015","journal-title":"Brain Pathol."},{"key":"10.1016\/j.physbeh.2025.115042_bib0025","doi-asserted-by":"crossref","unstructured":"Baskin P., Salamone J., SALAt J., Vacuous I. (1993) Vacuous jaw movements in rats induced by acute reserpine administration: interactions with different doses of apomorphine.","DOI":"10.1016\/0091-3057(93)90203-6"},{"issue":"1","key":"10.1016\/j.physbeh.2025.115042_bib0026","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0091-3057(95)00164-6","article-title":"Vacuous Jaw Movements Induced by Acute Reserpine and Low-Dose Apomorphine: Possible Model of Parkinsonian Tremor Vacuous jaw Movements in Rats Induced By Acute Reserpine and Low-Dose Apomor-Phine administration: Possible model Ofparkinsonian Tremor","volume":"53","author":"Salamone","year":"1996","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.physbeh.2025.115042_bib0027","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.757714","article-title":"Female rats are resistant to cognitive, motor and dopaminergic deficits in the reserpine-induced progressive model of Parkinson\u2019s Disease","volume":"13","author":"Lima","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.physbeh.2025.115042_bib0028","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.bbr.2012.03.008","article-title":"Repeated treatment with a low dose of reserpine as a progressive model of Parkinson\u2019s disease","volume":"231","author":"Fernandes","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2025.115042_bib0029","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.bbr.2013.06.031","article-title":"Cognitive, motor and tyrosine hydroxylase temporal impairment in a model of parkinsonism induced by reserpine","volume":"253","author":"Santos","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2025.115042_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnagi.2017.00078","article-title":"Spontaneously hypertensive rats (SHR) are resistant to a reserpine-induced progressive model of Parkinson\u2019s disease: differences in motor behavior, tyrosine hydroxylase and \u03b1-synuclein expression","volume":"9","author":"Le\u00e3o","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.physbeh.2025.115042_bib0031","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241914582","article-title":"The involvement of neuroinflammation in the onset and progression of Parkinson\u2019s disease","volume":"24","author":"Jurcau","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.physbeh.2025.115042_bib0032","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S1474-4422(21)00061-2","article-title":"Progress towards therapies for disease modification in Parkinson\u2019s disease","volume":"20","author":"Vijiaratnam","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.physbeh.2025.115042_bib0033","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fncel.2021.718324","article-title":"Modulation of glial function in health, aging, and neurodegenerative disease","volume":"15","author":"Hanslik","year":"2021","journal-title":"Front. Cell Neurosci."},{"key":"10.1016\/j.physbeh.2025.115042_bib0034","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.bbr.2012.03.008","article-title":"Repeated treatment with a low dose of reserpine as a progressive model of Parkinson\u2019s disease","volume":"231","author":"Fernandes","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2025.115042_bib0035","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.bbr.2013.06.031","article-title":"Cognitive, motor and tyrosine hydroxylase temporal impairment in a model of parkinsonism induced by reserpine","volume":"253","author":"Santos","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2025.115042_bib0036","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.757714","article-title":"Female rats are resistant to cognitive, motor and dopaminergic deficits in the reserpine-induced progressive model of Parkinson\u2019s Disease","volume":"13","author":"Lima","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.physbeh.2025.115042_bib0037","first-page":"1","article-title":"Preclinical reserpine models recapitulating motor and non-motor features of Parkinson\u2019s disease: roles of epigenetic upregulation of alpha-synuclein and autophagy impairment","volume":"13","author":"Li","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.physbeh.2025.115042_bib0038","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2022.867180","article-title":"Effects of immediate aversive stimulation on haloperidol-induced catalepsy in rats","volume":"16","author":"Waku","year":"2022","journal-title":"Front. Behav. Neurosci."