{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T20:55:18Z","timestamp":1786136118780,"version":"build-2736575974"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017607","name":"Shenzhen Basic Research Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology & Behavior"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.physbeh.2026.115443","type":"journal-article","created":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T23:19:04Z","timestamp":1783725544000},"page":"115443","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The PPC neurons modulate memory generalization via NR2B-type NMDA receptors in mice"],"prefix":"10.1016","volume":"315","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3206-7336","authenticated-orcid":false,"given":"Yujun","family":"Deng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Da","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunjian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjie","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2820-450X","authenticated-orcid":false,"given":"Hong","family":"Qing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2557-0371","authenticated-orcid":false,"given":"Zhenzhen","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2026.115443_bib0001","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.cell.2020.09.031","article-title":"The Geometry of Abstraction in the Hippocampus and Prefrontal Cortex","volume":"183","author":"Bernardi","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.physbeh.2026.115443_bib0002","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.2004633","article-title":"Memory instability as a gateway to generalization","volume":"16","author":"Robertson","year":"2018","journal-title":"PLoS Biol"},{"key":"10.1016\/j.physbeh.2026.115443_bib0003","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1038\/s41467-023-36583-0","article-title":"Abstract representations emerge naturally in neural networks trained to perform multiple tasks","volume":"14","author":"Johnston","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.physbeh.2026.115443_bib0004","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.rehab.2016.01.002","article-title":"Visual perception is dependent on visuospatial working memory and thus on the posterior parietal cortex","volume":"60","author":"Pisella","year":"2017","journal-title":"Ann Phys Rehabil Med"},{"key":"10.1016\/j.physbeh.2026.115443_bib0005","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.neuron.2019.01.029","article-title":"The Spatial Structure of Neural Encoding in Mouse Posterior Cortex during Navigation","volume":"102","author":"Minderer","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.physbeh.2026.115443_bib0006","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-024-54736-7","article-title":"Organizing space through saccades and fixations between primate posterior parietal cortex and hippocampus","volume":"15","author":"Vericel","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.physbeh.2026.115443_bib0007","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev-neuro-071714-033919","article-title":"Neuronal Mechanisms of Visual Categorization: An Abstract View on Decision Making","volume":"39","author":"Freedman","year":"2016","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.physbeh.2026.115443_bib0008","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112246","article-title":"Geometric transformation of cognitive maps for generalization across hippocampal-prefrontal circuits","volume":"42","author":"Tang","year":"2023","journal-title":"Cell Rep"},{"key":"10.1016\/j.physbeh.2026.115443_bib0009","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.neuron.2018.04.002","article-title":"Cortical Lifelogging: The Posterior Parietal Cortex as Sensory History Buffer","volume":"98","author":"Bitzidou","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.physbeh.2026.115443_bib0010","unstructured":"Klinkowski S, Seewald A, Fath B, et al. Specialized Memory Subsystems for Detailed and Conceptual Information Assessed with Multimodal MRI. In: 48. Jahrestagung Psychologie & Gehirn (PuG 2023). T\u00fcbingen, Germany, p. 129."},{"key":"10.1016\/j.physbeh.2026.115443_bib0011","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1038\/nn.2878","article-title":"Generalized associative representations in parietal cortex","volume":"14","author":"Fitzgerald","year":"2011","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.physbeh.2026.115443_bib0012","doi-asserted-by":"crossref","first-page":"4315","DOI":"10.1523\/JNEUROSCI.2241-22.2023","article-title":"Posterior Parietal Cortex Plays a Causal Role in Abstract Memory-Based Visual Categorical Decisions","volume":"43","author":"Zhou","year":"2023","journal-title":"J Neurosci"},{"key":"10.1016\/j.physbeh.2026.115443_bib0013","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s13041-020-0556-y","article-title":"Posterior parietal cortex mediates fear renewal in a novel context","volume":"13","author":"Joo","year":"2020","journal-title":"Mol Brain"},{"key":"10.1016\/j.physbeh.2026.115443_bib0014","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.1038\/nn.4390","article-title":"Neural substrate of dynamic Bayesian inference in the cerebral cortex","volume":"19","author":"Funamizu","year":"2016","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.physbeh.2026.115443_bib0015","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/s41593-019-0383-6","article-title":"Causal contributions of parietal cortex to perceptual decision-making during stimulus categorization","volume":"22","author":"Zhong","year":"2019","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.physbeh.2026.115443_bib0016","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/nature25510","article-title":"Posterior parietal cortex represents sensory history and mediates its effects on behaviour","volume":"554","author":"Akrami","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.physbeh.2026.115443_bib0017","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/s41398-025-03595-x","article-title":"Prefrontal cortical NR2B-containing NMDA receptors are essential for spatial working memory performance","volume":"15","author":"Peng","year":"2025","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.physbeh.2026.115443_bib0018","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.neuron.2012.12.032","article-title":"NMDA receptors subserve persistent neuronal firing during working memory in dorsolateral prefrontal