{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:52:37Z","timestamp":1791571957411,"version":"4.3.4"},"reference-count":93,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007684","name":"Ministry of Education and Science of Ukraine","doi-asserted-by":"publisher","award":["0123U101790"],"award-info":[{"award-number":["0123U101790"]}],"id":[{"id":"10.13039\/501100007684","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.physbeh.2025.115065","type":"journal-article","created":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T23:38:40Z","timestamp":1755128320000},"page":"115065","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Differential long-term effects of physical, social, and psychological stressors in male mice: down-regulation of inflammatory markers and unresponsiveness of the antioxidant system"],"prefix":"10.1016","volume":"301","author":[{"given":"Vitalii","family":"Balatskyi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmytro","family":"Gospodaryov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleksandra","family":"Abrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olha","family":"Strilbytska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleh","family":"Demianchuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasiia","family":"Tkachyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oksana","family":"Vasylyshyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oleh","family":"Lushchak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volodymyr I.","family":"Lushchak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6268-8910","authenticated-orcid":false,"given":"Maria","family":"Bayliak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2025.115065_bib0001","article-title":"Prevalence of stress, anxiety, and symptoms of post-traumatic stress disorder among Ukrainians after the first year of Russian invasion: a nationwide cross-sectional study","volume":"36","author":"Lushchak","year":"2024","journal-title":"Lancet Reg. Health - Eur."},{"key":"10.1016\/j.physbeh.2025.115065_bib0002","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1222826","article-title":"Mitochondrial dysfunction as a possible trigger of neuroinflammation at post-traumatic stress disorder (PTSD)","volume":"14","author":"Dmytriv","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.physbeh.2025.115065_bib0003","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1266575","article-title":"Potential oxidative stress related targets of mitochondria-focused therapy of PTSD","volume":"14","author":"Kmita","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.physbeh.2025.115065_bib0004","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.1094076","article-title":"An orchestrating role of mitochondria in the origin and development of post-traumatic stress disorder","volume":"13","author":"Lushchak","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.physbeh.2025.115065_bib0005","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1097\/FBP.0000000000000467","article-title":"Animal models of post-traumatic stress disorder and novel treatment targets","volume":"30","author":"Aspesi","year":"2019","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.physbeh.2025.115065_bib0006","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1038\/s41380-018-0272-5","article-title":"Animal models of PTSD: a challenge to be met","volume":"24","author":"Richter-Levin","year":"2019","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.physbeh.2025.115065_bib0007","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1038\/s41398-020-0806-x","article-title":"Rodent models of post-traumatic stress disorder: behavioral assessment","volume":"10","author":"Verbitsky","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.physbeh.2025.115065_bib0008","article-title":"Metabolic and immune dysfunctions in post-traumatic stress disorder: what can we learn from animal models?","volume":"1611-215","author":"Lushchak","year":"2023","journal-title":"EXCLI J."},{"key":"10.1016\/j.physbeh.2025.115065_bib0009","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076146","article-title":"Inflammation and oxidative stress are elevated in the brain, blood, and adrenal glands during the progression of post-traumatic stress disorder in a predator exposure animal model","volume":"8","author":"Wilson","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.physbeh.2025.115065_bib0010","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0160923","article-title":"The anti-inflammatory effects of blueberries in an animal model of post-traumatic stress disorder (PTSD)","volume":"11","author":"Ebenezer","year":"2016","journal-title":"PLOS ONE"},{"key":"10.1016\/j.physbeh.2025.115065_bib0011","doi-asserted-by":"crossref","first-page":"e2620","DOI":"10.1002\/brb3.2620","article-title":"Modulation of astrocyte activity and improvement of oxidative stress through blockage of NO\/NMDAR pathway improve posttraumatic stress disorder (PTSD)-like behavior induced by social isolation stress","volume":"12","author":"Li","year":"2022","journal-title":"Brain Behav"},{"key":"10.1016\/j.physbeh.2025.115065_bib0012","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3934\/Neuroscience.2022005","article-title":"Long lasting effect of acute restraint stress on behavior and brain anti-oxidative status","volume":"9","author":"Chaoui","year":"2022","journal-title":"AIMS Neurosci."