{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:55:55Z","timestamp":1778630155561,"version":"3.51.4"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytochemistry"],"published-print":{"date-parts":[[2013,3]]},"DOI":"10.1016\/j.phytochem.2012.11.011","type":"journal-article","created":{"date-parts":[[2012,12,12]],"date-time":"2012-12-12T16:18:29Z","timestamp":1355329109000},"page":"102-111","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Sesquiterpene lactones from the extracts of two Balkan endemic Laserpitium species and their cytotoxic activity"],"prefix":"10.1016","volume":"87","author":[{"given":"Vi\u0161nja","family":"Popovi\u0107","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arne","family":"Heyerick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana","family":"Petrovi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge","family":"Van Calenbergh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izet","family":"Karali\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjan","family":"Niketi\u0107","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dieter","family":"Deforce","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phytochem.2012.11.011_b0005","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1016\/S0031-9422(00)81252-2","article-title":"Sesquiterpene lactones from Laserpitium garganicum","volume":"25","author":"Appendino","year":"1985","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2012.11.011_b0010","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/S0031-9422(00)90411-4","article-title":"Sesquiterpene lactones and other constituents of Seseli vayredanum","volume":"37","author":"Barrero","year":"1994","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2012.11.011_b0015","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0031-9422(96)00846-1","article-title":"Guaianolides and other terpenoids from Anthemis aetnensis","volume":"45","author":"Bruno","year":"1997","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2012.11.011_b0020","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1021\/np200864m","article-title":"Reversal multidrug resistance by morning glory resin glycosides in human breast cancer cells","volume":"75","author":"Figueroa-Gonz\u00e1les","year":"2011","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2012.11.011_b0025","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.drudis.2010.06.002","article-title":"What made sesquiterpene lactones reach cancer clinical trials?","volume":"15","author":"Ghantous","year":"2010","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.phytochem.2012.11.011_b0030","first-page":"726","article-title":"Laserpitium L","volume":"vol. 1","author":"Hartvig","year":"1986"},{"key":"10.1016\/j.phytochem.2012.11.011_b0035","series-title":"Illustrierte Flora von Mitteleuropa, Band V (2)","first-page":"1467","article-title":"Siler Miller, Laserpitium L","author":"Hegi","year":"1906"},{"key":"10.1016\/j.phytochem.2012.11.011_b0040","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1186\/1471-2407-9-188","article-title":"Expression of matrix metalloproteinases (MMPs) in primary human breast cancer and breast cancer cell lines: new findings and review of the literature","volume":"9","author":"K\u00f6hrmann","year":"2009","journal-title":"BMC Cancer"},{"key":"10.1016\/j.phytochem.2012.11.011_b0045","series-title":"Izdateljstvo","first-page":"520","article-title":"Lekarstvenije rasteniju i ih primenie","author":"Kuprevi\u010d","year":"1974"},{"key":"10.1016\/j.phytochem.2012.11.011_b0050","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1021\/np900821e","article-title":"Discovery and development of natural product-derived chemotherapeutic agents based on a medicinal chemistry approach","volume":"73","author":"Lee","year":"2010","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2012.11.011_b0055","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.2174\/138945011798109437","article-title":"Perspectives on sesquiterpene lactones in inflammation and cancer","volume":"12","author":"Merfort","year":"2011","journal-title":"Curr. Drug Targets"},{"key":"10.1016\/j.phytochem.2012.11.011_b0060","series-title":"Flora na Republika Makedonija Tom I (6)","first-page":"1647","article-title":"Laserpitium L","author":"Micevski","year":"2005"},{"key":"10.1016\/j.phytochem.2012.11.011_b0065","doi-asserted-by":"crossref","first-page":"397","DOI":"10.2298\/JSC9908397M","article-title":"Sesquiterpene lactones from Yugoslavian wild growing plant families Asteraceae and Apiaceae","volume":"64","author":"Milosavljevi\u0107","year":"1999","journal-title":"J. Serb. Chem. Soc."},{"key":"10.1016\/j.phytochem.2012.11.011_b0070","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.phytochem.2012.11.011_b0075","doi-asserted-by":"crossref","first-page":"2790","DOI":"10.1135\/cccc19842790","article-title":"Stereostructure of slovanolides: X-ray crystallography of the 3-oxo-4\u03b1H,8\u03b1-benzoyloxy-10\u03b2,11\u03b1-diacetoxyslovanolide","volume":"49","author":"Rychlewska","year":"1984","journal-title":"Collect. Czech. Chem. Commun."},{"key":"10.1016\/j.phytochem.2012.11.011_b0080","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.drudis.2007.10.010","article-title":"Plant-derived compounds in clinical trials","volume":"13","author":"Saklani","year":"2008","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.phytochem.2012.11.011_b0085","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/jnci\/82.13.1107","article-title":"New colorimetric cytotoxic assay for anticancer-drug screening","volume":"82","author":"Skehan","year":"1990","journal-title":"J. Natl. Cancer I"},{"key":"10.1016\/j.phytochem.2012.11.011_b0090","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1135\/cccc19840852","article-title":"Components of the extract from the underground parts of Laserpitium siler L. of Slovenian origin, mainly sesquiterpenic lactones","volume":"49","author":"Smitalova","year":"1984","journal-title":"Collect. Czech. Chem. Commun."},{"key":"10.1016\/j.phytochem.2012.11.011_b0095","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1135\/cccc19861323","article-title":"Minor sesquiterpenic lactones of Laser trilobum (L.) Borkh. Species","volume":"51","author":"Smitalova","year":"1985","journal-title":"Collect. Czech. Chem. Commun."},{"key":"10.1016\/j.phytochem.2012.11.011_b0100","first-page":"639","article-title":"Sesquiterpene lactones from Laserpitium siler L. (Umbelliferae)","volume":"42","author":"Stefanovi\u0107","year":"1977","journal-title":"Bull. Soc. Chim. Beograd"},{"key":"10.1016\/j.phytochem.2012.11.011_b0105","series-title":"Flora Europaea 2","first-page":"368","article-title":"Laserpitium L","author":"Tutin","year":"1968"},{"key":"10.1016\/j.phytochem.2012.11.011_b0110","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0031-9422(00)00160-6","article-title":"Further sesquitrepene lactones from Anthemis carpatica","volume":"54","author":"Vajs","year":"2000","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2012.11.011_b0115","first-page":"724","article-title":"Phenolic compounds of Laserpitium latifolium","volume":"6","author":"Vereskovskii","year":"1992","journal-title":"Khim. Prir. Soedin."},{"key":"10.1016\/j.phytochem.2012.11.011_b0120","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1021\/np50072a012","article-title":"New proazulene guaianolides from Thapsia villosa","volume":"53","author":"Wagner Smitt","year":"1990","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2012.11.011_b0125","series-title":"Spectroscopic Methods in Organic Chemistry","author":"Williams","year":"1995"}],"container-title":["Phytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942212004852?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942212004852?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,6]],"date-time":"2019-07-06T20:03:18Z","timestamp":1562443398000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031942212004852"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,3]]},"references-count":25,"alternative-id":["S0031942212004852"],"URL":"https:\/\/doi.org\/10.1016\/j.phytochem.2012.11.011","relation":{},"ISSN":["0031-9422"],"issn-type":[{"value":"0031-9422","type":"print"}],"subject":[],"published":{"date-parts":[[2013,3]]}}}