{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:42:25Z","timestamp":1786995745016,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,5,19]],"date-time":"2027-05-19T00:00:00Z","timestamp":1810684800000},"content-version":"am","delay-in-days":230,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["P50AA017823"],"award-info":[{"award-number":["P50AA017823"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R21AA030402"],"award-info":[{"award-number":["R21AA030402"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology & Behavior"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.physbeh.2026.115376","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:31:48Z","timestamp":1778729508000},"page":"115376","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Transcriptional profiling of the anterior cingulate cortex and nucleus accumbens using a double-hit model of prenatal and adolescent alcohol exposure"],"prefix":"10.1016","volume":"314","author":[{"given":"Esther M.","family":"Marquez-Wilkins","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven L.","family":"Youngentob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlita","family":"Favero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1514-4600","authenticated-orcid":false,"given":"Terrence","family":"Deak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anny","family":"Gano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.physbeh.2026.115376_bib0001","doi-asserted-by":"crossref","first-page":"10","DOI":"10.15585\/mmwr.mm7101a2","article-title":"Alcohol consumption and binge drinking during pregnancy among adults aged 18\u201349 years \u2014 United States, 2018\u20132020","volume":"71","author":"Gosdin","year":"2022","journal-title":"Morb. Mortal. Wkly. Rep."},{"issue":"2","key":"10.1016\/j.physbeh.2026.115376_bib0002","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s11065-011-9166-x","article-title":"Fetal Alcohol Spectrum disorders: an overview","volume":"21","author":"Riley","year":"2011","journal-title":"Neuropsychol. Rev."},{"issue":"5","key":"10.1016\/j.physbeh.2026.115376_bib0003","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.tins.2012.01.006","article-title":"Does moderate drinking harm the fetal brain? insights from animal models","volume":"35","author":"Valenzuela","year":"2012","journal-title":"Trends. Neurosci."},{"issue":"4","key":"10.1016\/j.physbeh.2026.115376_bib0004","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0149-7634(00)00014-2","article-title":"The adolescent brain and age-related behavioral manifestations","volume":"24","author":"Spear","year":"2000","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"12","key":"10.1016\/j.physbeh.2026.115376_bib0005","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1111\/ejn.12913","article-title":"Prenatal ethanol increases ethanol intake throughout adolescence, alters ethanol-mediated aversive learning, and affects \u03bc but not \u03b4 or \u03ba opioid receptor mRNA expression","volume":"41","author":"Fabio","year":"2015","journal-title":"Eur. J. Neurosci."},{"issue":"13","key":"10.1016\/j.physbeh.2026.115376_bib0006","doi-asserted-by":"crossref","first-page":"5359","DOI":"10.1073\/pnas.0809804106","article-title":"Fetal ethanol exposure increases ethanol intake by making it smell and taste better","volume":"106","author":"Youngentob","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.physbeh.2026.115376_bib0007","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2022.173390","article-title":"Prenatal and adolescent alcohol exposure programs immunity across the lifespan: CNS-mediated regulation","volume":"216","author":"Deak","year":"2022","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"9","key":"10.1016\/j.physbeh.2026.115376_bib0008","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1111\/j.1530-0277.2006.00177.x","article-title":"The Alcoholism Generator","volume":"30","author":"Miller","year":"2006","journal-title":"Alcohol.: Clin. Exp. Res."},{"issue":"5","key":"10.1016\/j.physbeh.2026.115376_bib0009","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1176\/appi.ajp.157.5.745","article-title":"Age at first alcohol use: a risk factor for the development of alcohol disorders","volume":"157","author":"DeWit","year":"2000","journal-title":"Am. J. Psychiatry"},{"issue":"2","key":"10.1016\/j.physbeh.2026.115376_bib0010","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/acer.12622","article-title":"Prenatal alcohol exposure alters steady-State and activated gene expression in the adult rat brain","volume":"39","author":"Lussier","year":"2015","journal-title":"Alcohol.: Clin. Exp. Res."},{"key":"10.1016\/j.physbeh.2026.115376_bib0011","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2020.155126","article-title":"Gene expression profiling reveals a lingering effect of prenatal alcohol exposure on inflammatory-related genes during adolescence and adulthood","volume":"133","author":"Gano","year":"2020","journal-title":"Cytokine"},{"key":"10.1016\/j.physbeh.2026.115376_bib0012","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fnbeh.2020.00082","article-title":"Lingering effects of prenatal alcohol exposure on basal and ethanol-evoked expression of inflammatory-related genes in the CNS of adolescent and adult rats","volume":"14","author":"Doremus-Fitzwater","year":"2020","journal-title":"Front. Behav. Neurosci."},{"issue":"1","key":"10.1016\/j.physbeh.2026.115376_bib0013","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0006-8993(92)91447-M","article-title":"Circadian rhythm of cell proliferation in the telencephalic ventricular zone: effect of in utero exposure to ethanol","volume":"595","author":"Miller","year":"1992","journal-title":"Brain Res."},{"issue":"6","key":"10.1016\/j.physbeh.2026.115376_bib0014","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1037\/0735-7044.121.6.1306","article-title":"The effect of gestational ethanol exposure on voluntary ethanol intake in early postnatal and adult rats","volume":"121","author":"Youngentob","year":"2007","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.physbeh.2026.115376_bib0015","series-title":"The Rat Brain in Stereotaxic Coordinates","year":"2005"},{"issue":"1","key":"10.1016\/j.physbeh.2026.115376_bib0016","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/imr.13147","article-title":"C3-dependent effector functions of complement","volume":"313","author":"Zarantonello","year":"2023","journal-title":"Immunol. Rev."