{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:52:50Z","timestamp":1791417170856,"version":"4.3.3"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["R01HD104640"],"award-info":[{"award-number":["R01HD104640"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["contract #275201000006C-3-0-1"],"award-info":[{"award-number":["contract #275201000006C-3-0-1"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R01DC019735"],"award-info":[{"award-number":["R01DC019735"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.physbeh.2026.115515","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:34:05Z","timestamp":1790231645000},"page":"115515","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The impact of postweaning food texture on swallow function in the juvenile Ts65Dn mouse model of Down syndrome"],"prefix":"10.1016","volume":"318","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9460-0159","authenticated-orcid":false,"given":"Gaurav","family":"Singhal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayde C.","family":"Sitko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin H.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda J.","family":"Cullins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine P.","family":"Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany J.","family":"Glass","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.physbeh.2026.115515_bib0001","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1469-8749.1996.tb12139.x","article-title":"Swallow function in children with Down syndrome: a retrospective study","volume":"38","author":"Frazier","year":"1996","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.physbeh.2026.115515_bib0002","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00455-016-9725-7","article-title":"Clinical characteristics of dysphagia in children with Down syndrome","volume":"31","author":"Jackson","year":"2016","journal-title":"Dysphagia"},{"key":"10.1016\/j.physbeh.2026.115515_bib0003","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s00455-013-9479-4","article-title":"An observational study of adults with Down syndrome eating independently","volume":"29","author":"Smith","year":"2014","journal-title":"Dysphagia"},{"key":"10.1016\/j.physbeh.2026.115515_bib0004","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2023.113749","article-title":"The influence of food sensory properties on eating behaviours in children with Down syndrome","volume":"175","author":"Ross","year":"2024","journal-title":"Food Res. Int."},{"issue":"7","key":"10.1016\/j.physbeh.2026.115515_bib0005","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/S0002-8223(98)00178-3","article-title":"Eating habits of young children with Down syndrome in The Netherlands: adequate nutrient intakes but delayed introduction of solid food","volume":"98","author":"Hopman","year":"1998","journal-title":"J. Am. Diet. Assoc."},{"issue":"6","key":"10.1016\/j.physbeh.2026.115515_bib0006","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.jormas.2021.01.007","article-title":"Evaluation of the craniofacial and oral characteristics of individuals with Down syndrome: a review of the literature","volume":"122","author":"D\u00edaz-Quevedo","year":"2021","journal-title":"J. Stomatol. Oral Maxillofac. Surg."},{"key":"10.1016\/j.physbeh.2026.115515_bib0007","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s40474-021-00236-y","article-title":"The effectiveness of oral sensorimotor intervention in children with feeding disorders","volume":"8","author":"Voniati","year":"2021","journal-title":"Curr. Dev. Disord. Rep."},{"issue":"4","key":"10.1016\/j.physbeh.2026.115515_bib0008","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1007\/s00455-021-10359-4","article-title":"Comparing the tongue and lip strength and endurance of children with Down syndrome with their typical peers using IOPI","volume":"37","author":"Farpour","year":"2022","journal-title":"Dysphagia"},{"issue":"6","key":"10.1016\/j.physbeh.2026.115515_bib0009","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1177\/154411130301400604","article-title":"Tongue movements in feeding and speech","volume":"14","author":"Hiiemae","year":"2003","journal-title":"Crit. Rev. Oral Biol. Med."},{"issue":"8","key":"10.1016\/j.physbeh.2026.115515_bib0010","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1111\/jir.12617","article-title":"Feeding and swallowing difficulties in children with Down syndrome","volume":"63","author":"Anil","year":"2019","journal-title":"J. Intellect. Disabil. Res."},{"issue":"2","key":"10.1016\/j.physbeh.2026.115515_bib0011","first-page":"248","article-title":"Feeding and swallowing difficulties in children with down syndrome","volume":"3","author":"Usman","year":"2023","journal-title":"J. Health Rehabil. Res."},{"issue":"11","key":"10.1016\/j.physbeh.2026.115515_bib0012","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1093\/jpepsy\/jsad060","article-title":"A Scoping Review of the complementary feeding practices and early eating experiences of children with Down Syndrome","volume":"48","author":"Hielscher","year":"2023","journal-title":"J. Pediatr. Psychol."},{"key":"10.1016\/j.physbeh.2026.115515_bib0013","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1007\/s00431-020-03591-x","article-title":"Feeding difficulty and gastrostomy tube placement in infants with Down syndrome","volume":"179","author":"Poskanzer","year":"2020","journal-title":"Eur. J. Pediatr."