{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T17:34:10Z","timestamp":1775237650863,"version":"3.50.1"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005153","name":"China National Funds for Distinguished Young Scientists","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005153","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005240","name":"Changjiang Scholar Program of Chinese Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005240","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014718","name":"Innovative Research Group Project of the National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014718","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Phytochemistry"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.phytochem.2019.05.014","type":"journal-article","created":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T16:20:30Z","timestamp":1560442830000},"page":"112041","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Anti-BACE1 and anti-AchE activities of undescribed spiro-dioxolane-containing meroterpenoids from the endophytic fungus Aspergillus terreus Thom"],"prefix":"10.1016","volume":"165","author":[{"given":"Changxing","family":"Qi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weixi","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunmei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Nian","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongji","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengxi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hucheng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonghui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.phytochem.2019.05.014_bib1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1089\/adt.2006.029","article-title":"A high throughput luminescent assay for glycogen synthase kinase-3\u03b2 inhibitors","volume":"5","author":"Baki","year":"2007","journal-title":"Assay Drug Dev. Technol."},{"key":"10.1016\/j.phytochem.2019.05.014_bib2","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.phytochem.2019.05.014_bib3","doi-asserted-by":"crossref","first-page":"S107","DOI":"10.3233\/JAD-179921","article-title":"Multifactorial hypothesis and multi-targets for Alzheimer's disease","volume":"64","author":"Gong","year":"2018","journal-title":"J. Alzheimer's Dis."},{"key":"10.1016\/j.phytochem.2019.05.014_bib4","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/jcph.393","article-title":"Confirmatory population pharmacokinetic analysis for bapineuzumab phase 3 studies in patients with mild to moderate Alzheimer's disease","volume":"55","author":"Hu","year":"2015","journal-title":"J. Clin. Pharmacol."},{"key":"10.1016\/j.phytochem.2019.05.014_bib5","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.cell.2012.02.040","article-title":"Alzheimer mechanisms and therapeutic strategies","volume":"148","author":"Huang","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.phytochem.2019.05.014_bib6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.neuroimage.2018.06.028","article-title":"Multimodal imaging-based therapeutic fingerprints for optimizing personalized interventions: Application to neurodegeneration","volume":"179","author":"Iturria-Medina","year":"2018","journal-title":"Neuroimage"},{"key":"10.1016\/j.phytochem.2019.05.014_bib7","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1002\/anie.200802808","article-title":"Alzheimer's disease: From pathology to therapeutic approaches","volume":"48","author":"Jakob-Roetne","year":"2009","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.phytochem.2019.05.014_bib8","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1111\/cbdd.12550","article-title":"Inhibition of acetylcholinesterase (AChE): A potential therapeutic target to treat Alzheimer's disease","volume":"86","author":"Li","year":"2015","journal-title":"Chem. Biol. Drug Des."},{"key":"10.1016\/j.phytochem.2019.05.014_bib9","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1021\/np0501738","article-title":"Sesterterpenoids, Terretonins A\u2212D, and an alkaloid, asterrelenin, from Aspergillus terreus","volume":"68","author":"Li","year":"2005","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2019.05.014_bib10","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1523\/JNEUROSCI.4129-14.2015","article-title":"The potent BACE1 inhibitor LY2886721 elicits robust central Abeta pharmacodynamic responses in mice, dogs, and humans","volume":"35","author":"May","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.phytochem.2019.05.014_bib11","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3233\/JAD-140219","article-title":"Cholinesterase inhibition in Alzheimer's disease: Is specificity the answer?","volume":"42","author":"Macdonald","year":"2014","journal-title":"J. Alzheimer's Dis."},{"key":"10.1016\/j.phytochem.2019.05.014_bib12","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1039\/C5NP00090D","article-title":"Biosynthesis of fungal meroterpenoids","volume":"33","author":"Matsuda","year":"2016","journal-title":"Nat. Prod. Rep."},{"key":"10.1016\/j.phytochem.2019.05.014_bib13","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1074\/jbc.M208888200","article-title":"Usage of tautomycetin, a novel inhibitor of protein phosphatase 1 (PP1), reveals that PP1 is a positive regulator of Raf-1 in vivo","volume":"278","author":"Mitsuhashi","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.phytochem.2019.05.014_bib14","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neurobiolaging.2014.06.021","article-title":"Cortical pyroglutamate amyloid-beta levels and cognitive decline in Alzheimer's disease","volume":"36","author":"Pivtoraiko","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.phytochem.2019.05.014_bib15","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1021\/acs.jmedchem.7b00393","article-title":"BACE-1 inhibitors: From recent single-target molecules to multitarget compounds for Alzheimer's disease","volume":"61","author":"Prati","year":"2018","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.phytochem.2019.05.014_bib16","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1021\/acs.jnatprod.7b00438","article-title":"3,5-Dimethylorsellinic acid derived meroterpenoids from Penicillium chrysogenum MT-12, an endophytic fungus isolated from Huperzia serrata","volume":"80","author":"Qi","year":"2017","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2019.05.014_bib17","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1021\/acs.jnatprod.7b01050","article-title":"BACE1 inhibitory meroterpenoids from Aspergillus terreus","volume":"81","author":"Qi","year":"2018","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.phytochem.2019.05.014_bib18","doi-asserted-by":"crossref","first-page":"9046","DOI":"10.1039\/C8OB02741B","article-title":"New 3,5-dimethylorsellinic acid-based meroterpenoids with BACE1 and AchE inhibitory activities from Aspergillus terreus","volume":"16","author":"Qi","year":"2018","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.phytochem.2019.05.014_bib19","doi-asserted-by":"crossref","first-page":"6563","DOI":"10.1039\/C6SC02464E","article-title":"Asperterpenes A and B, two unprecedented meroterpenoids from Aspergillus terreus with BACE1 inhibitory activities","volume":"7","author":"Qi","year":"2016","journal-title":"Chem. Sci."},{"key":"10.1016\/j.phytochem.2019.05.014_bib20","doi-asserted-by":"crossref","first-page":"4336","DOI":"10.1016\/j.ejmech.2011.07.004","article-title":"Multi-target strategy to address Alzheimer's disease: Design, synthesis and biological evaluation of new tacrine-based dimers","volume":"46","author":"Rizzo","year":"2011","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.phytochem.2019.05.014_bib21","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ejmech.2013.09.050","article-title":"Acetylcholinesterase inhibitors as Alzheimer therapy: From nerve toxins to neuroprotection","volume":"70","author":"Singh","year":"2013","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.phytochem.2019.05.014_bib22","doi-asserted-by":"crossref","first-page":"94","DOI":"10.3390\/md16030094","article-title":"Anti-BACE1 and antimicrobial activities of steroidal compounds isolated from marine Urechis unicinctus","volume":"16","author":"Zhu","year":"2018","journal-title":"Mar. Drugs"}],"container-title":["Phytochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942219300433?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0031942219300433?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T18:38:22Z","timestamp":1758479902000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0031942219300433"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":22,"alternative-id":["S0031942219300433"],"URL":"https:\/\/doi.org\/10.1016\/j.phytochem.2019.05.014","relation":{},"ISSN":["0031-9422"],"issn-type":[{"value":"0031-9422","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-BACE1 and anti-AchE activities of undescribed spiro-dioxolane-containing meroterpenoids from the endophytic fungus Aspergillus terreus Thom","name":"articletitle","label":"Article Title"},{"value":"Phytochemistry","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.phytochem.2019.05.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"112041"}}