{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:49:26Z","timestamp":1792021766329,"version":"4.4.0"},"reference-count":97,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Physiology &amp; Behavior"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.physbeh.2026.115538","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:22:25Z","timestamp":1792020145000},"page":"115538","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The effect of concurrent application of the deep brain stimulation of the nucleus accumbens and cannabidiol injection during extinction period on reinstatement of METH-induced conditioned place preference in extinguished rats"],"prefix":"10.1016","author":[{"given":"Mahsa","family":"Mohammadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morteza","family":"Zendehdel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Haghparast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.physbeh.2026.115538_bib0001","article-title":"Oral manifestations in drug users: A review","volume":"12","author":"Cossa","year":"2020","journal-title":"Journal of clinical and experimental dentistry"},{"key":"10.1016\/j.physbeh.2026.115538_bib0002","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/B978-0-12-420118-7.00002-0","article-title":"The vesicular monoamine transporter-2: an important pharmacological target for the discovery of novel therapeutics to treat methamphetamine abuse","volume":"69","author":"Nickell","year":"2014","journal-title":"Advances in pharmacology"},{"key":"10.1016\/j.physbeh.2026.115538_bib0003","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2025.114892","article-title":"Forced wheel running pre-conditioning diminishes reward learning induced by methamphetamine: Involvement of orexin 1 receptor in the hippocampus","volume":"295","author":"Ahmadpour","year":"2025","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.physbeh.2026.115538_bib0004","series-title":"The brain\u2019s reward system in health and disease. Circadian clock in brain health and disease","first-page":"57","author":"Lewis","year":"2021"},{"key":"10.1016\/j.physbeh.2026.115538_bib0005","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.neuron.2010.11.022","article-title":"Dopamine in motivational control: rewarding, aversive, and alerting","volume":"68","author":"Bromberg-Martin","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.physbeh.2026.115538_bib0006","doi-asserted-by":"crossref","first-page":"92","DOI":"10.3389\/fpsyt.2014.00092","article-title":"Cannabinoid regulation of brain reward processing with an emphasis on the role of CB1 receptors: a step back into the future","volume":"5","author":"Panagis","year":"2014","journal-title":"Frontiers in psychiatry"},{"key":"10.1016\/j.physbeh.2026.115538_bib0007","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a039305","article-title":"A brain on cannabinoids: the role of dopamine release in reward seeking and addiction","volume":"11","author":"Peters","year":"2021","journal-title":"Cold Spring Harbor perspectives in medicine"},{"key":"10.1016\/j.physbeh.2026.115538_bib0008","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1089\/can.2022.0017","article-title":"Intra-accumbal D1-but not D2-like dopamine receptor antagonism reverses the inhibitory effects of cannabidiol on extinction and reinstatement of methamphetamine seeking behavior in rats","volume":"9","author":"Mirmohammadi","year":"2024","journal-title":"Cannabis & Cannabinoid Research"},{"key":"10.1016\/j.physbeh.2026.115538_bib0009","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2021.113158","article-title":"Cannabidiol efficiently suppressed the acquisition and expression of methamphetamine-induced conditioned place preference in the rat","volume":"404","author":"Anooshe","year":"2021","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.physbeh.2026.115538_bib0010","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1080\/00952990.2021.1898627","article-title":"Linalool attenuates acquisition and reinstatement and accelerates the extinction of nicotine-induced conditioned place preference in male mice","volume":"47","author":"Yunuso\u011flu","year":"2021","journal-title":"The American Journal of Drug and Alcohol Abuse"},{"key":"10.1016\/j.physbeh.2026.115538_bib0011","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.alcohol.2021.11.003","article-title":"Rewarding