{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:45:53Z","timestamp":1791254753796,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Sisbiota-Brasil"},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Ensino Superior"},{"name":"Danish Research Agency for Technology and Production"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytochemistry"],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1016\/j.phytochem.2014.12.020","type":"journal-article","created":{"date-parts":[[2015,1,10]],"date-time":"2015-01-10T16:30:37Z","timestamp":1420907437000},"page":"154-162","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Dereplication-guided isolation of depsides thielavins S\u2013T and lecanorins D\u2013F from the endophytic fungus Setophoma sp."],"prefix":"10.1016","volume":"111","author":[{"given":"L\u00edvia S.","family":"de Medeiros","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas M.","family":"Abreu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne","family":"Ingmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas O.","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian F.","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edson","family":"Rodrigues-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phytochem.2014.12.020_b0005","doi-asserted-by":"crossref","first-page":"565","DOI":"10.3852\/07-162R","article-title":"Light might regulate divergently depside and depsidone accumulation in the lichen Parmotrema hypotropum by affecting thallus temperature and water potential","volume":"100","author":"Armaleo","year":"2008","journal-title":"Mycologia"},{"key":"10.1016\/j.phytochem.2014.12.020_b0010","doi-asserted-by":"crossref","first-page":"741","DOI":"10.3852\/10-335","article-title":"Insights from the first putative biosynthetic gene cluster for a lichen depside and depsidone","volume":"103","author":"Armaleo","year":"2011","journal-title":"Mycologia"},{"key":"10.1016\/j.phytochem.2014.12.020_b0015","doi-asserted-by":"crossref","first-page":"5733","DOI":"10.1016\/j.tetlet.2011.08.125","article-title":"Thielavin B methyl ester: a cytotoxic benzoate trimer from an unidentified fungus (MSX 55526) from the order Sordariales","volume":"52","author":"Ayers","year":"2011","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.phytochem.2014.12.020_b0020","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1002\/cmdc.201200345","article-title":"Discovery of depsides and depsidones from lichen as potent inhibitors of microsomal prostaglandin E2 synthase-1 using pharmacophore models","volume":"7","author":"Bauer","year":"2012","journal-title":"ChemMedChem"},{"key":"10.1016\/j.phytochem.2014.12.020_b0025","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1021\/np400258f","article-title":"De novo production of metabolites by fungal co-culture of Trichophyton rubrum and Bionectria ochroleuca","volume":"76","author":"Bertrand","year":"2013","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2014.12.020_b0030","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1021\/np010626i","article-title":"Agonodepsides A and B: two new depsides from a filamentous fungus F7524","volume":"65","author":"Cao","year":"2002","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2014.12.020_b0035","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1038\/nrmicro1818","article-title":"The biology and future prospects of antivirulence therapies","volume":"6","author":"Cegelski","year":"2008","journal-title":"J. Nat. Rev. Microbiol."},{"key":"10.1016\/j.phytochem.2014.12.020_b0040","series-title":"Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically; Approved Standard","author":"Clinical and Laboratory Standards Institute (CLSI)","year":"2006"},{"key":"10.1016\/j.phytochem.2014.12.020_b0045","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1039\/b704420h","article-title":"Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets","volume":"5","author":"Cox","year":"2007","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.phytochem.2014.12.020_b0050","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.3852\/09-240","article-title":"Systematic reappraisal of species in Phoma section Paraphoma, Pyrenochaeta and Pleurophoma","volume":"102","author":"de Gruyter","year":"2010","journal-title":"Mycologia"},{"key":"10.1016\/j.phytochem.2014.12.020_b0055","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1002\/hlca.201000387","article-title":"Antimicrobial depsides produced by Cladosporium uredinicola, an endophytic fungus isolated from Psidium guajava fruits","volume":"94","author":"de Medeiros","year":"2011","journal-title":"Helv. Chim. Acta"},{"key":"10.1016\/j.phytochem.2014.12.020_b0060","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1590\/S0103-50532012005000018","article-title":"Evaluation of herbicidal potential of depsides from Cladosporium uredinicola, an endophytic fungus found in guava fruit","volume":"8","author":"de Medeiros","year":"2012","journal-title":"J. Braz. Chem. Soc."