{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T02:26:08Z","timestamp":1785378368676,"version":"3.55.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007957","name":"Chongqing Municipal Education Commission","doi-asserted-by":"publisher","award":["#KJQN202302704"],"award-info":[{"award-number":["#KJQN202302704"]}],"id":[{"id":"10.13039\/501100007957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["#CSTB2025NSCQ-GPX0981"],"award-info":[{"award-number":["#CSTB2025NSCQ-GPX0981"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["#wzstc-20 220 137"],"award-info":[{"award-number":["#wzstc-20 220 137"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["MSX1313"],"award-info":[{"award-number":["MSX1313"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Natural Science Foundation of Chongqing Municipality","doi-asserted-by":"publisher","award":["-20220137"],"award-info":[{"award-number":["-20220137"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012669","name":"Natural Science Foundation Project of Chongqing","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012669","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.physbeh.2025.115178","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T07:31:53Z","timestamp":1763537513000},"page":"115178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["The gut microbiota-brain axis in Alzheimer\u2019s disease model mice"],"prefix":"10.1016","volume":"304","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2396-1408","authenticated-orcid":false,"given":"Ning","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.physbeh.2025.115178_bib0001","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/procel\/pwae026","article-title":"Alzheimer's disease: insights into pathology, molecular mechanisms, and therapy","volume":"16","author":"Zheng","year":"2025","journal-title":"Protein cell"},{"key":"10.1016\/j.physbeh.2025.115178_bib0002","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.bbi.2024.03.031","article-title":"Multi-strain probiotics ameliorate Alzheimer's-like cognitive impairment and pathological changes through the AKT\/GSK-3\u03b2 pathway in senescence-accelerated mouse prone 8 mice","volume":"119","author":"Xiao-Hang","year":"2024","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.physbeh.2025.115178_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155394","article-title":"Gegen Qinlian tablets delay Alzheimer's disease progression via inhibiting glial neuroinflammation and remodeling gut microbiota homeostasis","volume":"128","author":"Wang","year":"2024","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.physbeh.2025.115178_bib0004","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00401-024-02790-2","article-title":"Inflammatory aspects of Alzheimer's disease","volume":"148","author":"Botella Lucena","year":"2024","journal-title":"Acta Neuropathol"},{"issue":"4","key":"10.1016\/j.physbeh.2025.115178_bib0005","first-page":"1537","article-title":"Microglia and Astrocytes in Alzheimer's Disease: significance and Summary of Recent Advances","volume":"15","author":"Deng","year":"2024","journal-title":"Aging Dis"},{"key":"10.1016\/j.physbeh.2025.115178_bib0006","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155624","article-title":"Berberine alleviates Alzheimer's disease by regulating the gut microenvironment, restoring the gut barrier and brain-gut axis balance","volume":"129","author":"Sun","year":"2024","journal-title":"Phytomedicine"},{"issue":"8","key":"10.1016\/j.physbeh.2025.115178_bib0007","doi-asserted-by":"crossref","first-page":"e656","DOI":"10.1002\/mco2.656","article-title":"2024. The gut microbiota-brain axis in neurological disorders","volume":"5","author":"You","year":"2020","journal-title":"MedComm"},{"issue":"1","key":"10.1016\/j.physbeh.2025.115178_bib0008","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.cmet.2024.10.006","article-title":"Microbiota-derived lysophosphatidylcholine alleviates Alzheimer's disease pathology via suppressing ferroptosis","volume":"37","author":"Zha","year":"2025","journal-title":"Cell Metab"},{"issue":"14","key":"10.1016\/j.physbeh.2025.115178_bib0009","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.3390\/nu16142366","article-title":"Correlation between Alzheimer's Disease and Gastrointestinal Tract Disorders","volume":"16","author":"Ku\u017aniar","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.physbeh.2025.115178_bib0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.tifs.2025.104942","article-title":"The microbiota-microglia axis: a novel clue for diet and brain health","volume":"158","author":"Song","year":"2025","journal-title":"Trends Food Sci Technol"},{"key":"10.1016\/j.physbeh.2025.115178_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2020.113629","article-title":"Tibetan medicine Duoxuekang ameliorates hypobaric hypoxia-induced brain injury in mice by restoration of cerebrovascular