effect of ethanol-induced conditioned place preference in mice: Effect of the monoterpenoid linalool","volume":"98","author":"Yunuso\u011flu","year":"2022","journal-title":"Alcohol"},{"key":"10.1016\/j.physbeh.2026.115538_bib0012","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1080\/01616412.2021.1948749","article-title":"Resveratrol impairs acquisition, reinstatement and precipitates extinction of alcohol-induced place preference in mice","volume":"43","author":"Yunuso\u011flu","year":"2021","journal-title":"Neurological Research"},{"key":"10.1016\/j.physbeh.2026.115538_bib0013","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/00952990.2023.2292976","article-title":"Effects of fisetin on ethanol-induced rewarding properties in mice","volume":"50","author":"Yalniz","year":"2024","journal-title":"The American Journal of Drug and Alcohol Abuse"},{"key":"10.1016\/j.physbeh.2026.115538_bib0014","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.bbr.2011.07.050","article-title":"Assessment of rewarding and reinforcing properties of biperiden in conditioned place preference in rats","volume":"225","author":"Allahverdiyev","year":"2011","journal-title":"Behavioural brain research"},{"key":"10.1016\/j.physbeh.2026.115538_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpsychires.2025.06.011","article-title":"Cannabidiol mechanism of action on modulating extinction and reinstatement of methamphetamine-seeking behavior: Targeting D2-like dopamine receptors in the hippocampus","author":"Omidiani","year":"2025","journal-title":"Journal of Psychiatric Research"},{"key":"10.1016\/j.physbeh.2026.115538_bib0016","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2025.114845","article-title":"Involvement of D2-like dopamine receptors within the ventral tegmental area in the cannabidiol's inhibitory effects on the methamphetamine-seeking behavior","volume":"293","author":"Ezzati","year":"2025","journal-title":"Physiology & Behavior"},{"key":"10.1016\/j.physbeh.2026.115538_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2021.110458","article-title":"Cannabidiol impairs the rewarding effects of methamphetamine: Involvement of dopaminergic receptors in the nucleus accumbens","volume":"113","author":"Sharifi","year":"2022","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.physbeh.2026.115538_bib0018","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41380-020-0683-y","article-title":"Nucleus accumbens fast-spiking interneurons in motivational and addictive behaviors","volume":"26","author":"Schall","year":"2021","journal-title":"Molecular psychiatry"},{"key":"10.1016\/j.physbeh.2026.115538_bib0019","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.neuro.29.051605.112824","article-title":"Deep brain stimulation","volume":"29","author":"Perlmutter","year":"2006","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.physbeh.2026.115538_bib0020","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1111\/joim.13541","article-title":"Deep brain stimulation for Parkinson's disease","volume":"292","author":"Hariz","year":"2022","journal-title":"Journal of internal medicine"},{"key":"10.1016\/j.physbeh.2026.115538_bib0021","doi-asserted-by":"crossref","first-page":"659","DOI":"10.5498\/wjp.v11.i9.659","article-title":"Deep brain stimulation for obsessive-compulsive disorder: a systematic review of worldwide experience after 20 years","volume":"11","author":"Mar-Barrutia","year":"2021","journal-title":"World journal of psychiatry"},{"key":"10.1016\/j.physbeh.2026.115538_bib0022","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1177\/25424823241297852","article-title":"Deep brain stimulation versus nonsurgical treatment for severe Alzheimer's disease: A long-term retrospective cohort study","volume":"8","author":"Xu","year":"2024","journal-title":"Journal of Alzheimer's Disease Reports"},{"key":"10.1016\/j.physbeh.2026.115538_bib0023","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2022.858638","article-title":"Deep brain stimulation in drug addiction treatment: research progress and perspective","volume":"13","author":"Chang","year":"2022","journal-title":"Frontiers in Psychiatry"},{"key":"10.1016\/j.physbeh.2026.115538_bib0024","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121613","article-title":"Distinct