{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T20:55:21Z","timestamp":1786136121551,"version":"build-2736575974"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100006377","name":"Purdue University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006377","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology & Behavior"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.physbeh.2026.115435","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T23:04:23Z","timestamp":1783119863000},"page":"115435","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["DHEA model of PCOS selectively alters reproductive but not metabolic or behavioral phenotypes in female Long-Evans rats"],"prefix":"10.1016","volume":"315","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6668-6002","authenticated-orcid":false,"given":"Claire E.","family":"Miller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erisa","family":"Met-Hoxha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle R.","family":"Bonanno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linnaea","family":"Krupke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly P.","family":"Kinzig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.physbeh.2026.115435_bib0001","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1001\/jama.2021.23769","article-title":"Diagnosis and treatment of polycystic ovarian syndrome","volume":"327","author":"Huddlestone","year":"2022","journal-title":"JAMa"},{"issue":"2","key":"10.1016\/j.physbeh.2026.115435_bib0002","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/humrep\/dep399","article-title":"The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria","volume":"25","author":"March","year":"2010","journal-title":"Human Reprod."},{"key":"10.1016\/j.physbeh.2026.115435_bib40","article-title":"Evolving global trends in PCOS burden: a three-decade analysis (1990\u20132021) with projections to 2036 among adolescents and young adults","volume":"16","author":"Wang","year":"2025","journal-title":"Front. Endocrinol."},{"issue":"7","key":"10.1016\/j.physbeh.2026.115435_bib0003","first-page":"598","article-title":"PCOS: a common but underdiagnosed condition in reproductive women","volume":"10","author":"Devi","year":"2021","journal-title":"World J. Pharm. Res."},{"issue":"3","key":"10.1016\/j.physbeh.2026.115435_bib0004","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1080\/00325481.2022.2140511","article-title":"Medical journey of patients with polycystic ovary syndrome and obesity: a cross-sectional survey of patients and primary care physicians","volume":"135","author":"Sherif","year":"2023","journal-title":"Postgrad. Med."},{"issue":"27","key":"10.1016\/j.physbeh.2026.115435_bib41","article-title":"Polycystic ovary syndrome","volume":"10","author":"Stener-Victorin","year":"2024","journal-title":"Nat Rev Dis Primers"},{"issue":"6","key":"10.1016\/j.physbeh.2026.115435_bib0005","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.3390\/diagnostics13061113","article-title":"Current guidelines for diagnosing PCOS","volume":"13","author":"Christ","year":"2023","journal-title":"Diagnostics"},{"issue":"6","key":"10.1016\/j.physbeh.2026.115435_bib0006","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1007\/s00404-024-07408-2","article-title":"PCOS phenotype focus: phenotype D under the magnifying glass","volume":"309","author":"Myers","year":"2024","journal-title":"Arch. Gynecol. Obstet."},{"issue":"41","key":"10.1016\/j.physbeh.2026.115435_bib0020","article-title":"Polycystic ovary syndrome: A complex condition with psychological, reproductive and metabolic manifestations that impacts on health across the lifespan","volume":"8","author":"Teede","year":"2010","journal-title":"BMC Med."},{"issue":"2","key":"10.1016\/j.physbeh.2026.115435_bib0007","first-page":"jc.2016","article-title":"Delayed diagnosis and a lack of information associated with dissatisfaction in women with polycystic ovary syndrome","volume":"102","author":"Gibson-Helm","year":"2017","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"6","key":"10.1016\/j.physbeh.2026.115435_bib0008","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1093\/humupd\/dms030","article-title":"Overweight, obesity and central-obesity in women with polycystic ovary syndrome: a systematic review and meta-analysis","volume":"18","author":"Lim","year":"2012","journal-title":"Hum. Reprod. Update"},{"issue":"10","key":"10.1016\/j.physbeh.2026.115435_bib0009","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.3390\/diagnostics12102313","article-title":"Comparing lean and obese PCOS in different PCOS phenotypes: evidence that body weight is more important than Rotterdam phenotype in influencing metabolic status","volume":"12","author":"Carmina","year":"2022","journal-title":"Diagnostics"},{"issue":"2","key":"10.1016\/j.physbeh.2026.115435_bib0010","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/humrep\/dew329","article-title":"Overweight and obese but not normal weight women with PCOS are at increased risk of type 2 diabetes mellitus\u2014a prospective, population-based cohort study","volume":"32","author":"Ollila","year":"2017","journal-title":"Human Reprod."