},{"issue":"5","key":"10.1016\/j.physbeh.2026.115515_bib0014","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1002\/jpen.2637","article-title":"Factors influencing gastrostomy tube feeding duration and nutrition outcomes in pediatric patients with Down syndrome: a descriptive cohort study","volume":"48","author":"Aviles","year":"2024","journal-title":"J. Parenter. Enter. Nutr."},{"issue":"2","key":"10.1016\/j.physbeh.2026.115515_bib0015","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/ddrr.16","article-title":"Development of swallowing and feeding: prenatal through first year of life","volume":"14","author":"Delaney","year":"2008","journal-title":"Dev. Disabil. Res. Rev."},{"issue":"4","key":"10.1016\/j.physbeh.2026.115515_bib0016","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s40141-021-00334-3","article-title":"Advances in swallowing neurophysiology across pediatric development: current evidence and insights","volume":"9","author":"Malandraki","year":"2021","journal-title":"Curr. Phys. Med. Rehabil. Rep."},{"issue":"5","key":"10.1016\/j.physbeh.2026.115515_bib0017","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/jtxs.12703","article-title":"Eating behaviors in children with Down syndrome: results of a home-use test","volume":"53","author":"Ross","year":"2022","journal-title":"J. Texture Stud."},{"key":"10.1016\/j.physbeh.2026.115515_bib0018","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2024.1461682","article-title":"Developmental deglutition and intrinsic tongue muscle maturation phenotypes in the Ts65Dn mouse model of Down syndrome","volume":"15","author":"Glass","year":"2024","journal-title":"Front. Neurol."},{"issue":"1","key":"10.1016\/j.physbeh.2026.115515_bib0019","first-page":"383","article-title":"Histological study of postnatal development of mouse tongues","volume":"15","author":"Jiang","year":"2018","journal-title":"Exp. Ther. Med."},{"issue":"6","key":"10.1016\/j.physbeh.2026.115515_bib0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0158008","article-title":"Digastric muscle phenotypes of the Ts65Dn mouse model of Down syndrome","volume":"11","author":"Glass","year":"2016","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.physbeh.2026.115515_bib0021","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/(SICI)1097-0177(200002)217:2<137::AID-DVDY1>3.0.CO;2-N","article-title":"Parallels of craniofacial maldevelopment in Down syndrome and Ts65Dn mice","volume":"217","author":"Richtsmeier","year":"2000","journal-title":"Dev. Dyn.: Off. Publ. Am. Assoc. Anat."},{"key":"10.1016\/j.physbeh.2026.115515_bib0022","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2024.1384572","article-title":"Altered tongue muscle contractile properties coincide with altered swallow function in the adult Ts65Dn mouse model of down syndrome","volume":"15","author":"Glass","year":"2024","journal-title":"Front. Neurol."},{"key":"10.1016\/j.physbeh.2026.115515_bib0023","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3389\/fphys.2020.00034","article-title":"Functional analysis of rhythmic jaw movements evoked by electrical stimulation of the cortical masticatory area during low occlusal loading in growing rats","volume":"11","author":"Aung","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.physbeh.2026.115515_bib0024","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.physbeh.2018.11.031","article-title":"Early impacts of modified food consistency on oromotor outcomes in mouse models of Down syndrome","volume":"199","author":"Glass","year":"2019","journal-title":"Physiol. Behav."},{"issue":"5","key":"10.1016\/j.physbeh.2026.115515_bib0025","doi-asserted-by":"crossref","DOI":"10.1002\/jmor.21696","article-title":"Prolonged use of a soft diet during early growth and development alters feeding behavior and chewing kinematics in a young animal model","volume":"285","author":"Montuelle","year":"2024","journal-title":"J. Morphol."},{"issue":"2","key":"10.1016\/j.physbeh.2026.115515_bib0026","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1177\/00220345980770020501","article-title":"Functional properties of jaw and tongue muscles in rats fed a liquid diet after being weaned","volume":"77","author":"Liu","year":"1998","journal-title":"J. Dent. Res."},{"issue":"4","key":"10.1016\/j.physbeh.2026.115515_bib0027","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/WNR.0000000000002140","article-title":"Time-course changes in videofluoroscopic findings during developmental and aging stages in mice","volume":"36","author":"Takahashi","year":"2025","journal-title":"Neuroreport"},{"issue":"1","key":"10.1016\/j.physbeh.2026.115515_bib0028","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nrn3379","article-title":"Neurotrophin regulation of neural circuit development and function","volume":"14","author":"Park","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"issue":"8","key":"10.1016\/j.physbeh.2026.115515_bib0029","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrn1726","article-title":"The yin and yang of neurotrophin action","volume":"6","author":"Lu","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"issue":"15","key":"10.1016\/j.physbeh.2026.115515_bib0030","doi-asserted-by":"crossref","first-page":"3027","DOI":"10.1007\/s00018-019-03337-5","article-title":"Running and swimming prevent the deregulation of the BDNF\/TrkB neurotrophic signalling at the neuromuscular junction in mice with amyotrophic lateral sclerosis","volume":"77","author":"Just-Borras","year":"2020","journal-title":"Cell. Mol. Life Sci."