},{"issue":"1","key":"10.1016\/j.physbeh.2025.115042_bib0039","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0014-2999(72)90086-6","article-title":"Morphine catalepsy in the rat: relation to striatal dopamine metabolism","volume":"19","author":"Kuschinsky","year":"1972","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.physbeh.2025.115042_bib0040","doi-asserted-by":"crossref","unstructured":"Schallert T., Upchurch M., Lobaugh N., et al. (1982) Tactile extinction: distinguishing between sensorimotor and motor asymmetries in rats with unilateral nigrostriatal damage.","DOI":"10.1016\/0091-3057(82)90452-X"},{"key":"10.1016\/j.physbeh.2025.115042_bib0041","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1038\/nprot.2009.125","article-title":"The adhesive removal test: a sensitive method to assess sensorimotor deficits in mice","volume":"4","author":"Bouet","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.physbeh.2025.115042_bib0042","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.brainresbull.2018.08.007","article-title":"Deltamethrin intranasal administration induces memory, emotional and tyrosine hydroxylase immunoreactivity alterations in rats","volume":"142","author":"Souza","year":"2018","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.physbeh.2025.115042_bib0043","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jchemneu.2018.05.004","article-title":"Pattern of tyrosine hydroxylase expression during aging of mesolimbic pathway of the rat","volume":"92","author":"Norrara","year":"2018","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.physbeh.2025.115042_bib0044","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnagi.2014.00258","article-title":"Astrocytosis in parkinsonism: considering tripartite striatal synapses in physiopathology?","volume":"6","author":"Charron","year":"2014","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.physbeh.2025.115042_bib0045","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.tins.2021.07.004","article-title":"Astrocyte and neuron cooperation in long-term depression","volume":"44","author":"Durkee","year":"2021","journal-title":"Trends. Neurosci."},{"key":"10.1016\/j.physbeh.2025.115042_bib0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108758","article-title":"The tripartite glutamatergic synapse","volume":"199","author":"Lalo","year":"2021","journal-title":"Neuropharmacology."},{"key":"10.1016\/j.physbeh.2025.115042_bib0047","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1007\/s11064-021-03317-x","article-title":"Sensing and regulating synaptic activity by astrocytes at tripartite synapse","volume":"46","author":"Noriega-Prieto","year":"2021","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.physbeh.2025.115042_bib0048","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnmol.2017.00427","article-title":"Involvement of astrocytes in Alzheimer\u2019s disease from a neuroinflammatory and oxidative stress perspective","volume":"10","author":"Gonz\u00e1lez-Reyes","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.physbeh.2025.115042_bib0049","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1002\/glia.22800","article-title":"GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer\u2019s disease","volume":"63","author":"Kamphuis","year":"2015","journal-title":"Glia"},{"key":"10.1016\/j.physbeh.2025.115042_bib0050","first-page":"248","article-title":"Randomized controlled trial of an intervention to improve nurses\u2019 hazardous drug handling","volume":"46","author":"Friese","year":"2019","journal-title":"Oncol. Nurs. Forum."},{"key":"10.1016\/j.physbeh.2025.115042_bib0051","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s12035-013-8483-x","article-title":"The role of inflammatory and oxidative stress mechanisms in the pathogenesis of parkinson\u2019s disease: focus on astrocytes","volume":"49","author":"Niranjan","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.physbeh.2025.115042_bib0052","doi-asserted-by":"crossref","first-page":"11835","DOI":"10.1523\/JNEUROSCI.0983-17.2017","article-title":"Human astrocytes transfer aggregated alpha-synuclein via tunneling nanotubes","volume":"37","author":"Rostami","year":"2017","journal-title":"J. Neurosci."},{"key":"10.1016\/j.physbeh.2025.115042_bib0053","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1177\/02698811221115762","article-title":"The effects of reserpine on depression: a systematic review","volume":"37","author":"Strawbridge","year":"2023","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.physbeh.2025.115042_bib0054","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1007\/s10072-022-06578-8","article-title":"Reserpine induced parkinsonism, a hidden threat of herbal medicine","volume":"44","author":"Marano","year":"2023","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.physbeh.2025.115042_bib0055","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1007\/s00213-023-06350-6","article-title":"Genetic effects in a progressive model of parkinsonism induced by reserpine","volume":"240","author":"Fadanni","year":"2023","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.physbeh.2025.115042_bib0056","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40035-023-00368-8","article-title":"Animal models of Parkinson\u2019s disease: bridging the gap between disease hallmarks and research questions","volume":"12","author":"Dovonou","year":"2023","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.physbeh.2025.115042_bib0057","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/bpa.12253","article-title":"Molecular, neurochemical, and behavioral hallmarks of Reserpine as a model for Parkinson\u2019s Disease: new perspectives to a long-standing model","volume":"25","author":"Le\u00e3o","year":"2015","journal-title":"Brain Pathol."