},{"key":"10.1016\/j.physbeh.2025.115065_bib0013","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2020.113026","article-title":"Lycopene ameliorates PTSD-like behaviors in mice and rebalances the neuroinflammatory response and oxidative stress in the brain","volume":"224","author":"Li","year":"2020","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.physbeh.2025.115065_bib0014","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1021\/acschembio.8b00454","article-title":"Targeting the FKBP51\/GR\/Hsp90 complex to identify functionally relevant treatments for depression and PTSD","volume":"13","author":"Sabbagh","year":"2018","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.physbeh.2025.115065_bib0015","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1172\/JCI130363","article-title":"The glucocorticoid receptor\u2013FKBP51 complex contributes to fear conditioning and posttraumatic stress disorder","volume":"130","author":"Li","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.physbeh.2025.115065_bib0016","doi-asserted-by":"crossref","first-page":"8708","DOI":"10.1073\/pnas.1300886110","article-title":"Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis","volume":"110","author":"Anacker","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.physbeh.2025.115065_bib0017","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s13104-025-07189-0","article-title":"Behavioral and metabolic effects of escapable electric foot shock stress in male mice","volume":"18","author":"Balatskyi","year":"2025","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.physbeh.2025.115065_bib0018","doi-asserted-by":"crossref","DOI":"10.1186\/2045-5380-2-3","article-title":"Sex differences, gonadal hormones and the fear extinction network: implications for anxiety disorders","volume":"2","author":"Lebron-Milad","year":"2012","journal-title":"Biol. Mood Anxiety Disord."},{"key":"10.1016\/j.physbeh.2025.115065_bib0019","doi-asserted-by":"crossref","first-page":"367","DOI":"10.3109\/10253890.2015.1053451","article-title":"Neuroimmune mechanisms of stress: sex differences, developmental plasticity, and implications for pharmacotherapy of stress-related disease","volume":"18","author":"Deak","year":"2015","journal-title":"Stress"},{"key":"10.1016\/j.physbeh.2025.115065_bib0020","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1111\/2041-210X.12874","article-title":"ToxTrac : a fast and robust software for tracking organisms","volume":"9","author":"Rodriguez","year":"2018","journal-title":"Methods Ecol. Evol."},{"key":"10.1016\/j.physbeh.2025.115065_bib0021","doi-asserted-by":"crossref","DOI":"10.3791\/52434-v","article-title":"Use of the open field maze to measure locomotor and anxiety-like behavior in mice","author":"Seibenhener","year":"2015","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.physbeh.2025.115065_bib0022","first-page":"8","article-title":"Use of CO2\/O2 anesthesia in the collection of samples for serum corticosterone analysis from Fischer 344 rats","volume":"43","author":"Fomby","year":"2004","journal-title":"Contemp. Top. Lab. Anim. Sci."},{"key":"10.1016\/j.physbeh.2025.115065_bib0023","doi-asserted-by":"crossref","first-page":"1","DOI":"10.20463\/jenb.2019.0017","article-title":"Influence of high fat and different types of carbohydrate diet on energy metabolism in growing mice","volume":"23","author":"Chung","year":"2019","journal-title":"J. Exerc. Nutr. Biochem."},{"key":"10.1016\/j.physbeh.2025.115065_bib0024","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.3389\/fphys.2019.01432","article-title":"Every-other-day feeding decreases glycolytic and mitochondrial energy-producing potentials in the brain and liver of young mice","volume":"10","author":"Sorochynska","year":"2019","journal-title":"Front. Physiol."},{"key":"10.1016\/j.physbeh.2025.115065_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0272-2712(03)00064-7","article-title":"Blood film preparation and staining procedures","volume":"22","author":"Houwen","year":"2002","journal-title":"Clin. Lab. Med."},{"key":"10.1016\/j.physbeh.2025.115065_bib0026","first-page":"96","article-title":"Practical murine hematopathology: a comparative review and implications for research","volume":"65","author":"O\u2019Connell","year":"2015","journal-title":"Comp. Med."},{"key":"10.1016\/j.physbeh.2025.115065_bib0027","doi-asserted-by":"crossref","first-page":"6","DOI":"10.15330\/jpnu.9.4.6-14","article-title":"Adapting of spectrophotometric assay of paraoxonase activity with 4-nitrophenylacetate for murine plasma and liver","volume":"9","author":"Vatashchuk","year":"2022","journal-title":"J. Vasyl Stefanyk Precarpathian Natl. Univ."