},{"key":"10.1016\/j.phytochem.2014.12.020_b0065","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1002\/hlca.201390007","article-title":"Erratum: antimicrobial depsides produced by Cladosporium uredinicola, an endophytic fungus isolated from Psidium guajava fruits","volume":"96","author":"de Medeiros","year":"2013","journal-title":"Helv. Chim. Acta"},{"key":"10.1016\/j.phytochem.2014.12.020_b0070","series-title":"Medicinal Natural Products: a Biosynthetic Approach","author":"Dewick","year":"2009"},{"key":"10.1016\/j.phytochem.2014.12.020_b0075","series-title":"Compendium of Soil Fungi","author":"Domsch","year":"2007"},{"key":"10.1016\/j.phytochem.2014.12.020_b0080","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1021\/np4004307","article-title":"High-Resolution MS, MS\/MS, and UV database of fungal secondary metabolites as a dereplication protocol for bioactive natural products","volume":"76","author":"El-Elimat","year":"2013","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2014.12.020_b0085","series-title":"Fungal Secondary Metabolism: Methods and Protocols, Methods in Molecular Biology","first-page":"47","article-title":"Media and growth conditions for induction of secondary metabolite production","author":"Frisvad","year":"2012"},{"key":"10.1016\/j.phytochem.2014.12.020_b0090","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.chroma.2012.03.069","article-title":"High resolution ultra high pressure liquid chromatography-time-of-flight mass spectrometry dereplication strategy for the metabolite profiling of Brazilian Lippia species","volume":"1259","author":"Funari","year":"2012","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.phytochem.2014.12.020_b0095","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1021\/np100859a","article-title":"High-throughput profiling of microbial extracts","volume":"74","author":"Ito","year":"2011","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2014.12.020_b0100","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1039\/b818398h","article-title":"Automated molecular formula determination by tandem mass spectrometry (MS\/MS)","volume":"134","author":"Jarussophon","year":"2009","journal-title":"Analyst"},{"key":"10.1016\/j.phytochem.2014.12.020_b0105","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1086\/656043","article-title":"Targeting of alpha-hemolysin by active or passive immunization decreases severity of USA300 skin infection in a mouse model","volume":"202","author":"Kennedy","year":"2010","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.phytochem.2014.12.020_b0110","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1007\/s00216-013-7582-x","article-title":"Aggressive dereplication using UHPLC\u2013DAD\u2013QTOF: screening extracts for up to 3000 fungal secondary metabolites","volume":"406","author":"Klitgaard","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.phytochem.2014.12.020_b0115","doi-asserted-by":"crossref","first-page":"15670","DOI":"10.1073\/pnas.2532165100","article-title":"Phylogenomic analysis of type I polyketide synthase genes in pathogenic and saprobic ascomycetes","volume":"100","author":"Kroken","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.phytochem.2014.12.020_b0120","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0223-5234(00)00132-X","article-title":"Depsides as non-redox inhibitors of leukotriene B4 biosynthesis and HaCaT cell growth, 2. Novel analogues of obtusatic acid","volume":"35","author":"Kumar","year":"2000","journal-title":"Eur. J. Med."},{"key":"10.1016\/j.phytochem.2014.12.020_b0125","series-title":"AntiBase 2012","author":"Laatsch","year":"2012"},{"key":"10.1016\/j.phytochem.2014.12.020_b0130","doi-asserted-by":"crossref","first-page":"590","DOI":"10.3109\/14756360903357551","article-title":"Novel depsides as potential anti-inflammatory agents with potent inhibitory activity against Escherichia coli-induced interleukin-8","volume":"25","author":"Lv","year":"2010","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"10.1016\/j.phytochem.2014.12.020_b0135","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1002\/anie.196902401","article-title":"Biosynthesis of lichen substances, products of a symbiotic association","volume":"8","author":"Mosbach","year":"1969","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.phytochem.2014.12.020_b0140","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0031-9422(98)00517-2","article-title":"Fungal