suppressing effects of deep brain stimulation in the orbitofrontal cortex on the development, extinction, and reinstatement of methamphetamine-seeking behaviors","volume":"322","author":"Fattahi","year":"2023","journal-title":"Life Sci"},{"key":"10.1016\/j.physbeh.2026.115538_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121503","article-title":"A wide range of Deep Brain Stimulation of the nucleus accumbens shell time independently reduces the extinction period and prevents the reinstatement of methamphetamine-seeking behavior in rats","volume":"319","author":"Eskandari","year":"2023","journal-title":"Life Sci"},{"key":"10.1016\/j.physbeh.2026.115538_bib0026","article-title":"Remission of alcohol dependency following deep brain stimulation of the nucleus accumbens: valuable therapeutic implications?","volume":"2009","author":"Kuhn","year":"2009","journal-title":"Case Reports"},{"key":"10.1016\/j.physbeh.2026.115538_bib0027","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1159\/000509313","article-title":"Deep brain stimulation of nucleus accumbens with anterior capsulotomy for drug addiction: a case report","volume":"98","author":"Zhu","year":"2020","journal-title":"Stereotactic and Functional Neurosurgery"},{"key":"10.1016\/j.physbeh.2026.115538_bib0028","doi-asserted-by":"crossref","first-page":"997","DOI":"10.3171\/2013.12.JNS13205","article-title":"Reduced ethanol consumption by alcohol-preferring (P) rats following pharmacological silencing and deep brain stimulation of the nucleus accumbens shell","volume":"120","author":"Wilden","year":"2014","journal-title":"Journal of neurosurgery"},{"key":"10.1016\/j.physbeh.2026.115538_bib0029","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.3171\/2016.4.JNS152524","article-title":"Intermittent bilateral deep brain stimulation of the nucleus accumbens shell reduces intravenous methamphetamine intake and seeking in Wistar rats","volume":"126","author":"Batra","year":"2017","journal-title":"J Neurosurg"},{"key":"10.1016\/j.physbeh.2026.115538_bib0030","article-title":"Modulatory function of cannabidiol on the extinction and reinstatement of methamphetamine-seeking behavior through the D2-like dopamine receptors in the dentate gyrus","author":"Azizbeigi","year":"2025","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.physbeh.2026.115538_bib0031","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2023.110778","article-title":"The inhibitory effect of cannabidiol on the rewarding properties of methamphetamine in part mediates by interacting with the hippocampal D1-like dopamine receptors","volume":"126","author":"Mohammadi","year":"2023","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.physbeh.2026.115538_bib0032","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2022.1104152","article-title":"Pharmacokinetics of cannabidiol following single oral and oral transmucosal administration in dogs","volume":"9","author":"Della Rocca","year":"2023","journal-title":"Frontiers in veterinary science"},{"key":"10.1016\/j.physbeh.2026.115538_bib0033","series-title":"The rat brain in stereotaxic coordinates, Cambridge","author":"Paxinos","year":"2007"},{"key":"10.1016\/j.physbeh.2026.115538_bib0034","article-title":"High-Frequency Deep Brain Stimulation of the Substantia Nigra Pars Reticulata Facilitates Extinction and Prevents Reinstatement of Methamphetamine-Induced Conditioned Place Preference","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.physbeh.2026.115538_bib0035","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12780","article-title":"Deep brain stimulation of the orbitofrontal cortex prevents the development and reinstatement of morphine place preference","volume":"25","author":"Fakhrieh-Asl","year":"2020","journal-title":"Addiction Biology"},{"key":"10.1016\/j.physbeh.2026.115538_bib0036","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.brs.2014.09.018","article-title":"Chronic unilateral stimulation of the nucleus accumbens at high or low frequencies attenuates relapse to cocaine seeking in an animal model","volume":"8","author":"Hamilton","year":"2015","journal-title":"Brain stimulation"},{"key":"10.1016\/j.physbeh.2026.115538_bib0037","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s11064-025-04655-w","article-title":"Deep Brain Stimulation of Lateral Habenula Ameliorates