cortex","volume":"77","author":"Wang","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.physbeh.2026.115443_bib0019","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.neubiorev.2015.06.022","article-title":"NR2B subunit in the prefrontal cortex: A double-edged sword for working memory function and psychiatric disorders","volume":"56","author":"Monaco","year":"2015","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.physbeh.2026.115443_bib0020","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s00424-024-02924-1","article-title":"Enhanced NMDA receptor pathway and glutamate transmission in the hippocampal dentate gyrus mediate the spatial learning and memory impairment of obese rats","volume":"476","author":"Lv","year":"2024","journal-title":"Pflugers Arch"},{"key":"10.1016\/j.physbeh.2026.115443_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2025.115685","article-title":"Blocking the NR2B in the hippocampal dentate gyrus reduced the spatial memory deficits and apoptosis through the PERK-CHOP pathway in a rat model of sporadic Alzheimer\u2019s disease","volume":"493","author":"Zhang","year":"2025","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.physbeh.2026.115443_bib0022","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2025.110644","article-title":"Neuropathic pain caused contextual fear generalization by reducing RIN1 expression in dorsal hippocampal CA1 pyramidal neurons","volume":"279","author":"Zhang","year":"2025","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.physbeh.2026.115443_bib0023","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.cub.2025.12.042","article-title":"Posterior parietal cortex maps progress along routes sharing the same meta-structure but opposite action series","volume":"36","author":"Johnson","year":"2026","journal-title":"Curr Biol"},{"key":"10.1016\/j.physbeh.2026.115443_bib0024","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1037\/0735-7044.108.5.899","article-title":"Working memory tasks in five-choice operant chambers: use of relative and absolute spatial memories","volume":"108","author":"Gutnikov","year":"1994","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.physbeh.2026.115443_bib0025","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3389\/fnbeh.2019.00193","article-title":"Operant Assessment of DMTP Spatial Working Memory in Mice","volume":"13","author":"Teutsch","year":"2019","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.physbeh.2026.115443_bib0026","doi-asserted-by":"crossref","first-page":"8788","DOI":"10.1038\/s41598-021-88200-z","article-title":"Delayed-matching-to-position working memory in mice relies on NMDA-receptors in prefrontal pyramidal cells","volume":"11","author":"Kilonzo","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.physbeh.2026.115443_bib0027","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nature14066","article-title":"Distinct relationships of parietal and prefrontal cortices to evidence accumulation","volume":"520","author":"Hanks","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.physbeh.2026.115443_bib0028","doi-asserted-by":"crossref","first-page":"4954","DOI":"10.1523\/JNEUROSCI.0105-17.2017","article-title":"Posterior Parietal Cortex Guides Visual Decisions in Rats","volume":"37","author":"Licata","year":"2017","journal-title":"J Neurosci"},{"key":"10.1016\/j.physbeh.2026.115443_bib0029","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nature05078","article-title":"Experience-dependent representation of visual categories in parietal cortex","volume":"443","author":"Freedman","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.physbeh.2026.115443_bib0030","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.cell.2020.10.024","article-title":"The Tolman-Eichenbaum Machine: Unifying Space and Relational Memory through Generalization in the Hippocampal Formation","volume":"183","author":"Whittington","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.physbeh.2026.115443_bib0031","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s41593-020-0614-x","article-title":"Hippocampal neurons represent events as transferable units of experience","volume":"23","author":"Sun","year":"2020","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.physbeh.2026.115443_bib0032","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.113317","article-title":"Recalling gist memory depends on CA1 hippocampal neurons for lifetime retention and CA3 neurons for memory precision","volume":"42","author":"Atucha","year":"2023","journal-title":"Cell Rep"},{"key":"10.1016\/j.physbeh.2026.115443_bib0033","doi-asserted-by":"crossref","first-page":"3688","DOI":"10.1016\/j.neuron.2021.08.013","article-title":"Orientation selectivity enhances context generalization and generative predictive coding in the hippocampus","volume":"109","author":"Liu","year":"2021","journal-title":"Neuron"},{"key":"10.1016\/j.physbeh.2026.115443_bib0034","doi-asserted-by":"crossref","first-page":"2977","DOI":"10.1038\/s41467-021-23260-3","article-title":"Distinct place cell dynamics in CA1 and CA3 encode experience in new environments","volume":"12","author":"Dong","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.physbeh.2026.115443_bib0035","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1038\/s41467-018-04498-w","article-title":"Specific hippocampal representations are linked to generalized cortical representations in memory","volume":"9","author":"Yu","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.physbeh.2026.115443_bib0036","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neuron.2020.01.015","article-title":"Replay of Behavioral Sequences in the Medial Prefrontal Cortex during Rule Switching","volume":"106","author":"Kaefer","year":"2020","journal-title":"Neuron"}],"container-title":["Physiology & Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003193842600226X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003193842600226X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T20:19:28Z","timestamp":1786133968000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S003193842600226X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":36,"alternative-id":["S003193842600226X"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2026.115443","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The PPC neurons modulate memory generalization via NR2B-type NMDA receptors in mice","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2026.115443","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115443"}}