},{"issue":"6","key":"10.1016\/j.physbeh.2026.115515_bib0031","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0166-2236(02)02143-4","article-title":"Exercise: a behavioral intervention to enhance brain health and plasticity","volume":"25","author":"Cotman","year":"2002","journal-title":"Trends. Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.physbeh.2026.115515_bib0032","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0166-4328(02)00082-7","article-title":"Frontal cortex BDNF levels correlate with working memory in an animal model of Down syndrome","volume":"139","author":"Bimonte-Nelson","year":"2003","journal-title":"Behav. Brain Res."},{"issue":"7","key":"10.1016\/j.physbeh.2026.115515_bib0033","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3000258","article-title":"Restoration of norepinephrine-modulated contextual memory in a mouse model of Down Syndrome","volume":"1","author":"Salehi","year":"2009","journal-title":"Sci. Transl. Med."},{"issue":"4","key":"10.1016\/j.physbeh.2026.115515_bib0034","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1044\/1092-4388(2008\/059)","article-title":"Differences in age-related alterations in muscle contraction properties in rat tongue and hindlimb","volume":"51","author":"Connor","year":"2008","journal-title":"J. Speech Lang. Hear. Res."},{"key":"10.1016\/j.physbeh.2026.115515_bib0035","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1023\/A:1020884312053","article-title":"Food intake, water intake, and drinking spout side preference of 28 mouse strains","volume":"32","author":"Bachmanov","year":"2002","journal-title":"Behav. Genet."},{"key":"10.1016\/j.physbeh.2026.115515_bib0036","unstructured":"The International Dysphagia Diet Standardisation Initiative 2019 https:\/\/iddsi.org\/framework."},{"key":"10.1016\/j.physbeh.2026.115515_bib0037","doi-asserted-by":"crossref","first-page":"906","DOI":"10.3389\/fnins.2019.00906","article-title":"The adult Ts65Dn mouse model of Down Syndrome shows altered swallow function","volume":"13","author":"Glass","year":"2019","journal-title":"Front. Neurosci."},{"issue":"97","key":"10.1016\/j.physbeh.2026.115515_bib0038","doi-asserted-by":"crossref","DOI":"10.3791\/52319-v","article-title":"Adapting human videofluoroscopic swallow study methods to detect and characterize dysphagia in murine disease models","author":"Lever","year":"2015","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.physbeh.2026.115515_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.clnu.2026.106667","article-title":"A multidisciplinary Delphi consensus on the formulation of an optimized oral diet for dysphagia and malnutrition (FOOD-DM)","volume":"61","author":"Brux","year":"2026","journal-title":"Clin. Nutr."},{"issue":"1\u20132","key":"10.1016\/j.physbeh.2026.115515_bib0040","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/jnr.23863","article-title":"Sex differences in brain-derived neurotrophic factor signaling and functions","volume":"95","author":"Chan","year":"2017","journal-title":"J. Neurosci. Res."},{"issue":"6","key":"10.1016\/j.physbeh.2026.115515_bib0041","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s12031-023-02131-0","article-title":"An imbalance in the pro\/mature BDNF ratio occurs in multiple brain regions during normal ageing in wild-type mice","volume":"73","author":"Cade","year":"2023","journal-title":"J. Mol. Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.physbeh.2026.115515_bib0042","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jneumeth.2004.03.026","article-title":"Exploring the relationship between serotonin and brain-derived neurotrophic factor: analysis of BDNF protein and extraneuronal 5-HT in mice with reduced serotonin transporter or BDNF expression","volume":"140","author":"Szapacs","year":"2004","journal-title":"J. Neurosci. Methods"},{"issue":"4","key":"10.1016\/j.physbeh.2026.115515_bib0043","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.5664\/jcsm.9866","article-title":"The role of craniofacial maldevelopment in the modern OSA epidemic: a scoping review","volume":"18","author":"Yu","year":"2022","journal-title":"J. Clin. Sleep Med."},{"issue":"3\u20134","key":"10.1016\/j.physbeh.2026.115515_bib0044","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.applanim.2010.04.006","article-title":"Leaving home: a study of laboratory mouse pup independence","volume":"125","author":"Bechard","year":"2010","journal-title":"Appl. Anim. Behav. Sci."}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938426002982?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938426002982?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:43:59Z","timestamp":1791416639000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938426002982"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":44,"alternative-id":["S0031938426002982"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2026.115515","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The impact of postweaning food texture on swallow function in the juvenile Ts65Dn mouse model of Down syndrome","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2026.115515","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"115515"}}