},{"key":"10.1016\/j.physbeh.2025.115065_bib0028","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.fsi.2014.06.005","article-title":"Innate immune response of Indian major carp, Labeo rohita infected with oomycete pathogen Aphanomyces invadans","volume":"39","author":"Yadav","year":"2014","journal-title":"Fish Shellfish Immunol"},{"key":"10.1016\/j.physbeh.2025.115065_bib0029","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.aquatox.2008.01.007","article-title":"The effect of potassium dichromate on free radical processes in goldfish: possible protective role of glutathione","volume":"87","author":"Lushchak","year":"2008","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.physbeh.2025.115065_bib0030","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1016\/j.bbrc.2005.10.147","article-title":"Diethyldithiocarbamate inhibits in vivo Cu,Zn-superoxide dismutase and perturbs free radical processes in the yeast Saccharomyces cerevisiae cells","volume":"338","author":"Lushchak","year":"2005","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.physbeh.2025.115065_bib0031","article-title":"High fat high fructose diet induces mild oxidative stress and reorganizes intermediary metabolism in male mouse liver: alpha-ketoglutarate effects","volume":"1866","author":"Bayliak","year":"2022","journal-title":"Biochim. Biophys. Acta BBA - Gen. Subj."},{"key":"10.1016\/j.physbeh.2025.115065_bib0032","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.physbeh.2025.115065_bib0033","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1749-6632.1964.tb14213.x","article-title":"Disc electrophoresis \u2013 II method and application to human serum proteins","volume":"121","author":"Davis","year":"1964","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.physbeh.2025.115065_bib0034","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/0003-2697(71)90370-8","article-title":"Superoxide dismutase: improved assays and an assay applicable to acrylamide gels","volume":"44","author":"Beauchamp","year":"1971","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.physbeh.2025.115065_bib0035","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.physbeh.2025.115065_bib0036","article-title":"High-fat high-fructose diet and alpha-ketoglutarate affect mouse behavior that is accompanied by changes in oxidative stress response and energy metabolism in the cerebral cortex","volume":"1868","author":"Demianchuk","year":"2024","journal-title":"Biochim. Biophys. Acta BBA - Gen. Subj."},{"key":"10.1016\/j.physbeh.2025.115065_bib0037","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.physbeh.2025.115065_bib0038","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1101\/sqb.2018.83.038109","article-title":"Neuropeptidergic control of an internal brain state produced by prolonged social isolation stress","volume":"83","author":"Zelikowsky","year":"2018","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/j.physbeh.2025.115065_bib0039","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.pnpbp.2018.12.014","article-title":"Social isolation as a promising animal model of PTSD comorbid suicide: neurosteroids and cannabinoids as possible treatment options","volume":"92","author":"Locci","year":"2019","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.physbeh.2025.115065_bib0040","doi-asserted-by":"crossref","DOI":"10.1038\/sj.bjp.0706428","article-title":"Neurotransmitter transporters and their impact on the development of psychopharmacology","volume":"147","author":"Iversen","year":"2006","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.physbeh.2025.115065_bib0041","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1111\/jcmm.13161","article-title":"Post-traumatic stress disorder and beyond: an overview of rodent stress models","volume":"21","author":"Sch\u00f6ner","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.physbeh.2025.115065_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2022.114023","article-title":"Two-hour acute restraint stress facilitates escape behavior and learning outcomes through the activation of the Cdk5\/GR P S211 pathway in male mice","volume":"354","author":"Wang","year":"2022","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.physbeh.2025.115065_bib0043","doi-asserted-by":"crossref","DOI":"10.1016\/j.applanim.2019.104843","article-title":"A new stress model by predatory sound produces persistent anxiety-like behaviours in male SD rats but not ICR mice","volume":"220","author":"Chen","year":"2019","journal-title":"Appl. Anim. Behav. Sci."},{"key":"10.1016\/j.physbeh.2025.115065_bib0044","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neulet.2012.11.016","article-title":"Predator threat stress promotes long lasting anxiety-like behaviors and modulates synaptophysin and CB1 receptors expression in brain areas associated with PTSD symptoms","volume":"533","author":"Campos","year":"2013","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.physbeh.2025.115065_bib0045","doi-asserted-by":"crossref","first-page":"298","DOI":"10.4103\/1673-5374.244792","article-title":"Predator stress-induced depression is associated with inhibition of hippocampal neurogenesis in adult male mice","volume":"14","author":"He","year":"2019","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.physbeh.2025.115065_bib0046","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/6212983","article-title":"Social isolation stress induces anxious-depressive-like behavior and alterations of neuroplasticity-related genes in adult