{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:17:07Z","timestamp":1790295427148,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81273428"],"award-info":[{"award-number":["81273428"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773587"],"award-info":[{"award-number":["81773587"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81274137"],"award-info":[{"award-number":["81274137"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytochemistry"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.phytochem.2017.09.010","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T11:30:12Z","timestamp":1505734212000},"page":"119-126","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":43,"special_numbering":"C","title":["A unique indolizinium alkaloid streptopertusacin A and bioactive bafilomycins from marine-derived Streptomyces sp. HZP-2216E"],"prefix":"10.1016","volume":"144","author":[{"given":"Xiufang","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiyun","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Yuan","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhizhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.phytochem.2017.09.010_bib1","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1039\/C3NP70111E","article-title":"Diversity, abundance and natural products of marine sponge-associated actinomycetes","volume":"31","author":"Abdelmohsen","year":"2014","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.phytochem.2017.09.010_bib2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2174\/1389200217666161013090610","article-title":"Bacteria from marine sponges: a source of new drugs","volume":"18","author":"Bibi","year":"2017","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.phytochem.2017.09.010_bib3","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1073\/pnas.85.21.7972","article-title":"Bafilomycins: a class of inhibitors of membrane ATPases from microorganisms, animal cells, and plant cells","volume":"85","author":"Bowman","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.phytochem.2017.09.010_bib4","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1021\/acs.jnatprod.6b01136","article-title":"Cytotoxic bagremycins from mangrove-derived Streptomyces sp. Q22","volume":"80","author":"Chen","year":"2017","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.phytochem.2017.09.010_bib5","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1016\/j.bmcl.2015.04.091","article-title":"Synthesis and bioactivity of tripolinolate A from Tripolium vulgare and its analogs","volume":"25","author":"Chen","year":"2015","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.phytochem.2017.09.010_bib6","doi-asserted-by":"crossref","first-page":"5668","DOI":"10.1021\/ol302660t","article-title":"Enantiomers of an indole alkaloid containing unusual dihydrothiopyran and 1,2,4-thiadiazole rings from the root of Isatis indigotica","volume":"14","author":"Chen","year":"2012","journal-title":"Org. Lett."},{"key":"10.1016\/j.phytochem.2017.09.010_bib7","series-title":"Gaussian 09, Rev. C 01","author":"Frisch","year":"2009"},{"key":"10.1016\/j.phytochem.2017.09.010_bib8","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.mib.2009.05.002","article-title":"Chasing the treasures of the sea \u2014 bacterial marine natural products","volume":"12","author":"Gulder","year":"2009","journal-title":"Curr. Opin. Microbiol."},{"key":"10.1016\/j.phytochem.2017.09.010_bib9","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s10593-017-2053-5","article-title":"Synthesis of indolizinium salts (microreview)","volume":"53","author":"Ivanova","year":"2017","journal-title":"Chem. Heterocycl. Com."},{"key":"10.1016\/j.phytochem.2017.09.010_bib10","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1039\/C4NP00167B","article-title":"The marine actinomycete genus Salinispora: a model organism for secondary metabolite discovery","volume":"32","author":"Jensen","year":"2015","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.phytochem.2017.09.010_bib11","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.phytochem.2015.03.014","article-title":"Isolation and bioactivity of diterpenoids from the roots of Salvia grandifolia","volume":"116","author":"Kang","year":"2015","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2017.09.010_bib12","first-page":"51","article-title":"The structure determination of a herbicidal compound, 3D5","volume":"3","author":"Kim","year":"1993","journal-title":"J.\u00a0Microbiol. Biotech."