{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:46:03Z","timestamp":1791805563263,"version":"4.3.4"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100005064","name":"Hebei Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["SG2021189"],"award-info":[{"award-number":["SG2021189"]}],"id":[{"id":"10.13039\/501100005064","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2506201"],"award-info":[{"award-number":["2023YFC2506201"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.physbeh.2026.115531","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T20:29:49Z","timestamp":1791318589000},"page":"115531","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Functional involvement of HMGB1-related neuroinflammation in depression and its modulation by intermittent theta-burst stimulation(iTBS)"],"prefix":"10.1016","volume":"318","author":[{"given":"Yaxing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaiming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0563-5122","authenticated-orcid":false,"given":"Cuixia","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.physbeh.2026.115531_bib0001","first-page":"336","article-title":"Epidemiology of adult DSM-5 major depressive disorder and its specifiers in the United States","volume":"75","author":"Hasin","year":"2018","journal-title":"JAMA Psych."},{"key":"10.1016\/j.physbeh.2026.115531_bib0002","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.clinph.2010.08.016","article-title":"The theoretical model of theta burst form of repetitive transcranial magnetic stimulation","volume":"122","author":"Huang","year":"2011","journal-title":"Clin. Neurophysiol."},{"issue":"2","key":"10.1016\/j.physbeh.2026.115531_bib0003","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.clinph.2019.11.002","article-title":"Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): an update (2014-2018)","volume":"131","author":"Lefaucheur","year":"2020","journal-title":"Clin. Neurophysiol."},{"issue":"8","key":"10.1016\/j.physbeh.2026.115531_bib0004","first-page":"833","article-title":"Manipulating reward sensitivity using reward circuit-targeted transcranial magnetic stimulation","volume":"7","author":"Ryan","year":"2022","journal-title":"Biol. Psychiatry Cogn. Neurosci. NeuroimAging"},{"key":"10.1016\/j.physbeh.2026.115531_bib0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2023.114338","article-title":"Different synaptic mechanisms of intermittent and continuous theta-burst stimulations in a severe foot-shock induced and treatment-resistant depression in a rat model","volume":"362","author":"Lee","year":"2023","journal-title":"Exp. Neurol."},{"issue":"6","key":"10.1016\/j.physbeh.2026.115531_bib0007","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1038\/npp.2015.310","article-title":"State-dependent partial occlusion of cortical LTP-like plasticity in major depression","volume":"41","author":"Kuhn","year":"2016","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.physbeh.2026.115531_bib0008","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.psyneuen.2018.12.233","article-title":"Microglial-driven changes in synaptic plasticity: a possible role in major depressive disorder","volume":"102","author":"Innes","year":"2019","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"10.1016\/j.physbeh.2026.115531_bib0009","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s12974-022-02501-2","article-title":"Intermittent theta-burst stimulation improves motor function by inhibiting neuronal pyroptosis and regulating microglial polarization via TLR4\/NF-\u03baB\/NLRP3 signaling pathway in cerebral ischemic mice","volume":"19","author":"Luo","year":"2022","journal-title":"J. Neuroinflammation."},{"issue":"6","key":"10.1016\/j.physbeh.2026.115531_bib0010","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1176\/appi.ajp.20250289","article-title":"Advancing an inflammatory subtype of major depression","volume":"182","author":"Miller","year":"2025","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.physbeh.2026.115531_bib0011","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jare.2023.06.003","article-title":"HMGB1\/STAT3\/p65 axis drives microglial activation and autophagy in chronic stress-induced major depressive disorder","volume":"59","author":"Xu","year":"2023","journal-title":"J. Adv. Res."},{"key":"10.1016\/j.physbeh.2026.115531_bib0012","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/14728222.2018.1439924","article-title":"Extracellular HMGB1 as a therapeutic target in inflammatory diseases","volume":"22","author":"Andersson","year":"2018","journal-title":"Expert. Opin. Ther. Targets."},{"issue":"6","key":"10.1016\/j.physbeh.2026.115531_bib0013","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1095\/biolreprod.116.144139","article-title":"HMGB1 induces an inflammatory response in the chorioamniotic membranes that is partially mediated by the inflammasome","volume":"95","author":"Plazyo","year":"2016","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.physbeh.2026.115531_bib0014","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.bbi.2020.06.019","article-title":"Minocycline prevents depressive-like behavior through inhibiting the release of HMGB1 from microglia and neurons","volume":"88","author":"Wang","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.physbeh.2026.115531_bib0015","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.bbi.2023.04.018","article-title":"High-mobility group box 1 (HMGB1) crosses the BBB bidirectionally","volume":"111","author":"Banks","year":"2023","journal-title":"Brain Behav. Immun."