male mice","author":"Ieraci","year":"2016","journal-title":"Neural Plast"},{"key":"10.1016\/j.physbeh.2025.115065_bib0047","doi-asserted-by":"crossref","DOI":"10.1016\/j.beproc.2020.104140","article-title":"Acute stress differentially affects grooming subtypes and ultrasonic vocalisations in the open-field and home-cage test in rats","volume":"176","author":"Rojas-Carvajal","year":"2020","journal-title":"Behav. Processes"},{"key":"10.1016\/j.physbeh.2025.115065_bib0048","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154225","article-title":"The anxiolytic effect of koumine on a predatory sound stress-induced anxiety model and its associated molecular mechanisms","volume":"103","author":"Xiong","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.physbeh.2025.115065_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2023.105237","article-title":"The nature and neurobiology of fear and anxiety: state of the science and opportunities for accelerating discovery","volume":"151","author":"Grogans","year":"2023","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.physbeh.2025.115065_bib0050","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1177\/0956797610384746","article-title":"Facing freeze: social threat induces bodily freeze in humans","volume":"21","author":"Roelofs","year":"2010","journal-title":"Psychol. Sci."},{"key":"10.1016\/j.physbeh.2025.115065_bib0051","series-title":"Compr. Physiol","first-page":"1339","article-title":"Central nervous system control of gastrointestinal motility and secretion and modulation of gastrointestinal functions","author":"Browning","year":"2014"},{"key":"10.1016\/j.physbeh.2025.115065_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.beproc.2022.104796","article-title":"Tactile cues are important to environmental novelty during repeated open field tests","volume":"204","author":"Chen","year":"2023","journal-title":"Behav. Processes"},{"key":"10.1016\/j.physbeh.2025.115065_bib0053","doi-asserted-by":"crossref","first-page":"953","DOI":"10.3390\/biomedicines10050953","article-title":"Neuroinflammation in post-traumatic stress disorder","volume":"10","author":"Lee","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.physbeh.2025.115065_bib0054","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.psychres.2017.08.052","article-title":"Increased circulating blood cell counts in combat-related PTSD: associations with inflammation and PTSD severity","volume":"258","author":"Lindqvist","year":"2017","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.physbeh.2025.115065_bib0055","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1182\/blood.V86.8.3181.3181","article-title":"Glucocorticoids inhibit apoptosis of human neutrophils","volume":"86","author":"Liles","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.physbeh.2025.115065_bib0056","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.exphem.2009.02.005","article-title":"Interaction between the glucocorticoid and erythropoietin receptors in human erythroid cells","volume":"37","author":"Stellacci","year":"2009","journal-title":"Exp. Hematol."},{"key":"10.1016\/j.physbeh.2025.115065_bib0057","series-title":"Clin. Methods Hist. Phys. Lab. Exam.","article-title":"Reticulocytes","author":"Bessman","year":"1990"},{"key":"10.1016\/j.physbeh.2025.115065_bib0058","doi-asserted-by":"crossref","first-page":"182","DOI":"10.3324\/haematol.2009.017285","article-title":"High hematocrit as a risk factor for venous thrombosis. Cause or innocent bystander?","volume":"95","author":"Schreijer","year":"2010","journal-title":"Haematologica"},{"key":"10.1016\/j.physbeh.2025.115065_bib0059","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.psyneuen.2018.12.010","article-title":"Role of corticosterone in altered neurobehavioral responses to acute stress in a model of compromised hypothalamic-pituitary-adrenal axis function","volume":"102","author":"Kinlein","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.physbeh.2025.115065_bib0060","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbi.2007.07.012","article-title":"Stressor-specific alterations in corticosterone and immune responses in mice","volume":"22","author":"Bowers","year":"2008","journal-title":"Brain. Behav. Immun."},{"key":"10.1016\/j.physbeh.2025.115065_bib0061","doi-asserted-by":"crossref","DOI":"10.1016\/j.yhbeh.2024.105538","article-title":"Effects of the combination of chronic unpredictable stress and environmental enrichment on anxiety-like behavior assessed using the elevated plus maze in Swiss male mice: hypothalamus-Pituitary-Adrenal Axis-mediated mechanisms","volume":"162","author":"Belo-Silva","year":"2024","journal-title":"Horm. Behav."},{"key":"10.1016\/j.physbeh.2025.115065_bib0062","first-page":"33","article-title":"Myeloperoxidase as an active disease biomarker: recent Biochemical and Pathological Perspectives","volume":"6","author":"Khan","year":"2018","journal-title":"Med. Sci."