function","volume":"270","author":"Li","year":"2021","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.physbeh.2025.115178_bib0012","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1260838","article-title":"Antidepressant sertraline increases thioflavin-S and Congo red deposition in APPswe\/PSEN1dE9 transgenic mice","volume":"14","author":"Liao","year":"2024","journal-title":"Front Pharmacol"},{"issue":"1","key":"10.1016\/j.physbeh.2025.115178_bib0013","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1186\/s13195-024-01618-1","article-title":"Unveiling the molecular mechanisms of Danggui-Shaoyao-San against Alzheimer's disease in APP\/PS1 mice via integrating proteomic and metabolomic approaches","volume":"16","author":"Wu","year":"2024","journal-title":"Alzheimers Res Ther"},{"issue":"3","key":"10.1016\/j.physbeh.2025.115178_bib0014","doi-asserted-by":"crossref","DOI":"10.1016\/j.neurot.2025.e00540","article-title":"Astrocyte and oligodendrocyte pathology in Alzheimer's disease","volume":"22","author":"Ziar","year":"2025","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.physbeh.2025.115178_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102707","article-title":"Antioxidants in anti-Alzheimer's disease drug discovery","volume":"107","author":"Guo","year":"2025","journal-title":"Ageing Res Rev"},{"issue":"5","key":"10.1016\/j.physbeh.2025.115178_bib0016","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.cell.2018.05.003","article-title":"Disease-associated microglia: a universal immune sensor of neurodegeneration","volume":"173","author":"Deczkowska","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.physbeh.2025.115178_bib0017","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1308345","article-title":"New insight on microglia activation in neurodegenerative diseases and therapeutics","volume":"17","author":"Xu","year":"2023","journal-title":"Front Neurosci"},{"issue":"7","key":"10.1016\/j.physbeh.2025.115178_bib0018","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s10654-024-01144-2","article-title":"Incidence and prevalence of Alzheimer's disease in China: a systematic review and meta-analysis","volume":"39","author":"Ji","year":"2024","journal-title":"Eur J Epidemiol"},{"issue":"10","key":"10.1016\/j.physbeh.2025.115178_bib0019","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1038\/s41591-024-03122-3","article-title":"Sex-dependent APOE4 neutrophil-microglia interactions drive cognitive impairment in Alzheimer's disease","volume":"30","author":"Rosenzweig","year":"2024","journal-title":"Nat Med"},{"issue":"6123","key":"10.1016\/j.physbeh.2025.115178_bib0020","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1126\/science.1233521","article-title":"Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity","volume":"339","author":"Markle","year":"2013","journal-title":"Sci"},{"issue":"1","key":"10.1016\/j.physbeh.2025.115178_bib0021","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s40168-018-0587-0","article-title":"Estrogen-mediated gut microbiome alterations influence sexual dimorphism in metabolic syndrome in mice","volume":"6","author":"Kaliannan","year":"2018","journal-title":"Microbiome"},{"key":"10.1016\/j.physbeh.2025.115178_bib0022","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1545566","article-title":"7-\u03b1-O-Methylmorroniside ameliorated brain injury in 5\u00d7FAD mice by regulating the gut microbiome and NMDAR2B","volume":"16","author":"Hao","year":"2025","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.physbeh.2025.115178_bib0023","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2147\/NDT.S393773","article-title":"Jiedu Yizhi Formula Improves Cognitive Function by Regulating the Gut Dysbiosis and TLR4\/NF-\u03baB Signaling Pathway","volume":"19","author":"Zhang","year":"2023","journal-title":"Neuropsychiatr Dis Treat"},{"key":"10.1016\/j.physbeh.2025.115178_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114591","article-title":"Heterophyllin B alleviates cognitive disorders in APP\/PS1 model mice via the spleen-gut microbiota-brain axis","volume":"154","author":"Jiang","year":"2025","journal-title":"Int Immunopharmacol"},{"issue":"41","key":"10.1016\/j.physbeh.2025.115178_bib0025","doi-asserted-by":"crossref","first-page":"12230","DOI":"10.1021\/acs.jafc.1c05038","article-title":"Protective Effect of Ginkgolide B against Cognitive Impairment in Mice via Regulation of Gut Microbiota","volume":"69","author":"Liu","year":"2021","journal-title":"J Agric Food Chem"},{"issue":"6","key":"10.1016\/j.physbeh.2025.115178_bib0026","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.01794-22","article-title":"Longitudinal Analysis of the Microbiome and Metabolome in the 5xfAD Mouse Model of Alzheimer's Disease","volume":"13","author":"Dunham","year":"2022","journal-title":"mBio"},{"issue":"1","key":"10.1016\/j.physbeh.2025.115178_bib0027","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12974-025-03447-x","article-title":"Inverted