},{"issue":"6","key":"10.1016\/j.physbeh.2026.115531_bib0016","doi-asserted-by":"crossref","first-page":"779","DOI":"10.5498\/wjp.v12.i6.779","article-title":"Role of high mobility group box protein 1 in depression: a mechanistic and therapeutic perspective","volume":"12","author":"Wang","year":"2022","journal-title":"World J. Psychiatry"},{"key":"10.1016\/j.physbeh.2026.115531_bib0017","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.1029891","article-title":"HMGB1 in nervous system diseases: a common biomarker and potential therapeutic target","volume":"13","author":"Mao","year":"2022","journal-title":"Front. Neurol."},{"issue":"1","key":"10.1016\/j.physbeh.2026.115531_bib0018","doi-asserted-by":"crossref","first-page":"6887","DOI":"10.1038\/s41467-023-42662-z","article-title":"Ventral striatal islands of Calleja neurons bidirectionally mediate depression-like behaviors in mice","volume":"14","author":"Zhang","year":"2023","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.physbeh.2026.115531_bib0019","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1016\/j.cmet.2024.07.018","article-title":"Physical exercise mediates cortical synaptic protein lactylation to improve stress resilience","volume":"36","author":"Yan","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.physbeh.2026.115531_bib0020","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.bbi.2024.04.036","article-title":"BGP-15 alleviates LPS-induced depression-like behavior by promoting mitophagy","volume":"119","author":"Liu","year":"2024","journal-title":"Brain Behav. Immun."},{"issue":"3","key":"10.1016\/j.physbeh.2026.115531_bib0021","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2022.101659","article-title":"A chronic unpredictable stress protocol to model anhedonic and resilient behaviors in C57BL\/6J mice","volume":"3","author":"Bijata","year":"2022","journal-title":"STAR. Protoc."},{"issue":"7","key":"10.1016\/j.physbeh.2026.115531_bib0022","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1038\/s41596-018-0011-z","article-title":"Sucrose preference test for measurement of stress-induced anhedonia in mice","volume":"13","author":"Liu","year":"2018","journal-title":"Nat. Protoc."},{"issue":"96","key":"10.1016\/j.physbeh.2026.115531_bib0023","doi-asserted-by":"crossref","DOI":"10.3791\/52434-v","article-title":"Use of the Open field maze to measure locomotor and anxiety-like behavior in mice","author":"Seibenhener","year":"2015","journal-title":"J. Vis. Exp."},{"issue":"3","key":"10.1016\/j.physbeh.2026.115531_bib0024","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology. (Berl)"},{"issue":"2","key":"10.1016\/j.physbeh.2026.115531_bib0025","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.physbeh.2026.115531_bib0026","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.bbr.2018.01.024","article-title":"Glycyrrhizic acid ameliorates the kynurenine pathway in association with its antidepressant effect","volume":"353","author":"Wang","year":"2018","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.physbeh.2026.115531_bib0028","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2024.118013","article-title":"Glycyrrhizic acid treatment ameliorates anxiety-like behaviour via GLT1 and Per1\/2-dependent pathways","volume":"328","author":"Ma","year":"2024","journal-title":"J. Ethnopharmacol."},{"issue":"10131","key":"10.1016\/j.physbeh.2026.115531_bib0029","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/S0140-6736(18)30295-2","article-title":"Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial","volume":"391","author":"Blumberger","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.physbeh.2026.115531_bib0030","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Paxinos","year":"2019"},{"issue":"1","key":"10.1016\/j.physbeh.2026.115531_bib0031","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41398-022-02297-y","article-title":"Neuroinflammation mechanisms of neuromodulation therapies for anxiety and depression","volume":"13","author":"Guo","year":"2023","journal-title":"Transl. Psychiatry"},{"issue":"3","key":"10.1016\/j.physbeh.2026.115531_bib0032","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.cytogfr.2006.01.003","article-title":"High-mobility group box 1 protein: friend and foe","volume":"17","author":"Ulloa","year":"2006","journal-title":"Cytokine Growth Factor Rev."