Depression-like Symptoms in Rats: Involvement of Mesolimbic Circuit","volume":"51","author":"Kanhere","year":"2026","journal-title":"Neurochemical Research"},{"key":"10.1016\/j.physbeh.2026.115538_bib0038","doi-asserted-by":"crossref","DOI":"10.1111\/ejn.70019","article-title":"Unilateral and Bilateral Subthalamic Deep Brain Stimulation Differently Favour Apathy in Parkinson's Disease","volume":"61","author":"Vachez","year":"2025","journal-title":"European Journal of Neuroscience"},{"key":"10.1016\/j.physbeh.2026.115538_bib0039","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2022.114122","article-title":"Electrophysiological and molecular effects of bilateral deep brain stimulation of the medial forebrain bundle in a rodent model of depression","volume":"355","author":"B\u00fchning","year":"2022","journal-title":"Experimental neurology"},{"key":"10.1016\/j.physbeh.2026.115538_bib0040","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.bbr.2014.12.025","article-title":"Deep brain stimulation of the nucleus accumbens shell attenuates cue-induced reinstatement of both cocaine and sucrose seeking in rats","volume":"281","author":"Guercio","year":"2015","journal-title":"Behavioural brain research"},{"key":"10.1016\/j.physbeh.2026.115538_bib0041","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2023.121613","article-title":"Distinct suppressing effects of deep brain stimulation in the orbitofrontal cortex on the development, extinction, and reinstatement of methamphetamine-seeking behaviors","volume":"322","author":"Fattahi","year":"2023","journal-title":"Life Sciences"},{"key":"10.1016\/j.physbeh.2026.115538_bib0042","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.clineuro.2009.11.006","article-title":"Unilateral deep brain stimulation of the nucleus accumbens in patients with treatment-resistant obsessive-compulsive disorder: outcomes after one year","volume":"112","author":"Huff","year":"2010","journal-title":"Clinical neurology and neurosurgery"},{"key":"10.1016\/j.physbeh.2026.115538_bib0043","article-title":"The impact of sex, variable stimulation mode and parameters on mfb-DBS evoked dopamine release dynamics in a rodent depression model","author":"Telega","year":"2025","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.physbeh.2026.115538_bib0044","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2024.1400414","article-title":"Asgharian Asl, A. Unilateral vs. bilateral DLPFC rTMS: comparative effects on depression, visual-spatial memory, inhibitory control and cognitive flexibility in major depressive disorder","volume":"15","author":"Asgharian Asl","year":"2024","journal-title":"Frontiers in Psychiatry"},{"key":"10.1016\/j.physbeh.2026.115538_bib0045","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00221-016-4830-2","article-title":"The effects of unilateral versus bilateral subthalamic nucleus deep brain stimulation on prosaccades and antisaccades in Parkinson\u2019s disease","volume":"235","author":"Goelz","year":"2017","journal-title":"Experimental brain research."},{"key":"10.1016\/j.physbeh.2026.115538_bib0046","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1007\/s00415-016-8191-3","article-title":"Comparative effects of unilateral and bilateral subthalamic nucleus deep brain stimulation on gait kinematics in Parkinson\u2019s disease: a randomized, blinded study","volume":"263","author":"Lizarraga","year":"2016","journal-title":"Journal of neurology"},{"key":"10.1016\/j.physbeh.2026.115538_bib0047","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1017\/S1355617711001925","article-title":"Verbal fluency in patients receiving bilateral versus left-sided deep brain stimulation of the subthalamic nucleus for Parkinson's disease","volume":"18","author":"Sj\u00f6berg","year":"2012","journal-title":"Journal of the International Neuropsychological Society"},{"key":"10.1016\/j.physbeh.2026.115538_bib0048","doi-asserted-by":"crossref","first-page":"E11","DOI":"10.3171\/2018.5.FOCUS18163","article-title":"Deep brain stimulation for the treatment of drug addiction","volume":"45","author":"Wang","year":"2018","journal-title":"Neurosurgical focus"},{"key":"10.1016\/j.physbeh.2026.115538_bib0049","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.peptides.2017.12.017","article-title":"Role of orexin-1 receptors in the dorsal