},{"key":"10.1016\/j.physbeh.2025.115042_bib0058","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnins.2022.923957","article-title":"Neuroinflammation in early, late and recovery stages in a progressive parkinsonism model in rats","volume":"16","author":"Cunha","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.physbeh.2025.115042_bib0059","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2022.105874","article-title":"Implications of glial metabolic dysregulation in the pathophysiology of neurodegenerative diseases","volume":"174","author":"Afridi","year":"2022","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.physbeh.2025.115042_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/biomedicines9101341","article-title":"Astrocytes, a promising opportunity to control the progress of parkinson\u2019s disease","volume":"9","author":"Sanchez","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.physbeh.2025.115042_bib0061","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22168689","article-title":"Glutathione and related molecules in parkinsonism","volume":"22","author":"Asanuma","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.physbeh.2025.115042_bib0062","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/antiox11010170","article-title":"Neuroprotection and disease modification by astrocytes and microglia in Parkinson disease","volume":"11","author":"Takahashi","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.physbeh.2025.115042_bib0063","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40035-020-00221-2","article-title":"Neuroinflammation in neurodegenerative disorders: the roles of microglia and astrocytes","volume":"9","author":"Kwon","year":"2020","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.physbeh.2025.115042_bib0064","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/bpa.12253","article-title":"Molecular, neurochemical, and behavioral hallmarks of Reserpine as a model for Parkinson\u2019s Disease: new perspectives to a long-standing model","volume":"25","author":"Le\u00e3o","year":"2015","journal-title":"Brain Pathol."},{"key":"10.1016\/j.physbeh.2025.115042_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2021.113349","article-title":"Changes in the mesocorticolimbic pathway after low dose reserpine-treatment in Wistar and spontaneously Hypertensive Rats (SHR): implications for cognitive deficits in a progressive animal model for Parkinson\u2019s disease","volume":"410","author":"Le\u00e3o","year":"2021","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2025.115042_bib0066","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.3233\/JPD-230284","article-title":"Astrocytes and alpha-synuclein: friend or foe?","volume":"13","author":"Ozoran","year":"2023","journal-title":"J. Parkinsons. Dis."},{"key":"10.1016\/j.physbeh.2025.115042_bib0067","doi-asserted-by":"crossref","unstructured":"Miyazaki I. (2020) Neuron-astrocyte interactions in Parkinson\u2019s disease.","DOI":"10.3390\/cells9122623"},{"key":"10.1016\/j.physbeh.2025.115042_bib0068","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1016\/j.ymthe.2021.04.035","article-title":"Cerebral dopamine neurotrophic factor reduces \u03b1-synuclein aggregation and propagation and alleviates behavioral alterations in vivo","volume":"29","author":"Albert","year":"2021","journal-title":"Mol. Therapy"},{"key":"10.1016\/j.physbeh.2025.115042_bib0069","doi-asserted-by":"crossref","first-page":"703","DOI":"10.3233\/JPD-160881","article-title":"Is axonal degeneration a key early event in Parkinson\u2019s disease?","volume":"6","author":"Kurowska","year":"2016","journal-title":"J. Parkinsons. Dis."},{"key":"10.1016\/j.physbeh.2025.115042_bib0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40035-021-00262-1","article-title":"Astrocytes and retrograde degeneration of nigrostriatal dopaminergic neurons in Parkinson\u2019s disease: removing axonal debris","volume":"10","author":"Morales","year":"2021","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.physbeh.2025.115042_bib0071","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/JPD-150769","article-title":"Retrograde axonal degeneration in Parkinson disease","volume":"6","author":"Tagliaferro","year":"2016","journal-title":"J. Parkinsons. Dis."},{"key":"10.1016\/j.physbeh.2025.115042_bib0072","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.bbr.2019.01.041","article-title":"Sex differences in the progressive model of parkinsonism induced by reserpine in rats","volume":"363","author":"Bispo","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2025.115042_bib0073","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchemneu.2022.102162","article-title":"Aging accentuates decrease in tyrosine hydroxylase immunoreactivity associated with the increase in the motor impairment in a model of reserpine-induced parkinsonism","author":"Melo","year":"2022","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.physbeh.2025.115042_bib0074","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s10919-019-00293-3","article-title":"Emotional expression: advances in basic emotion theory","volume":"43","author":"Keltner","year":"2019","journal-title":"J. Nonverbal. Behav."