},{"issue":"25","key":"10.1016\/j.physbeh.2026.115435_bib0011","article-title":"Development and evaluation of novel rodent model of PCOS mimicking clinical phenotype in human disease","volume":"27","author":"Kumar","year":"2022","journal-title":"Middle East. Fertil. Soc. J."},{"issue":"4","key":"10.1016\/j.physbeh.2026.115435_bib0012","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1530\/REP-15-0542","article-title":"High fat diets exaggerate endocrine and metabolic phenotypes in a rat model of DHEA-induced PCOS","volume":"151","author":"Zhang","year":"2016","journal-title":"Reproduction"},{"issue":"5","key":"10.1016\/j.physbeh.2026.115435_bib0013","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.fertnstert.2019.06.018","article-title":"Body-image distress is increased in women with polycystic ovary syndrome and mediates depression and anxiety","volume":"112","author":"Alur-Gupta","year":"2019","journal-title":"Fertil. Steril."},{"issue":"5","key":"10.1016\/j.physbeh.2026.115435_bib0014","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1093\/humrep\/dex044","article-title":"High prevalence of moderate and severe depressive and anxiety symptoms in polycystic ovary syndrome: a systematic review and meta-analysis","volume":"32","author":"Cooney","year":"2017","journal-title":"Human Reproduction."},{"issue":"5","key":"10.1016\/j.physbeh.2026.115435_bib0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0097041","article-title":"Risk of psychiatric disorders following polycystic ovary syndrome: a nationwide population-based cohort study","volume":"9","author":"Hung","year":"2014","journal-title":"PLoS. One"},{"key":"10.1016\/j.physbeh.2026.115435_bib0016","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1007\/s40519-018-0533-y","article-title":"Increased odds of disordered eating in polycystic ovary syndrome: a systematic review and meta-analysis","volume":"24","author":"Lee","year":"2019","journal-title":"Eating Weight Disorders"},{"key":"10.1016\/j.physbeh.2026.115435_bib0017","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s13679-015-0164-9","article-title":"An overview of links between obesity and mental health","volume":"4","author":"Avila","year":"2015","journal-title":"Curr. Obes. Rep."},{"issue":"1","key":"10.1016\/j.physbeh.2026.115435_bib0018","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/jog.14444","article-title":"Hyperandrogenism in polycystic ovary syndrome affects psychological well-being of adolescents","volume":"47","author":"Besenek","year":"2020","journal-title":"J. Obstet. Gynaecol. Res."},{"issue":"5S","key":"10.1016\/j.physbeh.2026.115435_bib0019","doi-asserted-by":"crossref","first-page":"68S","DOI":"10.1097\/01.AOG.0001013896.17095.ae","article-title":"Polycystic ovary syndrome and mental health: influence of hyperandrogenism during brain plasticity periods on emotional distress and social cognition","volume":"143","author":"Del Rio","year":"2024","journal-title":"Obstet. Gynecol."},{"issue":"12","key":"10.1016\/j.physbeh.2026.115435_bib0021","doi-asserted-by":"crossref","first-page":"E1076","DOI":"10.1152\/ajpendo.00182.2014","article-title":"Diet-induced obesity exacerbates metabolic and behavioral effects of polycystic ovary syndrome in a rodent model","volume":"308","author":"Ressler","year":"2015","journal-title":"Am. J. Physiol. - Endocrinol. Metabol."},{"issue":"23","key":"10.1016\/j.physbeh.2026.115435_bib0022","article-title":"Polycystic ovary syndrome can lead to neurocognitive changes in female rats treated with Letrozole","volume":"8","author":"Mohammadi","year":"2021","journal-title":"Arch. Neurosci."},{"key":"10.1016\/j.physbeh.2026.115435_bib0037","series-title":"Letrozole (oral route)","year":"2026"},{"issue":"2018","key":"10.1016\/j.physbeh.2026.115435_bib0023","article-title":"An improved dehydroepiandrosterone-induced rat model of polycystic ovary syndrome (PCOS): post-pubertal improve PCOS's features","volume":"9","author":"Kim","year":"2018","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"5","key":"10.1016\/j.physbeh.2026.115435_bib0024","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/j.tjog.2018.08.015","article-title":"The use of dehydroepiandrosterone-treated rats is not a good animal model for the study of metabolic abnormalities in polycystic ovary syndrome","volume":"57","author":"Seow","year":"2018","journal-title":"Taiwanese J. Obstet. Gynecol."