hippocampus (CA1 region) in expression and extinction of the morphine-induced conditioned place preference in the rats","volume":"101","author":"Farahimanesh","year":"2018","journal-title":"Peptides"},{"key":"10.1016\/j.physbeh.2026.115538_bib0050","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1152\/jn.00281.2015","article-title":"Mechanisms of deep brain stimulation","volume":"115","author":"Herrington","year":"2016","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.physbeh.2026.115538_bib0051","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s11916-015-0504-1","article-title":"Deep Brain Stimulation for Chronic Pain","volume":"19","author":"Falowski","year":"2015","journal-title":"Curr Pain Headache Rep"},{"key":"10.1016\/j.physbeh.2026.115538_bib0052","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/s41398-024-03060-1","article-title":"A systematic review of deep brain stimulation for substance use disorders","volume":"14","author":"Zammit Dimech","year":"2024","journal-title":"Transl Psychiatry"},{"key":"10.1016\/j.physbeh.2026.115538_bib0053","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/jnc.12054","article-title":"Deep brain stimulation of the accumbens increases dopamine, serotonin, and noradrenaline in the prefrontal cortex","volume":"123","author":"van Dijk","year":"2012","journal-title":"J Neurochem"},{"issue":"Suppl 6","key":"10.1016\/j.physbeh.2026.115538_bib0054","first-page":"4","article-title":"History and evolution of the monoamine hypothesis of depression","volume":"61","author":"Hirschfeld","year":"2000","journal-title":"J Clin Psychiatry"},{"key":"10.1016\/j.physbeh.2026.115538_bib0055","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/B978-0-444-53497-2.00021-8","article-title":"Deep brain stimulation in addiction due to psychoactive substance use","volume":"116","author":"Kuhn","year":"2013","journal-title":"Handb Clin Neurol"},{"key":"10.1016\/j.physbeh.2026.115538_bib0056","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1055\/s-0042-104507","article-title":"Nucleus Accumbens Deep Brain Stimulation for Alcohol Addiction - Safety and Clinical Long-term Results of a Pilot Trial","volume":"49","author":"Muller","year":"2016","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.physbeh.2026.115538_bib0057","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.1016\/j.biopsych.2015.06.023","article-title":"Deep Brain Stimulation for Refractory Cocaine Dependence","volume":"79","author":"Goncalves-Ferreira","year":"2016","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.physbeh.2026.115538_bib0058","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1038\/s41596-020-0296-6","article-title":"An operant social self-administration and choice model in rats","volume":"15","author":"Venniro","year":"2020","journal-title":"Nat Protoc"},{"key":"10.1016\/j.physbeh.2026.115538_bib0059","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1523\/JNEUROSCI.2873-17.2018","article-title":"Role of Anterior Intralaminar Nuclei of Thalamus Projections to Dorsomedial Striatum in Incubation of Methamphetamine Craving","volume":"38","author":"Li","year":"2018","journal-title":"J Neurosci"},{"key":"10.1016\/j.physbeh.2026.115538_bib0060","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00213-012-2727-8","article-title":"Sex differences in escalation of methamphetamine self-administration: cognitive and motivational consequences in rats","volume":"223","author":"Reichel","year":"2012","journal-title":"Psychopharmacology (Berl)."},{"key":"10.1016\/j.physbeh.2026.115538_bib0061","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00213-003-1670-0","article-title":"Sex differences in the acquisition of IV methamphetamine self-administration and subsequent maintenance under a progressive ratio schedule in rats","volume":"172","author":"Roth","year":"2004","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.physbeh.2026.115538_bib0062","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1093\/ijnp\/pyz050","article-title":"Sex differences in escalated methamphetamine self-administration and altered gene expression associated with incubation of methamphetamine seeking","volume":"22","author":"Daiwile","year":"2019","journal-title":"International Journal of