},{"key":"10.1016\/j.physbeh.2025.115042_bib0075","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.3390\/ijms25042009","article-title":"Parkinson\u2019s Disease: cells succumbing to lifelong dopamine-related oxidative stress and other bioenergetic challenges","volume":"25","author":"Watanabe","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.physbeh.2025.115042_bib0076","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2023.1187684","article-title":"Iron accumulation in the ventral tegmental area in Parkinson\u2019s disease","volume":"15","author":"Zhang","year":"2023","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.physbeh.2025.115042_bib0077","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.brainresbull.2022.06.018","article-title":"Testosterone propionate improves motor alterations and dopaminergic damage in the reserpine-induced progressive model of Parkinson\u2019s disease","volume":"187","author":"Bispo","year":"2022","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.physbeh.2025.115042_bib0078","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2016.00283","article-title":"Commentary: evaluation of models of Parkinson\u2019s disease","volume":"10","author":"Leal","year":"2016","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.physbeh.2025.115042_bib0079","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnagi.2017.00078","article-title":"Spontaneously hypertensive rats (SHR) are resistant to a reserpine-induced progressive model of Parkinson\u2019s disease: differences in motor behavior, tyrosine hydroxylase and \u03b1-synuclein expression","volume":"9","author":"Le\u00e3o","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.physbeh.2025.115042_bib0080","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.bbr.2017.04.028","article-title":"Exposure to an enriched environment facilitates motor recovery and prevents short-term memory impairment and reduction of striatal BDNF in a progressive pharmacological model of parkinsonism in mice","volume":"328","author":"Camp\u00ealo","year":"2017","journal-title":"Behav. Brain Res."},{"issue":"8","key":"10.1016\/j.physbeh.2025.115042_bib0081","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.2174\/0118715273270473231002104610","article-title":"Role of astrogliosis in the pathogenesis of Parkinson's disease: insights into astrocytic Nrf2 pathway as a potential therapeutic target","volume":"23","author":"Bhushan","year":"2024","journal-title":"CNS. Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.physbeh.2025.115042_bib0082","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.923957","article-title":"Neuroinflammation in early, late and recovery stages in a progressive parkinsonism model in rats","volume":"16","author":"Cunha","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.physbeh.2025.115042_bib0083","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cbi.2012.08.008","article-title":"The effect of guggulipid and nimesulide on MPTP-induced mediators of neuroinflammation in rat astrocytoma cells","volume":"200","author":"Niranjan","year":"2012","journal-title":"C6. Chem. Biol. Interact."},{"issue":"5","key":"10.1016\/j.physbeh.2025.115042_bib0084","doi-asserted-by":"crossref","first-page":"4508","DOI":"10.3390\/ijms24054508","article-title":"A semi-automatic method for the quantification of astrocyte number and branching in bulk immunohistochemistry images","volume":"24","author":"Marques","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"7638","key":"10.1016\/j.physbeh.2025.115042_bib0085","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.physbeh.2025.115042_bib0086","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.tins.2017.04.001","article-title":"The role of astrocyte dysfunction in Parkinson's disease pathogenesis","volume":"40","author":"Booth","year":"2017","journal-title":"Trends Neurosci."},{"issue":"3","key":"10.1016\/j.physbeh.2025.115042_bib0087","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41593-020-00783-4","article-title":"Reactive astrocyte nomenclature, definitions, and future directions","volume":"24","author":"Escartin","year":"2021","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.physbeh.2025.115042_bib0088","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.nbd.2019.02.020","article-title":"Genetic suppression of IKK2\/NF-\u03bab in astrocytes inhibits neuroinflammation and reduces neuronal loss in the MPTP-Probenecid model of Parkinson's disease","volume":"127","author":"Kirkley","year":"2019","journal-title":"Neurobiol. Dis."},{"issue":"271","key":"10.1016\/j.physbeh.2025.115042_bib0089","article-title":"\u03b2-2 agonist and antagonist adrenoceptors induce neuroprotection in a progressive model of parkinsonism","volume":"15","author":"de Gois","year":"2025","journal-title":"Neuropharmacology"}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938425002434?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938425002434?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T03:39:22Z","timestamp":1754624362000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938425002434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":89,"alternative-id":["S0031938425002434"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2025.115042","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Motor impairments and increased GFAP expression in different stages of a progressive model of parkinsonism induced by reserpine","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2025.115042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115042"}}