{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T09:07:02Z","timestamp":1779095222817,"version":"3.51.4"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"State of Sao Paulo Research Foundation","doi-asserted-by":"publisher","award":["2023\/14175-9"],"award-info":[{"award-number":["2023\/14175-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["445962\/2024-0"],"award-info":[{"award-number":["445962\/2024-0"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.physbeh.2026.115269","type":"journal-article","created":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:13:17Z","timestamp":1771027997000},"page":"115269","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Enhanced avoidance learning associated with elevated anxiety in the 3xTg-AD mouse model of Alzheimer\u2019s disease"],"prefix":"10.1016","volume":"308","author":[{"given":"Jonathas Rodrigo","family":"dos Santos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Francisco","family":"Pedrazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciane Carla","family":"Alberici","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2883-3103","authenticated-orcid":false,"given":"Carlos Henrique Rocha","family":"Catal\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2026.115269_bib0001","doi-asserted-by":"crossref","first-page":"345","DOI":"10.3233\/ADR-230130","article-title":"Novel development and prospects in pathogenesis, diagnosis, and therapy of Alzheimer's disease","volume":"8","author":"Teng","year":"2024","journal-title":"J. Alzheimers. Dis. Rep."},{"key":"10.1016\/j.physbeh.2026.115269_bib0002","article-title":"The impact of the microbiota-gut-brain axis on Alzheimer's disease pathophysiology","author":"Doifode","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.physbeh.2026.115269_bib0003","doi-asserted-by":"crossref","first-page":"4463","DOI":"10.1038\/s41380-023-02172-2","article-title":"Sepsis exacerbates Alzheimer's disease pathophysiology, modulates the gut microbiome, increases neuroinflammation and amyloid burden","volume":"28","author":"Giridharan","year":"2023","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.physbeh.2026.115269_bib0004","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nature20814","article-title":"Structural variation in amyloid-\u03b2 fibrils from Alzheimer's disease clinical subtypes","volume":"541","author":"Qiang","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.physbeh.2026.115269_bib0005","first-page":"440","article-title":"Neuropsychiatric signs and symptoms of Alzheimer's disease: new treatment paradigms","volume":"3","author":"Lanct\u00f4t","year":"2017","journal-title":"Alzheimers. Dement."},{"key":"10.1016\/j.physbeh.2026.115269_bib0006","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.jad.2015.09.069","article-title":"The prevalence of neuropsychiatric symptoms in Alzheimer's disease: systematic review and meta-analysis","volume":"190","author":"Zhao","year":"2016","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.physbeh.2026.115269_bib0007","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev-psych-010419-051044","article-title":"Emotional objectivity: neural representations of emotions and their interaction with cognition","volume":"71","author":"Todd","year":"2020","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.physbeh.2026.115269_bib0008","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/j.neuron.2018.01.016","article-title":"Anxiety cells in a hippocampal-hypothalamic circuit","volume":"97","author":"Jimenez","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.physbeh.2026.115269_bib0009","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.neubiorev.2020.02.012","article-title":"Behavioural and psychological symptoms of dementia in mouse models of Alzheimer's disease-related pathology","volume":"112","author":"Kosel","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.physbeh.2026.115269_bib0010","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S0896-6273(03)00434-3","article-title":"Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular abeta and synaptic dysfunction","volume":"39","author":"Oddo","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.physbeh.2026.115269_bib0011","article-title":"The 3xTg-AD mouse model of Alzheimer's disease exhibits lifelong reductions in circulating choline despite adequate dietary intake, with sex-specific neuropathological and behavioral phenotypes","volume":"25","author":"Judd","year":"2026","journal-title":"Ag. Cell"},{"key":"10.1016\/j.physbeh.2026.115269_bib0012","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1126\/science.aaw7570","article-title":"Are hormones a \"female problem\" for animal research?","volume":"364","author":"Shansky","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.physbeh.2026.115269_bib0013","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/j.neurobiolaging.2006.06.013","article-title":"Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice","volume":"28","author":"Freichel","year":"2007","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.physbeh.2026.115269_bib0014","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2023.1182661","article-title":"Effect of apparatus characteristics on anxiety-like behavior in young adult and old mice of both sexes assessed by the elevated plus maze assay","volume":"17","author":"Gaspar","year":"2023","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.physbeh.2026.115269_bib0015","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.neuron.2005.01.040","article-title":"Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice","volume":"45","author":"Billings","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.physbeh.2026.115269_bib0016","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1002\/cne.25032","article-title":"Remodeling of projections from ventral hippocampus to prefrontal cortex in Alzheimer's mice","volume":"529","author":"Xu","year":"2021","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.physbeh.2026.115269_bib0017","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1177\/153331750301800604","article-title":"Memory for emotional stimuli in patients with Alzheimer's disease","volume":"18","author":"Fleming","year":"2003","journal-title":"Am. J. Alzheimers. Dis. Other Demen."},{"key":"10.1016\/j.physbeh.2026.115269_bib0018","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neuron.2009.11.031","article-title":"Are the dorsal and ventral hippocampus functionally distinct structures?","volume":"65","author":"Fanselow","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.physbeh.2026.115269_bib0019","doi-asserted-by":"crossref","first-page":"17269","DOI":"10.1523\/JNEUROSCI.4095-11.2011","article-title":"Hippocampal and prefrontal projections to the basal amygdala mediate contextual regulation of fear after extinction","volume":"31","author":"Orsini","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.physbeh.2026.115269_bib0020","doi-asserted-by":"crossref","first-page":"8477","DOI":"10.1073\/pnas.91.18.8477","article-title":"Amygdala modulation of hippocampal-dependent and caudate nucleus-dependent memory processes","volume":"91","author":"Packard","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U S. A"},{"key":"10.1016\/j.physbeh.2026.115269_bib0021","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0166-4328(90)90072-M","article-title":"Hippocampus, amygdala, and memory deficits in rats","volume":"37","author":"Sutherland","year":"1990","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2026.115269_bib0022","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.biopsych.2009.06.015","article-title":"Intraneuronal beta-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice","volume":"67","author":"Espa\u00f1a","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.physbeh.2026.115269_bib0023","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1006\/nlme.2002.4082","article-title":"Amygdala modulation of memory consolidation: interaction with other brain systems","volume":"78","author":"McGaugh","year":"2002","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.physbeh.2026.115269_bib0024","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-25364-2","article-title":"Disruption of hippocampal neuronal circuit function depends upon behavioral state in the APP\/PS1 mouse model of Alzheimer's disease","volume":"12","author":"Zhou","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.physbeh.2026.115269_bib0025","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00213-018-5109-z","article-title":"Hippocampal network oscillations at the interplay between innate anxiety and learned fear","volume":"236","author":"\u00c7al\u0131\u015fkan","year":"2019","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.physbeh.2026.115269_bib0026","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.neurobiolaging.2019.10.008","article-title":"Apathy and anxiety are early markers of Alzheimer's disease","volume":"85","author":"Johansson","year":"2020","journal-title":"Neurobiol. Aging"}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938426000533?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938426000533?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T08:15:34Z","timestamp":1779092134000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938426000533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":26,"alternative-id":["S0031938426000533"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2026.115269","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enhanced avoidance learning associated with elevated anxiety in the 3xTg-AD mouse model of Alzheimer\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2026.115269","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115269"}}