Neuropsychopharmacology"},{"key":"10.1016\/j.physbeh.2026.115538_bib0063","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2025.105980","article-title":"RNA sequencing analysis identifies sex differences in transcriptional signatures in the dorsal striatum of female and male rats after withdrawal from methamphetamine self-administration","volume":"187","author":"Gujar","year":"2025","journal-title":"Neurochemistry International"},{"key":"10.1016\/j.physbeh.2026.115538_bib0064","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1038\/npp.2016.287","article-title":"Incubation of Methamphetamine but not Heroin Craving After Voluntary Abstinence in Male and Female Rats","volume":"42","author":"Venniro","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.physbeh.2026.115538_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2020.173032","article-title":"Conditioned place preference following concurrent treatment with 3, 4-methylenedioxypyrovalerone (MDPV) and methamphetamine in male and female Sprague-Dawley rats","volume":"198","author":"Risca","year":"2020","journal-title":"Pharmacology Biochemistry and Behavior"},{"key":"10.1016\/j.physbeh.2026.115538_bib0066","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.brs.2019.02.023","article-title":"Increased dopamine transporter levels following nucleus accumbens deep brain stimulation in methamphetamine use disorder: A case report","volume":"12","author":"Zhang","year":"2019","journal-title":"Brain Stimul"},{"key":"10.1016\/j.physbeh.2026.115538_bib0067","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/B978-0-444-62619-6.00003-3","article-title":"Neurocircuitry of alcohol addiction: synthesis from animal models","volume":"125","author":"Koob","year":"2014","journal-title":"Handb Clin Neurol"},{"key":"10.1016\/j.physbeh.2026.115538_bib0068","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0079318","article-title":"High-frequency stimulation of nucleus accumbens changes in dopaminergic reward circuit","volume":"8","author":"Yan","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.physbeh.2026.115538_bib0069","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.drugalcdep.2012.09.012","article-title":"DBS of nucleus accumbens on heroin seeking behaviors in self-administering rats","volume":"129","author":"Guo","year":"2013","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.physbeh.2026.115538_bib0070","doi-asserted-by":"crossref","first-page":"8735","DOI":"10.1523\/JNEUROSCI.5277-07.2008","article-title":"Deep brain stimulation of the nucleus accumbens shell attenuates cocaine priming-induced reinstatement of drug seeking in rats","volume":"28","author":"Vassoler","year":"2008","journal-title":"J Neurosci"},{"key":"10.1016\/j.physbeh.2026.115538_bib0071","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.wneu.2018.11.056","article-title":"Deep Brain Stimulation of Nucleus Accumbens for Methamphetamine Addiction","volume":"122","author":"Ge","year":"2019","journal-title":"Two Case Reports. World Neurosurg."},{"key":"10.1016\/j.physbeh.2026.115538_bib0072","doi-asserted-by":"crossref","first-page":"14446","DOI":"10.1523\/JNEUROSCI.4804-12.2013","article-title":"Deep brain stimulation of the nucleus accumbens shell attenuates cocaine reinstatement through local and antidromic activation","volume":"33","author":"Vassoler","year":"2013","journal-title":"J Neurosci"},{"key":"10.1016\/j.physbeh.2026.115538_bib0073","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.neuropharm.2012.04.036","article-title":"Cannabinoid receptors mediate methamphetamine induction of high frequency gamma oscillations in the nucleus accumbens","volume":"63","author":"Morra","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.physbeh.2026.115538_bib0074","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1097\/FBP.0000000000000544","article-title":"Neuroprotective effect of chronic administration of cannabidiol during the abstinence period on methamphetamine-induced impairment of recognition memory in the rats","volume":"31","author":"Razavi","year":"2020","journal-title":"Behav Pharmacol"},{"key":"10.1016\/j.physbeh.2026.115538_bib0075","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1177\/0269881118799954","article-title":"Cannabidiol treatment reduces the motivation to self-administer methamphetamine and methamphetamine-primed relapse in rats","volume":"32","author":"Hay","year":"2018","journal-title":"J