},{"issue":"3","key":"10.1016\/j.physbeh.2026.115531_bib0033","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1007\/s12035-012-8264-y","article-title":"HMGB1 in development and diseases of the central nervous system","volume":"45","author":"Fang","year":"2012","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.physbeh.2026.115531_bib0034","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.bbi.2016.09.017","article-title":"Ds-HMGB1 and fr-HMGB1 induce depressive behavior through neuroinflammation in contrast to nonoxid-HMGB1","volume":"59","author":"Lian","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.physbeh.2026.115531_bib0035","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.pnpbp.2019.02.005","article-title":"High-mobility group box 1-mediated microglial activation induces anxiodepressive-like behaviors in mice with neuropathic pain","volume":"92","author":"Hisaoka-Nakashima","year":"2019","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.physbeh.2026.115531_bib0036","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s11481-007-9071-5","article-title":"Toll-like receptors in defense and damage of the central nervous system","volume":"2","author":"Aravalli","year":"2007","journal-title":"J. Neuroimmune Pharmacol."},{"issue":"14","key":"10.1016\/j.physbeh.2026.115531_bib0037","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1096\/fj.07-8770com","article-title":"Anti-high mobility group box 1 monoclonal antibody ameliorates brain infarction induced by transient ischemia in rats","volume":"21","author":"Liu","year":"2007","journal-title":"FASEB J."},{"issue":"3","key":"10.1016\/j.physbeh.2026.115531_bib0038","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/ana.23602","article-title":"Anti-high mobility group box-1 antibody therapy for traumatic brain injury","volume":"72","author":"Okuma","year":"2012","journal-title":"Ann. Neurol."},{"issue":"5","key":"10.1016\/j.physbeh.2026.115531_bib0039","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.3390\/cells10051044","article-title":"The effect and regulatory mechanism of high mobility group Box-1 protein on immune cells in inflammatory diseases","volume":"10","author":"Ge","year":"2021","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.physbeh.2026.115531_bib0040","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1038\/s41598-017-01325-y","article-title":"Therapeutic effects of anti-HMGB1 monoclonal antibody on pilocarpine-induced status epilepticus in mice","volume":"7","author":"Fu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.physbeh.2026.115531_bib0041","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.bbi.2017.11.017","article-title":"HMGB1 mediates depressive behavior induced by chronic stress through activating the kynurenine pathway","volume":"72","author":"Wang","year":"2018","journal-title":"Brain Behav. Immun."},{"issue":"5","key":"10.1016\/j.physbeh.2026.115531_bib0042","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s12026-022-09295-8","article-title":"High mobility group box 1 (HMGB1) inhibition attenuates lipopolysaccharide-induced cognitive dysfunction and sickness-like behavior in mice","volume":"70","author":"Ghosh","year":"2022","journal-title":"Immunol. Res."},{"key":"10.1016\/j.physbeh.2026.115531_bib0043","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jad.2020.01.048","article-title":"Glycyrrhizic acid as an adjunctive treatment for depression through antiinflammation: a randomized placebo-controlled clinical trial","volume":"265","author":"Cao","year":"2020","journal-title":"J. Affect. Disord."},{"issue":"2","key":"10.1016\/j.physbeh.2026.115531_bib0045","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1248\/bpb.18.337","article-title":"Administration-route dependency of absorption of glycyrrhizin in rats","volume":"18","author":"Yamamura","year":"1995","journal-title":"Biol. Pharm. Bull."},{"issue":"7","key":"10.1016\/j.physbeh.2026.115531_bib0046","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1007\/s10571-012-9839-x","article-title":"The blood-brain barrier permeability of 18\u03b2-glycyrrhetinic acid","volume":"32","author":"Tabuchi","year":"2012","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.physbeh.2026.115531_bib0048","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.889983","article-title":"Intermittent theta burst stimulation ameliorates cognitive deficit and attenuates neuroinflammation via PI3K\/Akt\/mTOR signaling pathway in Alzheimer's-like disease model","volume":"14","author":"Stekic","year":"2022","journal-title":"Front. Aging Neurosci."},{"issue":"5","key":"10.1016\/j.physbeh.2026.115531_bib0049","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104201","article-title":"Selective activation of ABCA1\/ApoA1 signaling in the V1 by magnetoelectric stimulation ameliorates depression via regulation of synaptic plasticity","volume":"25","author":"Lu","year":"2022","journal-title":"iScience"}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938426003148?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938426003148?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T11:04:07Z","timestamp":1791803047000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938426003148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":45,"alternative-id":["S0031938426003148"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2026.115531","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Functional involvement of HMGB1-related neuroinflammation in depression and its modulation by intermittent theta-burst stimulation(iTBS)","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2026.115531","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115531"}}