},{"issue":"4","key":"10.1016\/j.physbeh.2026.115376_bib0017","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1080\/07853890600664608","article-title":"Complement C3 contributes to ethanol-induced liver steatosis in mice","volume":"38","author":"Bykov","year":"2006","journal-title":"Ann. Med."},{"issue":"17","key":"10.1016\/j.physbeh.2026.115376_bib0018","doi-asserted-by":"crossref","first-page":"4622","DOI":"10.1111\/j.1742-4658.2009.07174.x","article-title":"Brain angiogenesis in developmental and pathological processes: regulation, molecular and cellular communication at the neurovascular interface","volume":"276","author":"Lee","year":"2009","journal-title":"FEBS. J."},{"issue":"3","key":"10.1016\/j.physbeh.2026.115376_bib0019","doi-asserted-by":"crossref","DOI":"10.1177\/00368504221109212","article-title":"Physiologic and pathophysiologic roles of AKAP12","volume":"105","author":"Li","year":"2022","journal-title":"Sci. Prog."},{"issue":"1","key":"10.1016\/j.physbeh.2026.115376_bib0020","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13293-024-00670-8","article-title":"Sex differences in the role of AKAP12 in behavioral function of middle-aged mice","volume":"15","author":"Ishikawa","year":"2024","journal-title":"Biol. Sex. Differ."},{"issue":"1\u20132","key":"10.1016\/j.physbeh.2026.115376_bib0021","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0009-3084(99)00018-3","article-title":"Role of synaptotagmin, a Ca2+ and inositol polyphosphate binding protein, in neurotransmitter release and neurite outgrowth","volume":"98","author":"Mikoshiba","year":"1999","journal-title":"Chem. Phys. Lipids"},{"issue":"4","key":"10.1016\/j.physbeh.2026.115376_bib0022","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1111\/j.1365-2826.2008.01669.x","article-title":"Prenatal alcohol exposure: foetal programming, the hypothalamic-pituitary-adrenal axis and sex differences in outcome","volume":"20","author":"Weinberg","year":"2008","journal-title":"J. Neuroendocr."},{"issue":"11","key":"10.1016\/j.physbeh.2026.115376_bib0023","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.3390\/genes12111773","article-title":"Prenatal adversity alters the epigenetic profile of the prefrontal cortex: sexually dimorphic effects of Prenatal alcohol exposure and food-related stress","volume":"12","author":"Lussier","year":"2021","journal-title":"Genes. (Basel)"},{"issue":"10","key":"10.1016\/j.physbeh.2026.115376_bib0024","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0164179","article-title":"Signaling properties of Chemerin receptors CMKLR1, GPR1 and CCRL2","volume":"11","author":"Henau","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.physbeh.2026.115376_bib0025","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neulet.2012.06.075","article-title":"Chronic mild restraint stress rats decreased CMKLR1 expression in distinct brain region","volume":"524","author":"Guo","year":"2012","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.physbeh.2026.115376_bib0026","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2025.110335","article-title":"Neuroimmune regulation of the prefrontal cortex tetrapartite synapse","volume":"269","author":"Liss","year":"2025","journal-title":"Neuropharmacology"},{"issue":"12","key":"10.1016\/j.physbeh.2026.115376_bib0027","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1111\/acer.14957","article-title":"A double-hit model reveals individual and synergic consequences of prenatal and adolescent postnatal ethanol exposure","volume":"46","author":"Pautassi","year":"2022","journal-title":"Alcohol.: Clin. Exp. Res."},{"issue":"1","key":"10.1016\/j.physbeh.2026.115376_bib0028","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1744-9081-5-3","article-title":"The consequence of fetal ethanol exposure and adolescent odor re-exposure on the response to ethanol odor in adolescent and adult rats","volume":"5","author":"Eade","year":"2009","journal-title":"Behav. Brain Funct."},{"issue":"10","key":"10.1016\/j.physbeh.2026.115376_bib0029","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1111\/j.1530-0277.2010.01257.x","article-title":"The interaction of gestational and postnatal ethanol experience on the adolescent and adult odor-mediated responses to ethanol in observer and demonstrator rats","volume":"34","author":"Eade","year":"2010","journal-title":"Alcohol.: Clin. Exp. Res."},{"key":"10.1016\/j.physbeh.2026.115376_bib0030","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.brainres.2008.11.023","article-title":"Gestational ethanol exposure alters the behavioral response to ethanol odor and the expression of neurotransmission genes in the olfactory bulb of adolescent rats","volume":"1252","author":"Middleton","year":"2009","journal-title":"Brain Res."},{"issue":"6","key":"10.1016\/j.physbeh.2026.115376_bib0031","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.alcohol.2012.05.004","article-title":"Prenatal ethanol exposure leads to greater ethanol-induced appetitive reinforcement","volume":"46","author":"Pautassi","year":"2012","journal-title":"Alcohol"}],"container-title":["Physiology & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938426001605?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938426001605?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T13:17:01Z","timestamp":1783084621000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938426001605"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":31,"alternative-id":["S0031938426001605"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2026.115376","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptional profiling of the anterior cingulate cortex and nucleus accumbens using a double-hit model of prenatal and adolescent alcohol exposure","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2026.115376","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115376"}}