day-night feeding during pregnancy affects the brain health of both maternal and fetal brains through increasing inflammation levels associated with dysbiosis of the gut microbiome in rats","volume":"22","author":"Wang","year":"2025","journal-title":"J Neuroinflammation"},{"issue":"27","key":"10.1016\/j.physbeh.2025.115178_bib0028","doi-asserted-by":"crossref","first-page":"16933","DOI":"10.1021\/acs.jafc.5c02557","article-title":"Gut Microbiota-Driven Metabolic Alterations Reveal the Gut-Brain Communication of Ergothioneine in Ameliorating Cognitive Impairment in APP\/PS1 Mice","volume":"73","author":"Li","year":"2025","journal-title":"J Agric Food Chem"},{"issue":"50","key":"10.1016\/j.physbeh.2025.115178_bib0029","doi-asserted-by":"crossref","first-page":"21966","DOI":"10.1021\/acs.est.4c07427","article-title":"Organophosphate Insecticide Malathion Induces Alzheimer's Disease-Like Cognitive Impairment in Mice: evidence of the Microbiota-Gut-Brain Axis","volume":"58","author":"Cui","year":"2024","journal-title":"Env. Sci Technol"},{"issue":"1","key":"10.1016\/j.physbeh.2025.115178_bib0030","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2302310","article-title":"Gut microbiota-driven metabolic alterations reveal gut-brain communication in Alzheimer's disease model mice","volume":"16","author":"Chen","year":"2024","journal-title":"Gut Microbes"},{"key":"10.1016\/j.physbeh.2025.115178_bib0031","article-title":"Gut microbial characteristical comparison reveals potential anti-aging function of Dubosiella newyorkensis in mice","volume":"14","author":"Liu","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"1","key":"10.1016\/j.physbeh.2025.115178_bib0032","doi-asserted-by":"crossref","first-page":"6422","DOI":"10.1038\/s41467-025-61544-0","article-title":"Gut microbiota and brain-resident CD4+ T cells shape behavioral outcomes in autism spectrum disorder","volume":"16","author":"Park","year":"2025","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.physbeh.2025.115178_bib0033","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1002\/biof.2082","article-title":"Limosilactobacillus reuteri DSM 17938 relieves inflammation, endoplasmic reticulum stress, and autophagy in hippocampus of western diet-fed rats by modulation of systemic inflammation","volume":"50","author":"Mazzoli","year":"2024","journal-title":"Biofactors"},{"issue":"1","key":"10.1016\/j.physbeh.2025.115178_bib0034","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3390\/nu15010118","article-title":"Gut Microbiome and Serum Metabolome Profiles of Capsaicin with Cognitive Benefits in APP\/PS1 Mice","volume":"15","author":"Li","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.physbeh.2025.115178_bib0035","doi-asserted-by":"crossref","DOI":"10.1002\/alz.076520","article-title":"Poor cognition is associated with increased abundance of Alistipes and decreased abundance of Clostridium genera in the gut","volume":"19","author":"Muhammad","year":"2023","journal-title":"Alzheimer's Dement"},{"issue":"24","key":"10.1016\/j.physbeh.2025.115178_bib0036","doi-asserted-by":"crossref","first-page":"9404","DOI":"10.1021\/acs.jafc.3c01524","article-title":"Leucine-Restricted Diet Ameliorates Obesity-Linked Cognitive Deficits: involvement of the Microbiota-Gut-Brain Axis","volume":"71","author":"Wang","year":"2023","journal-title":"J Agric Food Chem"},{"issue":"27","key":"10.1016\/j.physbeh.2025.115178_bib0037","doi-asserted-by":"crossref","first-page":"16933","DOI":"10.1021\/acs.jafc.5c02557","article-title":"Gut Microbiota-Driven Metabolic Alterations Reveal the Gut-Brain Communication of Ergothioneine in Ameliorating Cognitive Impairment in APP\/PS1 Mice","volume":"73","author":"Li","year":"2025","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.physbeh.2025.115178_bib0038","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1042189","article-title":"Gut microbiome and human health: exploring how the probiotic genus Lactobacillus modulate immune responses","volume":"13","author":"Rastogi","year":"2022","journal-title":"Front Pharmacol"},{"issue":"2","key":"10.1016\/j.physbeh.2025.115178_bib0039","doi-asserted-by":"crossref","first-page":"399","DOI":"10.3233\/JAD-181220","article-title":"Gut Microbiota Alteration and Its Time Course in a Tauopathy Mouse Model","volume":"70","author":"Sun","year":"2019","journal-title":"J Alzheimers Dis"},{"issue":"1","key":"10.1016\/j.physbeh.2025.115178_bib0040","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1186\/s12967-021-03032-9","article-title":"Urinary metabolomic changes and microbiotic alterations in presenilin1\/2 conditional double knockout mice","volume":"19","author":"Gao","year":"2021","journal-title":"J Transl Med"},{"issue":"23","key":"10.1016\/j.physbeh.2025.115178_bib0041","doi-asserted-by":"crossref","first-page":"7251","DOI":"10.1007\/s00253-023-12754-3","article-title":"Gut microbiota regulation