},{"issue":"4","key":"10.1016\/j.physbeh.2026.115435_bib0025","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1095\/biolreprod18.4.614","article-title":"The induction of polycystic ovaries in mature cycling rats by the administration of dehydroepiandrosterone (DHA)","volume":"18","author":"Ward","year":"1978","journal-title":"Biol. Reprod."},{"issue":"8","key":"10.1016\/j.physbeh.2026.115435_bib0026","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.1210\/en.2014-1196","article-title":"Characterization of reproductive, metabolic, and endocrine features of polycystic ovary syndrome in female hyperandrogenic mouse models","volume":"155","author":"Caldwell","year":"2014","journal-title":"Endocrinology"},{"issue":"9","key":"10.1016\/j.physbeh.2026.115435_bib0027","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1038\/oby.2011.297","article-title":"Glucose tolerance in response to a high-fat diet is improved by a high-protein diet","volume":"20","author":"Honors","year":"2012","journal-title":"Obesity"},{"issue":"7","key":"10.1016\/j.physbeh.2026.115435_bib0028","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1210\/en.2010-0175","article-title":"Insulin sensitivity and glucose tolerance are altered by maintenance on a ketogenic diet","volume":"151","author":"Kinzig","year":"2010","journal-title":"Endocrinology"},{"key":"10.1016\/j.physbeh.2026.115435_bib0036","unstructured":"Leica Microsystems. (2018). Leica Application Suite X (LAS X) [Computer software]."},{"key":"10.1016\/j.physbeh.2026.115435_bib0029","series-title":"Developmental and Reproductive Toxicology (Special Issue: Female Reproductive Physiology and Toxicology Review Series)","first-page":"84","article-title":"The rodent estrous cycle: characterization of vaginal cytology and its utility in toxicological studies","volume":"80","author":"Goldman","year":"2007"},{"key":"10.1016\/j.physbeh.2026.115435_bib0035","series-title":"Prism (Version 10.0.0) [Computer Software]","year":"2023"},{"issue":"67","key":"10.1016\/j.physbeh.2026.115435_bib0030","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1477-7827-9-67","article-title":"Dehydroepiandrosterone (DHEA) supplementation in diminished ovarian reserve (DOR)","volume":"9","author":"Gleicher","year":"2011","journal-title":"Reprod. Biol. Endocrinol."},{"key":"10.1016\/j.physbeh.2026.115435_bib0031","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.jsbmb.2014.05.006","article-title":"Dehydroepiandrosterone, its metabolites and ion channels","volume":"145","author":"Hill","year":"2015","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"17","key":"10.1016\/j.physbeh.2026.115435_bib0032","doi-asserted-by":"crossref","first-page":"8568","DOI":"10.3390\/ijms26178568","article-title":"The sex hormone precursors dehydroepiandrosterone (DHEA) and its sulfate ester form (DHEAS): molecular mechanisms and actions on human body","volume":"26","author":"Lin","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.physbeh.2026.115435_bib0033","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1177\/1073858414558065","article-title":"Androgen modulation of hippocampal structure and function","volume":"22","author":"Atwi","year":"2016","journal-title":"Neuroscientist"},{"issue":"1","key":"10.1016\/j.physbeh.2026.115435_bib0034","first-page":"216","article-title":"Androgen effects on neural plasticity","volume":"2","author":"Kuwahara","year":"2021","journal-title":"Androg.: Clin. Res. Therapeut."}],"container-title":["Physiology & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938426002192?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938426002192?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T20:20:00Z","timestamp":1786134000000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938426002192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":39,"alternative-id":["S0031938426002192"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2026.115435","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"DHEA model of PCOS selectively alters reproductive but not metabolic or behavioral phenotypes in female Long-Evans rats","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2026.115435","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115435"}}