},{"key":"10.1016\/j.physbeh.2025.115065_bib0063","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1089\/ars.2020.8030","article-title":"The Role of myeloperoxidase in biomolecule modification, chronic inflammation, and Disease","volume":"32","author":"Davies","year":"2020","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.physbeh.2025.115065_bib0064","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2023.1195012","article-title":"Exploring brain glutathione and peripheral blood markers in posttraumatic stress disorder: a combined [1H]MRS and peripheral blood study","volume":"14","author":"Watling","year":"2023","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.physbeh.2025.115065_bib0065","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.3390\/antiox11112302","article-title":"Myeloperoxidase: regulation of neutrophil function and target for therapy","volume":"11","author":"Rizo-T\u00e9llez","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.physbeh.2025.115065_bib0066","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jpsychores.2014.05.001","article-title":"Behavioral health mediators of the link between posttraumatic stress disorder and dyslipidemia","volume":"77","author":"Dennis","year":"2014","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.physbeh.2025.115065_bib0067","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2022.847310","article-title":"A Systematic Review and meta-analysis of lipid signatures in post-traumatic stress disorder","volume":"13","author":"Bharti","year":"2022","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.physbeh.2025.115065_bib0068","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.amjcard.2011.02.340","article-title":"Post-traumatic stress disorder, coronary atherosclerosis, and mortality","volume":"108","author":"Ahmadi","year":"2011","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.physbeh.2025.115065_bib0069","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jad.2014.02.018","article-title":"Lowered plasma paraoxonase (PON)1 activity is a trait marker of major depression and PON1 Q192R gene polymorphism\u2013smoking interactions differentially predict the odds of major depression and bipolar disorder","volume":"159","author":"Bortolasci","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.physbeh.2025.115065_bib0070","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00406-015-0638-5","article-title":"Altered lipid peroxidation markers are related to post-traumatic stress disorder (PTSD) and not trauma itself in earthquake survivors","volume":"266","author":"Atli","year":"2016","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.physbeh.2025.115065_bib0071","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1042\/cs0980355","article-title":"Low paraoxonase activity in type II diabetes mellitus complicated by retinopathy","volume":"98","author":"Mackness","year":"2000","journal-title":"Clin. Sci. Lond. Engl."},{"key":"10.1016\/j.physbeh.2025.115065_bib0072","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.cbi.2017.02.005","article-title":"Transcriptional regulation of human Paraoxonase 1 by nuclear receptors","volume":"268","author":"Ponce-Ruiz","year":"2017","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.physbeh.2025.115065_bib0073","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.toxlet.2013.09.014","article-title":"Dexamethasone accelerates degradation of aryl hydrocarbon receptor (AHR) and suppresses CYP1A1 induction in placental JEG-3 cell line","volume":"223","author":"Stejskalova","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.physbeh.2025.115065_bib0074","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/5679517","article-title":"Crosstalk between aryl hydrocarbon receptor and glucocorticoid receptor in human retinal pigment epithelial cells","volume":"2017","author":"Jin","year":"2017","journal-title":"Int. J. Endocrinol."},{"key":"10.1016\/j.physbeh.2025.115065_bib0075","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1804412115","article-title":"Chronic social stress-induced hyperglycemia in mice couples individual stress susceptibility to impaired spatial memory","volume":"115","author":"Van Der Kooij","year":"2018","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.physbeh.2025.115065_bib0076","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.brainresbull.2016.03.014","article-title":"Blood glucose regulation mechanism in depressive disorder animal model during hyperglycemic states","volume":"124","author":"Lim","year":"2016","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.physbeh.2025.115065_bib0077","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/nrendo.2017.97","article-title":"Genomic and epigenomic mechanisms of glucocorticoids in the brain","volume":"13","author":"Gray","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.physbeh.2025.115065_bib0078","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/j.psychres.2018.03.037","article-title":"The effects of early trauma and the FKBP5 gene on PTSD and the HPA axis in a clinical sample of Gulf War veterans","volume":"270","author":"Young","year":"2018","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.physbeh.2025.115065_bib0079","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0175075","article-title":"Dynamic glucocorticoid-dependent regulation of Sgk1 expression in oligodendrocytes of adult male rat brain by acute stress and time of