of inflammatory cytokines and microRNAs in diabetes-associated cognitive dysfunction","volume":"107","author":"Huang","year":"2023","journal-title":"Appl Microbiol Biotechnol"},{"issue":"1","key":"10.1016\/j.physbeh.2025.115178_bib0042","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s40168-022-01452-3","article-title":"Gut microbiota-derived metabolites mediate the neuroprotective effect of melatonin in cognitive impairment induced by sleep deprivation","volume":"11","author":"Wang","year":"2023","journal-title":"Microbiome"},{"issue":"21","key":"10.1016\/j.physbeh.2025.115178_bib0043","doi-asserted-by":"crossref","first-page":"12184","DOI":"10.1021\/acs.jafc.4c01922","article-title":"Gut Microbiota Mediate the Neuroprotective Effect of Oolong Tea Polyphenols in Cognitive Impairment Induced by Circadian Rhythm Disorder","volume":"72","author":"Song","year":"2024","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.physbeh.2025.115178_bib0044","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.107033","article-title":"Baicalin circumvents anti-PD-1 resistance by regulating the gut microbiota metabolite short-chain fatty acids","volume":"199","author":"Yu","year":"2024","journal-title":"Pharmacol Res"},{"issue":"4","key":"10.1016\/j.physbeh.2025.115178_bib0045","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.14336\/AD.2021.1215","article-title":"Mechanisms of Short-Chain Fatty Acids Derived from Gut Microbiota in Alzheimer's Disease","volume":"13","author":"Qian","year":"2022","journal-title":"Aging Dis"},{"issue":"27","key":"10.1016\/j.physbeh.2025.115178_bib0046","doi-asserted-by":"crossref","first-page":"7619","DOI":"10.1021\/acs.jafc.1c01781","article-title":"Protective Effects of Microbiome-Derived Inosine on Lipopolysaccharide-Induced Acute Liver Damage and Inflammation in Mice via Mediating the TLR4\/NF-\u03baB Pathway","volume":"69","author":"Guo","year":"2021","journal-title":"J Agric Food Chem"},{"issue":"1","key":"10.1016\/j.physbeh.2025.115178_bib0047","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2023.2167172","article-title":"Gut-derived \u03b2-amyloid: likely a centerpiece of the gut-brain axis contributing to Alzheimer's pathogenesis","volume":"15","author":"Jin","year":"2023","journal-title":"Gut Microbes"},{"issue":"7","key":"10.1016\/j.physbeh.2025.115178_bib0048","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1084\/jem.20182386","article-title":"Sex-specific effects of microbiome perturbations on cerebral A\u03b2 amyloidosis and microglia phenotypes","volume":"216","author":"Dodiya","year":"2019","journal-title":"J Exp Med"},{"issue":"6","key":"10.1016\/j.physbeh.2025.115178_bib0049","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1016\/j.cell.2016.05.041","article-title":"From Dietary Fiber to Host Physiology: short-Chain Fatty Acids as Key Bacterial Metabolites","volume":"165","author":"Koh","year":"2016","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.physbeh.2025.115178_bib0050","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/14737175.2018.1400909","article-title":"Protective roles of intestinal microbiota derived short chain fatty acids in Alzheimer's disease-type beta-amyloid neuropathological mechanisms","volume":"18","author":"Ho","year":"2018","journal-title":"Expert Rev Neurother"},{"issue":"11","key":"10.1016\/j.physbeh.2025.115178_bib0051","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1111\/cns.14252","article-title":"Early changes of fecal short-chain fatty acid levels in patients with mild cognitive impairments","volume":"29","author":"Gao","year":"2023","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.physbeh.2025.115178_bib0052","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102690","article-title":"Promotion of astrocyte-neuron glutamate-glutamine shuttle by SCFA contributes to the alleviation of Alzheimer's disease","volume":"62","author":"Sun","year":"2023","journal-title":"Redox Biol"},{"issue":"6628","key":"10.1016\/j.physbeh.2025.115178_bib0053","doi-asserted-by":"crossref","first-page":"eadd1236","DOI":"10.1126\/science.add1236","article-title":"ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy","volume":"379","author":"Seo","year":"2023","journal-title":"Science"}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938425003798?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938425003798?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T07:34:36Z","timestamp":1773819276000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938425003798"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":53,"alternative-id":["S0031938425003798"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2025.115178","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The gut microbiota-brain axis in Alzheimer\u2019s disease model mice","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2025.115178","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115178"}}