},{"key":"10.1016\/j.phytochem.2017.09.010_bib13","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1021\/np040114e","article-title":"A\u00a0novel antimicrobial indolizinium alkaloid from Aniba panurensis","volume":"67","author":"Klausmeyer","year":"2004","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.phytochem.2017.09.010_bib14","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/cbic.200500087","article-title":"Natural products from marine organisms and their associated microbes","volume":"7","author":"K\u00f6nig","year":"2006","journal-title":"Chembiochem"},{"key":"10.1016\/j.phytochem.2017.09.010_bib15","first-page":"2509","article-title":"The structures of novel insecticidal macrolides: bafilomycins D and E, and oxohygrolidin","volume":"49","author":"Kretschmer","year":"1985","journal-title":"Agri. Bio. Chem."},{"key":"10.1016\/j.phytochem.2017.09.010_bib16","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3390\/md14010010","article-title":"Bioactive polycyclic quinones from marine Streptomyces sp. 182SMLY","volume":"14","author":"Liang","year":"2016","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.phytochem.2017.09.010_bib17","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/chir.22086","article-title":"Study on the absolute configurations of 3-alkylphthalides using TDDFT calculations of chiroptical properties","volume":"24","author":"Li","year":"2012","journal-title":"Chirality"},{"key":"10.1016\/j.phytochem.2017.09.010_bib18","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.etap.2014.05.014","article-title":"Marine actinobacteria: an important source of bioactive natural products","volume":"38","author":"Manivasagan","year":"2014","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.phytochem.2017.09.010_bib19","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.micres.2013.07.014","article-title":"Pharmaceutically active secondary metabolites of marine actinobacteria","volume":"169","author":"Manivasagan","year":"2014","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.phytochem.2017.09.010_bib20","doi-asserted-by":"crossref","first-page":"4313","DOI":"10.1016\/j.tetlet.2012.06.002","article-title":"Pd-catalyzed reductive cleavage of alkyl aryl sulfides with triethylsilane that is accelerated by trialkylsilyl chloride","volume":"53","author":"Matsumura","year":"2012","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.phytochem.2017.09.010_bib21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1039\/b509525p","article-title":"Indolizidine and quinolizidine alkaloids","volume":"24","author":"Michael","year":"2007","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.phytochem.2017.09.010_bib22","doi-asserted-by":"crossref","first-page":"3695","DOI":"10.1128\/aem.61.10.3695-3700.1995","article-title":"Evidence for indigenous Streptomyces populations in a marine environment determined with a 16S rRNA probe","volume":"61","author":"Moran","year":"1995","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.phytochem.2017.09.010_bib23","doi-asserted-by":"crossref","first-page":"3284","DOI":"10.1016\/j.tetlet.2016.06.040","article-title":"Absolute configuration of iminimycin B, a new indolizidine alkaloid, from Streptomyces griseus OS-3601","volume":"57","author":"Nakashima","year":"2016","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.phytochem.2017.09.010_bib24","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.7164\/antibiotics.50.1073","article-title":"Absolute configurations of macrolide antibiotics of the bafilomycin and leucanicidin groups","volume":"50","author":"Oshea","year":"1997","journal-title":"J.\u00a0Antibiot."},{"key":"10.1016\/j.phytochem.2017.09.010_bib25","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1111\/j.1574-6968.1993.tb06507.x","article-title":"Cell vacuolization induced by Helicobacter pylori: inhibition by bafilomycins A1, B1, C1, and D","volume":"113","author":"Papini","year":"1993","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.phytochem.2017.09.010_bib26","doi-asserted-by":"crossref","first-page":"4275","DOI":"10.1021\/jo016413f","article-title":"Studies on the synthesis of bafilomycin A (1): stereochemical aspects of the fragment assembly aldol reaction for construction of the C(13)-C(25) segment","volume":"67","author":"Roush","year":"2002","journal-title":"J.\u00a0Org. Chem."