day","volume":"12","author":"Hinds","year":"2017","journal-title":"PLOS ONE"},{"key":"10.1016\/j.physbeh.2025.115065_bib0080","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/s41423-019-0242-0","article-title":"Differential regulation of basal expression of inflammatory genes by NF-\u03baB family subunits","volume":"16","author":"De Jes\u00fas","year":"2019","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.physbeh.2025.115065_bib0081","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/s41398-020-0693-1","article-title":"Potential chemokine biomarkers associated with PTSD onset, risk and resilience as well as stress responses in US military service members","volume":"10","author":"Zhang","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.physbeh.2025.115065_bib0082","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.bbi.2020.11.033","article-title":"Chemokines in post-traumatic stress disorder: a network meta-analysis","volume":"92","author":"Pan","year":"2021","journal-title":"Brain. Behav. Immun."},{"key":"10.1016\/j.physbeh.2025.115065_bib0083","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1002\/hep.31800","article-title":"Stress-responsive gene FK506-binding protein 51 mediates alcohol-induced liver injury through the Hippo pathway and chemokine (C-X-C Motif) ligand 1 signaling","volume":"74","author":"Kusumanchi","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.physbeh.2025.115065_bib0084","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.pharmthera.2017.10.008","article-title":"CYP-mediated drug metabolism in the brain impacts drug response","volume":"184","author":"McMillan","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.physbeh.2025.115065_bib0085","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.pharmthera.2018.02.012","article-title":"Modulation of CYP1A1 metabolism: from adverse health effects to chemoprevention and therapeutic options","volume":"187","author":"Mescher","year":"2018","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.physbeh.2025.115065_bib0086","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jfda.2018.11.005","article-title":"The regulation of drug-metabolizing enzymes and membrane transporters by inflammation: evidences in inflammatory diseases and age-related disorders","volume":"27","author":"Wu","year":"2019","journal-title":"J. Food Drug Anal."},{"key":"10.1016\/j.physbeh.2025.115065_bib0087","first-page":"15","article-title":"P3-208: PKA\/CREB\/SHANK1 dysfunction induces cognitive impairment in salt treated rats","author":"Guo","year":"2019","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.physbeh.2025.115065_bib0088","doi-asserted-by":"crossref","first-page":"8390","DOI":"10.1073\/pnas.1701749114","article-title":"Altered metabotropic glutamate receptor 5 markers in PTSD: in vivo and postmortem evidence","volume":"114","author":"Holmes","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.physbeh.2025.115065_bib0089","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3389\/fnmol.2018.00337","article-title":"Sex hormones regulate SHANK expression","volume":"11","author":"Berkel","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.physbeh.2025.115065_bib0090","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.bbrc.2006.11.074","article-title":"Glucocorticoid receptor mediated repression of human insulin gene expression is regulated by PGC-1\u03b1","volume":"352","author":"Jang","year":"2007","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.physbeh.2025.115065_bib0091","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2022.985713","article-title":"A molecular framework for autistic experiences: mitochondrial allostatic load as a mediator between autism and psychopathology","volume":"13","author":"Mahony","year":"2022","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.physbeh.2025.115065_bib0092","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1038\/s41467-025-57363-y","article-title":"Neuron-specific isoform of PGC-1\u03b1 regulates neuronal metabolism and brain aging","volume":"16","author":"Souder","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.physbeh.2025.115065_bib0093","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.3390\/antiox12051075","article-title":"PGC-1\u03b1 is a master regulator of mitochondrial lifecycle and ROS stress response","volume":"12","author":"Abu Shelbayeh","year":"2023","journal-title":"Antioxidants"}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938425002665?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938425002665?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T04:14:56Z","timestamp":1780028096000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938425002665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":93,"alternative-id":["S0031938425002665"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2025.115065","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differential long-term effects of physical, social, and psychological stressors in male mice: down-regulation of inflammatory markers and unresponsiveness of the antioxidant system","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2025.115065","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115065"}}