depside, guisinol, from a marine derived strain of Emericella unguis","volume":"50","author":"Nielsen","year":"1999","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2014.12.020_b0145","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1128\/AAC.00940-09","article-title":"Method for screening compounds that influence virulence gene expression in Staphylococcus aureus","volume":"54","author":"Nielsen","year":"2010","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.phytochem.2014.12.020_b0150","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1021\/np200254t","article-title":"Dereplication of microbial natural products by LC\u2013DAD\u2013TOFMS","volume":"74","author":"Nielsen","year":"2011","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2014.12.020_b0155","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.phytochem.2013.05.021","article-title":"Thielavins A, J and K: \u03b1-Glucosidase inhibitors from MEXU 27095, an endophytic fungus from Hintonia latiflora","volume":"94","author":"Rivera-Ch\u00e1vez","year":"2013","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2014.12.020_b0160","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1021\/np0001326","article-title":"Effect of lichen metabolites on thylakoid electron transport and photophosphorylation in isolated spinach chloroplasts 1","volume":"63","author":"Rojas","year":"2000","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2014.12.020_b0165","doi-asserted-by":"crossref","first-page":"941","DOI":"10.7164\/antibiotics.55.941","article-title":"Thielavins as glucose-6-phosphatase (G6Pase) inhibitors: producing strain, fermentation, isolation, structural elucidation and biological activities","volume":"55","author":"Sakemi","year":"2002","journal-title":"J. Antibiot."},{"key":"10.1016\/j.phytochem.2014.12.020_b0170","doi-asserted-by":"crossref","first-page":"775","DOI":"10.4155\/fmc.11.43","article-title":"Antivirulence agents against MRSA","volume":"3","author":"Shoham","year":"2011","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.phytochem.2014.12.020_b0175","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s11101-013-9283-7","article-title":"Lichens: a promising source of antibiotic and anticancer drugs","volume":"12","author":"Shrestha","year":"2013","journal-title":"Phytochem. Rev."},{"key":"10.1016\/j.phytochem.2014.12.020_b0180","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/S0021-9673(96)00803-5","article-title":"Micro-scale extraction procedure for standardized screening of fungal metabolite production in cultures","volume":"760","author":"Smedsgaard","year":"1997","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.phytochem.2014.12.020_b0185","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1039\/B606983P","article-title":"Metabolic diversity of lichen-forming ascomycetous fungi: culturing, polyketide and shikimate metabolite production, and PKS genes","volume":"25","author":"Stocker-W\u00f6rg\u00f6tter","year":"2008","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.phytochem.2014.12.020_b0190","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1039\/C2RA23021F","article-title":"Directed biosynthesis through biohalogenation of secondary metabolites of the marine-derived fungus Aspergillus unguis","volume":"3","author":"Sureram","year":"2013","journal-title":"RSC Adv."},{"key":"10.1016\/j.phytochem.2014.12.020_b0195","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1517\/17460441.1.3.237","article-title":"The importance of hyphenated techniques in the discovery of new lead compounds from nature","volume":"1","author":"Wolfender","year":"2006","journal-title":"Expert Opin. Drug Discov."}],"container-title":["Phytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942214005524?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942214005524?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:35:38Z","timestamp":1758479738000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031942214005524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3]]},"references-count":39,"alternative-id":["S0031942214005524"],"URL":"https:\/\/doi.org\/10.1016\/j.phytochem.2014.12.020","relation":{},"ISSN":["0031-9422"],"issn-type":[{"value":"0031-9422","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dereplication-guided isolation of depsides thielavins S\u2013T and lecanorins D\u2013F from the endophytic fungus Setophoma sp.","name":"articletitle","label":"Article Title"},{"value":"Phytochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phytochem.2014.12.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}