Psychopharmacol"},{"key":"10.1016\/j.physbeh.2026.115538_bib0076","doi-asserted-by":"crossref","first-page":"5102","DOI":"10.1523\/JNEUROSCI.5335-09.2010","article-title":"Neural encoding of psychomotor activation in the nucleus accumbens core, but not the shell, requires cannabinoid receptor signaling","volume":"30","author":"Morra","year":"2010","journal-title":"J Neurosci"},{"key":"10.1016\/j.physbeh.2026.115538_bib0077","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.euroneuro.2008.11.003","article-title":"CB1 receptor knockout mice are hyporesponsive to the behavior-stimulating actions of d-amphetamine: role of mGlu5 receptors","volume":"19","author":"Tzavara","year":"2009","journal-title":"Eur Neuropsychopharmacol"},{"key":"10.1016\/j.physbeh.2026.115538_bib0078","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.jpsychires.2025.06.011","article-title":"Cannabidiol mechanism of action on modulating extinction and reinstatement of methamphetamine-seeking behavior: Targeting D2-like dopamine receptors in the hippocampus","volume":"189","author":"Omidiani","year":"2025","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.physbeh.2026.115538_bib0079","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2024.111025","article-title":"Hippocampal D1-like dopamine receptor as a novel target for the effect of cannabidiol on extinction and reinstatement of methamphetamine-induced CPP","volume":"133","author":"Farrokhi","year":"2024","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"10.1016\/j.physbeh.2026.115538_bib0080","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1080\/00952990.2022.2073450","article-title":"Cannabidiol attenuates methamphetamine-induced conditioned place preference in male rats and viability in PC12 cells through the Sigma1R\/AKT\/GSK3beta\/CREB signaling pathway","volume":"48","author":"Liu","year":"2022","journal-title":"Am J Drug Alcohol Abuse"},{"key":"10.1016\/j.physbeh.2026.115538_bib0081","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1016\/0024-3205(90)90309-F","article-title":"Interleukin-1 stimulates catecholamine release from the hypothalamus","volume":"47","author":"Palazzolo","year":"1990","journal-title":"Life Sci"},{"key":"10.1016\/j.physbeh.2026.115538_bib0082","doi-asserted-by":"crossref","DOI":"10.1111\/adb.12740","article-title":"Cannabidiol modulates the expression of neuroinflammatory factors in stress- and drug-induced reinstatement of methamphetamine in extinguished rats","volume":"25","author":"Karimi-Haghighi","year":"2020","journal-title":"Addict Biol"},{"key":"10.1016\/j.physbeh.2026.115538_bib0083","first-page":"152","article-title":"Therapeutic Effects of Cannabidiol on Methamphetamine Abuse: A Review of Preclinical Study","volume":"20","author":"Razavi","year":"2021","journal-title":"Iran J Pharm Res"},{"key":"10.1016\/j.physbeh.2026.115538_bib0084","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.brainres.2014.11.005","article-title":"Using c-fos to study neuronal ensembles in corticostriatal circuitry of addiction","volume":"1628","author":"Cruz","year":"2015","journal-title":"Brain research"},{"key":"10.1016\/j.physbeh.2026.115538_bib0085","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/BF00242905","article-title":"Time course of striatal changes induced by 6-hydroxydopamine lesion of the nigrostriatal pathway, as studied by combined evaluation of rotational behaviour and striatal Fos expression","volume":"108","author":"Labandeira-Garcia","year":"1996","journal-title":"Experimental brain research"},{"key":"10.1016\/j.physbeh.2026.115538_bib0086","doi-asserted-by":"crossref","first-page":"10579","DOI":"10.1523\/JNEUROSCI.18-24-10579.1998","article-title":"Amphetamine-induced behavior, dopamine release, and c-fos mRNA expression: modulation by environmental novelty","volume":"18","author":"Badiani","year":"1998","journal-title":"Journal of Neuroscience"},{"key":"10.1016\/j.physbeh.2026.115538_bib0087","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.neuroscience.2014.11.017","article-title":"Regulation of c-fos expression by the dopamine D1-D2 receptor heteromer","volume":"285","author":"Perreault","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.physbeh.2026.115538_bib0088","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1073\/pnas.88.4.1291","article-title":"Cocaine