},{"key":"10.1016\/j.phytochem.2017.09.010_bib27","series-title":"Version X 2.0","author":"Sybyl Software","year":"2013"},{"key":"10.1016\/j.phytochem.2017.09.010_bib28","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/chir.20733","article-title":"ECD cotton effect approximated by the Gaussian curve and other methods","volume":"22","author":"Stephens","year":"2010","journal-title":"Chirality"},{"key":"10.1016\/j.phytochem.2017.09.010_bib29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.2042-7158.2012.01567.x","article-title":"Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems","volume":"65","author":"Tacara","year":"2013","journal-title":"J.\u00a0Pharm. Pharmacol."},{"key":"10.1016\/j.phytochem.2017.09.010_bib30","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1038\/s41598-017-01912-z","article-title":"Rare polyene-polyol macrolides from mangrove-derived Streptomyces sp. ZQ4BG","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.phytochem.2017.09.010_bib31","doi-asserted-by":"crossref","first-page":"110","DOI":"10.7164\/antibiotics.37.110","article-title":"Metabolic products of microorganisms. 224. Bafilomycins, a new group of macrolide antibiotics. Production, isolation, chemical structure and biological activity","volume":"37","author":"Werner","year":"1984","journal-title":"J.\u00a0Antibiot."},{"key":"10.1016\/j.phytochem.2017.09.010_bib32","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.3390\/md10112388","article-title":"New capoamycin-type antibiotics and polyene acids from marine Streptomyces fradiae PTZ0025","volume":"10","author":"Xin","year":"2012","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.phytochem.2017.09.010_bib33","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.phytochem.2016.12.010","article-title":"Antiproliferative cyclodepsipeptides from the marine actinomycete Streptomyces sp. P11-23B downregulating the tumor metabolic enzymes of glycolysis, glutaminolysis, and lipogenesis","volume":"135","author":"Ye","year":"2017","journal-title":"Phytochemistry"},{"key":"10.1016\/j.phytochem.2017.09.010_bib34","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1080\/14786419.2015.1047775","article-title":"A\u00a0new curvularin glycoside and its cytotoxic and antibacterial analogs from marine actinomycete Pseudonocardia sp. HS7","volume":"30","author":"Ye","year":"2016","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.phytochem.2017.09.010_bib35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.steroids.2014.06.013","article-title":"Polyoxygenated 24,28-epoxyergosterols inhibiting the proliferation of glioma cells from sea anemone Anthopleura midori","volume":"88","author":"Yu","year":"2014","journal-title":"Steroids"},{"key":"10.1016\/j.phytochem.2017.09.010_bib36","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1055\/s-0034-1383404","article-title":"Bioactive sulfated saponins from sea cucumber Holothuria moebii","volume":"81","author":"Yu","year":"2015","journal-title":"Planta Med."},{"key":"10.1016\/j.phytochem.2017.09.010_bib37","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/ja.2010.147","article-title":"Bafilomycins produced by an endophytic actinomycete Streptomyces sp. YIM56209","volume":"64","author":"Yu","year":"2011","journal-title":"J.\u00a0Antibiot."},{"key":"10.1016\/j.phytochem.2017.09.010_bib38","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3390\/md14100181","article-title":"New metabolites and bioactive actinomycins from marine-derived Streptomyces sp. ZZ338","volume":"14","author":"Zhang","year":"2016","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.phytochem.2017.09.010_bib39","article-title":"Bioactive bafilomycins and a new N-arylpyrazinone derivative from marine-derived Streptomyces sp. HZP-2216E","author":"Zhang","year":"2017","journal-title":"Planta Med."}],"container-title":["Phytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942217303151?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942217303151?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:37:08Z","timestamp":1758479828000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031942217303151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":39,"alternative-id":["S0031942217303151"],"URL":"https:\/\/doi.org\/10.1016\/j.phytochem.2017.09.010","relation":{},"ISSN":["0031-9422"],"issn-type":[{"value":"0031-9422","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A unique indolizinium alkaloid streptopertusacin A and bioactive bafilomycins from marine-derived Streptomyces sp. HZP-2216E","name":"articletitle","label":"Article Title"},{"value":"Phytochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phytochem.2017.09.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}