induces striatal c-fos-immunoreactive proteins via dopaminergic D1 receptors","volume":"88","author":"Young","year":"1991","journal-title":"Proceedings of the national academy of sciences"},{"key":"10.1016\/j.physbeh.2026.115538_bib0089","doi-asserted-by":"crossref","first-page":"5764","DOI":"10.1073\/pnas.89.13.5764","article-title":"Regulation of immediate early gene expression and AP-1 binding in the rat nucleus accumbens by chronic cocaine","volume":"89","author":"HoPE","year":"1992","journal-title":"Proceedings of the National Academy of Sciences"},{"key":"10.1016\/j.physbeh.2026.115538_bib0090","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/syn.21592","article-title":"5-HT2A receptor blockade and 5-HT2C receptor activation interact to reduce cocaine hyperlocomotion and fos protein expression in the caudate-putamen","volume":"66","author":"Pockros","year":"2012","journal-title":"Synapse."},{"key":"10.1016\/j.physbeh.2026.115538_bib0091","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/syn.890180309","article-title":"Amphetamine-and cocaine-induced fos in the rat striatum depends on D2 dopamine receptor activation","volume":"18","author":"Ruskin","year":"1994","journal-title":"Synapse"},{"key":"10.1016\/j.physbeh.2026.115538_bib0092","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1152\/jn.1992.68.3.767","article-title":"Dopamine and glutamate agonists stimulate neuron-specific expression of Fos-like protein in the striatum","volume":"68","author":"Berretta","year":"1992","journal-title":"Journal of neurophysiology"},{"key":"10.1016\/j.physbeh.2026.115538_bib0093","doi-asserted-by":"crossref","DOI":"10.1111\/cns.70588","article-title":"Tenuifolin Attenuates Methamphetamine-Induced Reinstatement in Mice by Regulating Hippocampal Postsynaptic BDNF Signaling","volume":"31","author":"Qi","year":"2025","journal-title":"CNS Neuroscience & Therapeutics"},{"key":"10.1016\/j.physbeh.2026.115538_bib0094","article-title":"Methamphetamine Conditioned Place Preference in Adolescent Mice: Interaction Between Sex and Strain","author":"Severino","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.physbeh.2026.115538_bib0095","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.13006","article-title":"Melatonin Regulates Neuronal Synaptic Plasticity in the Supramammillary Nucleus and Attenuates Methamphetamine-Induced Conditioned Place Preference and Sensitization in Mice","volume":"76","author":"Ren","year":"2024","journal-title":"Journal of Pineal Research"},{"key":"10.1016\/j.physbeh.2026.115538_bib0096","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.975820","article-title":"Effects of 3-methylmethcathinone on conditioned place preference and anxiety-like behavior: Comparison with methamphetamine","volume":"15","author":"Chen","year":"2022","journal-title":"Frontiers in Molecular Neuroscience"},{"key":"10.1016\/j.physbeh.2026.115538_bib0097","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ejphar.2017.01.001","article-title":"Blockade of patch-based \u03bc opioid receptors in the striatum attenuates methamphetamine-induced conditioned place preference and reduces activation of the patch compartment","volume":"796","author":"Horner","year":"2017","journal-title":"European journal of pharmacology"}],"container-title":["Physiology &amp; Behavior"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938426003215?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031938426003215?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:22:36Z","timestamp":1792020156000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031938426003215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":97,"alternative-id":["S0031938426003215"],"URL":"https:\/\/doi.org\/10.1016\/j.physbeh.2026.115538","relation":{},"ISSN":["0031-9384"],"issn-type":[{"value":"0031-9384","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of concurrent application of the deep brain stimulation of the nucleus accumbens and cannabidiol injection during extinction period on reinstatement of METH-induced conditioned place preference in extinguished rats","name":"articletitle","label":"Article Title"},{"value":"Physiology & Behavior","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.physbeh.2026.115538","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115538"}}